The Timing of Normal Puberty and the Age Limits of Sexual Precocity: Variations around the World, Secular Trends, and Changes after Migration

Endocrine Reviews

Volumn 24, Issue 5, 2003, Pages 668-693

  Parent, Anne Simone ^a   Teilmann, Grete ^b   Juul, Anders ^b   Skakkebaek, Niels E ^b   Toppari, Jorma ^c   Bourguignon, Jean Pierre ^a,d  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORPHENOTANE; ENDOCRINE DISRUPTOR; HORMONE DERIVATIVE; ORGANOCHLORINE PESTICIDE; POLYBROMINATED BIPHENYL; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG;

ADOLESCENT; ADOPTION; AGE; BODY GROWTH; BREAST DEVELOPMENT; CATCH UP GROWTH; CHILD GROWTH; CHILD NUTRITION; CLIMATE; DEVELOPING COUNTRY; DISEASE MARKER; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ETHNIC DIFFERENCE; GENETIC SUSCEPTIBILITY; GEOGRAPHY; HEREDITY; HUMAN; LIGHT DARK CYCLE; MATERNAL DEPRIVATION; MENARCHE; MIGRATION; NUTRITION; ONSET AGE; PATHOPHYSIOLOGY; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; PUBERTY; REVIEW; SEXUAL MATURATION; SOCIOECONOMICS; STRESS; UNITED STATES; WESTERN EUROPE;

AGE FACTORS; CHILD; CLIMATE; DEVELOPING COUNTRIES; EMIGRATION AND IMMIGRATION; FEMALE; HUMANS; MALE; NUTRITION PHYSIOLOGY; PHOTOPERIOD; PUBERTY; PUBERTY, PRECOCIOUS; STRESS;

EID: 0142248155     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2002-0019     Document Type: Review

References (280)

1. Terasawa E, Fernandez DL 2001 Neurobiological mechanisms of the onset of puberty in primates. Endocr Rev 22:111-151
2. Tanner JM 1962 Growth at adolescence. 2nd ed. Oxford, UK: Blackwell
3. Kaprio J, Rimpela A, Winter T, Viken RJ, Rimpela M, Rose RJ 1995 Common genetic influences on BMI and age at menarche. Hum Biol 67:739-753
4. Van Wieringen JC 1978 Secular growth changes. In: Falkner F, Tanner JM, eds. Human growth. New York: Plenum Press; 445-473
5. Eveleth PB 1978 Population differences in growth: environmental and genetic factors. In Falkner F, Tanner JM, eds. Human growth. New York: Plenum Press; 373-394
6. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM 1997 Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99:505-512
7. NHANES III 1997 NHANES III Reference manuals and reports (CD-ROM). Analytic and reporting guidelines: the Third National Health and Nutrition Examination Survey (1988-94). Hyattsville, MD: National Center for Health Statistics, Centers for Disease Control and Prevention
8. Lee PA, Guo SS, Kulin HE 2001 Age of puberty: data from the United States of America. APMIS 109:81-88
9. Grumbach MM, Styne DM 1998 Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams' textbook of endocrinology. 9th ed. Philadelphia: W.B. Saunders Co; 1509-1625
10. Bridges NA, Christopher JA, Hindmarsh PC, Brook CG 1994 Sexual precocity: sex incidence and aetiology. Arch Dis Child 70: 116-118
11. Proos LA, Hofvander Y, Tuvemo T 1991 Menarcheal age and growth pattern of Indian girls adopted in Sweden. I. Menarcheal age. Acta Paediatr Scand 80:852-858
12. Bourguignon JP, Gerard A, Alvarez Gonzalez ML, Fawe L, Franchimont P 1992 Effects of changes in nutritional conditions on timing of puberty: clinical evidence from adopted children and experimental studies in the male rat. Horm Res 38(Suppl 1):97-105
13. Oostdijk W, Yap YN, Slijper FME, Wit JM, Drop SLS 1996 Puberteit en eindlengte bij uit het buitenland geadopteerde kinderen. Tijdschr Kindergeneeskd 64:39-43
14. Virdis R, Street ME, Zampolli M, Radetti G, Pezzini B, Benelli M, Ghizzoni L, Volta C 1998 Precocious puberty in girls adopted from developing countries. Arch Dis Child 78:152-154
15. de Monleon JV, Geneste B, Huet F 1999 Puberté précoce chez les enfants adoptés, un risque à ne pas oublier. Arch Pediatr 6:589-590
16. Baron S, Battin J, David A, Limal JM 2000 Puberté précoce chez des enfants adoptés de pays étrangers. Arch Pediatr 7:809-816
17. Krstevska-Konstantinova M, Charlier C, Craen M, Du Caju M, Heinrichs C, de Beaufort C, Plomteux G, Bourguignon JP 2001 Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum Reprod 16:1020-1026
18. Teilmann G, Main K, Skakkebaek N, Juul A 2002 High frequency of central precocious puberty in adopted and immigrant children in Denmark. Horm Res 58(Suppl 2):135 (Abstract)
19. Marshall WA, Tanner JM 1970 Variations in the pattern of pubertal changes in boys. Arch Dis Child 46:13-23
20. Tanner JM, Whitehouse RH 1976 Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51:170-179
21. Sklar CA, Kaplan SL, Grumbach MM 1980 Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence. J Clin Endocrinol Metab 51:548-556
22. Palmert MR, Hayden DL, Mansfield MJ, Crigler Jr JF, Crowley Jr WF, Chandler DW, Boepple PA 2001 The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process. J Clin Endocrinol Metab 86:4536-4542
23. Hergenroeder AC, Hill RB, Wong WW, Sangi-Haghpeykar H, Taylor W 1999 Validity of self-assessment of pubertal maturation in African-American and European-American adolescents. J Adolesc Health 24:201-205
24. Berg-Kelly K, Erdes L 1997 Self-assessment of sexual maturity by mid-adolescents based on a global question. Acta Paediatr 86:10-17
25. Marti-Henneberg C, Louw GJ 1995 Average menarcheal age of higher socioeconomic status urban Cape coloured girls assessed by means of status quo and recall methods. Am J Phys Anthropol 96:1-5
26. Koo MM, Rohan TE 1997 Accuracy of short-term recall of age at menarche. Ann Hum Biol 24:61-64
27. Artaria MD, Marti-Henneberg C 2000 Why did they lie? Socioeconomic bias in reporting menarcheal age. Ann Hum Biol 27:561-569
