Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action

Indian Journal of Pharmacology

Volumn 44, Issue 3, 2012, Pages 326-332

  Davis, Joseph Alex ^a,c   Sharma, Suchitra ^a   Mittra, Shivani ^a   Sujatha, S ^b,d   Kanaujia, Anil ^a,c   Shukla, Gyanesh ^a,c   Katiyar, Chandrakant ^a   Lakshmi, B S ^b   Bansal, Vinay Sheel ^a   Bhatnagar, Pradip Kumar ^a,c  

^a RANBAXY LABORATORIES LTD   (India)

^b ANNA UNIVERSITY   (India)

^c DAIICHI SANKYO CO   (Japan)

^d SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Annona squamosa; insulin mimetics; ob ob mice; OGTT; PTP1B inhibitor; type 2 diabetes mellitus

Indexed keywords

ANNONA SQUAMOSA EXTRACT; CHOLESTEROL; DIPEPTIDYL PEPTIDASE IV; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEXANE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; ROSIGLITAZONE; SIRTUIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANNONA SQUAMOSA; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; GLUCOSE TRANSPORT; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT GAIN;

EID: 84861881199     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.96304     Document Type: Article

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