Selected mucolytic, anti-inflammatory and cardiovascular drugs change the ability of neutrophils to form extracellular traps (NETs)

Acta Biochimica Polonica

Volumn 62, Issue 3, 2015, Pages 465-473

  Zawrotniak, Marcin ^a   Kozik, Andrzej ^a   Rapala Kozik, Maria ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Inflammation; Neutrophil extracellular trap; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; CARDIOVASCULAR AGENT; CLEMASTINE; ETAMSYLATE; HYDROGEN PEROXIDE; KETOPROFEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EXTRACELLULAR TRAP; HUMAN; METABOLISM; NEUTROPHIL; NORMAL HUMAN; PHAGOCYTOSIS;

ACETYLCYSTEINE; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR AGENTS; CELL SURVIVAL; CLEMASTINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHAMSYLATE; EXTRACELLULAR TRAPS; HEALTHY VOLUNTEERS; HUMANS; HYDROGEN PEROXIDE; KETOPROFEN; NADPH OXIDASE; NEUTROPHILS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES;

EID: 84943225074     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2015_1055     Document Type: Article

References (69)

1. Alvarez-Guerra M, Hernandez MR, Escolar G, Chiavaroli C, Garay RP, Hannaert P (2002) The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Thromb Res 107: 329-335.
2. Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A (2012) Neutrophil function: from mechanisms to disease. Annu Rev Immunol 30: 459-489.
3. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troché G (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288: 862-871.
4. Aruoma OI, Halliwell B, Hoey BM, Butler J (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 6: 593-597.
5. Benbarek H, Ayad A, Deby-Dupont G, Boukraa L, Serteyn D (2012) Modulatory effects of non-steroidal anti-inflammatory drugs on the luminol and lucigenin amplified chemiluminescence of equine neutrophils. Vet Res Commun 36: 29-33.
6. Bianchi M, Hakkim A, Brinkmann V, Siler U, Seger R, Zychlinsky A, Reichenbach, J (2009) Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 114: 2619-2622.
7. Bjornson BH, Harvey JM, Rose L (1985) Differential effect of hydrocortisone on eosinophil and neutrophil proliferation. J Clin Invest 76: 924-929.
8. Borgström L, Kågedal B, Paulsen O (1986) Pharmacokinetics of Nacetylcysteine in man. Eur J Clin Pharmacol 31: 217-222.
9. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A (2004) Neutrophil extracellular traps kill bacteria. Science 303: 1532-1535.
10. Brinkmann V, Zychlinsky A (2012) Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol 198: 773-783.
11. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Looney MR (2012) Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest 122: 2661-2671.
12. Chow O, Von Köckritz-Blickwede M, Bright T, Hensler ME, Zinkernagel AS, Cogen AL, Nizet V (2010) Statins enhance formation of phagocyte extracellular traps. Cell Host and Microbe 8: 445-454.
13. Cíž M, Lojek A (2013) Modulation of neutrophil oxidative burst via histamine receptors. Br J Pharmacol 170: 17-22.
14. Coates TD, Wolach B, Tzeng DY, Higgins C, Baehner RL, Boxer LA (1983) The mechanism of action of the antiinflammatory agents dexamethasone and Auranofin in human polymorphonuclear leukocytes. Blood 62: 1070-1077.
15. Costa D, Moutinho L, Lima JLFC, Fernandes E (2006) Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull 29: 1659-1670.
16. Dale DC, Fauci AS, Guerry D, Wolff SM (1975) Comparison of agents producing a neutrophilic leukocytosis in man Hydrocortisone, prednisone, endotoxin, and etiocholanolone. J Clin Invest 56: 808-813.
17. Dandona P, Aljada A, Ghanim H, Mohanty P, Hamouda W, AlHaddad W (2001) Acute suppressive effect of hydrocortisone on p47 subunit of nicotinamide adenine dinucleotide phosphate oxidase. Metabolism 50: 548-552.
18. Dandona P, Suri M, Hamouda W, Aljada A, Kumbkarni Y, Thusu K (1999) Hydrocortisone-induced inhibition of reactive oxygen species by polymorphonuclear neutrophils. Crit Care Med 27: 2442-2444.
19. Dandona P, Thusu K, Hafeez R, Abdel-Rahman E, Chaudhuri A (1998) Effect of hydrocortisone on oxygen free radical generation by mononuclear cells. Metabolism 47: 788-791.
