Evolocumab and clinical outcomes in patients with cardiovascular disease

New England Journal of Medicine

Volumn 376, Issue 18, 2017, Pages 1713-1722

  Sabatine, Marc S ^a   Giugliano, Robert P ^a   Keech, Anthony C ^b   Honarpour, Narimon ^c   Wiviott, Stephen D ^a   Murphy, Sabina A ^a   Kuder, Julia F ^a   Wang, Huei ^c   Liu, Thomas ^c   Wasserman, Scott M ^c   Sever, Peter S ^d   Pedersen, Terje R ^e   Fish, M P ^f   Abrahamsen, T E ^f   Im, K ^f   Kanevsky, E ^f   Bonaca, M P ^f   Lira Pineda, A ^f   Hanlon, K ^f   Knusel, B ^f   Somaratne, R ^f   Kurtz, C ^f   Scott, R ^f   Accini Mendoza, J L ^f   Amerena, J ^f   Badariene, J ^f   Burgess, L ^f   Ceska, R ^f   Charng, M J ^f   Choi, D ^f   Cobos, J L ^f   Dan, G A ^f   De Ferrari, G M ^f   Deedwania, P C ^f   Chopra, V K ^f   Erglis, A ^f   Ezhov, M V ^f   Ferreira, J ^f   Filipova S ^f   Gaciong, Z A ^f   Pasierski, T ^f   Georgiev, B G ^f   Gonzalez Galvez, G ^f   Gouni Berthold, I ^f   Schaufele T ^f   Hirayama, A ^f   Huber, K ^f   Rammer, M ^f   Kjaerulf Jensen, H ^f   Wermuth, S ^f   Jiang, L ^f   Jukema, J W ^f   Kraydashenko, O ^f   Leiter, L A ^f   Lewis, B S ^f   Lopez Miranda J ^f   Lorenzatti, A J ^f   Mach, F ^f   McAdam, B ^f   Nilsson, L ^f   Olsson, A ^f   Rallidis, L ^f   Rogelio, G G ^f   Kerr Saraiva, J F ^f   Scheen, A ^f   Schiele, F ^f   Connolly, D ^f   Siu, C W ^f   Tay, L ^f   Thorgeirsson, G ^f   Tikkanen, M J ^f   Tokgozoglu, S L ^f   Toth, K ^f   Viigimaa, M ^f   Wan Ahmad, W A ^f   Hennekens, C H ^f   Andreotti, F ^f   Baigent, C ^f   Brown, W V ^f   Davis, B R ^f   Newcomer, J W ^f   Wood, S K ^f   LaRosa, J ^f   Ansell, B ^f   Lowe, C ^f   Zahn, L ^f   Awtry, E ^f   Berger, C ^f   Croce, K ^f   Desai, A ^f   Gelfand, E ^f   Ho, C ^f   Leeman, D ^f   Link, M ^f   Norden, A ^f   Pande, A ^f   Rost, N ^f   Ruberg, F ^f   Silverman, S ^f   Singhal, A ^f   Vita, J ^f   Mackinnon, I ^f   Vogel, D R ^f   Leon de la Fuente, R ^f   Perna, E ^f   Amuchastegui, M ^f   Pacora, F ^f   Hershson, A ^f   Blumberg, E ^f   Glenny, J A ^f   Colombo, H ^f   Cuadrado, J A ^f   Nicolosi, L ^f   Rojas, C G ^f   Ulla, M R ^f   Hasbani, E G ^f   Cuneo, C ^f   Lopez Santi, R G ^f   Sanabria, H D ^f   Hrabar, A ^f   Lozada, A ^f   Begg, A ^f   Lehman, S ^f   Wittert, G ^f   Juergens, C ^f   Kostner, K ^f   Beltrame, J ^f   Simpson, R ^f   Sinhal, A ^f   Adams, M ^f   Kritharides, L ^f   Roberts Thomson, P ^f   Cross, D ^f   Thompson, P ^f   Van Gaal, W ^f   Cox, N ^f   Farshid, A ^f   Hammett, C ^f   Garrahy, P ^f   Prasan, A ^f   Horrigan, M ^f   Ebenbichler, C ^f   Hanusch, U ^f   Prager, R ^f   Schernthaner, G ^f   Luger, A ^f   Siostrzonek, P ^f   Toplak, H ^f   Bergler Klein, J ^f   Paulweber, B ^f   Sinzinger, H ^f   Buysschaert, I ^f   Thoeng, J ^f   Vandekerckhove, H ^f   Catez, E ^f   Verheye, S ^f   Descamps, O ^f   Hoffer, E ^f   Wollaert, B ^f   Chenu, P ^f   van de Borne, P ^f   De Meulemeester, M ^f   Friart, A ^f   Charlier, F ^f   De Raedt, H ^f   Rietzschel, E ^f   Roelandt, R ^f   Lalmand, J ^f   Tavares Russo, L A ^f   Reis, G ^f   Duarte Barbosa, E C ^f   Vidotti, M H ^f   Fernandes Manenti, E R ^f   Dutra, O ^f   Leaes, P E ^f   Rech, R L ^f   Bertolim Precoma, D ^f   Nicolau, J C ^f   Amoedo, R ^f   Eliaschewitz, F G ^f   Pereira, A ^f   Kurtz Lisboa, H R ^f   Soares Piegas, L ^f   Cunha Borges, J L ^f   Ferreira Rossi, P R ^f   Pimentel Filho, P ^f   Bodanese, L C ^f   de Sa Cunha, R ^f   Moura Jorge, J C ^f   Ardito, W R ^f   Barroso de Souza, W K ^f   Hissa, M ^f   Izar, M C ^f   Manolova, A ^f   Kitova, L ^f   Kinova, E ^f   Tzekova, M ^f   Velchev, V ^f   Tarnovska Kadreva, R ^f   Gotchev, D ^f   Petrov, I ^f   Raev, D ^f   Trendafilova Lazarova, D ^f   Yotov, Y ^f   Lazov, P ^f   Rahimi, S ^f   St Amour, E ^f   Constance, C ^f   Pesant, Y ^f   Hess, A ^f   Anderson, T ^f   Sussex, B ^f   Henein, S ^f   Tsoukas, G ^f   Pandey, A S ^f   Bergeron, J ^f   Hart, R ^f   Gosselin, G ^f   Chehayeb, R ^f   Hamet, P ^f   Hartleib, M ^f   Mukherjee, A ^f   Halperin, F ^f   Petrella, R ^f   Bhargava, R ^f   Lonn, E ^f   Sabbah, E ^f   Bata, I ^f   Cha, J ^f   Gaudet, D ^f   Chapman, K ^f   Murthy, D ^f   Nigro, F ^f   Rupka, D ^f   Gossard, D ^f   Gupta, M ^f   Dowell, A ^f   Mansour, S ^f   Baass, A ^f   Geadah, C ^f   Huynh, T ^f   Peterson, S ^f   Poirier, P ^f   Sabe Affaki, G ^f   Vertes, G ^f   Crowley, D ^f   Duchesne, L ^f   Pincetti Jofre, C P ^f   Potthoff Cardenas, S ^f   Conejeros Kindel, C ^f   Saavedra Gajardo, V A ^f   Lanas Zanetti, F ^f   Sepulveda Varela, P A ^f   Stockins Fernandez, B A ^f   Li, W ^f   Li, D ^f   Zhao, S ^f   Li, Z ^f   Wang, J ^f   Yang, Y ^f   Zhang, L ^f   Yang, P ^f   Zhang, X ^f   Huang, H ^f   Xue, L ^f   Zheng, Z ^f   Huang, W ^f   Dai, H ^f   Su, H ^f   Zeng, X ^f   Zheng, Y ^f   Tang, Y ^f   Yao, Z ^f   Sun, Y ^f   Du, Y ^f   Ge, Z ^f   Yan, J ^f   Chen, X ^f   Liu, F ^f   Pei, H ^f   Yang, X ^f   Cui, H ^f   Gu, Y ^f   Yang, Z ^f   Li, J ^f   Lian, Y ^f   Cui, Y ^f   Wang, D ^f   Jiang, J ^f   Li, X ^f   Chen, J ^f   Mo, Z ^f   Xu, P ^f   He, Y ^f   Zhou, C ^f   Qu, P ^f   Zhu, Y ^f   Liu, Y ^f   Shen, X ^f   Gao, X ^f   Terront Lozano, M A ^f   Moncada Corredor, M A ^f   Hernandez Triana, E ^f   Botero Lopez, R ^f   Coronel Arroyo, J A ^f   Quintero Baiz, A E ^f   Sanchez Vallejo, G ^f   Arana Londono C ^f   Molina de Salazar, D I ^f   Castellanos Bueno, R ^f   Manzur Jattin, F ^f   Cure Cure, C A ^f   Sotomayor Herazo, A ^f   Spinar, J ^f   Hala, T ^f   Machkova, M ^f   Klimsa, Z ^f   Polasek, R ^f   Jerabek, O ^f   Kazdera, P ^f   Pozdisek, Z ^f   Vaclavik, J ^f   Frana, P ^f   Elbl, L ^f   Kucera, D ^f   Kryza, R ^f   Malecha, J ^f   Reichert, P ^f   Sochor, K ^f   Ludka, O ^f   Kellnerova, I ^f   Peterka, K ^f   Zidkova, E ^f   Cech, V ^f   Brabec, T ^f   Fiserova, N ^f   Kvasnicka, J ^f   Rosolova, H ^f   Nemecek, E ^f   Adamkova, V ^f   Dunaj, M ^f   Pojsl, S ^f   Cepelak, M ^f   Podpera, I ^f   Kuchar, L ^f   Rysava, D ^f   Burianova, H ^f   Spinarova, L ^f   Skrobakova, J ^f   Charvat, J ^f   Homza, M ^f   Zemanek, J ^f   Koleckar, P ^f   Karen, I ^f   Krupicka, J ^f   Blaha, V ^f   Matuska, J ^f   Brotanek, J ^f   Cifkova, R ^f   Kuchar, R ^f   Vomacka, Z ^f   Kosek, Z ^f   Hulinsky, V ^f   Krejcova, H ^f   Kuchar, J ^f   Jelinek, Z ^f   Jelinek, P ^f   Markdanner Lindgren, L ^f   Saetre Lihn, A ^f   Korsgaard Thomsen, K ^f   Bronnum Schou, J ^f   Nielsen, H ^f   Nielsen, T ^f   Egstrup, K ^f   Klausen, I C ^f   Mickley, H ^f   Hove, J ^f   Jeppesen, J ^f   Melchior, T ^f   Schmidt, E B ^f   Valter, I ^f   Rosenthal, A ^f   Kaik, J ^f   Kork, A ^f   Alt, I ^f   Strand, J ^f   Nieminen, S ^f   Kahri, J ^f   Suomi, J ^f   Nyman, K ^f   Strandberg, T E ^f   Piippo, T ^f   Savolainen, M ^f   Vikman, S ^f   Pucheu, Y ^f   Cariou, B ^f   Henry, P ^f   Ferrari, E ^f   Montalescot, G ^f   Ferrieres, J ^f   Roubille, F ^f   Bonnet, B ^f   Angoulvant, D ^f   Range, G ^f   Bammert, A ^f   Delarche, N ^f   Mariat, C ^f   Cayla, G ^f   Durlach, V ^f   Coisne, D ^f   Paillard, F ^f   Rouzier, R ^f   Goralski, M ^f   Khanoyan, P ^f   Cottin, Y ^f   Ziegler, O ^f   Khalife, K ^f   Le Corvoisier, P ^f   Motreff, P ^f   Spaulding, C ^f   VanBelle, E ^f   Bourhaial, H ^f   Opitz, C ^f   Kahrmann, G ^f   Contzen, C ^f   Appel, K ^f   Schenkenberger, I ^f   Rinke, A ^f   Trenk, D ^f   Maus, O ^f   Karakas, M ^f   Hanefeld, M ^f   Darius, H ^f   Hetzel, G ^f   Munzel T ^f   Wohrle J ^f   Stawowy, P ^f   Marten, I ^f   Isermann, B ^f   Kast, P ^f   Vorpahl, M ^f   Bosiljanoff, P ^f   Hengstenberg, C ^f   Kassner, U ^f   Salbach, P ^f   Fischer, M ^f   Steiner, S ^f   Wagner, S ^f   Kraatz, U ^f   von Hodenberg, E ^f   Weyland, K ^f   Mantas, I ^f   Tziakas, D ^f   Bousboulas, S ^f   Patsilinakos, S ^f   Mertzanos, G ^f   Panagoulis, C ^f   Bilianou, H ^f   Skoumas, I ^f   Elisaf, M ^f   Manolis, A ^f   Moschos, N ^f   Kochiadakis, G ^f   Ntaios, G ^f   Richter, D ^f   Athyros, V ^f   Kolovou, G ^f   Danias, P ^f   Melidonis, A ^f   Fan, K Y Y ^f   Siu, S C ^f   Hornyik, A ^f   Lakatos, F ^f   Zilahi, Z ^f   Nagy, K ^f   Laszlo, Z ^f   Peterfai, E ^f   Lupkovics, G ^f   Andreka, P ^f   Merkely, B ^f   Herczeg, B ^f   Piros, G A ^f   Salamon, C ^f   Mark, L ^f   Papp, A ^f   Szakal, I ^f   Edes, I ^f   Mohacsi, A ^f   Tomcsanyi, J ^f   Hajko, E ^f   Nagy, A ^f   Papp, E ^f   Kiss, R ^f   Karadi, I ^f   Sigurdsson, A ^f   Jain, A ^f   Pai, R ^f   Kothiwale, V ^f   Kulkarni, G ^f   Mahajan, A ^f   Aggarwal, S ^f   Mehta, V ^f   Rajadhyaksha, G ^f   Joshi, A ^f   Khandait, V ^f   Parmar, M ^f   Tyagi, S ^f   Airody Govinda, R ^f   Dwivedi, S K ^f   Parikh, K ^f   Pothineni, R B ^f   Solanki, B ^f   O'Donnell, M ^f   Crean, P ^f   Barton, J ^f   Shechter, M ^f   Shotan, A ^f   Klutstein, M ^f   Chorin, E ^f   Gavish, D ^f   Kracoff, O ^f   Atar, S ^f   Rigler, S ^f   Hasin, Y ^f   Schiff, E ^f   Merlini, P ^f   Rapezzi, C ^f   Pirro, M ^f   Gonnelli, S ^f   Floresta, A M ^f   Mennuni, M ^f   Ardissino, D ^f   Senni, M ^f   Marenzi, G ^f   Marcucci, R ^f   Sampietro, T ^f   Cosmi, F ^f   Perrone Filardi, P ^f   De Caterina, R ^f   Fedele, F ^f   Moretti, L ^f   Biasucci, L M ^f   Ferri, C ^f   Go, Y ^f   Kiyosue, A ^f   Higashi, Y ^f   Tokunaga, T ^f   Kawasaki, T ^f   Sakagami, S ^f   Namba, S ^f   Saku, K ^f   Oku, K ^f   Arakawa, T ^f   Iida, H ^f   Nakamura, Y ^f   Yamamoto, K ^f   Hata, Y ^f   Katsuda, Y ^f   Koga, Y ^f   Shimizu, M ^f   Uehara, H ^f   Kajiyama, S ^f   Okamoto, H ^f   Shinozaki, T ^f   Fujino, Y ^f   Funazaki, T ^f   Higa, N ^f   Kaigawa, K ^f   Koike, A ^f   Nakane, H ^f   Sato, K ^f   Satoh, Y ^f   