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Volumn 2017, Issue 4, 2017, Pages

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PCSK9; PROPROTEIN CONVERTASE 9; PROPROTEIN CONVERTASE 9 INHIBITOR; UNCLASSIFIED DRUG; ALIROCUMAB; BOCOCIZUMAB; CHOLINERGIC RECEPTOR BLOCKING AGENT; EVOLOCUMAB; RG7652;

EID: 85018245564     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD011748.pub2     Document Type: Review
Times cited : (61)

References (111)
  • 1
    • 84927578440 scopus 로고    scopus 로고
    • Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia
    • 5479801
    • Ballantyne CM, Neutel J, Cropp A, Duggan W, Wang EQ, Plowchalk D, et al. Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. American Journal of Cardiology 2015;115(9):1212-21. 5479801
    • (2015) American Journal of Cardiology , vol.115 , Issue.9 , pp. 1212-1221
    • Ballantyne, C.M.1    Neutel, J.2    Cropp, A.3    Duggan, W.4    Wang, E.Q.5    Plowchalk, D.6
  • 3
    • 85018321284 scopus 로고    scopus 로고
    • Effects of RG7652, a monoclonal antibody against proprotein convertase Subtilisin/Kexin type 9, on LDL cholesterol in patients with coronary heart disease or high risk: results from the EQUATOR study
    • 5479805
    • Tingley W, Mosesova S, Baruch A, Davis JD, Budha N, Vilimovskij A, et al. Effects of RG7652, a monoclonal antibody against proprotein convertase Subtilisin/Kexin type 9, on LDL cholesterol in patients with coronary heart disease or high risk: results from the EQUATOR study. European Heart Journal. 2014:371. 5479805
    • (2014) European Heart Journal , pp. 371
    • Tingley, W.1    Mosesova, S.2    Baruch, A.3    Davis, J.D.4    Budha, N.5    Vilimovskij, A.6
  • 5
    • 84947965019 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: the ODYSSEY ALTERNATIVE randomized trial
    • 5479809
    • Moriarty PM, Thompson PD, Cannon CP, Guyton JR, Bergeron J, Zieve FJ, et al. Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: the ODYSSEY ALTERNATIVE randomized trial. Journal of Clinical Lipidology 2015;9(6):758-69. 5479809
    • (2015) Journal of Clinical Lipidology , vol.9 , Issue.6 , pp. 758-769
    • Moriarty, P.M.1    Thompson, P.D.2    Cannon, C.P.3    Guyton, J.R.4    Bergeron, J.5    Zieve, F.J.6
  • 6
    • 85018295535 scopus 로고    scopus 로고
    • Efficacy and safety of 150 mg and 300 mg every 3 weeks in patients with poorly controlled hypercholesterolemia: the ODYSSEY CHOICE I and CHOICE II studies
    • Exhibit 991 5479811
    • Stroes E, Guyton JR, Farnier M, Rader D, Moriarty PM, Bergeron J, et al. Efficacy and safety of 150 mg and 300 mg every 3 weeks in patients with poorly controlled hypercholesterolemia: the ODYSSEY CHOICE I and CHOICE II studies. Journal of the American College of Cardiology. 2015; Vol. abstract:Exhibit 99.1. 5479811
    • (2015) Journal of the American College of Cardiology
    • Stroes, E.1    Guyton, J.R.2    Farnier, M.3    Rader, D.4    Moriarty, P.M.5    Bergeron, J.6
  • 7
    • 85018295535 scopus 로고    scopus 로고
    • Efficacy and safety of 150 mg and 300 mg every 3 weeks in patients with poorly controlled hypercholesterolemia: the ODYSSEY CHOICE I and CHOICE II studies
    • Exhibit 991 5479813
    • Stroes E, Guyton JR, Farnier M, Rader D, Moriarty PM, Bergeron J, et al. Efficacy and safety of 150 mg and 300 mg every 3 weeks in patients with poorly controlled hypercholesterolemia: the ODYSSEY CHOICE I and CHOICE II studies. Journal of the American College of Cardiology. 2015; Vol. abstract:Exhibit 99.1. 5479813
    • (2015) Journal of the American College of Cardiology
    • Stroes, E.1    Guyton, J.R.2    Farnier, M.3    Rader, D.4    Moriarty, P.M.5    Bergeron, J.6
  • 8
    • 84930179904 scopus 로고    scopus 로고
    • Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study
    • 5479815
    • Kereiakes DJ, Robinson JG, Cannon CP, Lorenzato C, Pordy R, Chaudhari U, et al. Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study. American Heart Journal 2015;169(6):906. 5479815
    • (2015) American Heart Journal , vol.169 , Issue.6 , pp. 906
    • Kereiakes, D.J.1    Robinson, J.G.2    Cannon, C.P.3    Lorenzato, C.4    Pordy, R.5    Chaudhari, U.6
  • 9
    • 84929322473 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial
    • 5479817
    • Cannon CP, Cariou B, Blom D, McKenney JM, Lorenzato C, Pordy R, et al. Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial. European Heart Journal 2015;36(19):1186-94. 5479817
    • (2015) European Heart Journal , vol.36 , Issue.19 , pp. 1186-1194
    • Cannon, C.P.1    Cariou, B.2    Blom, D.3    McKenney, J.M.4    Lorenzato, C.5    Pordy, R.6
  • 10
    • 84983160332 scopus 로고    scopus 로고
    • ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
    • 5479819
    • Kastelein JJ, Ginsberg HN, Langslet G, Hovingh GK, Ceska R, Dufour R, et al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. European Heart Journal 2015;36(43):2996-3003. 5479819
    • (2015) European Heart Journal , vol.36 , Issue.43 , pp. 2996-3003