20. Dayrens P, Ivanoff B, Cussac M, Fontanges R (1983) Antiinflammatory and immunostimulant activities of six sulphur compounds-four benzenesulphonates, levamisole, and pyritinol hydrochloride-assayed in mouse cell activation studies. Arzneimittelforschung 33: 372-377.
21. Douda DN, Khan M, Grasemann H, Palaniyar N (2015) SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc Natl Acad Sci 112: 2817-2822.
22. Drost E, Lannan S, Bridgeman MME, Brown D, Selby C, Donaldson K, MacNee W (1991) Lack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophages. Eur Respir J 4: 723-729.
23. Duranton J, Belorgey D, Carrère J, Donato L, Moritz T, Bieth JG (2000) Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA. FEBS Lett 473: 154-156.
24. El-Shabrawy Y, El-Enany N, Salem K (2004) Sensitive kinetic spectrophotometric determination of captopril and ethamsylate in pharmaceutical preparations and biological fluids. Farmaco 59: 803-808.
25. Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V, Zychlinsky A (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176: 231-241.
26. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Wagner D D (2010) Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA 107: 15880-15885.
27. Fuchs TA, Brill A, Wagner DD (2012) Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology 32: 1777-1783.
28. Gerilechaogetu, HH, Abe A, Kondo Y (2009) Extracellular signal-regulated kinase (ERK) activation in chicken heterophils stimulated with phorbol 12-myristate 13-acetate (PMA), formyl-methionylleucyl-phenylalanine (fMLP) and lipopolysaccharide (LPS). Anim Sci J 80: 577-584.
29. Guimarães-Costa AB, Nascimento MTC, Wardini AB, Pinto-da-Silva LH, Saraiva E M (2012) ETosis: a microbicidal mechanism beyond cell death. J Parasitol Res 2012: 929743.
30. Gupta AK, Giaglis S, Hasler P, Hahn S (2014) Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. PLoS ONE 9: 19-21.
31. Hakkim A, Fuchs T, Martinez NE, Hess S, Prinz H, Zychlinsky A, Waldmann H (2011) Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol 7: 75-77.
32. Hernandez MR, Alvarez-Guerra M, Escolar G, Chiavaroli C, Hannaert P, Garay, RP (2004) The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury. Fundam Clin Pharmacol 18: 423-430.
33. Heyn J, Beiras-Fernandez A, Luchting B, Briegel J, Weis F (2011) Inflammatory reactions and hydrocortisone in the setting of cardiac surgery: an overview. Cardiovasc Hematol Agents Med Chem 9: 56-61.
34. Holdiness, MR (1991) Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet 20: 123-134.
35. Kaplan MJ, Radic M (2012) Neutrophil extracellular traps: doubleedged swords of innate immunity. J Immunol 189: 2689-2695.
36. Keshari RS, Verma A, Barthwal MK, Dikshit M (2012) Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils. J Cell Biochem 15: 1-24.
37. Kharazmi A, Nielsen H, Schiøtz PO (1988) N-acetylcysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolism. Int J Immunopharmacol 10: 39-46.
38. Kirchner T, Hermann E, Möller S, Klinger M, Solbach W, Laskay T, Behnen M (2013) Flavonoids and 5-aminosalicylic acid inhibit the formation of neutrophil extracellular traps. Mediators Inflamm 2013: 1-10.
39. Kumar V, Sharma A (2010) Neutrophils: Cinderella of innate immune system. Int Immunopharmacol 10: 1325-1334.
40. Lapponi MJ, Carestia A, Landoni VI, Rivadeneyra L, Etulain J, Negrotto S, Pozner RG, Schattner M (2013) Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther 345: 430-437.
41. Li Y, Trush MA (1998) Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Biochem Biophys Res Commun 253: 295-299.
42. Liles WC, Dale DC, Klebanoff SJ (1995) Glucocorticoids inhibit apoptosis of human neutrophils. Blood 86: 3181-3188.
43. Lojek A, Cíž M, Pekarová M, Ambrožová G, Vašícek O, Moravcová J, Kubala L, Drábiková K, Jancinová V, Perecko T (2011) Modulation of metabolic activity of phagocytes by antihistamines. Interdiscip Toxicol 4: 15-19.
44. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I (2008) Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Critical Care Med 1937-1949.
