Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients

Journal of Autoimmunity

Volumn 82, Issue , 2017, Pages 31-40

  Perez Sanchez C ^a   Ruiz Limon P ^a,c   Aguirre, M A ^a,b,c   Jimenez Gomez Y ^a,c   Arias de la Rosa, I ^a   Abalos Aguilera M C ^a   Rodriguez Ariza, A ^a   Castro Villegas, M C ^a,b   Ortega Castro, R ^a,b   Segui, P ^a   Martinez, C ^d   Gonzalez Conejero, R ^d   Rodriguez Lopez S ^c   Gonzalez Reyes, J A ^c   Villalba, J M ^c   Collantes Estevez E ^a,b,c   Escudero, A ^a,b   Barbarroja, N ^a   López Pedrera, Ch ^a,b  

^a Maimonides Institute for Research in Biomedicine of Cordoba   (Spain)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DEOXYRIBONUCLEASE I; HYDROGEN PEROXIDE; INFLIXIMAB; LEUKOCYTE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; SUPEROXIDE; TOCILIZUMAB; ANTIRHEUMATIC AGENT; AUTACOID; BIOLOGICAL MARKER; INTERLEUKIN 6; PEROXIDASE; TUMOR NECROSIS FACTOR;

ADULT; AGED; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; B SCAN; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; EXTRACELLULAR TRAP; FEMALE; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUTROPHIL; NUCLEOSOME; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SCANNING ELECTRON MICROSCOPY; VISUAL ANALOG SCALE; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; COMORBIDITY; COMPLICATION; METABOLISM; MIDDLE AGED; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; ATHEROSCLEROSIS; BIOMARKERS; CASE-CONTROL STUDIES; COMORBIDITY; EXTRACELLULAR TRAPS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MIDDLE AGED; OXIDATIVE STRESS; PEROXIDASE; RISK FACTORS; ROC CURVE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85018434488     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2017.04.007     Document Type: Article

References (34)