    • Kastelein, J.J.1    Ginsberg, H.N.2    Langslet, G.3    Hovingh, G.K.4    Ceska, R.5    Dufour, R.6
  • 11
    • 84983160332 scopus 로고    scopus 로고
    • ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
    • 5479821
    • Kastelein JJ, Ginsberg HN, Langslet G, Hovingh GK, Ceska R, Dufour R, et al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. European Heart Journal 2015;36(43):2996-3003. 5479821
    • (2015) European Heart Journal , vol.36 , Issue.43 , pp. 2996-3003
    • Kastelein, J.J.1    Ginsberg, H.N.2    Langslet, G.3    Hovingh, G.K.4    Ceska, R.5    Dufour, R.6
  • 12
    • 84963669487 scopus 로고    scopus 로고
    • ODYSSEY HIGH FH: Efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia
    • Conference abstract. Published online 2014. 5479823
    • Ginsberg HN, Rader DJ, Raal F, Guyton JR, Lorenzato C, Pordy R, et al. ODYSSEY HIGH FH: Efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia. Conference abstract. Published online 2014. 5479823
    • Ginsberg, H.N.1    Rader, D.J.2    Raal, F.3    Guyton, J.R.4    Lorenzato, C.5    Pordy, R.6
  • 14
    • 84906323762 scopus 로고    scopus 로고
    • Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial
    • 5479827
    • Roth EM, Taskinen MR, Ginsberg HN, Kastelein JJP, Colhoun HM, Robinson JG, et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial. International Journal of Cardiology 2014;176:55-61. 5479827
    • (2014) International Journal of Cardiology , vol.176 , pp. 55-61
    • Roth, E.M.1    Taskinen, M.R.2    Ginsberg, H.N.3    Kastelein, J.J.P.4    Colhoun, H.M.5    Robinson, J.G.6
  • 16
    • 84947976529 scopus 로고    scopus 로고
    • Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: the ODYSSEY OPTIONS II randomized trial
    • 5479831
    • Farnier M, Jones P, Severance R, Averna M, Steinhagen-Thiessen E, Colhoun HM, et al. Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: the ODYSSEY OPTIONS II randomized trial. Atherosclerorsis 2016;244:138-46. 5479831
    • (2016) Atherosclerorsis , vol.244 , pp. 138-146
    • Farnier, M.1    Jones, P.2    Severance, R.3    Averna, M.4    Steinhagen-Thiessen, E.5    Colhoun, H.M.6
  • 17
    • 84892679366 scopus 로고    scopus 로고
    • Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial
    • 5479833
    • Koren MJ, Giugliano RP, Raal FJ, Sullivan D, Bolognese M, Langslet G, et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation 2014;129:234-43. 5479833
    • (2014) Circulation , vol.129 , pp. 234-243
    • Koren, M.J.1    Giugliano, R.P.2    Raal, F.J.3    Sullivan, D.4    Bolognese, M.5    Langslet, G.6
  • 20
    • 85018247254 scopus 로고    scopus 로고
    • Effect of RG7652, a mAb against PCSK9, on apolipoprotein B, oxidized LDL, lipoprotein(A) and lipoprotein-associated phospholipase a2 in healthy individuals with elevated LDL-C
    • 5479839
    • Baruch A, Peng K, Leabman M, Budha N, Luca D, Cowan KJ, et al. Effect of RG7652, a mAb against PCSK9, on apolipoprotein B, oxidized LDL, lipoprotein(A) and lipoprotein-associated phospholipase a2 in healthy individuals with elevated LDL-C. Circulation. 2013; Vol. 22. 5479839
    • (2013) Circulation , vol.22
    • Baruch, A.1    Peng, K.2    Leabman, M.3    Budha, N.4    Luca, D.5    Cowan, K.J.6
  • 22
    • 84893230270 scopus 로고    scopus 로고
    • AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of National Cholesterol Education Program-Adult Treatment Panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57)
    • 5479843
    • Desai NR, Giugliano RP, Zhou J, Kohli P, Somaratne R, Hoffman E, et al. AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of National Cholesterol Education Program-Adult Treatment Panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57). Journal of the American College of Cardiology 2014;63:430-3. 5479843
    • (2014) Journal of the American College of Cardiology , vol.63 , pp. 430-433
    • Desai, N.R.1    Giugliano, R.P.2    Zhou, J.3    Kohli, P.4    Somaratne, R.5    Hoffman, E.6
  • 23
    • 84868206496 scopus 로고    scopus 로고
    • Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
    • 5479845
    • Dias CS, Shaywitz AJ, Wasserman SM, Smith BP, Gao B, Stolman DS, et al. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. Journal of the American College of Cardiology 2012;60:1888-98. 5479845
    • (2012) Journal of the American College of Cardiology , vol.60 , pp. 1888-1898
    • Dias, C.S.1    Shaywitz, A.J.2    Wasserman, S.M.3    Smith, B.P.4    Gao, B.5    Stolman, D.S.6
  • 24
    • 85018280333 scopus 로고    scopus 로고
    • Effect of REGN727/SAR236553 anti-proprotein convertase subtilisin/kexin type 9 fully human monoclonal antibody in patients with elevated triglycerides/low high-density lipoprotein cholesterol: data from three phase 2 studies (NCT:01266876; 01288469; 01288443)
    • 5479847
