A motivational interviewing intervention by pharmacy students to improve medication adherence

Journal of Managed Care and Specialty Pharmacy

Volumn 23, Issue 5, 2017, Pages 549-560

  Abughosh, Susan ^a   Wang, Xin ^a   Serna, Omar ^b   Esse, Tara ^b   Mann, Amanda ^b   Masilamani, Santhi ^c   Holstad, Marcia McDonnell ^c   Essien, Ekere James ^a   Fleming, Marc ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b Cigna HealthSpring   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

AGE; AGED; ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DIABETES MELLITUS; FEMALE; FOLLOW UP; GENDER; HEALTH CARE PLANNING; HOSPITALIZATION; HUMAN; HYPERTENSION; INTERVENTION STUDY; LOWEST INCOME GROUP; MAJOR CLINICAL STUDY; MALE; MEDICAID; MEDICAL EDUCATION; MEDICARE; MEDICATION COMPLIANCE; MOTIVATIONAL INTERVIEWING; OUTCOME ASSESSMENT; PATIENT CARE; PATIENT COMPLIANCE; PHARMACY STUDENT; PROSPECTIVE STUDY; SKILL; TELEPHONE INTERVIEW; MIDDLE AGED; ORGANIZATION AND MANAGEMENT; PHARMACY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TELEPHONE; TEXAS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; DIABETES MELLITUS; FEMALE; HUMANS; HYPERTENSION; LINEAR MODELS; LOGISTIC MODELS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; MOTIVATIONAL INTERVIEWING; PHARMACEUTICAL SERVICES; PROSPECTIVE STUDIES; STUDENTS, PHARMACY; TELEPHONE; TEXAS;

EID: 85018280272     PISSN: 23760540     EISSN: 23761032     Source Type: Journal    
DOI: 10.18553/jmcp.2017.23.5.549     Document Type: Article

References (110)

1. Butler RJ, Davis TK, Johnson WG, Gardner HH. Effects of nonadherence with prescription drugs among older adults. Am J Manag Care. 2011;17(2):153-60.
2. MacLaughlin EJ, Raehl CL, Treadway AK, Sterling TL, Zoller DP, Bond CA. Assessing medication adherence in the elderly: which tools to use in clinical practice? Drugs Aging. 2005;22(3):231-55.
3. Foreman KF, Stockl KM, Le LB, et al. Impact of a text messaging pilot program on patient medication adherence. Clin Ther. 2012;34(5):1084-91.
4. Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540-50.
5. Murray MD, Morrow DG, Weiner M, et al. A conceptual framework to study medication adherence in older adults. Am J Geriatr Pharmacother. 2004;2(1):36-43.
6. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-97.
7. Deedwania PC. Blood pressure control in diabetes mellitus: is lower always better, and how low should it go? Circulation. 2011;123(24):2776-78.
8. Cooke CE, Fatodu H. Physician conformity and patient adherence to ACE inhibitors and ARBs in patients with diabetes, with and without renal disease and hypertension, in a Medicaid managed care organization. J Manag Care Pharm. 2006;12(8):649-55. Available at: http://www.jmcp.org/doi/ pdf/10.18553/jmcp.2006.12.8.649.
9. Jindal A, Whaley-Connell A, Sowers JR. Type 2 diabetes in older people; the importance of blood pressure control. Curr Cardiovasc Risk Rep. 2013;7(3):233-37.
10. Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications. Physical Ther. 2008;88(11):1254-64.
11. McLean DL, Simpson SH, McAlister FA, Tsuyuki RT. Treatment and blood pressure control in 47,964 people with diabetes and hypertension: a systematic review of observational studies. Can J Cardiol. 2006;22(10):855-60.
12. Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension. 2001;37(4):1053-59.
13. Natarajan N, Putnam W, Van Aarsen K, Beverley Lawson K, Burge F. Adherence to antihypertensive medications among family practice patients with diabetes mellitus and hypertension. Can Fam Physician. 2013;59(2):e93-100.
