Possible link of Interleukin-6 and Interleukin-2 with psychiatric diagnosis, ethnicity, disaster or BMI

Cytokine

Volumn 96, Issue , 2017, Pages 247-252

  Tucker, Phebe ^a   Pfefferbaum, Betty ^a   Nitiéma, Pascal ^a,b   Khan, Qaiser ^a   Aggarwal, Ruchi ^c   Walling, Erin E ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cytokines; Hurricane, African American, BMI; Interleukin 2; Interleukin 6; Psychiatric diagnosis

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 6; BIOLOGICAL MARKER; IL2 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; ASIAN; BODY MASS; CAUCASIAN; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNICITY; FEMALE; HUMAN; HURRICANE; MAJOR DEPRESSION; MALE; NATURAL DISASTER; POSTTRAUMATIC STRESS DISORDER; PSYCHIATRIC DIAGNOSIS; SEX DIFFERENCE; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; BLOOD; ETHNIC GROUP; ETHNOLOGY; IMMUNOLOGY; MENTAL DISEASE; MENTAL STRESS; MIDDLE AGED; PSYCHOLOGY; STATISTICS AND NUMERICAL DATA; SURVIVOR; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICAN AMERICANS; BIOMARKERS; BODY MASS INDEX; CYCLONIC STORMS; DEPRESSIVE DISORDER, MAJOR; ETHNIC GROUPS; FEMALE; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; MALE; MENTAL DISORDERS; MIDDLE AGED; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; SURVIVORS; YOUNG ADULT;

EID: 85018262808     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2017.04.025     Document Type: Article

References (53)