    • Dufour R, Moriarty PM, Genestin E, Sasiela WJ, Du Y, Ferrand AC, et al. Effect of REGN727/SAR236553 anti-proprotein convertase subtilisin/kexin type 9 fully human monoclonal antibody in patients with elevated triglycerides/low high-density lipoprotein cholesterol: data from three phase 2 studies (NCT:01266876; 01288469; 01288443). Circulation. 2012. 5479847
    • (2012) Circulation
    • Dufour, R.1    Moriarty, P.M.2    Genestin, E.3    Sasiela, W.J.4    Du, Y.5    Ferrand, A.C.6
  • 25
    • 85018267732 scopus 로고    scopus 로고
    • Effect of SAR236553/REGN727 fully human monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody on plasma lipoprotein(a) concentrations: pooled analysis from three phase 2 studies (NCT:01266876; 01288469; 01288443)
    • 5479849
    • Gaudet D, Kereiakes D, McKenney J, Roth E, Hanotin C, Gipe D, et al. Effect of SAR236553/REGN727 fully human monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody on plasma lipoprotein(a) concentrations: pooled analysis from three phase 2 studies (NCT:01266876; 01288469; 01288443). Circulation. 2012. 5479849
    • (2012) Circulation
    • Gaudet, D.1    Kereiakes, D.2    McKenney, J.3    Roth, E.4    Hanotin, C.5    Gipe, D.6
  • 26
    • 85018281467 scopus 로고    scopus 로고
    • Alirocumab, a fully human monoclonal antibody to PCSK9, reduces high plasma lp(a) concentration: pooled analysis of 352 patients from phase 2
    • 5479851
    • Gaudet D, Kereiakes D, McKenney J, Roth E, Hanotin C, Gipe D, et al. Alirocumab, a fully human monoclonal antibody to PCSK9, reduces high plasma lp(a) concentration: pooled analysis of 352 patients from phase 2. Journal of Clinical Lipidology 2013;7(3):283-4. 5479851
    • (2013) Journal of Clinical Lipidology , vol.7 , Issue.3 , pp. 283-284
    • Gaudet, D.1    Kereiakes, D.2    McKenney, J.3    Roth, E.4    Hanotin, C.5    Gipe, D.6
  • 27
    • 84880113632 scopus 로고    scopus 로고
    • The effects of multiple dose administration of RN316 (PF-04950619), a humanized IgG2a monoclonal antibody binding proprotein convertase snbtilisin kexin type 9, in hypercholesterolemic subjects
    • 5479853
    • Gumbiner B, Udata C, Joh T, Liang H, Wan H, Shelton D, et al. The effects of multiple dose administration of RN316 (PF-04950619), a humanized IgG2a monoclonal antibody binding proprotein convertase snbtilisin kexin type 9, in hypercholesterolemic subjects. Circulation. 2012; Vol. 126, issue 21. 5479853
    • (2012) Circulatio , vol.126 , Issue.21
    • Gumbiner, B.1    Udata, C.2    Joh, T.3    Liang, H.4    Wan, H.5    Shelton, D.6
  • 28
    • 85018307745 scopus 로고    scopus 로고
    • A randomized placebo-phase clinical trial with the monoclonal antibody alirocumab demonstrates reductions in low-density lipoprotein cholesterol in patients with proprotein convertase subtilisin/kexin type 9 gain-of-function mutations
    • 5479855
    • Hopkins PN, Swergold GD, Mellis S, Bruckert E, Luc G, Mendoza J, et al. A randomized placebo-phase clinical trial with the monoclonal antibody alirocumab demonstrates reductions in low-density lipoprotein cholesterol in patients with proprotein convertase subtilisin/kexin type 9 gain-of-function mutations. Circulation. 2013. 5479855
    • (2013) Circulation
    • Hopkins, P.N.1    Swergold, G.D.2    Mellis, S.3    Bruckert, E.4    Luc, G.5    Mendoza, J.6
  • 30
    • 84951907437 scopus 로고    scopus 로고
    • Safety and efficacy of LY 3015014, a new monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK 9) with an inherently longer duration of action, in patients with primary hypercholesterolemia: a randomized, placebo-controlled, dose-ranging, phase 2 study
    • 5479859
    • Kastelein J, Nissen S, Rader D, Krueger K, Wang MD. Safety and efficacy of LY 3015014, a new monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK 9) with an inherently longer duration of action, in patients with primary hypercholesterolemia: a randomized, placebo-controlled, dose-ranging, phase 2 study. Journal of the American College of Cardiology. 2015:A1591. 5479859
    • (2015) Journal of the American College of Cardiology , pp. A1591
    • Kastelein, J.1    Nissen, S.2    Rader, D.3    Krueger, K.4    Wang, M.D.5
  • 31
    • 84855954546 scopus 로고    scopus 로고
    • Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia
    • 5479861
    • Kawashiri MA, Nohara A, Noguchi T, Tada H, Nakanishi C, Mori M, et al. Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia. American Journal of Cardiology 2012;109:364-9. 5479861
    • (2012) American Journal of Cardiology , vol.109 , pp. 364-369
    • Kawashiri, M.A.1    Nohara, A.2    Noguchi, T.3    Tada, H.4    Nakanishi, C.5    Mori, M.6
  • 32
    • 84927175751 scopus 로고    scopus 로고
    • Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia
    • 5479863
    • Mabuchi H, Nohara A. Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia. Nature Reviews Endocrinology 2015;11(1):8-9. 5479863
    • (2015) Nature Reviews Endocrinology , vol.11 , Issue.1 , pp. 8-9
    • Mabuchi, H.1    Nohara, A.2
  • 33
    • 84864206454 scopus 로고    scopus 로고
    • Antibodies to PCSK9: a superior way to lower LDL cholesterol?