Shirasawa, K ^f   Sugino, H ^f   Tanabe, J ^f   Uemura, O ^f   Yoshimichi, G ^f   Akai, A ^f   Himeno, H ^f   Inage, T ^f   Inoko, M ^f   Kadokami, T ^f   Noguchi, Y ^f   Yamashita, K ^f   Yasumura, Y ^f   Yuge, M ^f   Hosokawa, S ^f   Kawamitsu, K ^f   Kozuma, K ^f   Matsuo, H ^f   Nakashima, E ^f   Okada, M ^f   Wada, A ^f   Yokoya, K ^f   Iwade, K ^f   Kawabata, K ^f   Tanno, H ^f   Ako, J ^f   Fujita, H ^f   Izumiya, Y ^f   Kanno, M ^f   Nunohiro, T ^f   Ohmura, H ^f   Ueno, T ^f   Kakurina, N ^f   Jasinkevica, I ^f   Stukena, I ^f   Veze, I ^f   Eglite, R ^f   Teterovska, D ^f   Sime, I ^f   Strazdiene, V ^f   Venceviciene, L ^f   Gustiene, O ^f   Radzeviciene Jurgute, R ^f   Kucinskiene, A ^f   Maskon, O ^f   Lee, C Y ^f   Erng, T ^f   Gan, H W ^f   Mohamed Yusof, A K ^f   Ramanathan, G L ^f   Liew, H ^f   Lopez Alvarado, A ^f   Nevarez Ruiz, L A ^f   De los Rios Ibarra, M O ^f   Bazzoni Ruiz, A E ^f   Ramos Lopez, G A ^f   Llamas Esperon, G A ^f   De la Pena Topete G D J ^f   Violante Ortiz, R M ^f   Illescas Diaz, J J ^f   Leon Gonzalez, S ^f   Sanchez Diaz, C J ^f   Mendez Machado, G F ^f   Venegas Carrillo, L A ^f   Aldrete Velasco, J A ^f   Cardona Munoz E G ^f   Leiva Pons, J L ^f   Perez Alva, J C ^f   van der Zwaan, C ^f   Oomen, A ^f   van de Wal, R ^f   Magro, M ^f   Boswijk, D ^f   Janus, C ^f   Groutars, R ^f   Tonino, W ^f   Cornel, J H ^f   Oude Ophuis, A ^f   Troquay, R ^f   Liem, A ^f   Westendorp, I ^f   Van Hessen, M ^f   Lok, D ^f   De Nooijer, C ^f   Den Hartog, F ^f   Van Beek, E ^f   Bendermacher, P ^f   Jansen, R ^f   Romer T ^f   Rensing, B ^f   Hersbach, F ^f   Herrman, J ^f   Ladyjanskaia, G ^f   Karalis, I ^f   Linssen, G ^f   Bokern, M ^f   Visman, A ^f   Kooij, A ^f   Monajemi, H ^f   Lieverse, A ^f   Baker, J ^f   Tie, S ^f   Risberg, K ^f   Hysing, J ^f   Hoivik, H O ^f   Norheim, P ^f   Solnor, L ^f   Hovland, A ^f   Kjaernli, T ^f   Jocson, G ^f   Coching, R M ^f   Batalla, E ^f   Go, A ^f   Habaluyas, R ^f   Barcinas, R ^f   Sy, R A ^f   Estepar, R A ^f   Germar, A ^f   Trebacz, J ^f   Szymkowiak, K ^f   Wnetrzak Michalska, R ^f   Kopaczewski, J ^f   Przekwas Jaruchowska, M ^f   Kania, G ^f   Zabowka, M ^f   Mirek Bryniarska, E ^f   Dabrowska, M ^f   Napora, P ^f   Konieczny, M ^f   Spyra, J ^f   Lysek, R ^f   Pijanowski, Z ^f   Grzegorzewski, B ^f   Bednarkiewicz, Z ^f   Kinasz, L ^f   Antkowiak Piatyszek, K ^f   Stania, K ^f   Szpajer, M ^f   Staneta, P ^f   Skonieczny, G ^f   Ksiezycka Majczynska, E ^f   Blicharski, T ^f   Piepiorka, M ^f   Wozakowska Kaplon, B ^f   Zechowicz, T ^f   Ilkowski, J ^f   Lubiszewska, B ^f   Hiczkiewicz, J ^f   Wierzbicka, K ^f   Kosior, D ^f   Garbocz, P ^f   Kubica, J ^f   Raczak, G ^f   Wozniak, I ^f   Cygler, J ^f   Kramarczuk, E ^f   Bystryk, L ^f   Pentela Nowicka, J ^f   Dabrowski, M ^f   Podolec, P ^f   Zieba, B ^f   Mosiewicz, J ^f   Dubaniewicz, W ^f   Banach, M ^f   Tyszecka, G ^f   Lepich, T ^f   Rychlewska Hanczewska, A ^f   Guzik, T ^f   Monteiro, P ^f   Pereira, H ^f   Oliveira, L ^f   Matos, P ^f   Soares Goncalves, S ^f   Leitao, A ^f   Vasco Salgado, A ^f   Timoteo, A T ^f   Pintilei, E ^f   Badila, E ^f   Militaru, C ^f   Tudoran, M ^f   Arsenescu Georgescu, C ^f   