A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 6, 2000, Pages 1549-1555

  Katayama, Y ^a   Ito, T ^a   Hiramatsu, K ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE CASSETTE; GENE EXPRESSION; GENE INSERTION; GENE LOCATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CARRIER PROTEINS; CHROMOSOMES, BACTERIAL; HEXOSYLTRANSFERASES; METHICILLIN; METHICILLIN RESISTANCE; MOLECULAR SEQUENCE DATA; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PENICILLINS; PEPTIDYL TRANSFERASES; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS;

EID: 0034038098     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.6.1549-1555.2000     Document Type: Article

References (32)

1. Ayliffe, G. A. 1997. The progressive intercontinental spread of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 24(Suppl. 1):74-79.
2. Barberis-Maino, L., B. Berger-Bachi, H. Weber, W. D. Beck, and F. H. Kayser. 1987. IS431, a staphylococcal insertion sequence-like element related to IS26 from Proteus vulgaris. Gene 59:107-113.
3. Chambers, H. F., and H. C. Neu. 1995. Penicillins, p. 233-246. In G. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases. Churchill Livingstone, New York, N.Y.
4. Christiansen, B., L. Brondsted, F. K. Vogensen, and K. Hammer. 1996. A resolvase-like protein is required for the site-specific integration of the temperate lactococcal bacteriophage TP901-1. J. Bacteriol. 178:5164-5173.
5. Clewell, D. B. 1998. Conjugative transposons, p. 130-139. In F. J. de Bruijn, J. R. Lupski, and G. M. Weinstock (ed.), Bacterial genomes. Chapman and Hall, New York, N.Y.
6. Cohen, S., and H. M. Sweeney. 1970. Transduction of methicillin resistance in Staphylococcus aureus dependent on an unusual specificity of the recipient strain. J. Bacteriol. 104:1158-1167.
7. Dubin, D. T., P. R. Matthews, S. G. Chikramane, and P. R. Stewart. 1991. Physical mapping of the mec region of an American methicillin-resistant Staphylococcus aureus strain. Antimicrob. Agents Chemother. 35:1661-1665.
8. Hanaki, H., K. Kuwahara-Arai, S. Boyle-Vavra, R. S. Daum, H. Labischinski, and K. Hiramatsu. 1998. Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. J. Antimicrob. Chemother. 42:199-209.
9. Hartman, B. J., and A. Tomasz. 1984. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol. 158:513-516.
10. Hiramatsu, K., K. Asada, E. Suzuki, K. Okonogi, and T. Yokota. 1992. Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Lett. 298:133-136.
11. Hiramatsu, K., E. Suzuki, H. Katayama, Y. Katayama, and T. Yokota. 1990. Role of penicillinase plasmids in the stability of the mecA gene in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 34:600-604.
12. Hiramatsu, K., T. Ito, and H. Hanaki. 1999. Evolution of methicillin and glycopeptide resistance in Staphylococcus aureus, p. 221-242. In R. G. Finch and R. J. Williams (ed.), Bailliere's clinical infectious disease. Bailliere Tindall, London, United Kingdom.
13. Hurlimann-Dalei, R. L., C. Ryffel, F. H. Kayser, and B. Berger-Bachi. 1992. Survey of the methicillin resistance-associated genes mecA, mecR1-mecI, and femA-femB in clinical isolates of methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 36:2617-2621.
14. Ito, T., Y. Katayama, and K. Hiramatsu. 1999. Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob. Agents Chemother. 43:1449-1458.
15. Jevons, M. P. 1961. "Celbenin"-resistant staphylococci. Br. Med. J. 1:124-125.
16. Kreiswirth, B., J. Kornblum, R. D. Arbeit, W. Eisner, J. N. Maslow, A. McGeer, D. E. Low, and P. R. Novick. 1993. Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science 259:227-230.
17. Kuwahara-Arai, K., N. Kondo-Hori, E. Tateda-Suzuki, and K. Hiramatsu. 1996. Suppression of methicillin resistance in a mecA-containing pre-methicillin-resistant Staphylococcus aureus strain is caused by the mecI-mediated repression of PBP2' production. Antimicrob. Agents Chemother. 40:2680-2685.
18. Lee, C. A. 1996. Pathogenicity islands and the evolution of bacterial pathogens. Infect. Agents Dis. 5:1-7.
19. Lindsay, J. A., A. Ruzin, H. F. Ross, N. Kurepina, and R. P. Novick. 1998. The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus. Mol. Microbiol. 29:527-543.
20. Matsuhashi, M., M. D. Song, F. Ishino, M. Wachi, M. Doi, M. Inoue, K. Ubukata, N. Yamashita, and M. Konno. 1986. Molecular cloning of the gene of a penicillin binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus. J. Bacteriol. 167:975-980.
21. Matthews, P., and A. Tomasz. 1990. Insertional inactivation of the mec gene in a transposon mutant of a methicillin-resistant clinical isolate of Staphylococcus aureus. Antimicrob. Agents Chemother. 34:1777-1779.
22. McKenzie, H. T., T. Hoshino, T. Tanaka, and N. Sueoka. 1986. The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid 15:93-103.
23. Murphy, E. L. Huwyler, and M. C. Bastos. 1985. Transposon Tn554: complete nucleotide sequence and isolation of transposition-defective and antibiotic-sensitive mutants. EMBO J. 4:3357-3365.
24. Reynolds, P. E., and D. F. J. Brown. 1985. Penicillin-binding proteins of beta-lactam-resistant strains of Staphylococcus aureus. FEBS Lett. 192:28-32.
25. Sherratt, D. 1989. Tn3 and related transposable elements: site-specific recombination and transposition, p. 163-184. In D. E. Berg and M. M. Howe (ed.), Mobile DNA. American Society for Microbiology, Washington, D.C.
26. Song, M. D., M. Wachi, M. Doi, F. Ishino, and M. Matsuhashi. 1987. Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion. FEBS Lett. 221:167-171.
27. Stewart, P. R., D. T. Dubin, S. G. Chikramane, B. Ingli, P. R. Matthews, and S. M. Poston. 1994. IS257 and small plasmid insertions in the mec region of the chromosome of Staphylococcus aureus. Plasmid 31:12-20.
28. Suzuki, E., K. Hiramatsu, and T. Yokota. 1992. Survey of methicillin-resistant clinical strains of coagulase-negative staphylococci for mecA gene distribution. Antimicrob. Agents Chemother. 36:429-434.
29. Thompson, J. F., and A. Landy. 1989. Regulation of bacteriophage lambda site-specific recombination, p. 1-22. In D. E. Berg and M. M. Howe (ed.), Mobile DNA. American Society for Microbiology, Washington, D.C.
30. Utsui, Y., and T. Yokota. 1985. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 28:397-403.
31. Wada, A., Y. Katayama, K. Hiramatsu, and T. Yokota. 1991. Southern hybridization analysis of the mecA deletion from methicillin-resistant Staphylococcus aureus. Biochem. Biophys. Res. Commun. 176:1319-1325.
32. Yoshida, T., N. Kondo, Y. A. Hanifah, and K. Hiramatsu. 1997. Combined use of ribotyping, PFGE typing and IS431 typing the discrimination of nosocomical strains of methicillin-resistant Staphylococcus aureus. Microbiol. Immunol. 41:687-695.