    • 5479865
    • Maxwell KN, Breslow JL. Antibodies to PCSK9: a superior way to lower LDL cholesterol?. Circulation Research 2012;111:274-7. 5479865
    • (2012) Circulation Research , vol.111 , pp. 274-277
    • Maxwell, K.N.1    Breslow, J.L.2
  • 34
    • 84893706591 scopus 로고    scopus 로고
    • Dyslipidaemia: 1-year results from OSLER trial of anti-PCSK9 monoclonal antibody evolocumab
    • 5479867
    • Mearns BM. Dyslipidaemia: 1-year results from OSLER trial of anti-PCSK9 monoclonal antibody evolocumab. Nature Reviews Cardiology 2014;11:63. 5479867
    • (2014) Nature Reviews Cardiology , vol.11 , pp. 63
    • Mearns, B.M.1
  • 35
    • 84906307733 scopus 로고    scopus 로고
    • Alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9: therapeutic dosing in phase 3 studies
    • 5479869
    • Pordy R, Lecorps G, Bessac L, Sasiela WJ, Ginsberg H. Alirocumab, a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9: therapeutic dosing in phase 3 studies. Journal of Clinical Lipidology 2013;7(3):279. 5479869
    • (2013) Journal of Clinical Lipidology , vol.7 , Issue.3 , pp. 279
    • Pordy, R.1    Lecorps, G.2    Bessac, L.3    Sasiela, W.J.4    Ginsberg, H.5
  • 36
    • 85018244775 scopus 로고    scopus 로고
    • Safety, tolerability, and efficacy of long-term administration of monthly AMG 145 in subjects with heterozygous familial hypercholesterolemia
    • 5479871
    • Raal F, Nelson P, Langslet G, Basart DCG, Civeira F, Lopez-Miranda J, et al. Safety, tolerability, and efficacy of long-term administration of monthly AMG 145 in subjects with heterozygous familial hypercholesterolemia. Global Heart. 2014; Vol. 1:e139. 5479871
    • (2014) Global Heart , vol.1
    • Raal, F.1    Nelson, P.2    Langslet, G.3    Basart, D.C.G.4    Civeira, F.5    Lopez-Miranda, J.6
  • 37
    • 84969211319 scopus 로고    scopus 로고
    • Long-term reduction in lipoprotein(A) with the PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of 3278 patients in phase 2, 3, and open label extension studies
    • 5479873
    • Raal F, Giugliano RP, Sabatine MS, Koren MJ, Blom D, Honarpour N, et al. Long-term reduction in lipoprotein(A) with the PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of 3278 patients in phase 2, 3, and open label extension studies. Circulation. 2014. 5479873
    • (2014) Circulation
    • Raal, F.1    Giugliano, R.P.2    Sabatine, M.S.3    Koren, M.J.4    Blom, D.5    Honarpour, N.6
  • 38
    • 85018240661 scopus 로고    scopus 로고
    • AMG 145, a fully human monoclonal antibody against PCSK9, reduces LDL-C in healthy volunteers and patients on stable doses of statins+
    • 5479875
    • Shaywitz AJ, Dias C, Smith B, Gao B, Gibbs J, Emery M, et al. AMG 145, a fully human monoclonal antibody against PCSK9, reduces LDL-C in healthy volunteers and patients on stable doses of statins+. Journal of Clinical Lipidology. 2012; Vol. 6, issue 3:286-7. 5479875
    • (2012) Journal of Clinical Lipidology , vol.6 , Issue.3 , pp. 286-287
    • Shaywitz, A.J.1    Dias, C.2    Smith, B.3    Gao, B.4    Gibbs, J.5    Emery, M.6
  • 39
    • 84899993254 scopus 로고    scopus 로고
    • Inhibition of PCSK9: a novel approach for the treatment of dyslipidemia
    • 5479877
    • Stawowy P, Just IA, Kaschina E. Inhibition of PCSK9: a novel approach for the treatment of dyslipidemia. Coronary Artery Disease 2014;25:353-9. 5479877
    • (2014) Coronary Artery Disease , vol.25 , pp. 353-359
    • Stawowy, P.1    Just, I.A.2    Kaschina, E.3
  • 41
    • 85018365819 scopus 로고    scopus 로고
    • Efficacy and tolerability of long-term treatment with AMG 145 in patients with statin intolerance
    • 5479881
    • Stein EA, Somaratne R, Schou MB, Civeira F, Sullivan D, Watts GF, et al. Efficacy and tolerability of long-term treatment with AMG 145 in patients with statin intolerance. Circulation. 2013. 5479881
    • (2013) Circulation
    • Stein, E.A.1    Somaratne, R.2    Schou, M.B.3    Civeira, F.4    Sullivan, D.5    Watts, G.F.6
  • 42
    • 84862161906 scopus 로고    scopus 로고
    • Safety, lipid, and lipoprotein effects of REGN727/SAR236553, a fully-human proprotein convertase subtilisin kexin 9 (PCSK9) monoclonal antibody administered intravenously to healthy volunteers
    • 5479883
    • Swergold G, Biedermann S, Renard R, Nadler D, Wu R, Mellis S. Safety, lipid, and lipoprotein effects of REGN727/SAR236553, a fully-human proprotein convertase subtilisin kexin 9 (PCSK9) monoclonal antibody administered intravenously to healthy volunteers. Circulation 2010;122:2. 5479883
    • (2010) Circulation , vol.122 , pp. 2
    • Swergold, G.1    Biedermann, S.2    Renard, R.3    Nadler, D.4    Wu, R.5    Mellis, S.6
  • 43
    • 84857251001 scopus 로고    scopus 로고
    • Inhibition of proprotein convertase subtilisin/kexin type 9 with a monoclonal antibody REGN727/SAR236553, effectively reduces low-density-lipoprotein cholesterol, as mono or add-on therapy in heterozygous familial and non familial hypercholesterolemia
    • 5479885
