Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci

PLoS Genetics

Volumn 13, Issue 4, 2017, Pages

  Rolo, Joana ^a   Worning, Peder ^b   Boye Nielsen, Jesper ^b   Sobral, Rita ^c   Bowden, Rory ^d   Bouchami, Ons ^a   Damborg, Peter ^e   Guardabassi, Luca ^e,f   Perreten, Vincent ^g   Westh, Henrik ^b,e   Tomasz, Alexander ^h   de Lencastre, Hermínia ^a,h   Miragaia, Maria ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b HVIDOVRE HOSPITAL   (Denmark)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f ROSS UNIVERSITY SCHOOL OF VETERINARY MEDICINE   (Saint Kitts and Nevis)

^g UNIVERSITY OF BERN   (Switzerland)

^h ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; PENICILLIN BINDING PROTEIN;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENOME; CONTROLLED STUDY; EVOLUTION; GENE SEQUENCE; HUMAN; MECA GENE; MUTATION RATE; NONHUMAN; PHYLOGENY; PROMOTER REGION; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; STAPHYLOCOCCUS; STAPHYLOCOCCUS FLEURETTII; STAPHYLOCOCCUS SCIURI; STAPHYLOCOCCUS VITULINUS; BAYES THEOREM; DRUG EFFECTS; GENETICS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BAYES THEOREM; BETA-LACTAM RESISTANCE; BETA-LACTAMS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PENICILLIN-BINDING PROTEINS; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS;

EID: 85018372872     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006674     Document Type: Article

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