메뉴 건너뛰기




Volumn 4, Issue , 2015, Pages

P-cadherin linking breast cancer stem cells and invasion: A promising marker to identify an "intermediate/metastable" EMT state

Author keywords

Breast cancer; EMT transition; Metastable phenotype; Metastasis; P cadherin

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALPHA6 INTEGRIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE TRANSPORTER 1; HERMES ANTIGEN; HUMAN MONOCLONAL ANTIBODY; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MATRIX METALLOPROTEINASE; NERVE CELL ADHESION MOLECULE; P CADHERIN; PEPTIDES AND PROTEINS; PF 03732010; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 85018189090     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00371     Document Type: Article
Times cited : (82)

References (64)
  • 1
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe
    • Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol (2009) 174:1588-93. doi:10.2353/ajpath.2009.080545
    • (2009) Am J Pathol , vol.174 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 2
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 9:265-73. doi:10.1038/nrc2620
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 3
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell (2009) 139:871-90. doi:10.1016/j.cell. 2009.11.007
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 4
    • 65349132693 scopus 로고    scopus 로고
    • Emt, the cytoskeleton, and cancer cell invasion
    • Yilmaz M, Christofori G. Emt, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev (2009) 28:15-33. doi:10.1007/s10555-008-9169-0
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 5
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA (2003) 100:8418-23. doi:10.1073/pnas.0932692100
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3    Hastie, T.4    Marron, J.S.5    Nobel, A.6
  • 6
    • 84870806564 scopus 로고    scopus 로고
    • Emt and met in metastasis: where are the cancer stem cells?
    • Brabletz T. Emt and met in metastasis: where are the cancer stem cells? Cancer Cell (2012) 22:699-701. doi:10.1016/j.ccr.2012.11.009
    • (2012) Cancer Cell , vol.22 , pp. 699-701
    • Brabletz, T.1
  • 7
    • 84897502349 scopus 로고    scopus 로고
    • Microenvironment-dependent cues trigger mirna-regulated feedback loop to facilitate the emt/met switch
    • Carstens JL, Lovisa S, Kalluri R. Microenvironment-dependent cues trigger mirna-regulated feedback loop to facilitate the emt/met switch. J Clin Invest (2014) 124:1458-60. doi:10.1172/JCI75239
    • (2014) J Clin Invest , vol.124 , pp. 1458-1460
    • Carstens, J.L.1    Lovisa, S.2    Kalluri, R.3
  • 8
    • 56749176437 scopus 로고    scopus 로고
    • Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
    • Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 27:6920-9. doi:10.1038/ onc.2008.343
    • (2008) Oncogene , vol.27 , pp. 6920-6929
    • Jeanes, A.1    Gottardi, C.J.2    Yap, A.S.3
  • 9
    • 84934876375 scopus 로고    scopus 로고
    • The cytoskeleton and classical cadherin adhesions
    • Han SP, Yap AS. The cytoskeleton and classical cadherin adhesions. Subcell Biochem (2012) 60:111-35. doi:10.1007/978-94-007-4186-7_6
    • (2012) Subcell Biochem , vol.60 , pp. 111-135
    • Han, S.P.1    Yap, A.S.2
  • 10
    • 84873708996 scopus 로고    scopus 로고
    • Cadherin junctions and their cytoskeleton(s)
    • Brieher WM, Yap AS. Cadherin junctions and their cytoskeleton(s). Curr Opin Cell Biol (2013) 25:39-46. doi:10.1016/j.ceb.2012.10.010
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 39-46
    • Brieher, W.M.1    Yap, A.S.2
  • 11
    • 84890844835 scopus 로고    scopus 로고
    • Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition
    • Azmi AS. Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition. Curr Cancer Drug Targets (2013) 13:906-14. doi:10.2174/ 15680096113136660096
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 906-914
    • Azmi, A.S.1
  • 12
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • Hay ED. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn (2005) 233:706-20. doi:10.1002/ dvdy.20345
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 14
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 172:973-81. doi:10.1083/jcb.200601018
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 15
    • 84859416224 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells
    • Ksiazkiewicz M, Markiewicz A, Zaczek AJ. Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology (2012) 79:195-208. doi:10.1159/000337106
    • (2012) Pathobiology , vol.79 , pp. 195-208
    • Ksiazkiewicz, M.1    Markiewicz, A.2    Zaczek, A.J.3
  • 16
    • 83455210823 scopus 로고    scopus 로고
    • Is the epithelial-to-mesenchymal transition clinically relevant for the cancer patient?
