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Volumn 11, Issue 1, 2015, Pages 8-9

Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia

Author keywords

[No Author keywords available]

Indexed keywords

HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SERINE PROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; SERINE PROTEINASE;

EID: 84927175751     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2014.205     Document Type: Article
Times cited : (10)

References (10)
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    • Mechanisms of disease: Genetic causes of familial hypercholesterolemia
    • Soutar, A. K. & Naoumova, R. P. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nat. Clin. Pract. Cardiovasc. Med. 4, 214-225 (2007)
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    • Soutar, A.K.1    Naoumova, R.P.2
  • 2
    • 84905865817 scopus 로고    scopus 로고
    • Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation
    • Mabuchi, H. et al. Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation. Atherosclerosis 236, 54-61 (2014)
    • (2014) Atherosclerosis , vol.236 , pp. 54-61
    • Mabuchi, H.1
  • 3
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel, M. et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34, 154-156 (2003)
    • (2003) Nat. Genet , vol.34 , pp. 154-156
    • Abifadel, M.1
  • 4
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobb, H. H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264-1272 (2006)
    • (2006) N. Engl. J. Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobb, H.H.4
  • 5
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    • Effect of an inhibitor of 3-hydroxy-3-methyglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10-levels in patients with familial hypercholesterolemia
    • Mabuchi, H. et al. Effect of an inhibitor of 3-hydroxy-3-methyglutaryl coenzyme A reductase on serum lipoproteins and ubiquinone-10-levels in patients with familial hypercholesterolemia. N. Engl. J. Med. 305, 478-482 (1981)
    • (1981) N. Engl. J. Med , vol.305 , pp. 478-482
    • Mabuchi, H.1
  • 6
    • 0019418333 scopus 로고
    • Lowering plasma cholesterol by raising LDL receptors
    • Brown, M. S. & Goldstein, J. L. Lowering plasma cholesterol by raising LDL receptors. N. Engl. J. Med. 305, 515-517 (1981)
    • (1981) N. Engl. J. Med , vol.305 , pp. 515-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 84908397421 scopus 로고    scopus 로고
    • National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1- executive summary
    • Jacobson, T. A. et al. National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1- executive summary. J. Clin. Lipidol. 8, 473-488 (2014)
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    • Jacobson, T.A.1
  • 8
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    • Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
    • Stein, E. A. et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N. Engl. J. Med. 366, 1108-1118 (2012)
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    • Stein, E.A.1
  • 9
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    • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebo-controlled trial
    • Raal, F. J. et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet http://dx.doi.org/10.1016/S0140-6736(14)61399-4.
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    • Lancet
    • Raal, F.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.