1. Khan, F., Galarraga, B., Belch, J.J., The role of endothelial function and its assessment in rheumatoid arthritis. Nat. Rev. Rheumatol. 6:5 (2010), 253–261.
2. Skeoch, S., Bruce, I.N., Atherosclerosis in rheumatoid arthritis: is it all about inflammation?. Nat. Rev. Rheumatol. 11:7 (2015), 390–400.
3. Mayadas, T.N., Rosetti, F., Ernandez, T., Sethi, S., Neutrophils: game changers in glomerulonephritis?. Trends Mol. Med. 16:8 (2010), 368–378.
4. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D.S., Weinrauch, Y., Zychlinsky, A., Neutrophil extracellular traps kill bacteria. Sci. (New York, N.Y.) 303:5663 (2004), 1532–1535.
5. Fuchs, T.A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., Zychlinsky, A., Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 176:2 (2007), 231–241.
6. Brinkmann, V., Laube, B., Abu Abed, U., Goosmann, C., Zychlinsky, A., Neutrophil extracellular traps: how to generate and visualize them. J. Vis. Exp. JoVE(36), 2010.
7. Megens, R.T., Vijayan, S., Lievens, D., Döring, Y., van Zandvoort, M.A., Grommes, J., Weber, C., Soehnlein, O., Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 107:3 (2012), 597–598.
8. Shao, B., Pennathur, S., Heinecke, J.W., Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions. J. Biol. Chem. 287:9 (2012), 6375–6386.
9. Griendling, K.K., Novel NAD(P)H oxidases in the cardiovascular system. Heart (British Card. Soc. 90:5 (2004), 491–493.
10. Tsutsui, M., Shimokawa, H., Otsuji, Y., Yanagihara, N., Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases. Pharmacol. Ther. 128:3 (2010), 499–508.
11. Döring, Y., Drechsler, M., Wantha, S., Kemmerich, K., Lievens, D., Vijayan, S., Gallo, R.L., Weber, C., Soehnlein, O., Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circul Res. 110:8 (2012), 1052–1056.
12. Liu, M.L., Bashir, M., Williams, K., Werth, V., Cholesterol loading induces neutrophil extracellular traps, and atorvastatin attenuates this effect. Arthritis Rheumatol., 66, 2014, S530.
13. Khandpur, R., Carmona-Rivera, C., Vivekanandan-Giri, A., Gizinski, A., Yalavarthi, S., Knight, J.S., Friday, S., Li, S., Patel, R.M., Subramanian, V., Thompson, P., Chen, P., Fox, D.A., Pennathur, S., Kaplan, M.J., NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci. Transl. Med., 5(178), 2013, 178ra40.
14. Sur Chowdhury, C., Giaglis, S., Walker, U.A., Buser, A., Hahn, S., Hasler, P., Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility. Arthritis Res. Ther., 16, 2014, R122.
15. Aletaha, D., Neogi, T., Silman, A.J., Funovits, J., Felson, D.T., Bingham, C.O. 3rd, Birnbaum, N.S., Burmester, G.R., Bykerk, V.P., Cohen, M.D., Combe, B., Costenbader, K.H., Dougados, M., Emery, P., Ferraccioli, G., Hazes, J.M., Hobbs, K., Huizinga, T.W., Kavanaugh, A., Kay, J., Kvien, T.K., Laing, T., Mease, P., Ménard, H.A., Moreland, L.W., Naden, R.L., Pincus, T., Smolen, J.S., Stanislawska-Biernat, E., Symmons, D., Tak, P.P., Upchurch, K.S., Vencovský, J., Wolfe, F., Hawker, G., 2010 rheumatoid arthritis classification criteria: an american College of rheumatology/european league against rheumatism collaborative initiative. Arthritis Rheumat 62:9 (2010), 2569–2581.
16. Barbarroja, N., Pérez-Sanchez, C., Ruiz-Limon, P., Castro-Villegas, C., Aguirre, M.A., Carretero, R., Segui, P., Jimenez-Gomez, Y., Sanna, M., Rodriguez-Ariza, A., Collantes-Estevez, E., Escudero, A., López-Pedrera, C., Anticyclic citrullinated protein antibodies are implicated in the development of cardiovascular disease in rheumatoid arthritis. Arterioscl, Thromb, Vasc. Biol. 34:12 (2014), 2706–2716.
17. Wells, G., Becker, J.C., Teng, J., Dougados, M., Schiff, M., Smolen, J., Aletaha, D., van Riel, P.L., Validation of the 28-joint Disease Activity Score (DAS28) and European League against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann. Rheumat Dis. 68:6 (2009), 954–960.
18. Wright, H.L., Moots, R.J., Edwards, S.W., The multifactorial role of neutrophils in rheumatoid arthritis. Nat. Rev. Rheumatol. 10:10 (2014), 593–601.
19. Kim, I., Hur, N.W., Shin, H.D., Park, B.L., Cheong, H.S., Bae, S.C., Associations of DNase IV polymorphisms with autoantibodies in patients with systemic lupus erythematosus. Rheumatol. Oxf. Engl. 47:7 (2008), 996–999.
20. Belguith-Maalej, S., Hadj-Kacem, H., Kaddour, N., Bahloul, Z., Ayadi, H., DNase1 exon2 analysis in Tunisian patients with rheumatoid arthritis, systemic lupus erythematosus and Sjögren syndrome and healthy subjects. Rheumatol. Int. 30:1 (2009), 69–74.
21. Dittmar, M., Bischofs, C., Matheis, N., Poppe, R., Kahaly, G.J., A novel mutation in the DNASE1 gene is related with protein instability and decreased enzyme activity in thyroid autoimmunity. J. Autoimmun. 32:1 (2009), 7–13.
22. Grayson, P.C., Kaplan, M.J., At the Bench: neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases. J. Leukoc. Biol. 99:2 (2016), 253–264.
23. Becattini, C., Agnelli, G., Schenone, A., Eichinger, S., Bucherini, E., Silingardi, M., Bianchi, M., Moia, M., Ageno, W., Vandelli, M.R., Grandone, E., Prandoni, P., WARFASA Investigators, Aspirin for preventing the recurrence of venous thromboembolism. N. Engl. J. Med. 366:21 (2012), 1959–1967.
24. Brighton, T.A., Eikelboom, J.W., Mann, K., Mister, R., Gallus, A., Ockelford, P., Gibbs, H., Hague, W., Xavier, D., Diaz, R., Kirby, A., Simes, J., ASPIRE Investigators, Low-dose aspirin for preventing recurrent venous thromboembolism. N. Engl. J. Med. 367:21 (2012), 1979–1987.
25. Lapponi, M.J., Carestia, A., Landoni, V.I., Rivadeneyra, L., Etulain, J., Negrotto, S., Pozner, R.G., Schattner, M., Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 345:3 (2013), 430–437.
26. Fuchs, T.A., Brill, A., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D.D. Jr., Wrobleski, S.K., Wakefield, T.W., Hartwig, J.H., Wagner, D.D., Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. U. S. A. 107:36 (2010), 15880–15885.
27. Fuchs, T.A., Bhandari, A.A., Wagner, D.D., Histones induce rapid and profound thrombocytopenia in mice. Blood 118:13 (2011), 3708–3714.
28. Zawrotniak, M., Kozik, A., Rapala-Kozik, M., Selected mucolytic, anti-inflammatory and cardiovascular drugs change the ability of neutrophils to form extracellular traps (NETs). Acta biochim. Pol. 62:3 (2015), 465–473.
29. Wong, M., Ziring, D., Korin, Y., Desai, S., Kim, S., Lin, J., Gjertson, D., Braun, J., Reed, E., Singh, R.R., TNFalpha blockade in human diseases: mechanisms and future directions. Clin. Immunol. Orl. Fla.) 126:2 (2008), 121–136.
30. Alunno, A., Manetti, M., Caterbi, S., Ibba-Manneschi, L., Bistoni, O., Bartoloni, E., Valentini, V., Terenzi, R., Gerli, R., Altered immunoregulation in rheumatoid arthritis: the role of regulatory T cells and proinflammatory Th17 cells and therapeutic implications. Mediat. Inflamm., 2015, 2015, 751793.
31. Obeng, J.A., Amoruso, A., Camaschella, G.L., Sola, D., Brunelleschi, S., Fresu, L.G., Modulation of human monocyte/macrophage activity by tocilizumab, abatacept and etanercept: an in vitro study. Eur. J. Pharmacol. 780 (2016), 33–37.
32. Wright, H.L., Cross, A.L., Edwards, S.W., Moots, R.J., Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatol. Oxf. Engl. 53:7 (2014), 1321–1331.
33. Protogerou, A.D., Zampeli, E., Fragiadaki, K., Stamatelopoulos, K., Papamichael, C., Sfikakis, P.P., A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis. Atherosclerosis 219:2 (2011), 734–736.
34. Schaper, F., Rose-John, S., Interleukin-6: biology, signaling and strategies of blockade. Cytokine & growth factor Rev. 26:5 (2015), 475–487.