    • Swergold G, Smith W, Mellis S, Logan D, Webb C, Wu R, et al. Inhibition of proprotein convertase subtilisin/kexin type 9 with a monoclonal antibody REGN727/SAR236553, effectively reduces low-density-lipoprotein cholesterol, as mono or add-on therapy in heterozygous familial and non familial hypercholesterolemia. Circulation. 2011; Vol. 124:2. 5479885
    • (2011) Circulation , vol.124 , pp. 2
    • Swergold, G.1    Smith, W.2    Mellis, S.3    Logan, D.4    Webb, C.5    Wu, R.6
  • 44
    • 84892492904 scopus 로고    scopus 로고
    • Effects of RN316 (pf-04950615), a humanized igg2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, on lipoprotein particles in hypercholesterolemic subjects
    • 5479887
    • Wan H, Gumbiner B, Joh T, Udata C, Forgues P, Garzone PD. Effects of RN316 (pf-04950615), a humanized igg2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, on lipoprotein particles in hypercholesterolemic subjects. Journal of the American College of Cardiology. 2013:E1387. 5479887
    • (2013) Journal of the American College of Cardiology , pp. E1387
    • Wan, H.1    Gumbiner, B.2    Joh, T.3    Udata, C.4    Forgues, P.5    Garzone, P.D.6
  • 46
    • 85018302490 scopus 로고    scopus 로고
    • Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflamation Study in Patients With Elevated Lipoprotein(a) (Lp(a)). (ANITSCHKOW)
    • 5479891 (first received: March 8, 2016)
    • NCT02729025 . Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflamation Study in Patients With Elevated Lipoprotein(a) (Lp(a)). (ANITSCHKOW). https://clinicaltrials.gov/ct2/show/NCT02729025 (first received: March 8, 2016). 5479891
  • 47
    • 84985897064 scopus 로고    scopus 로고
    • Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects (EBBINGHAUS)
    • 5479893 (first received July 31, 2014)
    • NCT02207634 . Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects (EBBINGHAUS). https://clinicaltrials.gov/ct2/show/NCT02207634 (first received July 31, 2014). 5479893
  • 48
    • 85018239244 scopus 로고    scopus 로고
    • Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders (HAUSER-RCT)
    • 5479895 (first received February 25, 2015)
    • NCT02392559 . Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders (HAUSER-RCT). https://clinicaltrials.gov/ct2/show/NCT02392559 (first received February 25, 2015). 5479895
  • 49
    • 85018285477 scopus 로고    scopus 로고
    • Safety, Tolerability & Efficacy on LDL-C of Evolocumab in Subjects With HIV & Hyperlipidemia/Mixed Dyslipidemia
    • 5479897 (first received June 13, 2016)
    • NCT02833844 . Safety, Tolerability & Efficacy on LDL-C of Evolocumab in Subjects With HIV & Hyperlipidemia/Mixed Dyslipidemia. https://clinicaltrials.gov/ct2/show/NCT02833844 (first received June 13, 2016). 5479897
  • 50
    • 85018314066 scopus 로고    scopus 로고
    • Efficacy and Safety of Alirocumab Versus Usual Care on Top of Maximally Tolerated Statin Therapy in Patients With Type 2 Diabetes and Mixed Dyslipidemia (ODYSSEY DM-Dyslipidemia)
    • 5479899 (first received December 24, 2015)
    • NCT02642159 . Efficacy and Safety of Alirocumab Versus Usual Care on Top of Maximally Tolerated Statin Therapy in Patients With Type 2 Diabetes and Mixed Dyslipidemia (ODYSSEY DM-Dyslipidemia). https://clinicaltrials.gov/ct2/show/NCT02642159 (first received December 24, 2015). 5479899
  • 51
    • 84893868258 scopus 로고    scopus 로고
    • ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab
    • 5479901 (first received August 8, 2012)
    • NCT01663402 . ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab. https://clinicaltrials.gov/ct2/show/NCT01663402 (first received August 8, 2012). 5479901
  • 52
    • 84921504707 scopus 로고    scopus 로고
    • Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders (TAUSSIG)
    • 5479903 (first received June 5, 2012)
    • NCT01624142 . Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders (TAUSSIG). https://clinicaltrials.gov/ct2/show/NCT01624142 (first received June 5, 2012). 5479903
  • 54
    • 84921702413 scopus 로고    scopus 로고
    • Interaction revisited: the difference between two estimates
    • Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ 2003;326(7382):219.
    • (2003) BMJ , vol.326 , Issue.7382 , pp. 219
    • Altman, D.G.1    Bland, J.M.2
  • 55
    • 77953309816 scopus 로고    scopus 로고
    • PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    • Benn M, Nordestgaard BG, Grande P, Schnohr P, Tybjaerg-Hansen A. PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. Journal of the American College of Cardiology 2010;55(22):2833-42.
    • (2010) Journal of the American College of Cardiology , vol.55 , Issue.22 , pp. 2833-2842
    • Benn, M.1    Nordestgaard, B.G.2    Grande, P.3    Schnohr, P.4    Tybjaerg-Hansen, A.5
  • 56
    • 84868628467 scopus 로고    scopus 로고
    • Familial hypercholesterolemia in the Danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication
    • Benn M, Watts GF, Tybjaerg-Hansen A, Nordestgaard BG. Familial hypercholesterolemia in the Danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication. Journal of Clinical Endocrinology and Metabolism 2012;97(11):3956-64.