28. de Ridder CM, Thijssen JH, Bruning PF, Van den Brande JL, Zonderland ML, Erich WB 1992 Body fat mass, body fat distribution, and pubertal development: a longitudinal study of physical and hormonal sexual maturation of girls. J Clin Endocrinol Metab 75:442-446
29. Bourguignon JP 1988 Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr Rev 9:467-488
30. Marti-Henneberg C, Vizmanos B 1997 The duration of puberty in girls is related to the timing of its onset. J Pediatr 131:618-621
31. Tanner JM, Davies PSW 1985 Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 107:317-329
32. Carrillo JC, Ireton MJ, Caro LE, Hauspie R, Morales JC, Pagezy H 2001 Growth traits and sexual maturation in a sample of schoolchildren from El Yopal, Casanare, Colombia. Acta Med Auxol 33:105-111
33. Ducros A, Pasquet P 1978 Evolution de l'áge d'apparition des premières règles (ménarche) en France. Biometrie Humaine 13: 35-43
34. Warren MP 1983 Effects of undernutrition on reproductive function in the human. Endocr Rev 4:363-377
35. Mac Mahon B 1973 Age at menarche, United States. DHEW Pub. no. (HRA) 74-1615 Natl Health Surv 133
36. Rosenfield RL, Bachrach LK, Chernausek SD, Gertner JM, Gottschalk M, Hardin DS, Pescovitz OH, Saenger P 2000 Current age of onset of puberty. Pediatrics 106:622-623
37. Lee PA, Kulin HE, Shumei SG 2001 Letter to the editor: age of puberty among girls and the diagnosis of precocious puberty. Pediatrics 107:1493-1494
38. Sun SS, Schubert CM, Chumlea WC, Roche AF, Kulin HE, Lee PA, Himes JH, Ryan AS 2002 National estimates of the timing of sexual maturation and racial differences among US children. Pediatrics 110:911-919
39. Chumlea WC, Schubert CM, Roche AF, Kulin HE, Lee PA, Himes JH, Sun SS 2003 Age at menarche and racial comparisons in US girls. Pediatrics 111:110-113
40. Anderson SE, Dallal GE, Must A 2003 Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics 111:844-850
41. Wattigney WA, Srinivasan SR, Chen W, Greenlund KJ, Berenson GS 1999 Secular trend of earlier onset of menarche with increasing obesity in black and white girls: the Bogalusa Heart study. Ethn Dis 9:181-189
42. Freedman DS, Srinivasan SR, Valdez RA, Williamson DF, Berenson GS 1997 Secular increases in relative weight and adiposity among children over two decades: the Bogalusa heart study. Pediatrics 99:420-426
43. Troiano RP, Flegal KM, Kuczmarski RJ, Campbell SM, Johnson CL 1995 Overweight prevalence and trends for children and adolescents. Arch Pediatr Adolesc Med 149:1085-1091
44. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL 1994 Increasing prevalence of overweight among US adults. JAMA 272: 205-211
45. Freedman DS, Kettel Khan L, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS 2002 The relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa Heart Study. Pediatrics 110:43-49
46. Biro FM, McMahon RP, Striegel-Moore R, Crawford PB, Obarzanek E, Morrison JA, Barton BA, Falkner F 2001 Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 138:636-643
47. Harlan WR, Harlan EA, Grillo GP 1980 Secondary sex characteristics of girls 12 to 16 years of age: the US Health Examination Survey. J Pediatr 96:1074-1078
48. De Muinck Keizer-Schrama SMPF, Mul D 2001 Trends in pubertal development in Europe. Hum Reprod Update 7:287-291
49. Rimpelä AH, Rimpelä MK 1993 Towards an equal distribution of health? Socioeconomic and regional differences of the secular trend of the age at menarche in Finland from 1979 to 1989. Acta Paediatr 82:87-90
50. Lindgren GW, Degerfors IL, Fredriksson A, Loukili A, Mannerfeldt R, Nordin M, Palm K, Petterson M, Sundstrand G, Sylvan E 1991 Menarche 1990 in Stockholm schoolgirls. Acta Paediatr Scand 80:953-955
51. Lindgren G 1996 Pubertal stages 1980 of Stockholm schoolchildren. Acta Paediatr 85:1365-1367
52. Helm P, Grolund L 1998 A halt in the secular trend towards earlier menarche in Denmark. Acta Obstet Gynecol Scand 77:198-200
53. Buckler J 1990 A longitudinal study of adolescent growth. London: Springer-Verlag
54. Rees M 1993 Menarche when and why? Lancet 342:1375-1376
55. Engelhardt L, Willers B, Pelz L 1995 Sexual maturation in East German girls. Acta Paediatr 84:1362-1365
56. Fredriks AM, van Buuren S, Burgmeijer RJ, Meulmeester JF, Beuker RJ, Brugman E, Roede MJ, Verloove-Vanhorick SP, Wit JM 2000 Continuing positive secular growth change in the Netherlands 1955-1997. Pediatr Res 47:316-323
57. Mul D, Fredriks M, van Buuren S, Oosdijk W, Verloove-Vanhorick SP, Wit JM 2001 Pubertal development in The Netherlands 1965-1997. Pediatr Res 50:479-486
58. Vercauteren M, Susanne C 1985 The secular trend of height and menarche in Belgium: are there any signs of a future stop? Eur J Pediatr 144:306-309
59. Largo RH, Prader A 1983 Pubertal development in Swiss girls. Helv Paediatr Acta 38:229-243
60. de La Rochebrochard E 1999 Les âges à la puberté des filles et des garçons en France. Population 54:933-962
61. Borneman M, Vienna A, Tommaseo M, Capucci E 1995 Menarcheal age and environmental factors in a sample from the province of Rome. Acta Med Auxol 27:97-104
62. de la Puente ML, Canela J, Alvarez J, Salleras L, Vicens-Calvet E 1997 Cross-sectional growth study of the child and adolescent population of Catalonia (Spain). Ann Hum Biol 24:435-452
63. Rueda C, Labena C, Boldova C, Leon E, Labarta J, Mayayo E, Ferrandez Longas A 2002 Spanish longitudinal study of growth and development: pubertal development standards. Horm Res 58(Suppl 2):36 (Abst)
64. Papadimitriou A, Gousia E, Pitaouli E, Tapaki G, Philippidis P 1999 Age at menarche in Greek girls. Ann Hum Biol 26:175-177