1. [1] Wilson, S.N., van der Koli, B., Burbridge, J., Phenotype of blood lympohcytes in PTSD suggests chronic immune activation. Psychosomatics 40 (1999), 222–225.
2. [2] Ironson, G., Wynings, C., Schneiderman, N., Baum, A., Rodriguez, M., Greenwood, D., Benight, C., Antoni, M., LaPerriere, A., Huang, H.S., Klimas, N., Fletcher, M.A., Posttraumatic stress symptoms, intrusive thoughts, loss of immune function after Hurricane Andrew. Psychosom. Med. 59 (1997), 128–141.
3. [3] Song, Y., Zhou, D., Guan, Z., Wang, X., Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China. NeuroImmunoModulation 14 (2007), 248–254.
4. [4] Maes, M., Bosmans, E., Meltzer, H.Y., Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble Interleukin-2 receptor, prolactin and cortisol. Eur. Arch. Psychiatry. Clin. Neurosci. 245 (1995), 172–178.
5. [5] Petitto, J.M., Huang, Z., Meola, D., Ha, G.K., Dauer, D., Interleukin-2 and the septohippocampal system: intrinsic actions and autoimmune processes relevant to neuropsychiatric disorders. Methods Mol. Biol. 829 (2012), 433–443.
6. [6] Michopoulos, Vasiliki., Rothbaum, Alex O., Jovanovic, Tanja., Almli, Lynn M., Bradley, Bekh., Rothbaum, Barbara O., Gillespie, Charles F., Ressler, Kerry J., Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiologic responses in a civilian population with high levels of trauma. Am. J. Psychiatry 172:4 (2015), 307–309.
7. [7] Gola, H., Engler, H., Sommershof, A., Adenauer, H., Kolassa, S., Schedlowski, M., Groettrup, M., Elbert, T., Kolassa, I.T., Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry, 13, 2013, 40 Accessed at: .
8. [8] Liao, W., Lin, J.-X., Wang, L., Li, P., Warren, J.L., Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol. 12:6 (2011), 551–559.
9. [9] Tucker, P., Ruwe, W.D., Masters, B.K., Parker, D.E., Hossain, A., Trautman, R.P., et al. Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder. Biol. Psychiatry 56 (2004), 121–128.
10. [10] Nunes, S.O., Reiche, E.M., Morimoto, H.K., Matsuo, T., Itano, E.N., Xavier, E.C., et al. Immune and hormonal activity in adults suffering from depression. Braz. J. Med. Biol. Res. 35:5 (2002), 581–587.
11. [11] PotvinS, Stip E., Sepehry, A.A., Gendron, A., Bah, R., Kouassi, E., Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol. Psychiatry 63 (2008), 801–808.
12. [12] Miller, B.J., Buckley, P., Seabolt, W., Mellor, A., Kirkpatrick, B., Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol. Psychiatry 70 (2011), 663–671.
13. [13] Kimball, P., Elswick, R.K., Shiffman, M., Ethnicity and cytokine production gauge response of patients with hepatitis C to Interferon-α therapy. J. Med. Virol. 65 (2001), 510–516.
14. [14] Hoffman, S.C., Stanley, E.M., Cox, E.D., DiMercurio, B.S., Koziol, D.E., Harlan, D.M., et al. Ethnicity greatly influences cytokine gene polymorphism distribution. Am. J. Transplantation 2 (2002), 560–567.
15. [15] Cox, E.D., Hoffmann, S.C., DiMercurio, B.S., Wesley, R.A., Harlan, D.M., Kirk, A.D., et al. Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of Interleukin-2 and Interleukin-6. Transplantation 72:4 (2001), 720–726.
16. [16] Ovsyannikova, I.G., Haralambieva, I.H., Kennedy, R.B., Pankratz, V.S., Vierkant, R.A., Jacobson, R.M., et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. Gene 510 (2012), 59–65.
17. [17] Danese, A., Moffitt, T.E., Harrington, H.L., Milne, B.J., Polanczyk, G., Pariante, C.M., Poulton, R., Caspi, A., Adverse childhood experiences and adult risk factors for age-related disease. Arch. Pediatr. Adolesc. Med. 163:12 (2009), 1135–1143.
18. [18] Spitzer, C., Barnow, S., Volzke, H., Wallaschofski, H., John, U., Freyberger, H.J., et al. Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. J. Psychiatr. Res. 44:1 (2010), 15–21.
19. [19] Eraly, S.A., Nievergelt, C.M., Maihofer, A.X., Barkauskas, D.A., Biswas, N., Agorastos, A., et al. Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry, 2014, 10.1001/jamapsychiatry.2013.4374.
20. [20] Hunter, C.A., Jones, S.A., IL-6 as a keystone cytokine in health and disease. Nature Immunol. 16:5 (2015), 448–455.
21. [21] Tucker, P., Jeon-Slaughter, H., Pfefferbaum, B., Khan, Q., Davis, N.J., Emotional and biological stress measures in Katrina survivors relocated to Oklahoma. Am. J. Disaster Med. 5:2 (2010), 113–125.
22. [22] Plantings, L., Bremner, J.D., Miller, A.H., Jones, D.P., Veledar, E., Goldberg, J., et al. Association between posttraumatic stress disorder and inflammation: a twin study. Brain Behav. Immun. 30 (2013), 125–132.
23. [23] Maes, M., Lin, A.H., Delmeire, L., Van Gastel, A., Kenis, G., DeJongh, R., et al. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol. Psychiatry 45 (1999), 833–839.
24. [24] Maes, M., Song, C., Lin, A., DeJongh, R., Van Gastel, A., Kenis, G., et al. The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 10 (1998), 313–318.
25. [25] Rooks, C., Veledar, E., Goldberg, J., Bremner, D., Vaccarino, V., Early trauma and inflammation: role of familial factors in a study of twins. Psychosom. Med. 74 (2012), 146–152.
26. [26] Suareza, E.C., Joint effect of hostility and severity of depressive symptoms on plasma Interleukin-6 concentration. Psychosom. Med. 65:4 (2003), 523–527.
