메뉴 건너뛰기




Volumn 8, Issue , 2017, Pages

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

EID: 85018370681     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15081     Document Type: Article
Times cited : (714)

References (60)
  • 1
    • 0032896905 scopus 로고    scopus 로고
    • Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer
    • Harvey, J. M., Clark, G. M., Osborne, C. K. & Allred, D. C. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J. Clin. Oncol. 17, 1474-1481 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1474-1481
    • Harvey, J.M.1    Clark, G.M.2    Osborne, C.K.3    Allred, D.C.4
  • 2
    • 80053426842 scopus 로고    scopus 로고
    • Targeted therapies for breast cancer
    • Higgins, M. J. & Baselga, J. Targeted therapies for breast cancer. J. Clin. Invest. 121, 3797-3803 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3797-3803
    • Higgins, M.J.1    Baselga, J.2
  • 3
    • 39149123547 scopus 로고    scopus 로고
    • Clinical application of the 70-gene profile: The MINDACT trial
    • Cardoso, F. et al. Clinical application of the 70-gene profile: the MINDACT trial. J. Clin. Oncol. 26, 729-735 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 729-735
    • Cardoso, F.1
  • 4
    • 39149113165 scopus 로고    scopus 로고
    • Development of the 21-gene assay and its application in clinical practice and clinical trials
    • Sparano, J. A. & Paik, S. Development of the 21-gene assay and its application in clinical practice and clinical trials. J. Clin. Oncol. 26, 721-728 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 721-728
    • Sparano, J.A.1    Paik, S.2
  • 5
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang, Y. et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 512, 155-160 (2014).
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1
  • 6
    • 84939165961 scopus 로고    scopus 로고
    • Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
    • Ng, C. K. et al. Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome Biol. 16, 107 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 107
    • Ng, C.K.1
  • 7
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne, C. K. & Schiff, R. Mechanisms of endocrine resistance in breast cancer. Annu. Rev. Med. 62, 233-247 (2011).
    • (2011) Annu. Rev. Med. , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 8
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak, G. et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat. Med. 14, 518-527 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 518-527
    • Finak, G.1
  • 9
    • 84924076132 scopus 로고    scopus 로고
    • The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: Recommendations by an International TILs Working Group 2014
    • Salgado, R. et al. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann. Oncol. 26, 259-271 (2015).
    • (2015) Ann. Oncol. , vol.26 , pp. 259-271
    • Salgado, R.1
  • 10
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 11
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez, N., Truitt, M., Olson, P., Arron, S. T. & Hanahan, D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 17, 135-147 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 12
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T. F., Schreiber, H. & Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014-1022 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 13
    • 33746718151 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages as a novel strategy against breast cancer
    • Luo, Y. et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J. Clin. Invest. 116, 2132-2141 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2132-2141
    • Luo, Y.1
  • 14
    • 84997610846 scopus 로고    scopus 로고
    • B cell regulation of the anti-tumor response and role in carcinogenesis
    • Schwartz, M., Zhang, Y. & Rosenblatt, J. D. B cell regulation of the anti-tumor response and role in carcinogenesis. J. Immunother. Cancer 4, 40 (2016).
    • (2016) J. Immunother. Cancer , vol.4 , pp. 40
    • Schwartz, M.1    Zhang, Y.2    Rosenblatt, J.D.3
  • 15
    • 84859102962 scopus 로고    scopus 로고
    • The prognostic significance of B lymphocytes in invasive carcinoma of the breast
    • Mahmoud, S. M. et al. The prognostic significance of B lymphocytes in invasive carcinoma of the breast. Breast Cancer Res. Treat. 132, 545-553 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.132 , pp. 545-553
    • Mahmoud, S.M.1
  • 16
    • 84942917849 scopus 로고    scopus 로고
    • The first five years of single-cell cancer genomics and beyond
    • Navin, N. E. The first five years of single-cell cancer genomics and beyond. Genome Res. 25, 1499-1507 (2015).
    • (2015) Genome Res. , vol.25 , pp. 1499-1507
    • Navin, N.E.1
  • 17
    • 84937573360 scopus 로고    scopus 로고
    • Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
    • Kim, K. T. et al. Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. Genome Biol. 16, 127 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 127
    • Kim, K.T.1
  • 18
    • 84937160316 scopus 로고    scopus 로고
    • Delineating cancer evolution with single-cell sequencing
    • Navin, N. E. Delineating cancer evolution with single-cell sequencing. Sci. Transl. Med. 7, 296fs229 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 296fs229
    • Navin, N.E.1
  • 19
    • 65549165975 scopus 로고    scopus 로고
    • Genetic alterations and oncogenic pathways associated with breast cancer subtypes
    • Hu, X. et al. Genetic alterations and oncogenic pathways associated with breast cancer subtypes. Mol. Cancer Res. 7, 511-522 (2009).
