Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4

Molecular Vision

Volumn 23, Issue , 2017, Pages 185-197

  Du, Mei ^a,c   Martin, Ashley ^a,c   Hays, Franklin ^a,c   Johnson, Jennifer ^a   Farjo, Rafal A ^b   Farjo, Krysten M ^a,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b EyeCRO LLC   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PREALBUMIN; RESATORVID; RETINOL BINDING PROTEIN 4; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; VASCULAR CELL ADHESION MOLECULE 1; NEUTRALIZING ANTIBODY; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN; RBP4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN RETINAL MICROVASCULAR ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOSTASIS; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY; RETINA NERVE CELL;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PREALBUMIN; RETINAL NEURONS; RETINOL-BINDING PROTEINS, PLASMA; TOLL-LIKE RECEPTOR 4;

EID: 85018509468     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (86)

1. Aeberli I, Biebinger R, Lehmann R, L’Allemand D, Spinas GA, Zimmermann MB. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab 2007; 92:4359-65. [PMID: 17726085].
2. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006; 354:2552-63. [PMID: 16775236].
3. Bremer AA, Devaraj S, Afify A, Jialal I. Adipose tissue dysregulation in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96:E1782-8. [PMID: 21865369].
4. Kowalska I, Straczkowski M, Adamska A, Nikolajuk A, Karczewska-Kupczewska M, Otziomek E, Gorska M. Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. J Clin Endocrinol Metab 2008; 93:2786-9. [PMID: 18430770].
5. Mostafaie N, Sebesta C, Zehetmayer S, Jungwirth S, Huber KR, Hinterberger M, Leitha T, Hofman J, Hejtman M, Schrattbauer K, Krugluger W, Tragl KH, Fischer P. Circulating retinol-binding protein 4 and metabolic syndrome in the elderly. Wien Med Wochenschr 2011; 161:505-10. [PMID: 21442217].
6. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005; 436:356-62. [PMID: 16034410].
7. Bobbert T, Raila J, Schwarz F, Mai K, Henze A, Pfeiffer AF, Schweigert FJ, Spranger J. Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness. Atherosclerosis 2010; 213:549-51. [PMID: 20832065].
8. Ingelsson E, Sundstrom J, Melhus H, Michaelsson K, Berne C, Vasan RS, Riserus U, Blomhoff R, Lind L, Arnlov J. Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. Atherosclerosis 2009; 206:239-44. [PMID: 19339013].
9. Sasaki M, Otani T, Kawakami M, Ishikawa SE. Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction. Metabolism 2010; 59:527-32. [PMID: 19846170].
10. Solini A, Santini E, Madec S, Rossi C, Muscelli E. Retinol-binding protein-4 in women with untreated essential hypertension. Am J Hypertens 2009; 22:1001-6. [PMID: 19556974].
11. Bobbert P, Weithauser A, Andres J, Bobbert T, Kuhl U, Schultheiss HP, Rauch U, Skurk C. Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy. Eur J Heart Fail 2009; 11:1163-8. [PMID: 19926600].
12. Li ZZ, Lu XZ, Liu JB, Chen L. Serum retinol-binding protein 4 levels in patients with diabetic retinopathy. J Int Med Res 2010; 38:95-9. [PMID: 20233518].
13. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab 2007; 92:2712-9. [PMID: 17440021].
14. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase-and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol 2012; 32:5103-15. [PMID: 23071093].
15. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase-and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism. Mol Cell Biol 2012; 32:2010-9. [PMID: 22431523].
16. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab 2014; 19:512-26. [PMID: 24606904].
17. Chan CB, Liu X, Ensslin MA, Dillehay DL, Ormandy CJ, Sohn P, Serra R, Ye K. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J 2010; 29:956-68. [PMID: 20075866].
18. Quadro L, Blaner WS, Hamberger L, Van Gelder RN, Vogel S, Piantedosi R, Gouras P, Colantuoni V, Gottesman ME. Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice. J Biol Chem 2002; 277:30191-7. [PMID: 12048218].
19. Kawai T, Akira S. TLR signaling. Semin Immunol 2007; 19:24-32. [PMID: 17275323].
20. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511. [PMID: 15229469].
21. Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 2008; 584:40-8. [PMID: 18299127].