Mitu, F ^f   Zdrenghea, D ^f   Lighezan, D ^f   Teodorescu, I ^f   Popescu, M I ^f   Coman, I ^f   Vintila, M M ^f   Vishnevsky, A ^f   Lukyanov, Y ^f   Blokhin, A ^f   Kostenko, V ^f   Shvarts, Y ^f   Markov, V ^f   Motylev, I ^f   Dronov, D ^f   Sherenkov, A ^f   Barbarash, O ^f   Shutemova, E ^f   Bolshakova, O ^f   Kobalava, Z ^f   Voevoda, M ^f   Treshkur, T ^f   Zrazhevskiy, K ^f   Pimenov, L ^f   Solovev, O ^f   Tarasov, N ^f   Arkhipov, M ^f   Freidlin, M ^f   Shalaev, S ^f   Yakhontova, P ^f   Shustov, S ^f   Goloshchekin, B ^f   Panov, A ^f   Bart, B ^f   Bubnova, M ^f   Gordeev, I ^f   Osipova, I ^f   Tereshenko, S ^f   Solovieva, E ^f   Meshkov, A ^f   Zateyshchikov, D ^f   Tan, J L ^f   Subramaniam, T ^f   Pella, D ^f   Fulop, P ^f   Antalik, L ^f   Dzupina, A ^f   Banikova, A ^f   Sosovec, D ^f   Urgeova, L ^f   Mazur, J ^f   Hranai, M ^f   Banik, M ^f   Vinanska, D ^f   Lennerova, J ^f   Kovar, F ^f   Pastrnakova, E ^f   Uhliar, R ^f   Blasko, P ^f   Gonsorcik, J ^f   Lukacova, J ^f   Oriesek, R ^f   Hatalova, K ^f   du Toit, M ^f   Ebrahim, I ^f   Vawda, G ^f   Lipschitz, S ^f   Blignaut, S ^f   Engelbrecht, J ^f   Coetzer, T F ^f   Pretorius, M ^f   Urbach, D ^f   Badat, A ^f   Pillay, S ^f   Van Zyl, L ^f   Abelson, M ^f   van der Walt, E ^f   Moodley, R ^f   Jacovides, A ^f   Oosthuysen, W M ^f   Klug, E ^f   Lottering, H ^f   Kok, J ^f   Saaiman, J ^f   Dawood, S ^f   De Jong, D M ^f   Kapp, C ^f   Makotoko, E ^f   Bayat, J ^f   Sarvan, M ^f   Vally, T ^f   Stapelberg, A ^f   Kim, M ^f   Bae, J ^f   Cho, Y ^f   Kim, S ^f   Han, K H ^f   Her, S ^f   Kim, B ^f   Lee, S ^f   Hong, B ^f   Kim, W ^f   Rha, S ^f   Jeong, M ^f   Shin, G J ^f   Vida Gutierrez, M ^f   Valdes Chavarri, M ^f   Pinto Sala, X ^f   Gonzalez Juanatey, J R ^f   Civeira Murillo, F ^f   Zamorano Gomez, J L ^f   Lekuona Goya, I ^f   Iniguez Romo A ^f   Cordero Fort, A ^f   Ascaso Gimilio, J F ^f   Millan Nunez Cortes J ^f   Lindholm, C ^f   Soderberg S ^f   Suutari, A ^f   Berglund, S ^f   Mooe, T ^f   Kusiak, D ^f   Bandh, S ^f   Dahlen G ^f   Olsson, S ^f   Witt, N ^f   Tyden P ^f   Johansson, P ^f   Cizinsky, S ^f   Falck, G ^f   Pettersson, S I ^f   Rasmanis, G ^f   Ostergren J ^f   Moccetti, T ^f   Beer, H J ^f   Eberli, F ^f   Krahenbuhl S ^f   Linka, A ^f   Ackermann, D ^f   Michel, P ^f   Yeh, H ^f   Tsai, C F ^f   Wu, C ^f   Hsia, C ^f   Juang, J ^f   Hsieh, I ^f   Lai, W ^f   Huang, C ^f   Hsieh, Y ^f   Sahin, T ^f   Duzenli, M ^f   Yigit, Z ^f   Demir, M ^f   Yilmaz, M B ^f   Muderrisoglu, I H ^f   Kirma, C ^f   Ercan, E ^f   Kayikcioglu, L ^f   Balbay, Y ^f   Lymar, I ^f   Kulynych, O ^f   Prokhorov, O ^f   Karpenko, O ^f   Kraіz, I ^f   Vakaliuk, I ^f   Stanislavchuk, M ^f   Korzh, O ^f   Rudyk, I ^f   Zhurba, S ^f   Svishchenko, Y ^f   Tseluyko, V ^f   Gyrina, O ^f   Reshotko, D ^f   Kopytsya, M ^f   Volkov, V ^f   Myshanych, G ^f   Rebrov, B ^f   Rishko, M ^f   Rudenko, L ^f   Shatylo, V ^f   Parkhomenko, O ^f   Yena, L ^f   Golovchenko, O ^f   Sorokina, I ^f   Malynovsky, Y ^f   Ivan, P ^f   Blagden, M ^f   Dear, H ^f   Mathew, A ^f   Lagocki, S ^f   Kondagunta, V ^f   Ahsan, A ^f   McKinnon, C ^f   Douglas, F ^f   Thom, S ^f   Fiore, G ^f   