27. [27] Spooren, A., Krzysztof, K., Laureys, G., Clinckers, R., De Keyser, J., Haegeman, G., et al. Interleukin-6, a mental Cytokine. Brain Res. Rev. 67 (2011), 157–183.
28. [28] Gola, H., Engler, H., Sommershof, A., Adenauer, H., Kolassa, S., Schedlowski, M., et al. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry, 13, 2013, 40 http://www.biomedcentral.com/1471-244X/13/40.
29. [29] Kerr, R., Stirling, D., Ludlam, C.A., Interleukin 6 and haemostasis. Br. J. Hematol. 115 (2001), 3–12.
30. [30] Watanabe, Y., Someya, T., Nawa, H., Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models. Psychiatry Clin. Neurosci. 64:3 (2010), 217–230, 10.1111/j.1440-1819.2010.02094.x.
31. [31] Müller, N., Schwarz, M.J., Immune system and Schizophrenia. CIR Curr. Immunol. Rev. 6:3 (2010), 213–220, 10.2174/157339510791823673.
32. [32] First, M.B., Spitzer, R.L., Gibbon, M., Williams, B.W., Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-IV), Clinician Version (Administrative Booklet). 1997, American Psychiatric Association, Washington, DC.
33. [33] Ventura, J., Liberman, R.P., Green, M.F., Shaner, A., Mintz, J., Training and quality assurance with the Structured Clinical Interview for DSM-IV (SCID-IV). Psychiat. Res. 79:2 (1998), 163–173.
34. [34] Faul, F., Erdfelder, E., Buchner, A., Lang, A.-G., Statistical power analyses using G∗Power 3.1: Tests for correlation and regression analyses. Behav. Res. Methods 41 (2009), 1149–1160.
35. [35] Cohen, J., Statistical Power Analysis for the Behavioral Sciences. 1988, Lawrence Erlbaum Associates, Hillsdale, New Jersey, 412.
36. [36] National Institute of Mental Health, National Survey on Drug use and Health (NSDUH). http://www.nimh.nih.gov/health/statistics/prevalence/any-mental-illness-ami-among-adults.shtml, 2012 (accessed October 19, 2014).
37. [37] American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. fifth ed., 2013, American Psychiatric Press, Arlington, VA, 277.
38. [38] Breslau, J., Kendler, K.S., Gaxiola-Aguilar, S., Kessler, R.C., Lifetime risk and persistence of psychiatric disorders across ethnic groups in the United States. Psychol. Med. 35 (2005), 317–327.
39. [39] Frommberger, U.H., Bauer, J., Haselbauer, P., Fraulin, A., Riemann, D., Berger, M., Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur. Arch. Psychiatry Clin. Neurosci. 247 (1997), 228–233.
40. [40] Knijff, E.M., Breunis, M.N., Kupka, R.W., de Wit, H.J., Ruwhof, C., Akkerhuis, G.W., et al. An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment. Bipolar Disord. 9:7 (2007), 743–753.
41. [41] Nicolaou, C., Chatzipanagiotou, S., Tzivos, D., Tzavellas, E.O., Boufidou, F., Liappas, I.A., Serum cytokine concentrations in alcohol-dependent individuals without liver disease. Alcohol 32:3 (2004), 243–247.
42. [42] Baker, D., Nievergelt, C.M., O'Connor, D.T., Biomarkers of PTSD: neuropeptides and immune signaling. Neuropharmacol 62:2012 (2012), 663–673.
43. [43] Na, K.-S., Jung, H.-Y., Kim, Y.-K., The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia. Prog. Neuro-Psychopharm. Biol. Psychiatry 48 (2014), 277–280.
44. [44] Tylee, D.S., Chandler, S.D., Nievergelt, C.M., Liu, X., Pazol, J., Woelk, C.H., Lohr, J.B., Kremen, W.S., Baker, D.G., Glatt, S.J., Tsuang, M.T., Marine Resiliency Study Investigators. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: a pilot study. Psychoneuroendocrinology 51 (2015), 472–494.
45. [45] Eisenlohr-Moul, T., Segerstrom, S., Autonomy, positive relationships, and IL-6: evidence for gender-specific effects. Br. J. Health Psychol. 18 (2012), 420–438.
46. [46] Khaodhiar, L., Ling, P.-R., Blackburn, G.L., Bistrain, B.R., Serum levels of Interleukin-6 and C-reactive protein correlate with body mass index across the road range of obesity. J. Parenteral. Enteral Nutrition 28:6 (2004), 410–415.
47. [47] Mohamed-Ali, V., Goodrick, A., Rawesh, A., Katz, D.R., Miles, J.M., Yudkin, J.S., Klein, S., Coppack, S.W., Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-a Vivo. J. Clin. Endocrinol. Metab. 82:12 (1997), 4196–4200.
48. [48] Scheller, J.I., Chalaris, A., Schmidt-Arras, D., Rose-John S (2011): The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 5 (1813), 878–888.
49. [49] Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.F., Achong, M.K., IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 101:2 (1998), 311–320.
50. [50] Kivimaki, M., Shipley, M.J., Batty, G.D., Hamer, M., Akbaraly, T.N., Kumari, M., Jokela, M., Virtanen, M., Lowe, G.D., Ebmeier, K.P., Brunner, E.J., Singh-Manoux, A., Long-term inflammation risk of common mental disorder: a cohort study. Mol. Psychiatry 19 (2014), 149–150.
51. [51] Yoon, H.K., Kim, Y.K., Lee, H.J., Kwon, D.Y., Kim, L., Role of cytokines in atypical depression. Nord. J. Psychiatry 66:3 (2012), 183–188.
52. [52] Ballesteros-Tato, A., Leon, B., Graf, B.A., Moquin, A., Adams, P.S., Lund, F.E., Randall, T.D., Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36:5 (2012), 847–856.
53. [53] Miller, G., Chen, E., Fok, A.K., Walker, H., Lim, A., Nicholls, E.F., et al. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc. Natl. Acad. Sci. USA 106 (2009), 14716–14721.