Caulerpa lentillifera inhibits protein-tyrosine phosphatase 1B and protects pancreatic beta cell via its insulin mimetic effect

Food Science and Biotechnology

Volumn 26, Issue 2, 2017, Pages 495-499

  Sharma, Bhesh Raj ^a   Kim, Hyun Jung ^a   Rhyu, Dong Young ^a  

^a Mokpo National University   (South Korea)

Author keywords

adipocytes; Caulerpa lentillifera; insulin signaling; pancreatic beta cells; protein tyrosine phosphatase (PTP) 1B

Indexed keywords

ALGAE; AMINO ACIDS; CELL DEATH; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; ENZYME ACTIVITY; ENZYMES; INSULIN; PHOSPHATASES; PROTEINS; SIGNALING;

ADIPOCYTES; CAULERPA LENTILLIFERA; INSULIN SIGNALING; PANCREATIC BETA CELLS; PROTEIN-TYROSINE PHOSPHATASE;

CELL SIGNALING;

EID: 85018466793     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10068-017-0068-4     Document Type: Article

References (16)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 33: S62–S69 (2010)
2. Kahn SE. The relative contributions of insulin resistance and beta cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46: 3–19 (2003)
3. Csorba TR, Lyon AW, Hollenberg MD. Autoimmunity and the pathogenesis of type 1 diabetes. CRC Cr. Rev. Cl. Lab. Sc. 47: 51–71 (2010)
4. Cerf ME. Beta cell dysfunction and insulin resistance. Front. Endocrinol. 4: 37 (2013)
5. Ruiz RF, Vieira E, Garcia-Roves PM, Gomis R. Protein tyrosin phosphatase 1B modulates pancreatic beta cell mass. PLoS ONE 9: e90344 (2014)
6. Johnson TO, Ernolieff J, Jirousek MR. Protein tyrosin phosphatase 1B inhibitors for diabetes. Nat. Rev. Drug Discov. 1: 696–709 (2002)
7. Cragg GM, Newman DJ. Natural products: A continuing source of novel drug leads. Biochim. Biophys. Acta 1830: 3670–3695 (2013)
8. Sharma BR, Rhyu DY. Anti-diabetic effects of Caulerpa lentillifera: Stimulation of insulin secretion in pancreatic beta cells and enhancement of glucose uptake in adipocytes. Asian Pac. J. Trop. Biomed. 4: 575–580 (2014)
9. Sharma BR. Kim HJ, Rhyu DY. Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes. J. Transl. Med. 13: 62 (2015)
10. Sharma BR, Kim MS, Rhyu DY. Nelumbo nucifera leaf extract attenuated pancreatic beta cells toxicity induced by interleukin-1ß and interferon-?, and increased insulin secretion of pancreatic beta cells in sterptozotocin-induced diabetic rats. J. Tradit. Chin. Med. 36: 71–77 (2016)
11. Park CH, Rhyu DY, Sharma BR, Yokazawa T. Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-D-sedoheptulose treatment in 3T3-L1 adipocytes. Biomed. Prev. Nutr. 3: 319–324 (2013)
12. Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM. Reduction of protein tyrosin phosphatase 1B increases insulin dependent signaling in ob/ob mice. Diabetes 52: 21–28 (2003)
13. Davis JA, Sharma S, Mittra S, Sujatha S, Kanaujia A, Shukla G, Katiyar C, Lakshmi BS, Bansa VS, Bhatnagar PK. Antihyperglycemic effect of Annona Squamosa hexane extract in type 2 diabetes animal model: Ptp1B inhibition, a possible mechanism of action? Indian J. Pharmacol. 44: 326–332 (2012)
14. Pirot P, Cardozo AK, Eizirik DL. Mediators and mechanisms of pancreatic beta cell death in type 1 diabetes. Arq. Bras. Endocrinol. Metab. 52: 156–165 (2008)
15. AbouZid SF, Ahmed OM, Ahmed RR, Mahmoud A, Addella E, Ashour MB. Antihyperglycemic effect of crude extracts of some Egyptian plants and algae. J. Med. Food 17: 400–406 (2014).
16. Mackenzie RW, Elliott BT. Akt/PKB activation and insulin signaling: A novel insulin-signaling pathway in the treatment of type 2 diabetes. Diabetes Metab. Syndr. Obes. 7: 55–64 (2014)