Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Ng, Charlotte K Y ^a   Martelotto, Luciano G ^a   Gauthier, Arnaud ^b   Wen, Huei Chi ^a   Piscuoglio, Salvatore ^a   Lim, Raymond S ^a   Cowell, Catherine F ^a   Wilkerson, Paul M ^c   Wai, Patty ^c   Rodrigues, Daniel N ^c   Arnould, Laurent ^d   Geyer, Felipe C ^e   Bromberg, Silvio E ^e   Lacroix Triki, Magali ^f   Penault Llorca, Frederique ^g   Giard, Sylvia ^h   Sastre Garau, Xavier ^b   Natrajan, Rachael ^c   Norton, Larry ^a   Cottu, Paul H ^b   Weigelt, Britta ^a   Vincent Salomon, Anne ^b   Reis Filho, Jorge S ^a   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b INSTITUT CURIE   (France)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d CENTRE GEORGES FRANÇOIS LECLERC   (France)

^e HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^f INSTITUT CLAUDIUS REGAUD   (France)

^g UNIVERSITÉ CLERMONT AUVERGNE   (France)

^h CENTRE OSCAR LAMBRET   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; BRF2 GENE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; COPY NUMBER VARIATION; DSN1 GENE; GENE; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC HETEROGENEITY; HUMAN; IN VITRO STUDY; MUTATIONAL ANALYSIS; ONCOGENE NEU; SEQUENCE ANALYSIS; SOMATIC MUTATION; BREAST TUMOR; FEMALE; GENE AMPLIFICATION; GENETICS; MCF-7 CELL LINE; METABOLISM; MUTATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BRF2 PROTEIN, HUMAN; DSN1 PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; NONHISTONE PROTEIN; TRANSCRIPTION FACTOR IIIB;

BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMAL PROTEINS, NON-HISTONE; FEMALE; GENE AMPLIFICATION; GENE DOSAGE; HUMANS; MCF-7 CELLS; MUTATION; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR TFIIIB;

EID: 84939165961     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0657-6     Document Type: Article

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