22. Matsunaga N, Tsuchimori N, Matsumoto T, Ii M. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol 2011; 79:34-41. [PMID: 20881006].
23. Peroval MY, Boyd AC, Young JR, Smith AL. A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. PLoS One 2013; 8:e51243-[PMID: 23405061].
24. Du M, Otalora L, Martin AA, Moiseyev G, Vanlandingham P, Wang Q, Farjo R, Yeganeh A, Quiambao A, Farjo KM. Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol Cell Biol 2015; 35:2771-89. [PMID: 26055327].
25. Raz A, Shiratori T, Goodman DS. Studies on the protein-protein and protein-ligand interactions involved in retinol transport in plasma. J Biol Chem 1970; 245:1903-12. [PMID: 4985906].
26. Hyung SJ, Deroo S, Robinson CV. Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex. ACS Chem Biol 2010; 5:1137-46. [PMID: 20845945].
27. Berry DC, Croniger CM, Ghyselinck NB, Noy N. Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6. Mol Cell Biol 2012; 32:3851-9. [PMID: 22826435].
28. Myron Johnson A, Merlini G, Sheldon J, Ichihara K. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition. Clin Chem Lab Med 2007; 45:419-26. [PMID: 17378745].
29. Li ZZ, Lu XZ, Liu JB, Chen L. Serum Retinol-Binding Protein 4 Levels in Patients with Diabetic Retinopathy. J Int Med Res 2010; 38:95-9. [PMID: 20233518].
30. Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, Esposito C, Hegarty H, Hurley W, Clauss M, Wang F, Pan YE, Tsang TC, Stern D. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem 1992; 267:14987-97. [PMID: 1321822].
31. Xie J, Mendez JD, Mendez-Valenzuela V, Aguilar-Hernandez MM. Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal 2013; 25:2185-97. [PMID: 23838007].
32. Harja E, Bu DX, Hudson BI, Chang JS, Shen X, Hallam K, Kalea AZ, Lu Y, Rosario RH, Oruganti S, Nikolla Z, Belov D, Lalla E, Ramasamy R, Yan SF, Schmidt AM. Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE−/− mice. J Clin Invest 2008; 118:183-94. [PMID: 18079965].
33. Yeh CH, Sturgis L, Haidacher J, Zhang XN, Sherwood SJ, Bjercke RJ, Juhasz O, Crow MT, Tilton RG, Denner L. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion. Diabetes 2001; 50:1495-504. [PMID: 11375353].
34. Ibrahim ZA, Armour CL, Phipps S, Sukkar MB. RAGE and TLRs: relatives, friends or neighbours? Mol Immunol 2013; 56:739-44. [PMID: 23954397].
35. Song PI, Abraham TA, Park Y, Zivony AS, Harten B, Edelhauser HF, Ward SL, Armstrong CA, Ansel JC. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci 2001; 42:2867-77. [PMID: 11687531].
36. Johnson AC, Heinzel FP, Diaconu E, Sun Y, Hise AG, Golenbock D, Lass JH, Pearlman E. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci 2005; 46:589-95. [PMID: 15671286].
37. Brito BE, Zamora DO, Bonnah RA, Pan Y, Planck SR, Rosenbaum JT. Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. Exp Eye Res 2004; 79:203-8. [PMID: 15325567].
38. Chang JH, McCluskey P, Wakefield D. Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen-presenting cells in the human uvea. Invest Ophthalmol Vis Sci 2004; 45:1871-8. [PMID: 15161852].
39. Tu Z, Portillo JA, Howell S, Bu H, Subauste CS, Al-Ubaidi MR, Pearlman E, Lin F. Photoreceptor cells constitutively express functional TLR4. J Neuroimmunol 2011; 230:183-7. [PMID: 20801528].
40. Kumar A, Shamsuddin N. Retinal Muller glia initiate innate response to infectious stimuli via toll-like receptor signaling. PLoS One 2012; 7:e29830-[PMID: 22253793].
41. Lin S, Liang Y, Zhang J, Bian C, Zhou H, Guo Q, Xiong Y, Li S, Su B. Microglial TIR-domain-containing adapter-inducing interferon-beta (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-kappaB. J Neuroinflammation 2012; 9:39-[PMID: 22361049].
