Retinal ischemia/reperfusion injury is mediated by tolllike receptor 4 activation of NLRP3 inflammasomes

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 9, 2014, Pages 5466-5475

  Qi, Yun ^a   Zhao, Min ^a   Bai, Yujing ^a   Huang, Lvzhen ^a   Yu, Wenzhen ^a   Bian, Zongmei ^b   Zhao, Mingwei ^a   Li, Xiaoxin ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

IL 18; IL 1 ; Inflammasomes; Ischemia reperfusion; Retina; Toll like receptor 4

Indexed keywords

APOPTOSIS REPRESSOR WITH CASPASE RECRUITMENT DOMAIN; CASPASE 3; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; KETAMINE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; XYLAZINE; BIOLOGICAL MARKER; CELL RECEPTOR; NOD LIKE RECEPTOR 3, RAT; NOD-LIKE RECEPTOR 3, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BROWN NORWAY RAT; CELL DEATH; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EYE FUNDUS; EYE PHOTOGRAPHY; FAR WESTERN BLOTTING; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REPERFUSION INJURY; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA GANGLION CELL; RETINA ISCHEMIA; SUPERIOR COLLICULUS; VISUAL SYSTEM FUNCTION; VITREOUS BODY; ANIMAL; CELL MEMBRANE; CYTOPLASM; IL-1Β; ISCHEMIA-REPERFUSION; METABOLISM; PHYSIOLOGY; RETINA; RETINA DISEASE; SIGNAL TRANSDUCTION;

IL-18; IL-1Β; INFLAMMASOMES; ISCHEMIA-REPERFUSION; RETINA; TOLL-LIKE RECEPTOR 4;

ANIMALS; BIOLOGICAL MARKERS; CELL MEMBRANE; CYTOPLASM; IMMUNOHISTOCHEMISTRY; INFLAMMASOMES; MALE; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, PATTERN RECOGNITION; REPERFUSION INJURY; RETINAL DISEASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84908108210     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-14380     Document Type: Article

References (25)

1. Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J. Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res. 2004; 23:91–147.
2. Baker ML, Hand PJ, Wang JJ, Wong TY. Retinal signs and stroke: revisiting the link between the eye and brain. Stroke. 2008;39: 1371–1379.
3. Durukan A, Tatlisumak T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav. 2007;87:179–197.
4. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805–820.
5. Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev. 2009;227:221–233.
6. Wang YC, Lin S, Yang QW. Toll-like receptors in cerebral ischemic inflammatory injury. J Neuroinflammation. 2011;8: 134.
7. Dvoriantchikova G, Barakat DJ, Hernandez E, Shestopalov VI, Ivanov D. Toll-like receptor 4 contributes to retinal ischemia/ reperfusion injury. Mol Vis. 2010;16:1907–1912.
8. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22: 240–273; Table of Contents.
9. Horvath GL, Schrum JE, De Nardo CM, Latz E. Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev. 2011;243:119–135.
10. Gross O, Thomas CJ, Guarda G, Tschopp J. The inflammasome: an integrated view. Immunol Rev. 2011;243:136–151.
11. Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 2012;481:278–286.
12. Kingeter LM, Lin X. C-type lectin receptor-induced NF-kappaB activation in innate immune and inflammatory responses. Cell Mol Immunol. 2012;9:105–112.
13. D’Onofrio PM, Koeberle PD. What can we learn about stroke from retinal ischemia models? Acta Pharmacol Sin. 2013;34: 91–103.
14. Jehle T, Wingert K, Dimitriu C, et al. Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology. Invest Ophthalmol Vis Sci. 2008;49:1056–1064.
15. Hata N, Oshitari T, Yokoyama A, Mitamura Y, Yamamoto S. Increased expression of IRE1alpha and stress-related signal transduction proteins in ischemia-reperfusion injured retina. Clin Ophthalmol. 2008;2:743–752.
16. Walsh JG, Muruve DA, Power C. Inflammasomes in the CNS. Nat Rev Neurosci. 2014;15:84–97.
17. Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140: 821–832.
18. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10: 417–426.
19. Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol. 2009;296:H1–H12.
20. Tang J, Allen Lee C, Du Y, et al. MyD88-dependent pathways in leukocytes affect the retina in diabetes. PLoS One. 2013;8: e68871.
21. Shamsuddin N, Kumar A. TLR2 mediates the innate response of retinal Muller glia to Staphylococcus aureus. J Immunol. 2011;186:7089–7097.
22. Lamkanfi M, Dixit VM. Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol. 2012;28:137–161.
23. Leemans JC, Cassel SL, Sutterwala FS. Sensing damage by the NLRP3 inflammasome. Immunol Rev. 2011;243:152–162.
24. Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 2009;10:241–247.
25. Inoue M, Williams KL, Gunn MD, Shinohara ML. NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Nat Acad Sci U S A. 2012;109:10480–10485.