14. Deedwania PC. Diabetes and hypertension, the deadly duet: importance, therapeutic strategy, and selection of drug therapy. Cardiol Clin. 2005;23(2):139-52.
15. Lopez-Jaramillo P, Lopez-Lopez J, Lopez-Lopez C, Rodriguez-Alvarez MI. The goal of blood pressure in the hypertensive patient with diabetes is defined: now the challenge is go from recommendations to practice. Diabetol Metab Syndr. 2014;6(1):31.
16. Putnam W, Lawson B, Buhariwalla F, et al. Hypertension and type 2 diabetes: what family physicians can do to improve control of blood pressure-an observational study. BMC Fam Pract. 2011;12:86.
17. Adler AI, Stratton IM, Neil HA, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ. 2000;321(7258):412-19.
18. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICROHOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet. 2000;355(9200):253-59.
19. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342(3):145-53.
20. Estacio RO, Jeffers BW, Hiatt WR, Biggerstaff SL, Gifford N, Schrier RW. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. N Engl J Med. 1998;338(10):645-52.
21. The ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358(15):1547-59.
22. Grant RW, Devita NG, Singer DE, Meigs JB. Polypharmacy and medication adherence in patients with type 2 diabetes. Diabetes Care. 2003;26(5):1408-12.
23. Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836-41.
24. Brown LC, Johnson JA, Majumdar SR, Tsuyuki RT, McAlister FA. Evidence of suboptimal management of cardiovascular risk in patients with type 2 diabetes mellitus and symptomatic atherosclerosis. CMAJ. 2004;171(10):1189-92.
25. McLean DL, McAlister FA, Johnson JA, et al. A randomized trial of the effect of community pharmacist and nurse care on improving blood pressure management in patients with diabetes mellitus: study of cardiovascular risk intervention by pharmacists-hypertension (SCRIP-HTN). Arch Intern Med. 2008;168(21):2355-61.
26. Planas LG, Crosby KM, Mitchell KD, Farmer KC. Evaluation of a hypertension medication therapy management program in patients with diabetes. J Am Pharm Assoc (2003). 2009;49(2):164-70.
27. Schmittdiel JA, Uratsu CS, Karter AJ, et al. Why don't diabetes patients achieve recommended risk factor targets? Poor adherence versus lack of treatment intensification. J Gen Intern Med. 2008;23(5):588-94.
28. Lau DT, Nau DP. Oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabetes Care. 2004;27(9):2149-53.
29. Grant R, Adams AS, Trinacty CM, et al. Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management. Diabetes Care. 2007;30(4):807-12.
30. Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract. 2008;62(1):76-87.
31. Armstrong MJ, Mottershead TA, Ronksley PE, Sigal RJ, Campbell TS, Hemmelgarn BR. Motivational interviewing to improve weight loss in overweight and/or obese patients: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2011;12(9):709-23.
32. Therapeutic Resource Center. Using motivational interviewing to create change. Online continuing education and webinars. Pharmacist's Letter. Volume 2012, Course No. 243, Self-Study Course #120243. Available at: http://pharmacistsletter.therapeuticresearch.com/ce/cecourse.aspx?pc=12-243&AspxAutoDetectCookieSupport=1. Accessed March 18, 2017.
33. Miller WR, Rollnick S. Motivational Interviewing: Helping People Change. 3rd ed. New York: Guilford Press; 2012.
34. Turner AP, Sloan AP, Kivlahan DR, Haselkorn JK. Telephone counseling and home telehealth monitoring to improve medication adherence: results of a pilot trial among individuals with multiple sclerosis. Rehabil Psychol. 2014;59(2):136-46.
35. Ogedegbe G, Chaplin W, Schoenthaler A, et al. A practice-based trial of motivational interviewing and adherence in hypertensive African Americans. Am J Hypertens. 2008;21(10):1137-43.