    • (2012) Journal of Clinical Endocrinology and Metabolism , vol.97 , Issue.11 , pp. 3956-3964
    • Benn, M.1    Watts, G.F.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 57
    • 33846260745 scopus 로고    scopus 로고
    • Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events
    • Bradburn MJ, Deeks JJ, Berlin JA, Localio AR. Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events. Statistics in Medicine 2007;26(1):53-77.
    • (2007) Statistics in Medicine , vol.26 , Issue.1 , pp. 53-77
    • Bradburn, M.J.1    Deeks, J.J.2    Berlin, J.A.3    Localio, A.R.4
  • 59
    • 85018281279 scopus 로고    scopus 로고
    • Modelling the UK burden of cardiovascular disease to 2020: a research report for the Cardio & Vascular Coalition and the British Heart Foundation. British Heart Foundation, 2008
    • accessed 01 February 2015)
    • Capewell S, Allender S, Critchley J, Lloyd-Williams F, O'Flaherty M, Rayner M, et al. Modelling the UK burden of cardiovascular disease to 2020: a research report for the Cardio & Vascular Coalition and the British Heart Foundation. British Heart Foundation, 2008. http://www.healthimpact.org.uk/Home/Links (accessed 01 February 2015).
    • Capewell, S.1    Allender, S.2    Critchley, J.3    Lloyd-Williams, F.4    O'Flaherty, M.5    Rayner, M.6
  • 60
    • 84876801739 scopus 로고    scopus 로고
    • The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway
    • Catapano AL, Papadopoulos N. The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 2013;228(1):18-28.
    • (2013) Atherosclerosis , vol.228 , Issue.1 , pp. 18-28
    • Catapano, A.L.1    Papadopoulos, N.2
  • 62
    • 84860798384 scopus 로고    scopus 로고
    • Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial
    • Chasman DI, Giulianini F, MacFadyen J, Barratt BJ, Nyberg F, Ridker PM. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circulation. Cardiovascular Genetics. 2012;5(2):257-64.
    • (2012) Circulation. Cardiovascular Genetics. , vol.5 , Issue.2 , pp. 257-264
    • Chasman, D.I.1    Giulianini, F.2    MacFadyen, J.3    Barratt, B.J.4    Nyberg, F.5    Ridker, P.M.6
  • 63
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nature Genetics 2005;37(2):161-5.
    • (2005) Nature Genetics , vol.37 , Issue.2 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 64
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. New England Journal of Medicine 2006;354(12):1264-72.
    • (2006) New England Journal of Medicine , vol.354 , Issue.12 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 65
    • 84989187956 scopus 로고    scopus 로고
    • Interpretation of the evidence for the efficacy and safety of statin therapy
    • Ahead of print
    • Collins R, Reith C, Emberson J, Armitage J, Baigent C, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet 2016;Ahead of print:1-30.
    • (2016) Lancet , pp. 1-30
    • Collins, R.1    Reith, C.2    Emberson, J.3    Armitage, J.4    Baigent, C.5
  • 66
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 2005;366(9493):1267-78.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
  • 67
    • 84933673677 scopus 로고    scopus 로고
    • Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Fulcher J, O'Connell R, Voysey M, Emberson J, Blackwell L, et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials. Lancet 2005;385(9976):1397-405.
    • (2005) Lancet , vol.385 , Issue.9976 , pp. 1397-1405
    • Fulcher, J.1    O'Connell, R.2    Voysey, M.3    Emberson, J.4    Blackwell, L.5
  • 68
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaborators, Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012;380(9841):581-90.
    • (2012) Lancet , vol.380 , Issue.9841 , pp. 581-590
    • Mihaylova, B.1    Emberson, J.2    Blackwell, L.3    Keech, A.4    Simes, J.5
  • 69
    • 84895075938 scopus 로고    scopus 로고
    • PCSK9: From discovery to therapeutic applications
    • Farnier M. PCSK9: From discovery to therapeutic applications. Archives of Cardiovascular Disease 2014;107(1):58-66.
    • (2014) Archives of Cardiovascular Disease , vol.107 , Issue.1 , pp. 58-66
    • Farnier, M.1
  • 70
    • 85018310131 scopus 로고    scopus 로고
    • Briefing document Praluent (alirocumab) injection
    • 09-06-2015; BLA 125559
    • Food and Drug Administration Center for Drug Evaluation and Research. Briefing document Praluent (alirocumab) injection. The Endocrinologic and Metabolic Drugs Advisory Committee Meeting 09-06-2015; Vol. BLA 125559.
    • The Endocrinologic and Metabolic Drugs Advisory Committee Meeting
  • 72
    • 0035906961 scopus 로고    scopus 로고
    • Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
    • Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science 2001;292(5520):1934-8.
    • (2001) Science , vol.292 , Issue.5520 , pp. 1934-1938
    • Garcia, C.K.1    Wilund, K.2    Arca, M.3    Zuliani, G.4    Fellin, R.5    Maioli, M.6
  • 73
    • 84974793861 scopus 로고    scopus 로고
    • Grading quality of evidence and strength of recommendations
    • GRADE Working Group. Grading quality of evidence and strength of recommendations. BMJ 2004;328(1):1490-4.
    • (2004) BMJ , vol.328 , Issue.1 , pp. 1490-1494
  • 75
    • 70049099036 scopus 로고    scopus 로고
    • Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011
    • Higgins JPT, Altman DG, Sterne JAC. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
    • Higgins, J.P.T.1    Altman, D.G.2    Sterne, J.A.C.3
  • 78
    • 77957661360 scopus 로고    scopus 로고
    • The impact of social determinants on cardiovascular disease
    • Kreatsoulas C, Anand SS. The impact of social determinants on cardiovascular disease. Canadian Journal of Cardiology 2010;26(Suppl C):8C-13C.