    • (2009) Mol. Cancer Res. , vol.7 , pp. 511-522
    • Hu, X.1
  • 20
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas N.
    • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 21
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji, S. et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486, 405-409 (2012).
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1
  • 22
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
    • Curtis, C. et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature 486, 346-352 (2012).
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1
  • 23
    • 84893910301 scopus 로고    scopus 로고
    • Quantitative assessment of single-cell RNA-sequencing methods
    • Wu, A. R. et al. Quantitative assessment of single-cell RNA-sequencing methods. Nat. Methods 11, 41-46 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 41-46
    • Wu, A.R.1
  • 24
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • Patel, A. P. et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344, 1396-1401 (2014).
    • (2014) Science , vol.344 , pp. 1396-1401
    • Patel, A.P.1
  • 25
    • 0032823523 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA copy-number changes using cDNA microarrays
    • Pollack, J. R. et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat. Genet. 23, 41-46 (1999).
    • (1999) Nat. Genet. , vol.23 , pp. 41-46
    • Pollack, J.R.1
  • 26
    • 84885673911 scopus 로고    scopus 로고
    • Inferring tumour purity and stromal and immune cell admixture from expression data
    • Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, 2612 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2612
    • Yoshihara, K.1
  • 27
    • 51349088017 scopus 로고    scopus 로고
    • Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
    • Desmedt, C. et al. Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Clin. Cancer Res. 14, 5158-5165 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5158-5165
    • Desmedt, C.1
  • 28
    • 58149330982 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures
    • Wirapati, P. et al. Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res. 10, R65 (2008).
    • (2008) Breast Cancer Res. , vol.10 , pp. R65
    • Wirapati, P.1
  • 29
    • 84943143136 scopus 로고    scopus 로고
    • Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
    • Lawson, D. A. et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature 526, 131-135 (2015).
    • (2015) Nature , vol.526 , pp. 131-135
    • Lawson, D.A.1
  • 30
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 31
    • 84924333189 scopus 로고    scopus 로고
    • Transfer of clinically relevant gene expression signatures in breast cancer: From Affymetrix microarray to Illumina RNA-Sequencing technology
    • Fumagalli, D. et al. Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology. BMC Genomics 15, 1008 (2014).
    • (2014) BMC Genomics , vol.15 , pp. 1008
    • Fumagalli, D.1
  • 32
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
    • (2015) Cell , vol.161 , pp. 1202-1214
    • Macosko, E.Z.1
  • 33
    • 0035881617 scopus 로고    scopus 로고
    • Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns
    • Gruvberger, S. et al. Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res. 61, 5979-5984 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5979-5984
    • Gruvberger, S.1
  • 34
    • 0031877301 scopus 로고    scopus 로고
    • C-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry
    • Prall, O. W., Rogan, E. M., Musgrove, E. A., Watts, C. K. & Sutherland, R. L. c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry. Mol. Cell Biol. 18, 4499-4508 (1998).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 4499-4508
    • Prall, O.W.1    Rogan, E.M.2    Musgrove, E.A.3    Watts, C.K.4    Sutherland, R.L.5
  • 35
    • 65249104546 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Distinguishing between basal and nonbasal subtypes
    • Rakha, E. A. et al. Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes. Clin. Cancer Res. 15, 2302-2310 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2302-2310
    • Rakha, E.A.1
  • 36
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann, B. D. et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 121, 2750-2767 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1
  • 37
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782-795 (2013).
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1
  • 38
    • 0344953578 scopus 로고    scopus 로고
    • Transcriptional analysis of the B cell germinal center reaction
    • Klein, U. et al. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl Acad. Sci. USA 100, 2639-2644 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2639-2644
    • Klein, U.1
  • 39
    • 84963614956 scopus 로고    scopus 로고
    • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
    • Tirosh, I. et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 (2016).
    • (2016) Science , vol.352 , pp. 189-196
    • Tirosh, I.1
  • 40
    • 84989844879 scopus 로고    scopus 로고
    • T-cell exhaustion in the tumor microenvironment
    • Jiang, Y., Li, Y. & Zhu, B. T-cell exhaustion in the tumor microenvironment. Cell Death Dis. 6, e1792 (2015).
    • (2015) Cell Death Dis , vol.6 , pp. e1792
    • Jiang, Y.1    Li, Y.2    Zhu, B.3
  • 41
    • 33747303831 scopus 로고    scopus 로고
    • Signatures of human regulatory T cells: An encounter with old friends and new players
    • Pfoertner, S. et al. Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol. 7, R54 (2006).
