Firemaster® 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Pparγ) on the adipocyte protein 2 (aP2) promoter

PLoS ONE

Volumn 12, Issue 4, 2017, Pages

  Tung, Emily W Y ^a   Ahmed, Shaimaa ^a   Peshdary, Vian ^a   Atlas, Ella ^a  

^a HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2 ETHYLHEXYL 2,3,4,5 TERTRABROMOBENZOATE; ADIPOCYTE PROTEIN 2; BIS(2 ETHYLHEXYL)TETRABROMOPHTHALATE; CELL MARKER; FLAME RETARDANT; ISOPROPYLATED TRIPHENYL PHOSPHATE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHORUS DERIVATIVE; TRANSCRIPTION FACTOR; TRIPHENYL PHOSPHATE; UNCLASSIFIED DRUG; FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; FIREMASTER 550; ORGANOPHOSPHATE; POLYBROMINATED BIPHENYL;

3T3 CELL LINE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; LIPID STORAGE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; 3T3-L1 CELL LINE; ADIPOCYTE; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; TRANSCRIPTION INITIATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID-BINDING PROTEINS; MICE; ORGANOPHOSPHATES; POLYBROMINATED BIPHENYLS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 85018604736     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0175855     Document Type: Article

References (44)

1. Boucher JG, Ahmed S, Atlas E. Bisphenol S Induces Adipogenesis in Primary Human Preadipocytes From Female Donors. Endocrinology. 2016; 157: 1397-1407. https://doi.org/10.1210/en.2015-1872 PMID: 27003841
2. Tung EWY, Boudreau A, Wade MG, Atlas E. Induction of Adipocyte Differentiation by Polybrominated Diphenyl Ethers (PBDEs) in 3T3-L1 Cells. PLoS One. 2014; 9: e94583. https://doi.org/10.1371/journal. pone.0094583 PMID: 24722056
3. Tung EWY, Yan H, Lefèvre PLC, Berger RG, Rawn DFK, Gaertner DW, et al. Gestational and Early Postnatal Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants: General Toxicity and Skeletal Variations. Birth Defects Res B Dev Reprod Toxicol. 2016; 107: 157-168. https:// doi.org/10.1002/bdrb.21180 PMID: 27286044
4. Patisaul HB, Roberts SC, Mabrey N, McCaffrey KA, Gear RB, Braun J, et al. Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment. J Biochem Mol Toxicol. 2013; 27: 124-136. https://doi.org/10.1002/jbt.21439 PMID: 23139171
5. Li X, Ycaza J, Blumberg B. The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes. J Steroid Biochem Mol Biol. 2011; 127: 9-15. http://dx.doi.org/10.1016/j.jsbmb.2011.03.012. PMID: 21397693
6. Biasiotto G, Zanella I, Masserdotti A, Pedrazzani R, Papa M, Caimi L, et al. Municipal wastewater affects adipose deposition in male mice and increases 3T3-L1 cell differentiation. Toxicol Appl Pharmacol. 2016; 297: 32-40. http://dx.doi.org/10.1016/j.taap.2016.02.023. PMID: 26944108
7. Hauner H. Complete Adipose Differentiation of 3T3 LI Cells in a Chemically Defined Medium: Comparison to Serum-Containing Culture Conditions. Endocrinology. 1990; 127: 865-872. https://doi.org/10. 1210/endo-127-2-865 PMID: 1695570
8. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, et al. A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis. Mol Endocrinol. 2005; 19: 2437-2450. https://doi.org/10.1210/me.2004-0539 PMID: 16051663
9. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 1994; 79: 1147-1156. http://dx.doi.org/10.1016/0092-8674(94)90006-X. PMID: 8001151
10. Tang QQ, Lane MD. Adipogenesis: From Stem Cell to Adipocyte. Annu Rev Biochem. 2012; 81: 715-736. https://doi.org/10.1146/annurev-biochem-052110-115718 PMID: 22463691
11. Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006; 7: 885-896. https://doi.org/10.1038/nrm2066 PMID: 17139329
12. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, et al. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa. Nucleic Acids Res. 1994; 22: 5628-5634. PMID: 7838715
13. Smathers RL, Petersen DR. The human fatty acid-binding protein family: Evolutionary divergences and functions. Hum Genomics. 2011; 5: 170-191. https://doi.org/10.1186/1479-7364-5-3-170 PMID: 21504868
14. Makowski L, Hotamisligil G. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Curr Opin Lipidol. 2005; 16: 543-548. PMID: 16148539
15. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, et al. A genetic variant at the fatty acidbinding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA. 2006; 103: 6970-6975. https://doi.org/10.1073/pnas.0602178103 PMID: 16641093
16. McGee SP, Konstantinov A, Stapleton HM, Volz DC. Aryl Phosphate Esters Within a Major PentaBDE Replacement Product Induce Cardiotoxicity in Developing Zebrafish Embryos: Potential Role of the Aryl Hydrocarbon Receptor. Toxicol Sci. 2013; 133: 144-156. https://doi.org/10.1093/toxsci/kft020 PMID: 23377616
17. Stapleton HM, Allen JG, Kelly SM, Konstantinov A, Klosterhaus S, Watkins D, et al. Alternate and New Brominated Flame Retardants Detected in U.S. House Dust. Environ Sci Technol. 2008; 42: 6910-6916. PMID: 18853808
18. Mendelsohn E, Hagopian A, Hoffman K, Butt CM, Lorenzo A, Congleton J, et al. Nail polish as a source of exposure to triphenyl phosphate. Environ Int. 2016; 86: 45-51. http://dx.doi.org/10.1016/j.envint. 2015.10.005. PMID: 26485058
19. Andersson PL, Öberg K, Örn U. Chemical characterization of brominated flame retardants and identification of structurally representative compounds. Environ Toxicol Chem. 2006; 25: 1275-1282. PMID: 16704058
20. Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. Effects of triaryl phosphates on mouse and human nuclear receptors. Biochem Pharmacol. 2004; 67: 97-106. http://dx.doi.org/10.1016/j.bcp. 2003.08.037. PMID: 14667932
21. Stapleton HM, Klosterhaus S, Keller A, Ferguson PL, van Bergen S, Cooper E, et al. Identification of Flame Retardants in Polyurethane Foam Collected from Baby Products. Environ Sci Technol. 2011; 45: 5323-5331. https://doi.org/10.1021/es2007462 PMID: 21591615
22. Hoffman K, Garantziotis S, Birnbaum LS, Stapleton HM. Monitoring Indoor Exposure to Organophosphate Flame Retardants: Hand Wipes and House Dust. Environ Health Perspect. 2015; 123: 160-165. https://doi.org/10.1289/ehp.1408669 PMID: 25343780
23. Wei G, Li D, Zhuo M, Liao Y, Xie Z, Guo T, et al. Organophosphorus flame retardants and plasticizers: Sources, occurrence, toxicity and human exposure. Environ Pollut. 2015; 196: 29-46. http://dx.doi.org/ 10.1016/j.envpol.2014.09.012. PMID: 25290907
24. Matthews J, Wihlén B, Heldring N, MacPherson L, Helguero L, Treuter E, et al. Co-planar 3, 3', 4, 4', 5- pentachlorinated biphenyl and non-co-planar 2, 2', 4, 6, '-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes. Biochem J. 2007; 406: 343-353. https://doi.org/10.1042/BJ20070585 PMID: 17511620
25. Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, et al. Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust. Environ Health Perspect. 2012; 120: 1711-1719. https://doi.org/10.1289/ehp.1204932 PMID: 23014847
26. Ogden CL, Carroll MD, Kit BK, Flegal KM. PRevalence of childhood and adult obesity in the united states, 2011-2012. JAMA. 2014; 311: 806-814. https://doi.org/10.1001/jama.2014.732 PMID: 24570244
27. Holtcamp W. Obesogens: An Environmental Link to Obesity. Environ Health Perspect. 2012; 120: a62-a68. https://doi.org/10.1289/ehp.120-a62 PMID: 22296745