65. Eveleth PB, Tanner JM 1990 Worldwide variation in human growth, 2nd ed. Cambridge, UK: Cambridge University Press
66. Huen KF, Leung SS, Lau JT, Cheung AY, Leung NK, Chiu MC 1997 Secular trend in the sexual maturation of Southern Chinese girls. Acta Paediatr 86:1121-1124
67. Murata M, Hibi I 1992 Nutrition and the secular trend of growth. Horm Res 38(Suppl 1):89-96
68. Rao S, Joshi S, Kanade A 1998 Height velocity, body fat and menarcheal age of Indian girls. Indian Pediatr 35:619-628
69. Chompootaweep S, Tankeyoon M, Poomsuwan P, Yamarat K, Dusitsin N 1997 Age at menarche in Thai girls. Ann Hum Biol 24:427-433
70. Ruiz A, Blanco R, Santander J, Miranda E 2000 Relationship between sex differences in onset of schizophrenia and puberty. J Psychiatr Res 34:349-353
71. Macias-Tomei C, Lopez-Blanco M, Espinoza I, Vasquez-Ramirez M 2000 Pubertal development in Caracas upper-middle-class boys and girls in a longitudinal context. Am J Hum Biol 12:88-96
72. Pasquet P, Biyong AM, Rikong-Adie H, Befidi-Mengue R, Garba MT, Froment A 1999 Age at menarche and urbanization in Cameroon: current status and secular trends. Ann Hum Biol 26:89-97
73. Cameron N, Wright CA 1990 The start of breast development and age at menarche in South African black females. S Afr Med J 78:536-539
74. Largo RH, Prader A 1983 Pubertal development in Swiss boys. Helv Paediat Acta 38:211-228
75. Herman-Giddens ME, Wang L, Koch G 2001 Secondary sexual characteristics in boys. Estimates from the National Health and Examination Survey III, 1988-1994. Arch Pediatr Adolesc Med 155:1022-1028
76. Reiter EO, Lee PA 2001 Editorial: Have the onset and tempo of puberty changed? Arch Pediatr Adolesc Med 155:988-989
77. Harlan WR, Grillo GP, Cornoni-Huntley J, Leaverton PE 1979 Secondary sex characteristics of boys 12 to 17 years of age: the US Health Examination Survey. J Pediatr 95:293-297
78. Roche AF, Wellens R, Attie KM, Siervogel RM 1995 The timing of sexual maturation in a group of US white youths. J Pediatr Endocrinol Metab 8:11-18
79. Biro FM, Lucky AW, Huster GA, Morrison JA 1995 Pubertal staging in boys. J Pediatr 127:100-102
80. Wong GW, Leung SS, Law WY, Yeung VT, Lau JT, Yeung WK 1996 Secular trend in the sexual maturation of southern Chinese boys. Acta Paediatr 85:620-621
81. Willers B, Engelhardt L, Pelz L 1996 Sexual maturation in East German boys. Acta Paediatr 85:785-788
82. Farid-Coupal N, Contreras ML, Castellano HM 1981 The age at menarche in Carabobo, Venezuela with a note on the secular trend. Ann Hum Biol 8:283-288
83. Singh SP, Malhotra P 1988 Secular shift in menarcheal age of Patiala (India) schoolgirls between 1974 and 1986. Ann Hum Biol 15:77-80
84. Ekele BA, Udoeyop EU, Otubu JA 1996 Age at menarche amongst school girls in a high altitude Nigerian town. West Afr J Med 15:170-172
85. Khan AD, Schroeder DG, Martorell R, Rivera JA 1995 Age at menarche and nutritional supplementation. J Nutr 125(Suppl 4): 1090-1096
86. Graham MJ, Larsen U, Xu X 1999 Secular trend in age at menarche in China: a case study of two rural counties in Anhui Province. J Biosoc Sci 31:257-267
87. Simondon KB, Simon I, Simondon F 1997 Nutritional status and age at menarche of Senegalese adolescents. Ann Hum Biol 24:521-532
88. Thomas F, Renaud F, Benefice E, de Meeus T, Guegan JF 2001 International variability of ages at menarche and menopause: patterns and main determinants. Hum Biol 73:271-290
89. Zacharias L, Wurtman RJ 1969 Age at menarche. Genetic and environmental influences. N Engl J Med 280:868-875
90. Wyshak G, Frisch RE 1982 Evidence for a secular trend in age of menarche. N Engl J Med 306:1033-1035
91. Dann TC, Roberts DF 1993 Menarcheal age in University of Warwick young women. J Biosoc Sci 25:531-538
92. Dubrova YE, Kurbatova OL, Kholod ON, Prokhorovskaya VD 1995 Secular growth trend in two generations of the Russian population. Hum Biol 67:755-767
93. Sultan C, Paris F, Jeandel C, Attal G, Lumbroso S, Dumas R 2001 L'âge de la puberté et de la ménarche. Rev Int Pediat 32:9-10
94. Marrodan MD, Mesa MS, Arechiga J, Perez-Magdaleno A 2000 Trend in menarcheal age in Spain: rural and urban comparison during a recent period. Ann Hum Biol 27:313-319
95. Bodzsar EB, Susanne C 1998 Secular growth change in Europe. Budapest: Eötvö University Press
96. Olesen AW, Jeune B, Boldsen JL 2000 A continuous decline in menarcheal age in Denmark. Ann Hum Biol 27:377-386
97. Mau C, Main KM, Hertel T, Holm K, Mosfeldt-Laursen E, Muller J, Skakkebaek N, Juul A 2002 No apparent secular change in age at puberty in Danish girls 1964-1991. Horm Res 58(Suppl 2):84 (Abstract)
98. Lebrethon MC, Bourguignon JP 2000 Management of central isosexual precocity: diagnosis, treatment, outcome. Curr Opin Pediatr 12:394-399
99. Klein KO 1999 Precocious puberty: who has it? Who should be treated? J Clin Endocrinol Metab 84:411-414
100. Kaplowitz PB, Oberfield SE 1999 Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Pediatrics 104: 936-941
101. Midyett LK, Moore WV, Jacobson JD 2003 Are pubertal changes in girls before age 8 benign? Pediatrics 111:47-51
102. Pescovitz OH, Comite F, Hench K, Barnes K, McNemar A, Foster C, Kenigsberg D, Loriaux DL, Cutler Jr GB 1986 The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr 108:47-54
103. Kappy MS, Ganong CS 1994 Advances in the treatment of precocious puberty. Adv Pediatr 41:223-226
104. Partsch CJ, Sippell WG 2001 Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum Reprod Update 7:292-302