    • (2010) Canadian Journal of Cardiology , vol.26 , pp. 8C-13C
    • Kreatsoulas, C.1    Anand, S.S.2
  • 79
    • 84888096727 scopus 로고    scopus 로고
    • Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010
    • Krishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet Global Health 2013;1(5):e259-81.
    • (2013) Lancet Global Health , vol.1 , Issue.5 , pp. e259-e281
    • Krishnamurthi, R.V.1    Feigin, V.L.2    Forouzanfar, M.H.3    Mensah, G.A.4    Connor, M.5    Bennett, D.A.6
  • 81
    • 84962159581 scopus 로고    scopus 로고
    • The impact of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis
    • Lipinsky MJ, Benedetto U, Escarcega RO, Biondi-Zoccai G, Lhermusier T, Baker NC, et al. The impact of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis. European Heart Journal 2016;37(6):536-45.
    • (2016) European Heart Journal , vol.37 , Issue.6 , pp. 536-545
    • Lipinsky, M.J.1    Benedetto, U.2    Escarcega, R.O.3    Biondi-Zoccai, G.4    Lhermusier, T.5    Baker, N.C.6
  • 82
    • 84995776151 scopus 로고    scopus 로고
    • Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes
    • Lotta LA, Sharp SJ, Burgess S, Perry JR, Stewart ID, Willems SM, et al. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes. JAMA 2016;13:1383-91.
    • (2016) JAMA , vol.13 , pp. 1383-1391
    • Lotta, L.A.1    Sharp, S.J.2    Burgess, S.3    Perry, J.R.4    Stewart, I.D.5    Willems, S.M.6
  • 84
    • 84911411495 scopus 로고    scopus 로고
    • A randomized study of the relative pharmacokinetics, pharmacodynamics, and safety of alirocumab, a fully human monoclonal antibody to PCSK9, after single subcutaneous administration at three different injection sites in healthy subjects
    • Lunven C, Paehler T, Poitiers F, Brunet A, Rey J, Hanotin C, et al. A randomized study of the relative pharmacokinetics, pharmacodynamics, and safety of alirocumab, a fully human monoclonal antibody to PCSK9, after single subcutaneous administration at three different injection sites in healthy subjects. Cardiovascascular Therapy 2014;32(6):297-301.
    • (2014) Cardiovascascular Therapy , vol.32 , Issue.6 , pp. 297-301
    • Lunven, C.1    Paehler, T.2    Poitiers, F.3    Brunet, A.4    Rey, J.5    Hanotin, C.6
  • 85
    • 81255165866 scopus 로고    scopus 로고
    • Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference
    • Mancini GBJ, Baker S, Bergeron J, Fitchett D, Frohlich J, Genest J, et al. Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference. Canadian Journal of Cardiology 2011;27(5):635-62.
    • (2011) Canadian Journal of Cardiology , vol.27 , Issue.5 , pp. 635-662
    • Mancini, G.B.J.1    Baker, S.2    Bergeron, J.3    Fitchett, D.4    Frohlich, J.5    Genest, J.6
  • 86
    • 0037541585 scopus 로고    scopus 로고
    • A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia
    • Marks D, Thorogood M, Neil HAW, Humpries SE. A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis 2003;168(1):1-14.
    • (2003) Atherosclerosis , vol.168 , Issue.1 , pp. 1-14
    • Marks, D.1    Thorogood, M.2    Neil, H.A.W.3    Humpries, S.E.4
  • 87
    • 84898040307 scopus 로고    scopus 로고
    • The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study
    • Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Flaxman A, et al. The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study. Circulation 2014;129(14):1493-501.
    • (2014) Circulation , vol.129 , Issue.14 , pp. 1493-1501
    • Moran, A.E.1    Forouzanfar, M.H.2    Roth, G.A.3    Mensah, G.A.4    Ezzati, M.5    Flaxman, A.6
  • 88
    • 84871099014 scopus 로고    scopus 로고
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    • Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380(9859):2197-223.
    • (2012) Lancet , vol.380 , Issue.9859 , pp. 2197-2223
    • Murray, C.J.1    Vos, T.2    Lozano, R.3    Naghavi, M.4    Flaxman, A.D.5    Michaud, C.6
  • 89
    • 84931849550 scopus 로고    scopus 로고
    • Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis
    • Navarese EP, Kołodziejczak M, Schulze V, Gurbel PA, Tantry U, et al. Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis. Annals of Internal Medicine 2015; Vol. 163, issue 1:40-51. [DOI: 10.7326/M14-2957]
    • (2015) Annals of Internal Medicine , vol.163 , Issue.1 , pp. 40-51
    • Navarese, E.P.1    Kołodziejczak, M.2    Schulze, V.3    Gurbel, P.A.4    Tantry, U.5
  • 90
    • 84895530589 scopus 로고    scopus 로고
    • Implementing GRADE: calculating the risk difference from the baseline risk and the relative risk
    • Newcombe RG, Bender R. Implementing GRADE: calculating the risk difference from the baseline risk and the relative risk. Evidence-Based Medicine 2014;19(1):6-8.
    • (2014) Evidence-Based Medicine , vol.19 , Issue.1 , pp. 6-8
    • Newcombe, R.G.1    Bender, R.2
  • 91
    • 84964330289 scopus 로고    scopus 로고
    • Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial
    • Nissen SE, Stroes E, Dent-Acosta RE, Rosenson RS, Lehman SJ, Sattar N, et al. Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial. JAMA 2016;315(15):1580-90.