36. Halterman JS, Szilagyi PG, Fisher SG, et al. Randomized controlled trial to improve care for urban children with asthma: results of the school-based asthma therapy trial. Arch Pediatr Adolesc Med. 2011;165(3):262-68.
37. DiIorio C, McCarty F, Resnicow K, et al. Using motivational interviewing to promote adherence to antiretroviral medications: a randomized controlled study. AIDS Care. 2008;20(3):273-83.
38. Haas L, Maryniuk M, Beck J, et al. National standards for diabetes self-management education and support. Diabetes Educ. 2012;38(5):619-29. Available at: https://www.diabeteseducator.org/docs/default-source/legacydocs/_ resources/pdf/general/2012NationalStandards.pdf. Accessed March 18, 2017.
39. Moore JM, Shartle D, Faudskar L, Matlin OS, Brennan TA. Impact of a patient-centered pharmacy program and intervention in a high-risk group. J Manag Care Spec Pharm. 2013;19(3):228-36. Available at: http://www.jmcp. org/doi/pdf/10.18553/jmcp.2013.19.3.228.
40. Lindenmeyer A, Hearnshaw H, Vermeire E, Van Royen P, Wens J, Biot Y. Interventions to improve adherence to medication in people with type 2 diabetes mellitus: a review of the literature on the role of pharmacists. J Clin Pharm Ther. 2006;31(5):409-19.
41. Brennan TA, Dollear TJ, Hu M, et al. An integrated pharmacy-based program improved medication prescription and adherence rates in diabetes patients. Health Aff (Millwood). 2012;31(1):120-29.
42. Odegard PS, Carpinito G, Christensen DB. Medication adherence program: adherence challenges and interventions in type 2 diabetes. J Am Pharm Assoc (2003). 2013;53(3):267-72.
43. Odegard PS, Christensen DB. MAP study: RCT of a medication adherence program for patients with type 2 diabetes. J Am Pharm Assoc (2003). 2012;52(6):753-62.
44. Morgado M, Rolo S, Castelo-Branco M. Pharmacist intervention program to enhance hypertension control: a randomised controlled trial. Int J Clin Pharm. 2011;33(1):132-40.
45. Fikri-Benbrahim N, Faus MJ, Martinez-Martinez F, Sabater-Hernández D. Impact of a community pharmacists' hypertension-care service on medication adherence. The AFenPA study. Res Social Adm Pharm. 2013;9(6):797-805.
46. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006;296(21):2563-71.
47. Lau R, Stewart K, McNamara KP, et al. Evaluation of a community pharmacy-based intervention for improving patient adherence to antihypertensives: a randomised controlled trial. BMC Health Serv Res. 2010;10:34.
48. Svarstad BL, Kotchen JM, Shireman TI, et al. Improving refill adherence and hypertension control in black patients: Wisconsin TEAM trial. J Am Pharm Assoc (2003). 2013;53(5):520-29.
49. Lowe CJ, Raynor DK, Purvis J, Farrin A, Hudson J. Effects of a medicine review and education programme for older people in general practice. Br J Clin Pharmacol. 2000;50(2):172-75.
50. ASHP statement on the pharmacist's role in primary care. Am J Health Syst Pharm. 1999;56(16):1665-67.
51. Rybacki JJ. Improving cardiovascular health in postmenopausal women by addressing medication adherence issues. J Am Pharm Assoc (Wash). 2002;42(1):63-71; quiz 72-73.
52. Raebel MA. Hyperkalemia associated with use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Cardiovasc Ther. 2012;30(3):e156-66.
53. Schoolwerth AC, Sica DA, Ballermann BJ, Wilcox CS; Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association. Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association. Circulation. 2001;104(16):1985-91.
54. Arlt S, Lindner R, Rösler A, von Renteln-Kruse W. Adherence to medication in patients with dementia: predictors and strategies for improvement. Drugs Aging. 2008;25(12):1033-47.
55. Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health. 2007;10(1):3-12.
56. Nau DP. Proportion of days covered (PDC) as a preferred method of measuring medication adherence. Pharmacy Quality Alliance. 2012. Available at: http://ep.yimg.com/ty/cdn/epill/pdcmpr.pdf. Accessed March 18, 2017.
57. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60.
58. Abughosh SM, Wang X, Serna O, et al. A pharmacist telephone intervention to identify adherence barriers and improve adherence among nonadherent patients with comorbid hypertension and diabetes in a Medicare Advantage Plan. J Manag Care Spec Pharm. 2016;22(1):63-73. Available at: http://www.jmcp.org/doi/pdf/10.18553/jmcp.2016.22.1.63.
59. Scales R, Miller J, Burden R. Why wrestle when you can dance? Optimizing outcomes with motivational interviewing. J Am Pharm Assoc (2003). 2003;43(5 Suppl 1):S46-47.
60. Gance-Cleveland B. Motivational interviewing: improving patient education. J Pediatr Health Care. 2007;21(2):81-88.
61. Borrelli B, Riekert KA, Weinstein A, Rathier L. Brief motivational interviewing as a clinical strategy to promote asthma medication adherence. J Allergy Clin Immunol. 2007;120(5):1023-30.
62. Possidente CJ, Bucci KK, McClain WJ. Motivational interviewing: a tool to improve medication adherence? Am J Health Syst Pharm. 2005;62(12):1311-14.
63. Butterworth SW. Influencing patient adherence to treatment guidelines. J Manag Care Pharm. 2008;14(6 Suppl B):21-24. Available at: http://www. jmcp.org/doi/pdf/10.18553/jmcp.2008.14.S6-B.21.
64. Schmittdiel JA, Nichols GA, Dyer W, Steiner JF, Karter AJ, Raebel MA. Health care system-level factors associated with performance on Medicare STAR adherence metrics in a large, integrated delivery system. Med Care. 2015;53(4):332-37.
65. Parikh NM, Morgan RO, Kunik ME, et al. Risk factors for dementia in patients over 65 with diabetes. Int J Geriatr Psychiatry. 2011;26(7):749-57.
66. Johnson ML, Parikh N, Kunik ME, et al. Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus. Alzheimers Dement. 2012;8(5):437-44.
67. Kaiser Family Foundation. The Medicare Part D Prescription Drug Benefit fact sheet. September 26, 2016. Available at: http://kff.org/medicare/ fact-sheet/the-medicare-prescription-drug-benefit-fact-sheet/. Accessed March 18, 2017.
68. Smart Retailing Rx. Insights for Better Pharmacy Health/Independent Pharmacy Blog. Star ratings explained. July 31, 2013. Available at: http:// smartretailingrx.com/regulatory-public-affairs/star-ratings-explained/. Accessed March 18, 2017.
69. MedicareHMO. Medicare Advantage and Prescription Drug Plan fact sheet. Available at: http://www.medicarehmo.com/factsheet. Accessed March 18, 2017.
70. Scribd. Medicare Advantage Rankings fact sheet. 2015 star ratings. Available at: http://www.scribd.com/doc/242943563/Medicare-Advantage-Rankings-Fact-Sheet#scribd. Accessed March 18, 2017.
71. Piette JD, Weinberger M, Kraemer FB, McPhee SJ. Impact of automated calls with nurse follow-up on diabetes treatment outcomes in a Department of Veterans Affairs Health Care System: a randomized controlled trial. Diabetes Care. 2001;24(2):202-08.
72. Walker EA, Shmukler C, Ullman R, Blanco E, Scollan-Koliopoulus M, Cohen HW. Results of a successful telephonic intervention to improve diabetes control in urban adults: a randomized trial. Diabetes Care. 2011;34(1):2-7.