105. Thamdrup E 1961 Precocious sexual development: a clinical study of 100 patients. Springfield, IL: Charles C Thomas
106. Wilkins L 1965 The diagnosis and treatment of endocrine disorders in childhood and adolescence. Springfield, IL: Charles C Thomas
107. Sigurjonsdottir TJ, Hayles AB 1968 Precocious puberty. Am J Dis Child 115:309-321
108. Kaplan SL, Grumbach MM 1990 Pathogenesis of sexual precocity. In: Grumbach M, Sizonenko PC, Aubert ML, eds. Control of the onset of puberty. Baltimore: Williams & Wilkins; 620-662
109. Blanco-Garcia M, Job JC, Chaussain JL, Canlorbe P 1983 Precocious puberty in boys. Arch Fr Pediatr 40:637-642
110. Garagorri JM, Chaussain JL, Job JC 1982 [Precocious puberty in girls. Study of 98 cases.] Arch Fr Pediatr 39:605-611 (French)
111. Lee PA, Page JG, and the Leuprolide Study Group 1989 Effects of leuprolide in the treatment of central precocious puberty. J Pediatr 114:321-324
112. Brauner R, Rappaport R 1990 Pubertés précoces centrales. Semin Hop Paris 66:1782-1787
113. Neely EK 1995 A multicenter trial of depot leuprolide for central precocious puberty. In: Plant TM, Lee PA, eds. The neurobiology of puberty. Bristol, UK: J Endocrinol Ltd; 313-318
114. Palmert MR, Mansfield J, Crowley WF, Grigler JF, Crawford JD, Boepple PA 1999 Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab 84:4480-4488
115. Mul D, Oostdijk W, Otten BJ, Rouwé C, Jansen M, Delemarre-van de Waal HA, Waelkens JJJ, Drop SLS 2000 Final height after gonadotropin releasing hormone agonist treatment for central precocious puberty: the Dutch experience. J Pediatr Endocrinol Metab 13:765-772
116. Klein KO, Barnes KM, Jones JV, Feuillan PP, Cutler GB 2001 Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab 86:4711-4716
117. Lebrethon MC, Bourguignon JP 2001 Central and peripheral isosexual precocious puberty. Curr Opin Endocrinol Diabetes 8:17-22
118. Adolfsson S, Westphal O 1981 Early pubertal development in girls adopted from Far-Eastern countries. Pediatr Res 15:82 (abstract)
119. Mason P, Narad C, Jester T, Parks J 2000 A survey of growth and development in the internationally adopted child. Pediatr Res 47: 209A (abstract)
120. Palmert ML, Boepple PA 2001 Variation in the timing of puberty: clinical spectrum and genetic investigation. J Clin Endocrinol Metab 86:2364-2368
121. Chicoine JF, Blancquaert I, Chicoine L, Raynault MF 1999 Bilan de santé de 808 chinoises nouvellement adoptées au Québec. Arch Pediatr 6(Suppl 2):544s
122. Gonzalez ER 1982 For puberty that comes too soon, new treatment highly effective. JAMA 248:1149-1152
123. Mason P, Narad C 2002 Growth and pubertal development in internationally adopted children. Curr Opin Endocrinol Diabetes 9:26-31
124. Mul D, Oostdijk W, Drop SLS 2002 Early puberty in adopted children. Horm Res 57:1-9
125. Tuvemo T, Gustafsson J, Proos LA 1999 Growth hormone treatment during suppression of early puberty in adopted girls. Acta Paediatr 88:928-932
126. Mul D, Oostdijk W, Waelkens JJ, Schulpen TW, Drop SL 2001 Gonadotrophin releasing hormone agonist treatment with or without recombinant human GH in adopted children with early puberty. Clin Endocrinol (Oxf) 55:121-129
127. Petri E 1935 Untersuchungen zur Erbbedingtheit der Menarche. Z Morphol Anthropol 33:43-48
128. Fischbein S 1977 Intra-pair similarity in physical growth of monozygotic and of dizygotic twins during puberty. Ann Hum Biol 4:417-430
129. Treloar SA, Martin NG 1990 Age at menarche as a fitness trait: nonadditive genetic variance detected in a large twin sample. Am J Hum Genet 47:137-148
130. Meyer JM, Eaves LJ, Heath AC, Martin NG 1991 Estimating genetic influences on the age-at-menarche: a survival analysis approach. Am J Med Genet 39:148-154
131. Loesch DZ, Hopper JL, Rogucka E, Huggins RM 1995 Timing and genetic rapport between growth in skeletal maturity and height around puberty: similarities and differences between girls and boys. Am J Hum Genet 56:753-759
132. Hamilton AS, Mack TM 2003 Puberty and genetic susceptibility to breast cancer in a case-control study in twins. N Engl J Med 348: 2313-2322
133. Stavrou I, Zois C, Ioannidis JP, Tsatsoulis A 2002 Association of polymorphisms of the oestrogen receptor α gene with the age of menarche. Hum Reprod 17:1101-1105
134. Gorai I, Tanaka K, Inada M, Morinaga H, Uchiyama Y, Kikuchi R, Chaki O, Hirahara F 2003 Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-α gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. J Clin Endocrinol Metab 88:799-803
135. Bergman-Jungestrom M, Gentile M, Lundin AC, Wingren S 1999 Association between CYP17 gene polymorphism and risk of breast cancer in young women. Int J Cancer 84:350-353
136. Kadlubar FF, Berkowitz GS, Delongchamp RR, Wang C, Green BL, Tang G, Lamba J, Schuetz E, Wolff MS 2003 The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiol Biomarkers Prev 12:327-331
137. Lai J, Vesprini D, Chu W, Jernstrom H, Narod SA 2001 CYP gene polymorphisms and menarche. Mol Genet Metab 74:449-457
138. McEwen B, Alves SE 1999 Estrogen actions in the central nervous system. Endocr Rev 20:279-307
139. Herbison AE 1998 Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr Rev 19:302-330
140. Ibanez L, Ong KK, Mongan N, Jaaskelainen J, Marcos MV, Hughes IA, De Zegher F, Dunger DB 2003 Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. J Clin Endocrinol Metab 88:3333-3338
141. Ojeda SR, Ma YJ, Dziedzic B, Prevot V 2000 Astrocyte-neuron signaling and the onset of female puberty. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 41-57
