Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfx, the gene containing the staphylococcal chromosome cassette mec (SCCmec) insertion site

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 132-140

  Boundy, Sam ^a   Safo, Martin K ^b   Wang, Lei ^a   Musayev, Faik N ^b   O'Farrell, Heather C ^b   Rife, Jason P ^b   Archer, Gordon L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACTERIAL GROWTH; BINDING AFFINITIES; C TERMINUS; GENE PRODUCTS; GENOMIC ISLANDS; INSERTION SITE; ISOTHERMAL TITRATION CALORIMETRY; METHYLTRANSFERASES; S ADENOSYL L METHIONINES; SOLUTION STUDY; STAPHYLOCOCCUS AUREUS; STRUCTURAL HOMOLOGY;

ALKYLATION; AMINO ACIDS; BACTERIA; BINDING ENERGY; CHROMOSOMES; ESCHERICHIA COLI; GENE ENCODING; GENE EXPRESSION; METHYLATION; MONOMERS; RNA;

ENZYME INHIBITION;

PROTEIN ORFX; RNA METHYLTRANSFERASE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE CASSETTE; GENE INSERTION SEQUENCE; NONHUMAN; ORFX GENE; PRIORITY JOURNAL; RNA METHYLATION; STAPHYLOCOCCAL CHROMOSOME CASSETTE MEC; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; METHYLTRANSFERASES; MODELS, GENETIC; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES; RNA, RIBOSOMAL; STAPHYLOCOCCUS AUREUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LOTUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 84872081024     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.385138     Document Type: Article

References (24)

1. Noto, M. J., Kreiswirth, B. N., Monk, A. B., and Archer, G. L. (2008) Gene acquisition at the insertion site for SCCmec, the genomic island conferring methicillin resistance in Staphylococcus aureus. J. Bacteriol. 190, 1276-1283 (Pubitemid 351215008)
2. Tkaczuk, K. L., Dunin-Horkawicz, S., Purta, E., and Bujnicki, J. M. (2007) Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. BMC Bioinformatics 8, 73
3. Sass, P., Berscheid, A., Jansen, A., Oedenkoven, M., Szekat, C., Strittmatter, A., Gottschalk, G., and Bierbaum, G. (2012) Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics. J. Bacteriol. 194, 2107-2108
4. Badger, J., Sauder, J. M., Adams, J. M., Antonysamy, S., Bain, K., Bergseid, M. G., Buchanan, S. G., Buchanan, M. D., Batiyenko, Y., Christopher, J. A., Emtage, S., Eroshkina, A., Feil, I., Furlong, E. B., Gajiwala, K. S., Gao, X., He, D., Hendle, J., Huber, A., Hoda, K., Kearins, P., Kissinger, C., Laubert, B., Lewis, H. A., Lin, J., Loomis, K., Lorimer, D., Louie, G., Maletic, M., Marsh, C. D., Miller, I., Molinari, J., Muller-Dieckmann, H. J., Newman, J. M., Noland, B. W., Pagarigan, B., Park, F., Peat, T. S., Post, K. W., Radojicic, S., Ramos, A., Romero, R., Rutter, M. E., Sanderson, W. E., Schwinn, K. D., Tresser, J., Winhoven, J., Wright, T. A., Wu, L., Xu, J., and Harris, T. J. (2005) Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins 60, 787-796 (Pubitemid 41266436)
5. Novick, R. (1967) Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33, 155-166
6. Kreiswirth, B. N., Löfdahl, S., Betley, M. J., O'Reilly, M., Schlievert, P. M., Bergdoll, M. S., and Novick, R. P. (1983) The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305, 709-712 (Pubitemid 13021519)
7. Wang, L., Safo, M., and Archer, G. L. (2012) Characterization of DNA sequences required for the CcrAB-mediated integration of staphylococcal cassette chromosome mec, a Staphylococcus aureus genomic island. J. Bacteriol. 194, 486-498
8. Niemeyer, D. M., Pucci, M. J., Thanassi, J. A., Sharma, V. K., and Archer, G. L. (1996) Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus. J. Bacteriol. 178, 5464-5471 (Pubitemid 26304381)
9. Ero, R., Peil, L., Liiv, A., and Remme, J. (2008) Identification of pseudouridine methyltransferase in Escherichia coli. RNA 14, 2223-2233
10. Farrar, C. E., and Clarke, S. (2005) Diet-dependent survival of protein repair-deficient mice. J. Nutr. Biochem. 16, 554-561 (Pubitemid 41188036)
11. Todd, M. J., and Gomez, J. (2001) Enzyme kinetics determined using calorimetry: a general assay for enzyme activity? Anal. Biochem. 296, 179-187 (Pubitemid 32868499)
12. Freyer, M. W., and Lewis, E. A. (2008) Isothermal titration calorimetry: experimental design, data analysis, and probing macromolecule/ligand binding and kinetic interactions. Methods Cell Biol. 84, 79-113
13. Adams, P. D., Grosse-Kunstleve, R. W., Hung, L. W., Ioerger, T. R., McCoy, A. J., Moriarty, N. W., Read, R. J., Sacchettini, J. C., Sauter, N. K., and Terwilliger, T. C. (2002) PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 58, 1948-1954 (Pubitemid 35337293)
14. Emsley, P., and Cowtan, K. (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132 (Pubitemid 41742764)
15. Holm, L., and Sander, C. (1993) Protein structure comparison by alignment of distance matrices. J. Mol. Biol. 233, 123-138 (Pubitemid 23288916)
16. Mallam, A. L., and Jackson, S. E. (2007) A comparison of the folding of two knotted proteins: YbeA and YibK. J. Mol. Biol. 366, 650-665 (Pubitemid 46136200)
17. 3ψ methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA 14, 2234-2244
18. 1G37)methyltransferase from Salmonella typhimurium affect tRNA substrate specificity. RNA 5, 395-408
19. 1G37)methyltransferase: insights into tRNA recognition. EMBO J. 22, 2593-2603
20. Schuwirth, B. S., Borovinskaya, M. A., Hau, C. W., Zhang, W., Vila-Sanjurjo, A., Holton, J. M., and Cate, J. H. (2005) Structures of the bacterial ribosome at 3.5 Å resolution. Science 310, 827-834 (Pubitemid 41567336)
21. Persson, B. C., Jäger, G., and Gustafsson, C. (1997) The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2′-O-methyltransferase activity. Nucleic Acids Res. 25, 4093-4097 (Pubitemid 27443340)
22. Chen, H. Y., and Yuan, Y. A. (2010) Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase. J. Mol. Cell. Biol. 2, 366-374
23. McGhee, G. C., and Sundin, G. W. (2011) Evaluation of kasugamycin for fire blight management, effect on nontarget bacteria, and assessment of kasugamycin resistance potential in Erwinia amylovora. Phytopathology 101, 192-204
24. + T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog. 5, e1000573