42. Ko MK, Saraswathy S, Parikh JG, Rao NA. The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest Ophthalmol Vis Sci 2011; 52:5824-35. [PMID: 21666244].
43. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem 2013; 288:15326-41. [PMID: 23572532].
44. Qi Y, Zhao M, Bai Y, Huang L, Yu W, Bian Z, Zhao M, Li X. Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes. Invest Ophthalmol Vis Sci 2014; 55:5466-75. [PMID: 25097240].
45. Ishizuka F, Shimazawa M, Inoue Y, Nakano Y, Ogishima H, Nakamura S, Tsuruma K, Tanaka H, Inagaki N, Hara H. Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappaB and spleen tyrosine kinase activation. Invest Ophthalmol Vis Sci 2013; 54:5807-16. [PMID: 23908181].
46. Stitt AW. The role of advanced glycation in the pathogenesis of diabetic retinopathy. Exp Mol Pathol 2003; 75:95-108. [PMID: 12834631].
47. Stitt AW. AGEs and diabetic retinopathy. Invest Ophthalmol Vis Sci 2010; 51:4867-74. [PMID: 20876889].
48. Zong H, Ward M, Stitt AW. AGEs, RAGE, and diabetic retinopathy. Curr Diab Rep 2011; 11:244-52. [PMID: 21590515].
49. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27:283-90. [PMID: 12657367].
50. Barber AJ. Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss. Science China 2015; 58:541-9. [PMID: 25951929].
51. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 2005; 46:2210-8. [PMID: 15914643].
52. Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest 1998; 102:783-91. [PMID: 9710447].
53. Bearse MA Jr, Adams AJ, Han Y, Schneck ME, Ng J, Bronson-Castain K, Barez S. A multifocal electroretinogram model predicting the development of diabetic retinopathy. Prog Retin Eye Res 2006; 25:425-48. [PMID: 16949855].
54. Bearse MA Jr, Han Y, Schneck ME, Adams AJ. Retinal function in normal and diabetic eyes mapped with the slow flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 2004; 45:296-304. [PMID: 14691187].
55. Bearse MA Jr, Han Y, Schneck ME, Barez S, Jacobsen C, Adams AJ. Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthalmol Vis Sci 2004; 45:3259-65. [PMID: 15326149].
56. Bresnick GH. Diabetic retinopathy viewed as a neurosensory disorder. Arch Ophthalmol 1986; 104:989-90. [PMID: 3729794].
57. Bresnick GH, Condit RS, Palta M, Korth K, Groo A, Syrjala S. Association of hue discrimination loss and diabetic retinopathy. Arch Ophthalmol 1985; 103:1317-24. [PMID: 4038123].
58. Bresnick GH, Korth K, Groo A, Palta M. Electroretinographic oscillatory potentials predict progression of diabetic retinopathy. Preliminary report. Arch Ophthalmol 1984; 102:1307-11. [PMID: 6383303].
59. Bresnick GH, Palta M. Predicting progression to severe proliferative diabetic retinopathy. Arch Ophthalmol 1987; 105:810-4. [PMID: 3579713].
60. Bresnick GH, Palta M. Temporal aspects of the electroretinogram in diabetic retinopathy. Arch Ophthalmol 1987; 105:660-4. [PMID: 3619742].
61. Di Leo MA, Falsini B, Caputo S, Ghirlanda G, Porciatti V, Greco AV. Spatial frequency-selective losses with pattern electroretinogram in type 1 (insulin-dependent) diabetic patients without retinopathy. Diabetologia 1990; 33:726-30. [PMID: 2073985].
62. Falsini B, Porciatti V, Scalia G, Caputo S, Minnella A, Di Leo MA, Ghirlanda G. Steady-state pattern electroretinogram in insulin-dependent diabetics with no or minimal retinopathy. Doc Ophthalmol 1989; 73:193-200. [PMID: 2638628].
63. Ghirlanda G, Di Leo MA, Caputo S, Cercone S, Greco AV. From functional to microvascular abnormalities in early diabetic retinopathy. Diabetes Metab Rev 1997; 13:15-35. [PMID: 9134346].
64. Greenstein VC, Shapiro A, Zaidi Q, Hood DC. Psychophysical evidence for post-receptoral sensitivity loss in diabetics. Invest Ophthalmol Vis Sci 1992; 33:2781-90. [PMID: 1526727].