142. Ito PK 1942 Comparative biometrical study of physique of Japanese women born and reared under different environments. Hum Biol 14:279-351
143. Danker-Hopfe H, Delibalta K 1990 Menarcheal age of Turkish girls in Bremen. Anthropol Anz 48:1-14
144. Johnson DE, Miller LC, Iverson S, Thomas W, Franchino B, Dole K, Kiernan MT, Georgieff MK, Hostetter MK 1992 The health of children adopted from Romania. JAMA 268:3446-3451
145. Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS 1993 Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938-941
146. Ibanez L, Potau N, Francois I, de Zegher F 1998 Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J Clin Endocrinol Metab 83:3558-3562
147. Francois I, de Zegher F, Spiessens C, D'Hooghe T, Vanderschueren DI 1997 Low birth weight and subsequent male subfertility. Pediatr Res 42:899-901
148. Silver HK 1964 Asymmetry, short stature, and variations in sexual development. Am J Dis Child 107:495-515
149. Marks LJ, Bergeson PS 1977 The Silver-Russell syndrome. Am J Dis Child 131:447-451
150. Tomkins DJ, Roux AF, Waye J, Freeman VC, Cox DW, Whelan DT 1996 Maternal uniparental isodisomy of human chromosome 14 associated with a paternal t(13q14q) and precocious puberty. Eur J Hum Genet 4:153-159
151. Fokstuen S, Ginsburg C, Zachmann M, Schinzel A 1999 Maternal uniparental disomy 14 as a cause of intrauterine growth retardation and early onset of puberty. J Pediatr 134:689-695
152. Cooper C, Kuh D, Egger P, Wadsworth M, Barker D 1996 Childhood growth and age at menarche. Br J Obstet Gynaecol 103:814-817
153. Ibanez L, Ferrer A, Marcos MV, Hierro FR, de Zegher F 2000 Early puberty: rapid progression and reduced final height in girls with low birth weight. Pediatrics 106:E72 (Abstract)
154. Lazar L, Pollack U, Kalter-Leibovici O, Pertzelan A, Phillip M 2002 Persistently short children with IGUR have a distinct pubertal growth pattern. Horm Res 58(Suppl 2):85 (Abstract)
155. Lienhardt A, Carel JC, Preux PM, Coutant R, Chaussain JL 2002 Amplitude of pubertal growth in short stature children with intrauterine growth retardation. Horm Res 57(Suppl 2):88-94
156. Stark O, Peckham CS, Moynihan C 1989 Weight and age at menarche. Arch Dis Child 64:383-387
157. Adair LS 2001 Size at birth predicts age at menarche. Pediatrics 107:E59
158. Karlberg J 2002 Secular trends in pubertal development. Horm Res 57(Suppl 2):19-30
159. Delemarre-van de Waal HA, van Coeverden SCCM, Engelbregt MJT 2002 Factors affecting onset of puberty. Horm Res 57(Suppl 2):15-18
160. Engelbregt MJ, Houdijk ME, Popp-Snijders C, Delemarre-van de Waal HA 2000 The effects of intra-uterine growth retardation and postnatal undernutrition on onset of puberty in male and female rats. Pediatr Res 48:803-807
161. Proos LA, Hofvander Y, Wennqvist K, Tuvemo T 1992 A longitudinal study on anthropometric and clinical development of Indian children adopted in Sweden. I. Clinical and anthropometric condition at arrival. Ups J Med Sci 97:79-92
162. Proos LA, Karlberg J, Hofvander Y, Tuvemo T 1993 Pubertal linear growth of Indian girls adopted in Sweden. Acta Paediatr 82:641-644
163. Krstevska-Konstantinova M, Craen M, Beckers D, Dooms L, Heinrichs C, Maes M, De Schepper J, Du Caju M, Thiry-Counson G, Bourguignon JP 1998 Growth pattern in idiopathic central precocious puberty: a comparison between Belgian native and adopted girls. Horm Res 50(Suppl 3):130 (Abstract)
164. Frisch RE, Revelle R 1970 Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169:397-399
165. Frisch RE, Revelle R 1971 Height and weight at menarche and a hypothesis of menarche. Arch Dis Child 46:695-701
166. Frisch RE, Revelle R, Cook S 1973 Components of weight at menarche and the initiation of the adolescent growth spurt in girls: estimated total water, lean body weight and fat. Hum Biol 45:469-483
167. Apter D, Viinikka L, Vihko R 1978 Hormonal pattern of adolescent menstrual cycles. J Clin Endocrinol Metab 47:944-954
168. Van der Spuy ZM 1985 Nutrition and reproduction. Clin Obstet Gynaecol 12:579-604
169. Williams NI, Helmreich DL, Parfitt DB, Caston-Balderrama A, Cameron JL 2001 Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training. J Clin Endocrinol Metab 86:5184-5185
170. Clavel-Chapelon F, E3N-EPIC (European Prospective Investigation into Cancer) Group 2002 Evolution of age at menarche and at onset of regular cycling in a large cohort of French women. Hum Reprod 17:228-232
171. Arslanian SA, Witchel SF 2002 Polycystic ovary syndrome in adolescents: is there an epidemic? Curr Opin Endocrinol Diabetes 9:32-42
172. Abbott DH, Dumesic DA, Franks S 2002 Developmental origin of polycystic ovary syndrome-a hypothesis. J Endocrinol 174:1-5
173. Moisan J, Meyer F, Gingras S 1990 A nested case-control study of the correlates of early menarche. Am J Epidemiol 132:953-961
174. Merzenich H, Boeing H, Wahrendorf J 1993 Dietary fat and sports activity as determinants for age at menarche. Am J Epidemiol 138:217-224
175. Adair LS, Gordon-Larsen P 2001 Maturational timing and overweight prevalence in US adolescent girls. Am J Public Health 91: 642-644
176. Garn SM, La Velle M, Pilkington JJ 1983 Comparisons of fatness in premenarcheal and postmenarcheal girls of the same age. J Pediatr 103:328-331
177. Vizmanos B, Marti-Henneberg C 2000 Puberty begins with a characteristic subcutaneous body fat mass in each sex. Eur J Clin Nutr 54:203-208
178. Legro RS, Lin HM, Demers LM, Lloyd T 2000 Rapid maturation of the reproductive axis during perimenarche independent of body composition. J Clin Endocrinol Metab 85:1021-1025