    • Krasnapolski MA, Todaro LB, de Kier Joffe EB. Is the epithelial-to-mesenchymal transition clinically relevant for the cancer patient? Curr Pharm Biotechnol (2011) 12:1891-9. doi:10.2174/138920111798377021
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 1891-1899
    • Krasnapolski, M.A.1    Todaro, L.B.2    de Kier Joffe, E.B.3
  • 17
    • 84866417140 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition (emt) biomarkers -e-cadherin, beta-catenin, apc and vimentin -in oral squamous cell carcinogenesis and transformation
    • Chaw SY, Majeed AA, Dalley AJ, Chan A, Stein S, Farah CS. Epithelial to mesenchymal transition (emt) biomarkers -e-cadherin, beta-catenin, apc and vimentin -in oral squamous cell carcinogenesis and transformation. Oral Oncol (2012) 48:997-1006. doi:10.1016/j.oraloncology.2012.05.011
    • (2012) Oral Oncol , vol.48 , pp. 997-1006
    • Chaw, S.Y.1    Majeed, A.A.2    Dalley, A.J.3    Chan, A.4    Stein, S.5    Farah, C.S.6
  • 18
    • 84869122494 scopus 로고    scopus 로고
    • Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
    • Markiewicz A, Ahrends T, Welnicka-Jaskiewicz M, Seroczynska B, Skokowski J, Jaskiewicz J, et al. Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer. J Transl Med (2012) 10:226. doi:10.1186/1479-5876-10-226
    • (2012) J Transl Med , vol.10 , pp. 226
    • Markiewicz, A.1    Ahrends, T.2    Welnicka-Jaskiewicz, M.3    Seroczynska, B.4    Skokowski, J.5    Jaskiewicz, J.6
  • 19
    • 0034176775 scopus 로고    scopus 로고
    • Dynamics of intercellular communication during melanoma development
    • Li G, Herlyn M. Dynamics of intercellular communication during melanoma development. Mol Med Today (2000) 6:163-9. doi:10.1016/S1357-4310(00) 01692-0
    • (2000) Mol Med Today , vol.6 , pp. 163-169
    • Li, G.1    Herlyn, M.2
  • 21
    • 0031984835 scopus 로고    scopus 로고
    • Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasiaadenocarcinoma sequence: correlation with disease progression and dedifferentiation
    • Bailey T, Biddlestone L, Shepherd N, Barr H, Warner P, Jankowski J. Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasiaadenocarcinoma sequence: correlation with disease progression and dedifferentiation. Am J Pathol (1998) 152:135-44.
    • (1998) Am J Pathol , vol.152 , pp. 135-144
    • Bailey, T.1    Biddlestone, L.2    Shepherd, N.3    Barr, H.4    Warner, P.5    Jankowski, J.6
  • 22
    • 0032778899 scopus 로고    scopus 로고
    • Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix
    • de Boer CJ, van Dorst E, van Krieken H, Jansen-van Rhijn CM, Warnaar SO, Fleuren GJ, et al. Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix. Am J Pathol (1999) 155:505-15. doi:10.1016/S0002-9440(10)65146-2
    • (1999) Am J Pathol , vol.155 , pp. 505-515
    • de Boer, C.J.1    van Dorst, E.2    van Krieken, H.3    Jansen-van Rhijn, C.M.4    Warnaar, S.O.5    Fleuren, G.J.6
  • 24
    • 84865839326 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: insights from development
    • Lim J, Thiery JP. Epithelial-mesenchymal transitions: insights from development. Development (2012) 139:3471-86. doi:10.1242/dev.071209
    • (2012) Development , vol.139 , pp. 3471-3486
    • Lim, J.1    Thiery, J.P.2
  • 25
    • 84871402255 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition transcription factor zeb1/zeb2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer
    • Chu PY, Hu FW, Yu CC, Tsai LL, Yu CH, Wu BC, et al. Epithelial-mesenchymal transition transcription factor zeb1/zeb2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer. Oral Oncol (2013) 49:34-41. doi:10.1016/j.oraloncology.2012.07.012
    • (2013) Oral Oncol , vol.49 , pp. 34-41
    • Chu, P.Y.1    Hu, F.W.2    Yu, C.C.3    Tsai, L.L.4    Yu, C.H.5    Wu, B.C.6
  • 26
    • 84919922284 scopus 로고    scopus 로고
    • Prrx1 promotes epithelial-mesenchymal transition through the wnt/beta-catenin pathway in gastric cancer
    • Guo J,Fu Z,Wei J,Lu W,Feng J,Zhang S. Prrx1 promotes epithelial-mesenchymal transition through the wnt/beta-catenin pathway in gastric cancer. Med Oncol (2015) 32:393. doi:10.1007/s12032-014-0393-x
    • (2015) Med Oncol , vol.32 , pp. 393
    • Guo, J.1    Fu, Z.2    Wei, J.3    Lu, W.4    Feng, J.5    Zhang, S.6
  • 27
    • 79960315948 scopus 로고    scopus 로고
    • Vimentin: central hub in emt induction?