Caulfield, M ^f   Lynch, M ^f   Thomas, H ^f   Bain, S ^f   Hall, A ^f   McNally, D ^f   Fisher, M ^f   Keeling, P ^f   Al Bahrani, A ^f   Lip, G ^f   Ellery, A ^f   Purohit, J ^f   Travill, C ^f   Cappuccio, F ^f   Davis, G ^f   Gaunt, R ^f   Adlam, D ^f   Asamoah, N ^f   Jaafar, F ^f   McCormack, T ^f   Jupp, B ^f   Pye, M ^f   Ainsworth, P ^f   Chauhan, A ^f   Paul, N ^f   Fairlie, H ^f   Fox, C ^f   Muzulu, S ^f   Trevelyan, J ^f   Aggarwal, R ^f   Issa, B ^f   Saravanan, P ^f   Cruickshank, K ^f   Gorog, D ^f   Heller, S ^f   Newby, D ^f   Nicolson, A ^f   Hare, P O ^f   Donnelly, P ^f   Rutherfurd, S ^f   de Belder, M ^f   Finlayson, J ^f   Harvey, J ^f   Hoye, A ^f   Kingston, D ^f   Sarkar, D ^f   Negahban, A ^f   Webster, J ^f   Wyatt, N ^f   Muir, S ^f   Cummings, M ^f   Mackenzie, I ^f   Senior, R ^f   Capps, N ^f   Fotherby, K ^f   McIntyre, H ^f   Aldegather, J ^f   Dixon, L ^f   Saksena, R ^f   Butler, R ^f   Ramstad, D ^f   Pierpont, B ^f   Levinson, D ^f   Mohammed, A ^f   Haddad, T ^f   Goel, A ^f   Dave, K ^f   Haught, W H ^f   Desire, A ^f   Hershon, K ^f   Napoli, M ^f   Tami, L ^f   Rothschild, R ^f   Khurana, S ^f   Gupta, D ^f   Cheung, D ^f   Hearne, S ^f   Grubb, S ^f   Miller, A ^f   Baird, I ^f   Marcus, A ^f   Srivastava, S ^f   Forgosh, L ^f   Fritz, R ^f   Mays, M ^f   Bertolet, B ^f   Reddy, J ^f   Khan, M ^f   Nakhle, S ^f   Dill, S ^f   Fishbein, G ^f   Khan, B ^f   Marais, H ^f   Reschak, M ^f   Malone, M ^f   Nadar, V ^f   Whitney, R ^f   Reichman, A ^f   Reyes, H ^f   El Shahawy, M ^f   Rabinowitz, A ^f   Weinstein, D ^f   Farhat, N ^f   Onyema, D ^f   Potu, R ^f   Runquist, L ^f   Barnum, O ^f   Crater, T ^f   Fialkow, J ^f   Shah, A ^f   Thompson, C ^f   Wiseman, A ^f   Doyle, T ^f   Henderson, D ^f   Herzog, W ^f   Schnitzler, R ^f   Carr, K ^f   Davis, M ^f   Nagajothi, N ^f   Olsen, S ^f   Rogers, W ^f   Rubino, J ^f   Singh, I ^f   Tarleton, G ^f   Bhagwat, R ^f   Clardy, D ^f   Jardula, M ^f   Robinson, J ^f   Torres, M ^f   Vijay, N ^f   Farris, N ^f   Lillo, J ^f   Moriarty, P ^f   Recknor, C ^f   Berlacher, P ^f   Christensen, T ^f   Gabra, N ^f   Issa, M ^f   Janik, M ^f   Lawless, A ^f   Molter, D ^f   Stout, E ^f   Brezina, B ^f   Claxton, E ^f   Linsky, R ^f   Poock, J ^f   Remler, R ^f   Roseman, H ^f   Schramm, E ^f   Al Joundi, T ^f   Amin, J ^f   Hitchcock, J ^f   Isserman, S ^f   Kirstein, J ^f   Rider, J ^f   Shalek, M ^f   Sherman, H ^f   Bernstein, M ^f   Chandra, L ^f   Hatharasinghe, R ^f   Ibrahim, H ^f   Iteld, B ^f   Linzmeyer, K ^f   Seaton, B ^f   Zeig, S ^f   Christofides, E ^f   Dunbar, R ^f   Griffin, S ^f   Kohli, N ^f   Koren, M ^f   Pharr, W ^f   Purdy, D ^f   Spencer, R ^f   Yeoman, G ^f   Banerjee, S ^f   Cheek, H B ^f   Engel, E ^f   Hamroff, G ^f   Huling, R ^f   Kozlowski, L ^f   Levin, P ^f   Makam, S ^f   Meengs, M ^f   Bhushan, R ^f   Erickson, B ^f   Herman, L ^f   Lo, E ^f   McDowell, E ^f   McGrew, F ^f   Miller, M ^f   Ord, J ^f   Webel, R ^f   Wilhoit, G ^f   Wise, J ^f   Yang, E ^f   Budoff, M ^f   Collins, J ^f   Dauber, I ^f   Dobkin, L ^f   Focil, A ^f   Gandy, W ^f   Pasquini, J ^f   Ramos, M ^f   Rodriguez, D ^f   Rosenson, R ^f   Sanford, K ^f   Schlau, A ^f   