179. Jaruratanasirikul S, Mo-suwan L, Lebel L 1997 Growth pattern and age at menarche of obese girls in a transitional society. J Pediatr Endocrinol Metab 10:487-490
180. Wang Y 2002 Is obesity associated with early sexual maturation? A comparison of the association in American boys vs. girls. Pediatrics 110:903-910
181. Sherman B, Wallace R, Bean J, Schlabaugh L 1981 Relationship of body weight to menarcheal and menopausal age: implications for breast cancer risk. J Clin Endocrinol Metab 52:488-493
182. van Lenthe FJ, Kemper CG, van Mechelen W 1996 Rapid maturation in adolescence results in greater obesity in adulthood: the Amsterdam growth and health study. Am J Clin Nutr 64:18-24
183. Qing H, Karlberg J 2001 BMI in childhood and its association with height gain, timing of puberty, and final height. Pediatr Res 49: 244-251
184. Davison KK, Susman EJ, Birch LL 2003 Percent body fat at age 5 predicts earlier pubertal development among girls at age 9. Pediatrics 111:815-821
185. Wong WW, Copeland KC, Hergenroeder AC, Hill RB, Stuff JE, Ellis KJ 1999 Serum concentrations of insulin, insulin-like growth factor-I, and insulin-like growth factor binding proteins are different between white and African American girls. J Pediatr 135: 296-300
186. Gower BA, Higgins PB 2003 Energy balance, body composition, and puberty in children and adolescents: importance of ethnicity. Curr Opin Endocrinol Diabetes 10:9-22
187. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME 2001 Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 108:347-353
188. Koprowski C, Ross RK, Mack WJ, Henderson BE, Bernstein L 1999 Diet, body size and menarche in a multiethnic cohort. Br J Cancer 79:1907-1911
189. Berkey CS, Gardner JD, Frazier AL, Colditz GA 2000 Relation of childhood diet and body size to menarche and adolescent growth in girls. Am J Epidemiol 152:446-452
190. Soriguer FJ, Gonzalez-Romero S, Esteva I, Garcia-Arnes JA, Tinahones F, Ruiz de Adana MS, Olveira G, Mancha I, Vazques F 1995 Does the intake of nuts and seeds alter the appearance of menarche? Acta Obstet Gynecol Scand 74:455-461
191. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263
192. McGarvey C, Cates PS, Brooks AN, Swanson IA, Milligan SR, Coen CW, O'Byrne KT 2001 Phytoestrogens and gonadotropin-releasing hormone pulse generator activity and pituitary luteinizing hormone release in the rat. Endocrinology 142:1202-1208
193. Mazur W, Adlercreutz H 2000 Overview of naturally occurring endocrine-active substances in the human diet in relation to human health. Nutrition 16:654-658
194. Adlercreutz H, Bannwart C, Wahala K, Mäkelä T, Brunow G, Hase T, Arosemena PJ, Kellis JTJ, Vickery LE 1993 Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 44:147-153
195. Mäkelä S, Poutanen M, Kostian ML, Lehtimäki N, Strauss L, Santti R, Vihko R 1998 Inhibition of 17β-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells. Proc Soc Exp Biol Med 217:310-316
196. Krazeisen A, Breitling R, Moller G, Adamski J 2001 Phytoestrogens inhibit human 17β-hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol 171:151-162
197. Mäkelä SI, Pylkkänen LH, Santti RS, Adlercreutz H 1995 Dietary soybean may be antiestrogenic in male mice. J Nutr 125:437-445
198. Krstevska-Konstantinova M, Craen M, Beckers D, Dooms L, Heinrichs C, Bourguignon JP 1999 Precocious puberty in adopted and non-adopted foreign girls moving to Belgium: a role for environmental factors independent of recovery from deprivation. Horm Res 51(Suppl 2):71 (Abstract)
199. Kulin HE, Bwibo N, Mutie D, Santner SJ 1982 The effect of chronic childhood malnutrition on pubertal growth and development. Am J Clin Nutr 36:527-536
200. Proos LA 1993 Anthropometry in adolescence-secular trends, adoption, ethnic and environmental differences. Horm Res 39(Suppl 3):18-24
201. de Onis M, Dasgupta P, Saha S, Sengupta D, Blössner M 2001 The National Center for Health statistics reference and the growth of Indian adolescent boys. Am J Clin Nutr 74:248-253
202. de Onis M, Blössner M 2000 Prevalence and trends of overweight among preschool children in developing countries. Am J Clin Nutr 72:1032-1039
203. Bourguignon JP, Lebrethon MC, Gérard A, Purnelle G, Vandersmissen E, Parent AS, Yamanaka C 2000 Amino acid neurotransmission and early ontogeny of pulsatile GnRH secretion from the rat hypothalamus. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 119-129
204. Foster DL, Nagatani S 1999 Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol Reprod 60:205-215
205. Hileman SM, Pierroz DD, Flier JS 2000 Leptin, nutrition, and reproduction: timing is everything. J Clin Endocrinol Metab 85: 804-807
206. Barker-Gibb ML, Sahu A, Pohl CR, Plant TM 2002 Elevating circulating leptin in prepubertal male rhesus monkeys (Macaca mulatta) does not elicit precocious gonadotropin-releasing hormone release, assessed indirectly. J Clin Endocrinol Metab 87:4976-4983
207. Farooqi IS, O'Rahilly S 2000 Human congenital leptin deficiency: the role of leptin in the onset of puberty. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 363-369
208. Kalra SP, Pu S, Horvath TL, Kalra PS 2000 Leptin and NPY regulation of GnRH secretion and energy homeostasis. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 317-327
209. Lebrethon MC, Vandersmissen E, Gérard A, Parent AS, Junien JL, Bourguignon JP 2000 Leptin and neuropeptide Y stimulation of pulsatile GnRH secretion in vitro through distinct mechanisms. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 329-337