    • Ivaska J. Vimentin: central hub in emt induction? Small GTPases (2011) 2:51-3. doi:10.4161/sgtp.2.1.15114
    • (2011) Small GTPases , vol.2 , pp. 51-53
    • Ivaska, J.1
  • 28
    • 80054040061 scopus 로고    scopus 로고
    • Cooperation between integrins and growth factor receptors in signaling and endocytosis
    • Ivaska J, Heino J. Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu Rev Cell Dev Biol (2011) 27:291-320. doi:10.1146/annurev-cellbio-092910-154017
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 291-320
    • Ivaska, J.1    Heino, J.2
  • 29
    • 84906978992 scopus 로고    scopus 로고
    • Central role of snail1 in the regulation of emt and resistance in cancer: a target for therapeutic intervention
    • Kaufhold S, Bonavida B. Central role of snail1 in the regulation of emt and resistance in cancer: a target for therapeutic intervention. J Exp Clin Cancer Res (2014) 33:62. doi:10.1186/s13046-014-0062-0
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 62
    • Kaufhold, S.1    Bonavida, B.2
  • 30
    • 84863481932 scopus 로고    scopus 로고
    • Twist expression associated with the epithelial-mesenchymal transition in gastric cancer
    • Liu AN, Zhu ZH, Chang SJ, Hang XS. Twist expression associated with the epithelial-mesenchymal transition in gastric cancer. Mol Cell Biochem (2012) 367:195-203. doi:10.1007/s11010-012-1333-8
    • (2012) Mol Cell Biochem , vol.367 , pp. 195-203
    • Liu, A.N.1    Zhu, Z.H.2    Chang, S.J.3    Hang, X.S.4
  • 31
    • 23844489449 scopus 로고    scopus 로고
    • Pcadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with cdh3 promoter hypomethylation
    • Paredes J, Albergaria A, Oliveira JT, Jeronimo C, Milanezi F, Schmitt FC. Pcadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with cdh3 promoter hypomethylation. Clin Cancer Res (2005) 11:5869-77. doi:10.1158/1078-0432.CCR-05-0059
    • (2005) Clin Cancer Res , vol.11 , pp. 5869-5877
    • Paredes, J.1    Albergaria, A.2    Oliveira, J.T.3    Jeronimo, C.4    Milanezi, F.5    Schmitt, F.C.6
  • 32
    • 84875054847 scopus 로고    scopus 로고
    • P-cadherin functional role is dependent on e-cadherin cellular context: a proof of concept using the breast cancer model
    • Ribeiro AS, Sousa B, Carreto L, Mendes N, Nobre AR, Ricardo S, et al. P-cadherin functional role is dependent on e-cadherin cellular context: a proof of concept using the breast cancer model. J Pathol (2013) 229:705-18. doi:10.1002/path.4143
    • (2013) J Pathol , vol.229 , pp. 705-718
    • Ribeiro, A.S.1    Sousa, B.2    Carreto, L.3    Mendes, N.4    Nobre, A.R.5    Ricardo, S.6
  • 33
    • 0034920218 scopus 로고    scopus 로고
    • The prognostic significance of p-cadherin in infiltrating ductal breast carcinoma
    • Gamallo C, Moreno-Bueno G, Sarrio D, Calero F, Hardisson D, Palacios J. The prognostic significance of p-cadherin in infiltrating ductal breast carcinoma. Mod Pathol (2001) 14:650-4. doi:10.1038/modpathol.3880367
    • (2001) Mod Pathol , vol.14 , pp. 650-654
    • Gamallo, C.1    Moreno-Bueno, G.2    Sarrio, D.3    Calero, F.4    Hardisson, D.5    Palacios, J.6
  • 34
    • 0038387379 scopus 로고    scopus 로고
    • Pcadherin expression in breast carcinoma indicates poor survival
    • Peralta Soler A, Knudsen KA, Salazar H, Han AC, Keshgegian AA. Pcadherin expression in breast carcinoma indicates poor survival. Cancer (1999) 86:1263-72. doi:10.1002/(SICI)1097-0142(19991001)86:77<1263::AIDCNCR23>3.0.CO;2-2
    • (1999) Cancer , vol.86 , pp. 1263-1272
    • Peralta Soler, A.1    Knudsen, K.A.2    Salazar, H.3    Han, A.C.4    Keshgegian, A.A.5
  • 35
    • 78650921170 scopus 로고    scopus 로고
    • P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer
    • Turashvili G, McKinney SE, Goktepe O, Leung SC, Huntsman DG, Gelmon KA, et al. P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer. Mod Pathol (2011) 24:64-81. doi:10.1038/modpathol.2010.189
    • (2011) Mod Pathol , vol.24 , pp. 64-81
    • Turashvili, G.1    McKinney, S.E.2    Goktepe, O.3    Leung, S.C.4    Huntsman, D.G.5    Gelmon, K.A.6
  • 36
    • 84868001125 scopus 로고    scopus 로고
    • P-cadherin expression and basal-like subtype in breast cancers
    • Liu N,Yu Q, Liu TJ, Gebreamlak EP, Wang SL, Zhang RJ, et al. P-cadherin expression and basal-like subtype in breast cancers. Med Oncol (2012) 29:2606-12. doi:10.1007/s12032-012-0218-8
    • (2012) Med Oncol , vol.29 , pp. 2606-2612
    • Liu, N.1    Yu, Q.2    Liu, T.J.3    Gebreamlak, E.P.4    Wang, S.L.5    Zhang, R.J.6
  • 37
    • 77956895496 scopus 로고    scopus 로고
    • P-cadherin, vimentin and ck14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study
    • Sousa B, Paredes J, Milanezi F, Lopes N, Martins D, Dufloth R, et al. P-cadherin, vimentin and ck14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study. Histol Histopathol (2010) 25:963-74.
    • (2010) Histol Histopathol , vol.25 , pp. 963-974
    • Sousa, B.1    Paredes, J.2    Milanezi, F.3    Lopes, N.4    Martins, D.5    Dufloth, R.6
  • 38
    • 79551649114 scopus 로고    scopus 로고
    • Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
    • Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, et al. Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol (2011) 24:157-67. doi:10.1038/modpathol.2010.200
    • (2011) Mod Pathol , vol.24 , pp. 157-167
    • Badve, S.1    Dabbs, D.J.2    Schnitt, S.J.3    Baehner, F.L.4    Decker, T.5    Eusebi, V.6
  • 40
    • 77951620350 scopus 로고    scopus 로고
    • Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer
    • Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. Oncogene (2010) 29:2427-40. doi:10.1038/onc.2009.523
    • (2010) Oncogene , vol.29 , pp. 2427-2440
    • Cheung, L.W.1    Leung, P.C.2    Wong, A.S.3
  • 41
    • 77955635129 scopus 로고    scopus 로고
    • P120ctn and p-cadherin but not e-cadherin regulate cell motility and invasion of du145 prostate cancer cells
    • Kumper S, Ridley AJ. P120ctn and p-cadherin but not e-cadherin regulate cell motility and invasion of du145 prostate cancer cells. PLoS One (2010) 5:e11801. doi:10.1371/journal.pone.0011801
    • (2010) PLoS One , vol.5
    • Kumper, S.1    Ridley, A.J.2
  • 42
    • 56649100878 scopus 로고    scopus 로고
    • P-cadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells
    • Mandeville JA, Silva Neto B, Vanni AJ, Smith GL, Rieger-Christ KM, Zeheb R, et al. P-cadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells. BJU Int (2008) 102:1707-14. doi:10.1111/j.1464-410X.2008.08115.x
    • (2008) BJU Int , vol.102 , pp. 1707-1714
    • Mandeville, J.A.1    Silva Neto, B.2    Vanni, A.J.3    Smith, G.L.4    Rieger-Christ, K.M.5    Zeheb, R.6
  • 44
    • 8544229187 scopus 로고    scopus 로고
    • Pcadherin is up-regulated by the antiestrogen ici 182,780 and promotes invasion of human breast cancer cells
    • Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, et al. Pcadherin is up-regulated by the antiestrogen ici 182,780 and promotes invasion of human breast cancer cells. Cancer Res (2004) 64:8309-17. doi:10.1158/0008-5472.CAN-04-0795
    • (2004) Cancer Res , vol.64 , pp. 8309-8317
    • Paredes, J.1    Stove, C.2    Stove, V.3    Milanezi, F.4    Van Marck, V.5    Derycke, L.6
  • 45
    • 75149183984 scopus 로고    scopus 로고
    • Extracellular cleavage and shedding of p-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells
    • Ribeiro AS, Albergaria A, Sousa B, Correia AL, Bracke M, Seruca R, et al. Extracellular cleavage and shedding of p-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. Oncogene (2010) 29:392-402. doi:10.1038/onc.2009.338
    • (2010) Oncogene , vol.29 , pp. 392-402
    • Ribeiro, A.S.1    Albergaria, A.2    Sousa, B.3    Correia, A.L.4    Bracke, M.5    Seruca, R.6
  • 46
    • 17144371898 scopus 로고    scopus 로고
    • Overexpressed p-cadherin/cdh3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family gtpases
    • Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H, et al. Overexpressed p-cadherin/cdh3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family gtpases. Cancer Res (2005) 65:3092-9. doi:10.1158/0008.5472.CAN-04-3646
    • (2005) Cancer Res , vol.65 , pp. 3092-3099
    • Taniuchi, K.1    Nakagawa, H.2    Hosokawa, M.3    Nakamura, T.4    Eguchi, H.5    Ohigashi, H.6
  • 47
    • 55449113706 scopus 로고    scopus 로고
    • Increased shedding of soluble fragments of p-cadherin in nipple aspirate fluids from women with breast cancer
    • Mannello F, Tonti GA, Medda V, Pederzoli A, Sauter ER. Increased shedding of soluble fragments of p-cadherin in nipple aspirate fluids from women with breast cancer. Cancer Sci (2008) 99:2160-9. doi:10.1111/j.1349-7006.2008. 00921.x
    • (2008) Cancer Sci , vol.99 , pp. 2160-2169
    • Mannello, F.1    Tonti, G.A.2    Medda, V.3    Pederzoli, A.4    Sauter, E.R.5
  • 48
    • 41049093810 scopus 로고    scopus 로고
    • Markers of subtypes in inflammatory breast cancer studied by immunohistochemistry: prominent expression of p-cadherin
    • Ben Hamida A, Labidi IS, Mrad K, Charafe-Jauffret E, Ben Arab S, Esterni B, et al. Markers of subtypes in inflammatory breast cancer studied by immunohistochemistry: prominent expression of p-cadherin. BMC Cancer (2008) 8:28. doi:10.1186/1471-2407-8-28
    • (2008) BMC Cancer , vol.8 , pp. 28
    • Ben Hamida, A.1    Labidi, I.S.2    Mrad, K.3    Charafe-Jauffret, E.4    Ben Arab, S.5    Esterni, B.6
  • 49
    • 79959850623 scopus 로고    scopus 로고
    • P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin
    • Cheung LW, Mak AS, Cheung AN, Ngan HY, Leung PC, Wong AS. P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. Oncogene (2011) 30:2964-74. doi:10.1038/onc.2011.7
    • (2011) Oncogene , vol.30 , pp. 2964-2974
    • Cheung, L.W.1    Mak, A.S.2    Cheung, A.N.3    Ngan, H.Y.4    Leung, P.C.5    Wong, A.S.6
  • 50
    • 70349984001 scopus 로고    scopus 로고
    • P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by gsk-3betamediated snail phosphorylation
    • Bauer K, Dowejko A, Bosserhoff AK, Reichert TE, Bauer RJ. P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by gsk-3betamediated snail phosphorylation. Carcinogenesis (2009) 30:1781-8. doi:10.1093/ carcin/bgp175
    • (2009) Carcinogenesis , vol.30 , pp. 1781-1788
    • Bauer, K.1    Dowejko, A.2    Bosserhoff, A.K.3    Reichert, T.E.4    Bauer, R.J.5
  • 52
    • 25644451938 scopus 로고    scopus 로고
    • P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma
    • Van Marck V, Stove C, Van Den Bossche K, Stove V, Paredes J, Vander Haeghen Y, et al. P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma. Cancer Res (2005) 65:8774-83. doi:10.1158/0008-5472. CAN-04-4414
    • (2005) Cancer Res , vol.65 , pp. 8774-8783
    • Van Marck, V.1    Stove, C.2    Van Den Bossche, K.3    Stove, V.4    Paredes, J.5    Vander Haeghen, Y.6
  • 53
    • 47049094012 scopus 로고    scopus 로고
    • Breast carcinomas that co-express e-and p-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival
    • Paredes J, Correia AL, Ribeiro AS, Milanezi F, Cameselle-Teijeiro J, Schmitt FC. Breast carcinomas that co-express e-and p-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival. J Clin Pathol (2008) 61:856-62. doi:10.1136/jcp.2007.052704