Snyder, B ^f   Stonesifer, L ^f   Tang, A ^f   De Souza, J ^f   Elam, M ^f   French, J ^f   Guyton, J ^f   Hage Korban, E ^f   Kereiakes, D ^f   King, M ^f   Loh, I ^f   Navarro, J ^f   Simons, R ^f   Tobin, T ^f   Younis, L ^f   Aboufakher, R ^f   Baldari, D ^f   Ballantyne, C ^f   Broughton, R ^f   Eaton, C ^f   Johnston, J ^f   Simon, W ^f   Thomson, S ^f   Vora, K ^f   Youngman, D ^f   Alzohaili, O ^f   Auerbach, E ^f   Brown, C ^f   Burrough, B ^f   Chen, Y ^f   Gilpatrick, M ^f   Landzberg, J ^f   Mitchell, C ^f   Rice, L ^f   Rubenfire, M ^f   Sofley, C W ^f   Strobl, D ^f   Atassi, K ^f   Davila, W ^f   Diogo, J ^f   Fagan, T ^f   Joffe, I ^f   Krishna, J ^f   Osea, E ^f   Penny, W ^f   Rowe, W ^f   Shapiro, M ^f   Welker, J ^f   Benton, R ^f   Dobratz, D ^f   Fortuin, F ^f   Graham, J ^f   Henry, B ^f   Kusnick, B ^f   Lutskiy, M ^f   McRae, A ^f   Saway, W ^f   Scott, J ^f   Shah, M ^f   Weinberg, B ^f   Zarich, S ^f   Acheatel, R ^f   Case, C ^f   Earl, J ^f   Fernandez, S ^f   Giugliano, G ^f   Handelsman, Y ^f   Hermany, P ^f   Holder, S ^f   Kashyap, M ^f   Khan, A ^f   Lader, E ^f   Peniston, J ^f   Raoof, T ^f   Sacco, J ^f   Shore, K ^f   Spriggs, D ^f   Stringam, S ^f   Tahirkheli, N ^f   Delgado, E ^f   Derian, W ^f   Greenwald, J ^f   Harris, M ^f   Jackson, R ^f   Marhefka, G ^f   McElveen, W ^f   Mooss, A ^f   Morris, P ^f   Murray, J ^f   Pearlstein, P ^f   Raisinghani, A ^f   Rezkalla, S ^f   Sakhrani, L ^f   Schreibman, D ^f   Shaoulian, E ^f   Steinsapir, J ^f   Yataco, A ^f   De La Cruz, A ^f   Fredrick, M ^f   Goldenberg, E ^f   Lee, D ^f   McCullum, K ^f   McLellan, B ^f   Stephens, L ^f   Wilson, S ^f   Alfieri, A ^f   Mandviwala, M ^f   ORourke, D ^f   Samal, A ^f   Schmedtje, J ^f   Waxman, F ^f   Carhart, R ^f   Clements, B ^f   Dyke, C ^f   Ghali, J ^f   Gruberg, L ^f   Hack, T ^f   Jehle, A ^f   Pogue, B ^f   Schooley, C ^f   Shifrin, G ^f   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c AMGEN INC   (United States)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

EVOLOCUMAB; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9;

ADULT; ALLERGIC REACTION; ARTICLE; CARDIOVASCULAR MORTALITY; CATARACT; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; DISORDERS OF HIGHER CEREBRAL FUNCTION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; INJECTION SITE REACTION; MAJOR CLINICAL STUDY; MALE; MUSCLE DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHABDOMYOLYSIS; RISK REDUCTION; STABLE ANGINA PECTORIS; AGED; ANTAGONISTS AND INHIBITORS; ATHEROSCLEROSIS; BLOOD; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; COMBINATION DRUG THERAPY; COMPLICATION; HYPERCHOLESTEROLEMIA; INCIDENCE; LEAST SQUARE ANALYSIS; MIDDLE AGED; MORTALITY; MULTICENTER STUDY;

AGED; ANTIBODIES, MONOCLONAL; ANTICHOLESTEREMIC AGENTS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; INCIDENCE; LEAST-SQUARES ANALYSIS; MALE; MIDDLE AGED; PROPROTEIN CONVERTASE 9;

EID: 85017341929     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1615664     Document Type: Article

References (33)

1. Giugliano RP, Sabatine MS. Are PCSK9 inhibitors the next breakthrough in the cardiovascular field? J Am Coll Cardiol 2015; 65: 2638-51.