    • (2006) Genome Biol. , vol.7 , pp. R54
    • Pfoertner, S.1
  • 42
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • Postow, M. A., Callahan, M. K. & Wolchok, J. D. Immune checkpoint blockade in cancer therapy. J. Clin. Oncol. 33, 1974-1982 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1974-1982
    • Postow, M.A.1    Callahan, M.K.2    Wolchok, J.D.3
  • 44
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49-61 (2014).
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 45
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression
    • Martinez, F. O., Gordon, S., Locati, M. & Mantovani, A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 177, 7303-7311 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 46
    • 84884204462 scopus 로고    scopus 로고
    • Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
    • Singh, J. K., Simoes, B. M., Howell, S. J., Farnie, G. & Clarke, R. B. Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells. Breast Cancer Res. 15, 210 (2013).
    • (2013) Breast Cancer Res. , vol.15 , pp. 210
    • Singh, J.K.1    Simoes, B.M.2    Howell, S.J.3    Farnie, G.4    Clarke, R.B.5
  • 47
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3-potential mechanisms of action
    • Nguyen, L. T. & Ohashi, P. S. Clinical blockade of PD1 and LAG3-potential mechanisms of action. Nat. Rev. Immunol. 15, 45-56 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 48
    • 84919494669 scopus 로고    scopus 로고
    • The immunoreceptor TIGIT regulates antitumor and antiviral CD8 T cell effector function
    • Johnston, R. J. et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8 T cell effector function. Cancer Cell 26, 923-937 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 923-937
    • Johnston, R.J.1
  • 49
    • 84923799606 scopus 로고    scopus 로고
    • Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues
    • Lee, J. H. et al. Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nat. Protoc. 10, 442-458 (2015).
    • (2015) Nat. Protoc. , vol.10 , pp. 442-458
    • Lee, J.H.1
  • 50
    • 84857540547 scopus 로고    scopus 로고
    • A three-gene model to robustly identify breast cancer molecular subtypes
    • Haibe-Kains, B. et al. A three-gene model to robustly identify breast cancer molecular subtypes. J. Natl Cancer Inst. 104, 311-325 (2012).
    • (2012) J. Natl Cancer Inst. , vol.104 , pp. 311-325
    • Haibe-Kains, B.1
  • 51
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 52
    • 79955483667 scopus 로고    scopus 로고
    • A framework for variation discovery and genotyping using next-generation DNA sequencing data
    • DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43, 491-498 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 491-498
    • De Pristo, M.A.1
  • 53
    • 84874025843 scopus 로고    scopus 로고
    • Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
    • Cibulskis, K. et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat. Biotechnol. 31, 213-219 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 213-219
    • Cibulskis, K.1
  • 54
    • 84856561659 scopus 로고    scopus 로고
    • Control-FREEC: A tool for assessing copy number and allelic content using next-generation sequencing data
    • Boeva, V. et al. Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics 28, 423-425 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 423-425
    • Boeva, V.1
  • 55
    • 84871809302 scopus 로고    scopus 로고
    • STAR: Ultrafast universal RNA-seq aligner
    • Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 56
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 57
    • 84861743958 scopus 로고    scopus 로고
    • RNA-SeQC: RNA-seq metrics for quality control and process optimization
    • DeLuca, D. S. et al. RNA-SeQC: RNA-seq metrics for quality control and process optimization. Bioinformatics 28, 1530-1532 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 1530-1532
    • DeLuca, D.S.1
  • 58
    • 84872202078 scopus 로고    scopus 로고
    • GSVA: Gene set variation analysis for microarray and RNA-seq data
    • Hanzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14, 7 (2013).
    • (2013) BMC Bioinformatics , vol.14 , pp. 7
    • Hanzelmann, S.1    Castelo, R.2    Guinney, J.3
  • 59
    • 84864579879 scopus 로고    scopus 로고
    • TNBCtype: A subtyping tool for triple-negative breast cancer
    • Chen, X. et al. TNBCtype: a subtyping tool for triple-negative breast cancer. Cancer Inform. 11, 147-156 (2012).
    • (2012) Cancer Inform. , vol.11 , pp. 147-156
    • Chen, X.1
  • 60
    • 77954069195 scopus 로고    scopus 로고
    • A flexible R package for nonnegative matrix factorization
    • Gaujoux, R. & Seoighe, C. A flexible R package for nonnegative matrix factorization. BMC Bioinformatics 11, 367 (2010).
    • (2010) BMC Bioinformatics , vol.11 , pp. 367
    • Gaujoux, R.1    Seoighe, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.