73. Wolever RQ, Dreusicke M, Fikkan J, et al. Integrative health coaching for patients with type 2 diabetes: a randomized clinical trial. Diabetes Educ. 2010;36(4):629-39.
74. Walker EA, Schechter CB, Caban A, Basch CE. Telephone intervention to promote diabetic retinopathy screening among the urban poor. Am J Prev Med. 2008;34(3):185-91.
75. Abrons J, Vadala T, Miller S, Cerulli J. Encouraging safe medication disposal through student pharmacist intervention. J Am Pharm Assoc (2003). 2010;50(2):169-73.
76. McCollum M, Nuffer W, Ellis SL, Turner CJ. Physician acceptance of pharmacotherapy recommendations made by pharmacy students in a rural pharmacy-based diabetes care and education clinic. Am J Pharm Educ. 2009;73(2):24.
77. Mueller BA, Abel SR. Impact of college of pharmacy-based educational services within the hospital. DICP. 1990;24(4):422-25.
78. Brockmiller H, Abel SR, Koh-Knox CP, Birk CW. Cost impact of Pharm.D. candidates' drug therapy recommendations. Am J Health Syst Pharm. 1999;56(9):882-84.
79. Marino J, Cabellero J, Liosent L, Hinkes R. Differences in pharmacy interventions at a psychiatric hospital: comparison of staff pharmacists, pharmacy faculty, and student pharmacists. Hosp Pharm. 2010;45(4):314-19.
80. Campbell AR, Nelson LA, Elliott E, Hieber R, Sommi RW. Analysis of cost avoidance from pharmacy students' clinical interventions at a psychiatric hospital. Am J Pharm Educ. 2011;75(1):8.
81. Burgin LB, Gamboa AM, Tierney DM, Lee JK. Interactive approach by pharmacy students to educate older adults on the safe use of over-thecounter medications. Consult Pharm. 2013;28(3):168-75.
82. Szkiladz A, Carey K, Ackerbauer K, Heelon M, Friderici J, Kopcza K. Impact of pharmacy student and resident-led discharge counseling on heart failure patients. J Pharm Pract. 2013;26(6):574-79.
83. Chou TI, Lash DB, Malcolm B, et al. Effects of a student pharmacist consultation on patient knowledge and attitudes about vaccines. J Am Pharm Assoc (2003). 2014;54(2):130-37.
84. Grant RW, Devita NG, Singer DE, Meigs JB. Improving adherence and reducing medication discrepancies in patients with diabetes. Ann Pharmacother. 2003;37(7-8):962-69.
85. Odegard PS, Goo A, Hummel J, Williams KL, Gray SL. Caring for poorly controlled diabetes mellitus: a randomized pharmacist intervention. Ann Pharmacother. 2005;39(3):433-40.
86. Moczygemba LR, Barner JC, Lawson KA, et al. Impact of telephone medication therapy management on medication and health-related problems, medication adherence, and Medicare Part D drug costs: a 6-month follow up. Am J Geriatr Pharmacother. 2011;9(5):328-38.
87. Moczygemba LR, Barner JC, Gabrillo ER. Outcomes of a Medicare Part D telephone medication therapy management program. J Am Pharm Assoc (2003). 2012;52(6):e144-52.
88. Prochaska JO, DiClemente CC. Stages and processes of self-change of smoking: toward an integrative model of change. J Consult Clin Psychol. 1983;51(3):390-95.
89. Prochaska JO, DiClemente CC, Norcross JC. In search of how people change. Applications to addictive behaviors. Am Psychol. 1992;47(9):1102-14.
90. DiClemente CC, Prochaska JO, Fairhurst SK, Velicer WF, Velasquez MM, Rossi JS. The process of smoking cessation: an analysis of precontemplation, contemplation, and preparation stages of change. J Consult Clin Psychol. 1991;59(2):295-304.
91. Jones H, Edwards L, Vallis TM, et al. Changes in diabetes self-care behaviors make a difference in glycemic control: the Diabetes Stages of Change (DiSC) study. Diabetes Care. 2003;26(3):732-37.