210. Pierroz DD, Gruaz-Gumowski NM, Lalaoui M, Blum WF, Aubert ML 2000 Leptin and NPY regulation of sexual maturation in the rat. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 339-349
211. Palmert MR, Radovick S, Boepple PA 1998 Leptin levels in children with central precocious puberty. J Clin Endocrinol Metab 83:2260-2265
212. Heger S, Partsch CJ, Peter M, Blum WF, Kiess W, Sippell WG 1999 Serum leptin levels in patients with progressive central precocious puberty. Pediatr Res 46:71-75
213. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M 2001 Minireview: Ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142:4163-4169
214. Lebrethon MC, Gérard A, Bourguignon JP 2002 Prepubertal acceleration of pulsatile GnRH secretion in vitro by Ghrelin. Horm Res 58(Suppl 2):19 (Abstract)
215. d'Allèves V, Gruaz-Gumowski NM, Aubert ML 2000 The GH-IGF-I axis in sexual maturation: the rat paradigm. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 59-69
216. Wilson ME, Suter KJ 2000 The GH-IGF-I axis in sexual maturation: the monkey paradigm. In: Bourguignon JP, Plant TM, eds. The onset of puberty in perspective. Amsterdam: Elsevier Science; 71-83
217. Bucholtz DC, Vidwans NM, Herbosa CG, Schillo KK, Foster DL 1996 Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability. Endocrinology 137:601-607
218. Schreihofer DA, Renda F, Cameron JL 1996 Feeding-induced stimulation of luteinizing hormone secretion in male rhesus monkeys is not dependent on a rise in blood glucose concentration. Endocrinology 137:3770-3776
219. Cameron JL 1997 Search for the signal that conveys metabolic status to the reproductive axis. Curr Opin Endocrinol Diabetes 4:158-163
220. Roemmich JN, Li X, Rogol AD, Rissman EF 1997 Food availability affects neural estrogen receptor immunoreactivity in prepubertal mice. Endocrinology 138:5366-5373
221. Hileman SM, Lubbers LS, Jansen HT, Lehman MN 1999 Changes in hypothalamic estrogen receptor-containing cell numbers in response to feed restriction in the female lamb. Neuroendocrinology 69:430-437
222. Zhu YS, Dellovade TL, Pfaff DW 1997 Interactions between hormonal and environmental signals on hypothalamic neurons: molecular mechanisms signaling environmental events. Trends Endocrinol Metab 8:111-115
223. Rosner W 1990 The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocr Rev 11:80-91
224. Pascal N, Amouzou EK, Sanni A, Namour F, Abdelmouttaleb I, Vidailhet M, Gueant JL 2002 Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus. Am J Clin Nutr 76:239-244
225. Van den Berghe G, de Zegher F, Bouillon R 1998 Clinical review: Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 83:1827-1834
226. Chrousos GP 1992 The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244-1252
227. Theintz GE, Howald H, Allemann Y, Sizonenko PC 1989 Growth and pubertal development of young female gymnasts and swimmers: a correlation with parental data. Int J Sports Med 10:87-91
228. Georgopoulos N, Markou K, Theodoropoulou A, Paraskevopoulou P, Varaki L, Kazantzi Z, Leglise M, Vagenakis AG 1999 Growth and pubertal development in elite female rhythmic gymnasts. J Clin Endocrinol Metab 84:4525-4530
229. Tahirovié HF 1998 Menarchal age and the stress of war: an example from Bosnia. Eur J Pediatr 157:978-980
230. Prebeg Z, Bralic I 2000 Changes in menarcheal age in girls exposed to war conditions. Am J Hum Biol 12:503-508
231. Wilson DC, Sutherland I 1950 Age at menarche. Br Med J 1:1267
232. Schreihofer DA, Parfitt DB, Cameron JL 1993 Suppression of luteinizing hormone secretion during short-term fasting in male rhesus monkeys: the role of metabolic vs. stress signals. Endocrinology 132:1881-1889
233. Pacak K, Palkovits M 2001 Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev 22:502-548
234. Rivest S, Rivier C 1995 The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions. Endocr Rev 16:177-199
235. Belsky J, Steinberg L, Draper P 1991 Childhood experience, interpersonal development and reproductive strategy: an evolutionary theory of socialization. Child Dev 62:647-670
236. Wierson M, Long PJ, Forehand RL 1993 Toward a new understanding of early menarche: the role of environmental stress in pubertal timing. Adolescence 28:913-924
237. Saar E, Shalev C, Dalal I, Sod-Moriah UA 1988 Age at menarche: the influence of environmental conditions. Int J Biometeorol 32: 33-35
238. Ellis RWB 1950 Age of puberty in tropics. Br Med J 1:85-89
239. Levine VE 1953 Studies in physiological anthropology: III. Age of onset of menstruation of Alaska Eskimos. Am J Phys Anthropol 11:252
240. Zacharias L, Wurtman RJ 1969 Blindness and menarche. Obstet Gynecol 33:603-608
241. Magee K, Basinska J, Quarrington B, Stancer HC 1970 Blindness and menarche. Life Sci 9:7-12
242. Bojlen K, Bentzon MW 1974 Seasonal variation in the occurrence of menarche. Dan Med Bull 21:161-168
243. Albright DL, Voda AM, Smolensky MH, Hsi BP, Decker M 1990 Seasonal characteristics of and age at menarche. Prog Clin Biol Res 341A:709-720
244. Cohen P 1993 Month at menarche: a re-evaluation of the seasonal hypothesis. Ann Hum Biol 20:198-202
245. Rojansky N, Brzezinski A, Schenker JG 1992 Seasonality in human reproduction: an update. Hum Reprod 7:735-745
246. Vanecek J 1999 Inhibitory effect of melatonin on GnRH-induced LH release. Rev Reprod 4:67-72
247. Esquifino AI, Villanua MA, Agrasal C 1987 Effect of neonatal melatonin administration on sexual development in the rat. J Steroid Biochem 27:1089-1093
248. Villanua MA, Agrasal C, Esquifino AI 1989 Neonatal melatonin administration advances rat vaginal opening and disrupts estrous cyclicity and estrogen-dependent regulatory mechanisms of luteinizing hormone and prolactin. J Pineal Res 7:165-174
