Safety and efficacy of anti-PCSK9 antibodies: A meta-analysis of 25 randomized, controlled trials

BMC Medicine

Volumn 13, Issue 1, 2015, Pages

  Zhang, Xin Lin ^a   Zhu, Qing Qing ^a   Zhu, Li ^a   Chen, Jian Zhou ^a   Chen, Qin Hua ^a   Li, Guan Nan ^a   Xie, Jun ^a   Kang, Li Na ^a   Xu, Biao ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Alirocumab; Efficacy; Evolocumab; LDL C; Meta analysis; Monoclonal antibody; PCSK9; Randomized controlled trials; Safety

Indexed keywords

ALANINE AMINOTRANSFERASE; ALIROCUMAB; APOLIPOPROTEIN A; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; EVOLOCUMAB; EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL; HYPOCHOLESTEROLEMIC AGENT; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACKACHE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COGNITIVE DEFECT; CONNECTIVE TISSUE DISEASE; CREATINE KINASE BLOOD LEVEL; DISEASE SEVERITY; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; GASTROINTESTINAL DISEASE; HEADACHE; HUMAN; INCIDENCE; INFLUENZA; INJECTION SITE REACTION; LIPOPROTEIN BLOOD LEVEL; LOW RISK PATIENT; META ANALYSIS; MUSCLE SPASM; MUSCULOSKELETAL DISEASE; MYALGIA; NEUROLOGIC DISEASE; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); RHINOPHARYNGITIS; TREATMENT DURATION; TREATMENT WITHDRAWAL; TRIACYLGLYCEROL BLOOD LEVEL; UPPER RESPIRATORY TRACT INFECTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; METABOLISM; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; HUMANS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; PROPROTEIN CONVERTASES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SERINE ENDOPEPTIDASES; TREATMENT OUTCOME;

EID: 84935001755     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0358-8     Document Type: Article

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