28. Janesick A, Blumberg B. Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity. Birth Defects Res C Embryo Today. 2011; 93: 34-50. https://doi.org/10.1002/ bdrc.20197 PMID: 21425440
29. Grün F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, et al. Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates. Mol Endocrinol. 2006; 20: 2141-2155. https://doi.org/10.1210/me.2005-0367 PMID: 16613991
30. Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, et al. Ligand Binding and Activation of PPARγ by Firemaster® 550: Effects on Adipogenesis and Osteogenesis in Vitro. Environ Health Perspect. 2014; 122: 1225-1232. https://doi.org/10.1289/ehp.1408111 PMID: 25062436
31. Yang W, Deeb SS. Sp1 and Sp3 transactivate the human lipoprotein lipase gene promoter through binding to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant. J Lipid Res. 1998; 39: 2054-2064. PMID: 9788252
32. Kimmel AR, Sztalryd C. The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis. Annu Rev Nutr. 2016; 36: 471-509. https://doi.org/10.1146/annurev-nutr-071813-105410 PMID: 27431369
33. Roberts SC, Macaulay LJ, Stapleton HM. In Vitro Metabolism of the Brominated Flame Retardants 2- Ethylhexyl-2, 3, 4, 5-Tetrabromobenzoate (TBB) and Bis(2-ethylhexyl) 2, 3, 4, 5-Tetrabromophthalate (TBPH) in Human and Rat Tissues. Chem Res Toxicol. 2012; 25: 1435-1441. https://doi.org/10.1021/ tx300086x PMID: 22575079
34. Rosen ED, Hsu C, Wang X, Sakai S, Freeman MW, Gonzalez FJ, et al. C/EBPα induces adipogenesis through PPARγ: a unified pathway. Genes Dev. 2002; 16: 22-26. https://doi.org/10.1101/gad.948702 PMID: 11782441
35. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000; 14: 1293-1307. PMID: 10837022
36. Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008; 7: 489-503. https://doi.org/10.1038/nrd2589 PMID: 18511927
37. Feige JN, Gelman L, Rossi D, Zoete V, Mé tivier R, Tudor C, et al. The Endocrine Disruptor Monoethylhexyl- phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis. J Biol Chem. 2007; 282: 19152-19166. https://doi.org/10.1074/jbc.M702724200 PMID: 17468099
38. Bakillah A, Hussain MM. Mice subjected to aP2-Cre mediated ablation of microsomal triglyceride transfer protein are resistant to high fat diet induced obesity. Nutr Metab (Lond). 2016; 13: 1.
39. Ikonomov OC, Sbrissa D, Delvecchio K, Rillema JA, Shisheva A. Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiol Rep. 2016; 4: e12812-n/a. https://doi.org/10.14814/phy2.12812 PMID: 27273882
40. Meeker JD, Stapleton HM. House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters. Environ Health Perspect. 2009; 118: 318-323.
41. Mizouchi S, Ichiba M, Takigami H, Kajiwara N, Takamuku T, Miyajima T, et al. Exposure assessment of organophosphorus and organobromine flame retardants via indoor dust from elementary schools and domestic houses. Chemosphere. 2015; 123: 17-25. http://dx.doi.org/10.1016/j.chemosphere.2014.11.028. PMID: 25532762
42. Peng H, Saunders DMV, Sun J, Codling G, Wiseman S, Jones PD, et al. Detection, Identification, and Quantification of Hydroxylated Bis(2-ethylhexyl)-Tetrabromophthalate Isomers in House Dust. Environ Sci Technol. 2015; 49: 2999-3006. https://doi.org/10.1021/es505743d PMID: 25621784
43. Hoffman K, Fang M, Horman B, Patisaul HB, Garantziotis S, Birnbaum LS, et al. Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster® 550. Environ Health Perspect. 2014; 122: 963-969. https://doi.org/10.1289/ehp.1308028 PMID: 24823833
44. Liu L, Salamova A, He K, Hites RA. Analysis of polybrominated diphenyl ethers and emerging halogenated and organophosphate flame retardants in human hair and nails. J Chromatogr A. 2015; 1406: 251-257. http://dx.doi.org/10.1016/j.chroma.2015.06.003. PMID: 26122855