2. Blom DJ, Hala T, Bolognese M, et al. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med 2014; 370: 1809-19.
3. Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: The LAPLACE-2 randomized clinical trial. JAMA 2014; 311: 1870-82.
4. Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol 2014; 63: 2531-40.
5. Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014; 63: 2541-8.
6. Raal FJ, Stein EA, Dufour R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebo-controlled trial. Lancet 2015; 385: 331-40.
7. Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354: 1264-72.
8. Kathiresan S. A PCSK9 missense variant associated with a reduced risk of earlyonset myocardial infarction. N Engl J Med 2008; 358: 2299-300.
9. Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015; 372: 1500-9.
10. Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015; 372: 1489-99.
11. Sabatine MS, Giugliano RP, Keech A, et al. Rationale and design of the Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk trial. Am Heart J 2016; 173: 94-101.
12. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129: Suppl 2: S1-S45.
13. Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004; 350: 1495-504.
14. LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 2005; 352: 1425-35.
15. Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med 2015; 372: 2387-97.
16. Giugliano RP, Cannon C, Blazing M, et al. Baseline LDL-C and clinical outcomes with addition of ezetimibe to statin in 18, 144 patients post ACS. J Am Coll Cardiol 2015; 65: Suppl: A4. abstract.
17. Nicholls SJ, Puri R, Anderson T, et al. Effect of evolocumab on progression of coronary disease in statin-Treated patients: The GLAGOV randomized clinical trial. JAMA 2016; 316: 2373-84.
18. Lloyd-Jones DM, Morris PB, Ballantyne CM, et al. 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol 2016; 68: 92-125.
19. Landmesser U, John Chapman M, Farnier M, et al. European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk. Eur Heart J 2016 October 27 (Epub ahead of print).
20. Sabatine MS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: comparing and contrasting guidance across the Atlantic. Eur Heart J 2017 January 21 (Epub ahead of print).
21. Collins R, Reith C, Emberson J, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet 2016; 388: 2532-61.
22. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984; 251: 351-64.
23. Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-Aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 1987; 317: 1237-45.
24. Buchwald H, Varco RL, Matts JP, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia-report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N Engl J Med 1990; 323: 946-55.
25. The Cholesterol Treatment Trialists' Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-Analysis of data from 170, 000 participants in 26 randomised trials. Lancet 2010; 376: 1670-81.
26. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-9.
27. Braunwald E, Morrow DA. Unstable angina: is it time for a requiem? Circulation 2013; 127: 2452-7.
28. Silverman MG, Ference BA, Im K, et al. Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: A systematic review and meta-Analysis. JAMA 2016; 316: 1289-97.
29. Ference BA, Robinson JG, Brook RD, et al. Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes. N Engl J Med 2016; 375: 2144-53.
30. Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: A collaborative meta-Analysis of randomised statin trials. Lancet 2010; 375: 735-42.
31. Preiss D, Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensivedose compared with moderate-dose statin therapy: A meta-Analysis. JAMA 2011; 305: 2556-64.
32. Pfizer discontinues global development of bococizumab, its investigational PCSK9 inhibitor. Press release from Pfizer, New York, November 1, 2016 (http://www .pfizer .com/news/press-release/press-release-detail/Pfizer-discontinues-global-development-of-bococizumab-its-investigational-pcsk9-inhibitor).
33. Koren MJ, Sabatine MS, Giugliano RP, et al. Long-Term low-density lipoprotein cholesterol-lowering efficacy, persistence, and safety of evolocumab in treatment of hypercholesterolemia: results up to 4 years from the open-label OSLER-1 extension study. JAMA Cardiol 2017 March 14 (Epub ahead of print).