65. Han Y, Adams AJ, Bearse MA Jr, Schneck ME. Multifocal electroretinogram and short-wavelength automated perimetry measures in diabetic eyes with little or no retinopathy. Arch Ophthalmol 2004; 122:1809-15. [PMID: 15596584].
66. Han Y, Bearse MA Jr, Schneck ME, Barez S, Jacobsen CH, Adams AJ. Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci 2004; 45:948-54. [PMID: 14985316].
67. Han Y, Schneck ME, Bearse MA Jr, Barez S, Jacobsen CH, Jewell NP, Adams AJ. Formulation and evaluation of a predictive model to identify the sites of future diabetic retinopathy. Invest Ophthalmol Vis Sci 2004; 45:4106-12. [PMID: 15505062].
68. Hombrebueno JR, Chen M, Penalva RG, Xu H. Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse. PLoS One 2014; 9:e97970-[PMID: 24848689].
69. Lieth E, LaNoue KF, Antonetti DA, Ratz M. Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group. Exp Eye Res 2000; 70:723-30. [PMID: 10843776].
70. Mizutani M, Gerhardinger C, Lorenzi M. Muller cell changes in human diabetic retinopathy. Diabetes 1998; 47:445-9. [PMID: 9519752].
71. Rungger-Brandle E, Dosso AA, Leuenberger PM. Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci 2000; 41:1971-80. [PMID: 10845624].
72. VanGuilder HD, Brucklacher RM, Patel K, Ellis RW, Freeman WM, Barber AJ. Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina. Eur J Neurosci 2008; 28:1-11. [PMID: 18662330].
73. Zeng HY, Green WR, Tso MO. Microglial activation in human diabetic retinopathy. Arch Ophthalmol 2008; 126:227-32. [PMID: 18268214].
74. Zeng XX, Ng YK, Ling EA. Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci 2000; 17:463-71. [PMID: 10910112].
75. Stuck BJ, Kahn BB. Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis? Am J Hypertens 2009; 22:948-9. [PMID: 19701163].
76. Bogdanov P, Corraliza L, Villena JA, Carvalho AR, Garcia-Arumi J, Ramos D, Ruberte J, Simo R, Hernandez C. The db/db mouse: a useful model for the study of diabetic retinal neurodegeneration. PLoS One 2014; 9:e97302-[PMID: 24837086].
77. Bogdanov P, Hernandez C, Corraliza L, Carvalho AR, Simo R. Effect of fenofibrate on retinal neurodegeneration in an experimental model of type 2 diabetes. Acta Diabetol 2015; 52:113-22. [PMID: 25029994].
78. Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK. Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 2005; 54:3119-25. [PMID: 16249434].
79. Clements RS Jr, Robison WG Jr, Cohen MP. Anti-glycated albumin therapy ameliorates early retinal microvascular pathology in db/db mice. J Diabetes Complications 1998; 12:28-33. [PMID: 9442812].
80. Midena E, Segato T, Radin S, di Giorgio G, Meneghini F, Piermarocchi S, Belloni AS. Studies on the retina of the diabetic db/db mouse. I. Endothelial cell-pericyte ratio. Ophthalmic Res 1989; 21:106-11. [PMID: 2734001].
81. Yang Q, Xu Y, Xie P, Cheng H, Song Q, Su T, Yuan S, Liu Q. Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes. J Ophthalmol 2015; 2015:757412-[PMID: 25821591].
82. Feit-Leichman RA, Kinouchi R, Takeda M, Fan Z, Mohr S, Kern TS, Chen DF. Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes. Invest Ophthalmol Vis Sci 2005; 46:4281-7. [PMID: 16249509].
83. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18:1450-2. [PMID: 15231732].
84. Lai AK, Lo AC. Animal models of diabetic retinopathy: summary and comparison. J Diabetes Res 2013; 2013:106594-[PMID: 24286086].
85. Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, Campbell-Thompson M, Jarajapu YP, Lei B, Hauswirth WW. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci 2010; 51:5240-6. [PMID: 20435587].
86. Tang J, Allen Lee C, Du Y, Sun Y, Pearlman E, Sheibani N, Kern TS. MyD88-dependent pathways in leukocytes affect the retina in diabetes. PLoS One 2013; 8:e68871-[PMID: 23874797].