45. Masha A, Martina V (2014) Endothelial dysfunction in metabolic diseases: role of oxidation and possible therapeutic employment of Nacetylcysteine. Curr Med Chem 32: 3616-3635.
46. McLeish KR, Merchant ML, Klein JB, Ward RA. (2013) Technical note: proteomic approaches to fundamental guestions about neutrophil biology. J Leucocyte Biol 94: 682-692.
47. Nanì S, Fumagalli L, Sinha U, Kamen L, Scapini P, Berton, G (2015) Src family kinases and syk are required for neutrophil extracellular trap formation in response to β-glucan particles. J Innate Immun 7: 59-73.
48. Nishinaka Y, Arai T, Adachi S, Takaori-Kondo A, Yamashita K (2011) Singlet oxygen is essential for neutrophil extracellular trap formation. Biochem Biophys Res Commun 413: 75-79.
49. Nosál R, Drábiková K, Cíž M, Lojek A, Danihelová E (2002) Effect of H1-antagonist Dithiaden® on human PMN-leukocyte aggregation and chemiluminescence is stimulus-dependent. Inflamm Res 51: 557-562.
50. Papayannopoulos V, Staab D, Zychlinsky A (2011) Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy. PloS One 6: e28526.
51. Parker H, Dragunow M, Hampton MB, Kettle J, Winterbourn CC (2012) Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. J Leukoc Biol 92: 841-849.
52. Petroni KC, Shen L, Guyre PM (1988) Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-γ and glucocorticoids. J Immunol 140: 3467-3472.
53. Pilsczek FH, Salina D, Poon KKH, Fahey C, Yipp BG, Sibley CD, Robbins SM, Green FHY, Surette MG, Sugai M (2010) A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol 185: 7413-7425.
54. Regenthal R, Krueger M, Koeppel C, Preiss R (1999) Drug levels: therapeutic and toxic serum/plasma concentrations of common drugs. J Clin Monit Comput 15: 529-544.
55. Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T (2011) Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ 18: 581-588.
56. Sack ES, Cerutti N (1973) Effects of cyclonamine on blood platelets II Changes in the surface charge and inhibition of the release reaction. Medicina (B Aires) 33: 685-694.
57. Sadowska, A M, Manuel-Y-Keenoy, B, Vertongen, T, Schippers, G, Radomska-Lesniewska, D, Heytens, E, and De Backer, W a (2006) Effect of N-acetylcysteine on neutrophil activation markers in healthy volunteers: In vivo and in vitro study. Pharmacol Res 53: 216-225.
58. Saffarzadeh M, Juenemann C, Queisser M, Lochnit G, Barreto G, Galuska SP, Preissner KT (2012) Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PloS One 7: e32366.
59. Schleimer RP, Freeland HS, Peters SP, Brown KE, Derse CP (1989) An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils. J Pharmacol Exp Ther 250: 598-605.
60. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, (2008) Hydrocortisone therapy for patients with septic shock. N Engl J Med 358: 111-124.
61. Stolarek R, Bialasiewicz P, Nowak D (2002) N-acetylcysteine effect on the luminol-dependent chemiluminescence pattern of reactive oxygen species generation by human polymorphonuclear leukocytes. Pulm Pharmacol Ther 15: 385-392.
62. Taniguchi K, Masuda Y, Takanaka K (1991) Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn 14: 87-93.
63. Urban CF, Ermert D, Schmid M, Abu-Abed U, Goosmann C, Nacken W, Brinkmann V, Jungblut PR, Zychlinsky A (2009) Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog 5.
64. Ward, PA (1966) The chemosuppression of chemotaxis. J Exp Med 124: 209-226.
65. Weyts FAA, Flik G, Verburg-Van Kemenade, BML (1998) Cortisol inhibits apoptosis in carp neutrophilic granulocytes. Dev Comp Immunol 22: 563-572.
66. Wozniok I, Hornbach A, Schmitt C, Frosch M, Einsele H, Hube B, Löffler J, Kurzai O (2008) Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 10: 807-820.
67. Wu XY, Luo AY, Zhou YR, Ren JH (2014) N-acetylcysteine reduces oxidative stress, nuclear factor ?B activity and cardiomyocyte apoptosis in heart failure. Mol Med Rep 10: 615-624.
68. Zafarullah M, Li WQ, Sylvester J, Ahmad M (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6-20.
69. Zawrotniak M, Rapala-Kozik M (2013) Neutrophil extracellular traps (NETs) formation and implications. Acta Biochim Pol 60: 277-284.