92. Miller WR, Rollnick S. Ten things that motivational interviewing is not. Behav Cogn Psychother. 2009;37(2):129-40.
93. Christie D, Channon S. The potential for motivational interviewing to improve outcomes in the management of diabetes and obesity in paediatric and adult populations: a clinical review. Diabetes Obes Metab. 2014;16(5):381-87.
94. Low KG, Giasson H, Connors S, Freeman D, Weiss R. Testing the effectiveness of motivational interviewing as a weight reduction strategy for obese cardiac patients: a pilot study. Int J Behav Med. 2013;20(1):77-81.
95. Brown RL, Saunders LA, Bobula JA, Mundt MP, Koch PE. Randomizedcontrolled trial of a telephone and mail intervention for alcohol use disorders: three-month drinking outcomes. Alcohol Clin Exp Res. 2007;31(8):1372-79.
96. Rubak S, Sandbaek A, Lauritzen T, Christensen B. Motivational interviewing: a systematic review and meta-analysis. Br J Gen Pract. 2005;55(513):305-12.
97. Hawkins SY. Improving glycemic control in older adults using a videophone motivational diabetes self-management intervention. Res Theory Nurs Pract. 2010;24(4):217-32.
98. Holstad MM, DiIorio C, Kelley ME, Resnicow K, Sharma S. Group motivational interviewing to promote adherence to antiretroviral medications and risk reduction behaviors in HIV infected women. AIDS Behav. 2011;15(5):885-96.
99. VanBuskirk KA, Wetherell JL. Motivational interviewing with primary care populations: a systematic review and meta-analysis. J Behav Med. 2014;37(4):768-80.
100. Menon U, Belue R, Wahab S, et al. A randomized trial comparing the effect of two phone-based interventions on colorectal cancer screening adherence. Ann Behav Med. 2011;42(3):294-303.
101. Cukor D, Rosenthal DS, Jindal RM, Brown CD, Kimmel PL. Depression is an important contributor to low medication adherence in hemodialyzed patients and transplant recipients. Kidney Int. 2009;75(11):1223-29.
102. van der Wal MH, Jaarsma T, van Veldhuisen DJ. Non-compliance in patients with heart failure; how can we manage it? Eur J Heart Fail. 2005;7(1):5-17.
103. van der Wal MH, Jaarsma T. Adherence in heart failure in the elderly: problem and possible solutions. Int J Cardiol. 2008;125(2):203-08.
104. Unni E, Farris KB. Determinants of different types of medication nonadherence in cholesterol lowering and asthma maintenance medications: a theoretical approach. Patient Educ Couns. 2011;83(3):382-90.
105. Abughosh SM, Kogut SJ, Andrade SE, Larrat P, Gurwitz JH. Persistence with lipid-lowering therapy: influence of the type of lipid-lowering agent and drug benefit plan option in elderly patients. J Manag Care Pharm. 2004;10(5):404-11. Available at: http://www.jmcp.org/doi/pdf/10.18553/ jmcp.2004.10.5.404.
106. Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA. 2002;288(4):462-67.
107. Shalansky SJ, Levy AR. Effect of number of medications on cardiovascular therapy adherence. Ann Pharmacother. 2002;36(10):1532-39.
108. Downer MK, Gea A, Stampfer M, et al. Predictors of short-and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial. Int J Behav Nutr Phys Act. 2016;13:67.
109. Chisholm-Burns MA, Spivey CA, Graff Zivin J, Lee JK, Sredzinski E, Tolley EA. Improving outcomes of renal transplant recipients with behavioral adherence contracts: a randomized controlled trial. Am J Transplant. 2013;13(9):2364-73.
110. Novick D, Haro JM, Suarez D, Perez V, Dittmann RW, Haddad PM. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res. 2010;176(2-3):109-13.