    • (2016) JAMA , vol.315 , Issue.15 , pp. 1580-1590
    • Nissen, S.E.1    Stroes, E.2    Dent-Acosta, R.E.3    Rosenson, R.S.4    Lehman, S.J.5    Sattar, N.6
  • 92
    • 84890461947 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia is underdiagnosedand undertreated in the general population:guidance for clinicians to prevent coronary heart disease
    • Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, et al. Familial hypercholesterolaemia is underdiagnosedand undertreated in the general population:guidance for clinicians to prevent coronary heart disease. European Heart Journal 2013;34(45):3478-90.
    • (2013) European Heart Journal , vol.34 , Issue.45 , pp. 3478-3490
    • Nordestgaard, B.G.1    Chapman, M.J.2    Humphries, S.E.3    Ginsberg, H.N.4    Masana, L.5    Descamps, O.S.6
  • 93
    • 85011425059 scopus 로고    scopus 로고
    • Pfizer discontinues global development of bococizumab, its investigational PCSK9 inhibitor
    • (accessed 24 April 2017)
    • Pfizer . Pfizer discontinues global development of bococizumab, its investigational PCSK9 inhibitor. http://www.pfizer.com/news/press-release/press-release-detail/pfizer_discontinues_global_development_of_bococizumab_its_investigational_pcsk9_inhibitor (accessed 24 April 2017).
  • 94
    • 84914179053 scopus 로고    scopus 로고
    • R: A language and environment for statistical computing
    • Vienna, Austria: R Foundation for Statistical Computing,
    • R Development Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2014.
    • (2014)
  • 95
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2011 update: a report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 2011;123(4):e18-209.
    • (2011) Circulation , vol.123 , Issue.4 , pp. e18-e209
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3    Adams, R.J.4    Berry, J.D.5    Brown, T.M.6
  • 97
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    • Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010;375(9716):735-42.
    • (2010) Lancet , vol.375 , Issue.9716 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3    Welsh, P.4    Buckley, B.M.5    de Craen, A.J.6
  • 98
    • 84891818553 scopus 로고    scopus 로고
    • Comments on 'the use of propensity scores and observational data to estimate randomized controlled trial generalizability bias' by Taylor R. Pressler and Eloise E. Kaizar, Statistics in Medicine 2013
    • Schmidt AF, Hoes AW, Groenwold RH. Comments on 'the use of propensity scores and observational data to estimate randomized controlled trial generalizability bias' by Taylor R. Pressler and Eloise E. Kaizar, Statistics in Medicine 2013. Statistics in Medicine 2014;33(3):536-7.
    • (2014) Statistics in Medicine , vol.33 , Issue.3 , pp. 536-537
    • Schmidt, A.F.1    Hoes, A.W.2    Groenwold, R.H.3
  • 103
    • 0022259920 scopus 로고
    • The LDL receptor gene: a mosaic of exons shared with different proteins
    • Sudhof TC, Goldstein JL, Brown MS, Russell DW. The LDL receptor gene: a mosaic of exons shared with different proteins. Science 1985;228(4701):815-22.
    • (1985) Science , vol.228 , Issue.4701 , pp. 815-822
    • Sudhof, T.C.1    Goldstein, J.L.2    Brown, M.S.3    Russell, D.W.4
  • 104
    • 2342661718 scopus 로고    scopus 로고
    • What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    • Sweeting MJ, Sutton AJ, Lambert, PC . What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Statistics in Medicine 2004;23(1):1351-75.
    • (2004) Statistics in Medicine , vol.23 , Issue.1 , pp. 1351-1375
    • Sweeting, M.J.1    Sutton, A.J.2    Lambert, P.C.3
  • 105
    • 84921493092 scopus 로고    scopus 로고
    • HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
    • Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet 2014;385(9965):351-61.
    • (2014) Lancet , vol.385 , Issue.9965 , pp. 351-361
    • Swerdlow, D.I.1    Preiss, D.2    Kuchenbaecker, K.B.3    Holmes, M.V.4    Engmann, J.E.5    Shah, T.6
  • 106
    • 0033619529 scopus 로고    scopus 로고
    • Explaining heterogeneity in meta-analysis: a comparison of methods
    • Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Statistics in Medicine 1999;18(20):2693-708.
    • (1999) Statistics in Medicine , vol.18 , Issue.20 , pp. 2693-2708
    • Thompson, S.G.1    Sharp, S.J.2
  • 107
    • 0037098178 scopus 로고    scopus 로고
    • How should meta-regression analyses be undertaken and interpreted?
    • Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted?. Statistics in Medicine 2002;21(11):1559-73.
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1559-1573
    • Thompson, S.G.1    Higgins, J.P.2
  • 108
    • 0035841813 scopus 로고    scopus 로고
    • Statistics notes: analysing controlled trials with baseline and follow up measurements
    • Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ 2001;323(7321):1123-4.
    • (2001) BMJ , vol.323 , Issue.7321 , pp. 1123-1124
    • Vickers, A.J.1    Altman, D.G.2
  • 109
    • 33745287793 scopus 로고    scopus 로고
    • The global burden of disease: 2004 update
    • (accessed 01 February 2015)
    • World Health Organization. The global burden of disease: 2004 update. http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/ (accessed 01 February 2015).
  • 111
    • 84935001755 scopus 로고    scopus 로고
    • Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 randomized, controlled trials
    • Zhang XL, Zhu QQ, Zhu L, Chen JZ, Chen QH, Li QN, et al. Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 randomized, controlled trials. BMC Medicine 2015;13(123):1-19.
    • (2015) BMC Medicine , vol.13 , Issue.123 , pp. 1-19
    • Zhang, X.L.1    Zhu, Q.Q.2    Zhu, L.3    Chen, J.Z.4    Chen, Q.H.5    Li, Q.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.