249. Silman RE, Leone RM, Hooper RJ, Preece MA 1979 Melatonin, the pineal gland and human puberty. Nature 282:301-303
250. Cavallo A, Ritschel WA 1996 Pharmacokinetics of melatonin in human sexual maturation. J Clin Endocrinol Metab 81:1882-1886
251. Salti R, Galluzzi F, Bindi G, Perfetto F, Tarquini R, Halberg F, Cornélissen G 2000 Nocturnal melatonin patterns in children. J Clin Endocrinol Metab 85:2137-2144
252. Waldhauser F, Boepple PA, Schemper M, Mansfield MJ, Crowley Jr WF 1991 Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children. J Clin Endocrinol Metab 73:793-796
253. Puig-Domingo M, Webb SM, Serrano J, Peinado MA, Corcoy R, Ruscalleda J, Reiter RJ, de Leiva A 1992 Melatonin-related hypogonadotropic hypogonadism. N Engl J Med 327:1356-1359
254. Luboshitzky R, Lavi S, Thuma I, Lavie P 1995 Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty. J Clin Endocrinol Metab 80: 2144-2148
255. Marshall E 1993 Search for a killer: focus shifts from fat to hormones. Science 259:618-621
256. Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean F, Guillette Jr LJ, Jegou B, Jensen TK, Jouannet F, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE 1996 Male reproductive health and environmental xenoestrogens. Environ Health Perspect 104(Suppl 4):741-803
257. Guillette Jr LJ 2000 Contaminant-induced endocrine disruption in wildlife. Growth Hormone IGF Res 10(Suppl B):45-50
258. Skakkebaek NE, Rajpert-De Meyts E, Main KM 2001 Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972-978
259. Snedeker SM 2001 Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin. Environ Health Perspect 109(Suppl 1): 35-47
260. Key T, Reeves G 1994 Organochlorines in the environment and breast cancer. Br Med J 308:1520-1521
261. Clark, EJ, Norris DO, Jones RE 1998 Interactions of gonadal steroids and pesticides (DDT, DDE) on gonadal duct in larval tiger salamanders, Ambystoma tigrinum. Gen Comp Endocrinol 109:94-105
262. Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM 1995 Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375:581-585
263. Sharpe RM, Skakkebaek NE 1993 Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392-1395
264. McLachlan JA 2001 Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 22:319-341
265. Cohn BA, Cirillo PM, Wolff MS, Schwingl PJ, Cohen RD, Sholtz RI, Ferrara A, Christianson RE, van den Berg BJ, Siiteri PK 2003 DDT and DDE exposure in mothers and time to pregnancy in daughters. Lancet 361:2205-2206
266. Herbst AL, Ulfelder H, Poskanzer DC 1971 Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878-881
267. Parent AS, Krstevska-Konstantinova M, Matagne V, Gérard A, Lebrethon MC, Charlier C, Bourguignon JP, the Belgian Study Group for Paediatric Endocrinology 2001 Endocrine disrupter contribution to sexual precocity: suggestive detection of pesticide derivatives in patients immigrant to Belgium and estradiol stimulation of GnRH pulsatility in rat hypothalamus. Pediatr Res 49: 139A (abstract)
268. Selevan SG, Rice DC, Hogan KA, Euling SY, Pfahles-Hutchens A, Bethel J 2003 Blood lead concentration and delayed puberty in girls. N Engl J Med 348:1527-1536
269. Wu T, Buck GM, Mendola P Blood lead levels and sexual maturation in US girls: the Third National Health and Nutrition Examination Survey, 1988-1994. Environ Health Perspect 111:737-741
270. Pescovitz OH, Comite F, Cassorla F, Dwyer AJ, Poth MA, Sperling MA, Hench K, McNemar A, Skerda M, Loriaux DL 1984 True precocious puberty complicating congenital adrenal hyperplasia: treatment with a luteinizing hormone-releasing hormone analog. J Clin Endocrinol Metab 58:857-861
271. Hochberg Z, Schechter J, Benderly A, Leiberman E, Rosler A 1985 Growth and pubertal development in patients with congenital adrenal hyperplasia due to 11-β-hydroxylase deficiency. Am J Dis Child 139:771-776
272. Kukuvitis A, Matte C, Polychronakos C 1995 Central precocious puberty following feminizing right ovarian granulosa cell tumor. Horm Res 44:268-270
273. Pasquino AM, Tebaldi L, Cives C, Maciocci M, Boscherini B 1987 Precocious puberty in the McCune Albright syndrome. Acta Paediatr Scand 76:841-844
274. Boepple PA, Frisch LS, Wierman ME, Huffman WH, Crowley Jr WF 1992 The natural history of autonomous gonadal function, adrenarche and central puberty in gonadotropin-independent precocious puberty. J Clin Endocrinol Metab 75:1550-1555
275. Wickman S, Dunkel L 2001 Inhibition of P450 aromatase enhances gonadotropin secretion in early and mid pubertal boys: evidence for a pituitary site of action of endogenous estradiol. J Clin Endocrinol Metab 86:4887-4894
276. Gore AC 2002 Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Mol Cell Endocrinol 192:157-170
277. Atanassova N, McKinnell C, Turner KJ, Walker M, Fisher JS, Morley M, Millar MR, Groome NP, Sharpe RM 2000 Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels. Endocrinology 141:3898-3907
278. Saenz de Rodriguez CA, Bongiovanni AM, Conde de Borrego L 1985 An epidemic of precocious development in Puerto Rican children. J Pediatr 107:393-396
279. Guarneri MP, Russo G, Sgaramella P, Peroni P, Chiumello G 2001 Epidemic of breast enlargement in a school population: twenty years of follow up. Pediatr Res 49(Suppl):148A (abstract)
280. Den Hond E, Roels HA, Hoppenbrouwers K, Nawrot T, Thijs L, Vandermeulen C, Winneke G, Vanderschueren D, Staessen JA 2002 Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environ Health Perspect 110:771-776