    • (2008) J Clin Pathol , vol.61 , pp. 856-862
    • Paredes, J.1    Correia, A.L.2    Ribeiro, A.S.3    Milanezi, F.4    Cameselle-Teijeiro, J.5    Schmitt, F.C.6
  • 54
    • 84863986523 scopus 로고    scopus 로고
    • Cancer stem cell markers in breast neoplasias: their relevance and distribution in distinct molecular subtypes
    • Schmitt F, Ricardo S, Vieira AF, Dionisio MR, Paredes J. Cancer stem cell markers in breast neoplasias: their relevance and distribution in distinct molecular subtypes. Virchows Arch (2012) 460:545-53. doi:10.1007/s00428-012-1237-8
    • (2012) Virchows Arch , vol.460 , pp. 545-553
    • Schmitt, F.1    Ricardo, S.2    Vieira, A.F.3    Dionisio, M.R.4    Paredes, J.5
  • 55
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader JE. Cells of origin in cancer. Nature (2011) 469:314-22. doi:10.1038/ nature09781
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 56
    • 43049165453 scopus 로고    scopus 로고
    • The epithelialmesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell (2008) 133:704-15. doi:10.1016/j.cell.2008.03.027
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 57
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 3:e2888. doi:10.1371/journal.pone.0002888
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 58
    • 84865494894 scopus 로고    scopus 로고
    • Stem cells in breast tumours: are they ready for the clinic?
    • Ablett MP, Singh JK, Clarke RB. Stem cells in breast tumours: are they ready for the clinic? Eur J Cancer (2012) 48:2104-16. doi:10.1016/j.ejca.2012.03.019
    • (2012) Eur J Cancer , vol.48 , pp. 2104-2116
    • Ablett, M.P.1    Singh, J.K.2    Clarke, R.B.3
  • 59
    • 84860499799 scopus 로고    scopus 로고
    • Pcadherin is coexpressed with cd44 and cd49f and mediates stem cell properties in basal-like breast cancer
    • Vieira AF, Ricardo S, Ablett MP, Dionisio MR, Mendes N, Albergaria A, et al. Pcadherin is coexpressed with cd44 and cd49f and mediates stem cell properties in basal-like breast cancer. Stem Cells (2012) 30:854-64. doi:10.1002/stem.1075
    • (2012) Stem Cells , vol.30 , pp. 854-864
    • Vieira, A.F.1    Ricardo, S.2    Ablett, M.P.3    Dionisio, M.R.4    Mendes, N.5    Albergaria, A.6
  • 60
    • 84871648551 scopus 로고    scopus 로고
    • Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis
    • Nassour M, Idoux-Gillet Y, Selmi A, Come C, Faraldo ML, Deugnier MA, et al. Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis. PLoS One (2012) 7:e53498. doi:10.1371/journal.pone.0053498
    • (2012) PLoS One , vol.7
    • Nassour, M.1    Idoux-Gillet, Y.2    Selmi, A.3    Come, C.4    Faraldo, M.L.5    Deugnier, M.A.6
  • 61
    • 84896821980 scopus 로고    scopus 로고
    • Pcadherin signals through the laminin receptor alpha6beta4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells
    • Vieira AF, Ribeiro AS, Dionisio MR, Sousa B, Nobre AR, Albergaria A, et al. Pcadherin signals through the laminin receptor alpha6beta4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells. Oncotarget (2014) 5:679-92.
    • (2014) Oncotarget , vol.5 , pp. 679-692
    • Vieira, A.F.1    Ribeiro, A.S.2    Dionisio, M.R.3    Sousa, B.4    Nobre, A.R.5    Albergaria, A.6
  • 62
    • 80054879984 scopus 로고    scopus 로고
    • Breast cancer stem cell markers cd44, cd24 and aldh1: expression distribution within intrinsic molecular subtype
    • Ricardo S, Vieira AF, Gerhard R, Leitao D, Pinto R, Cameselle-Teijeiro JF, et al. Breast cancer stem cell markers cd44, cd24 and aldh1: expression distribution within intrinsic molecular subtype. J Clin Pathol (2011) 64:937-46. doi:10.1136/jcp.2011.090456
    • (2011) J Clin Pathol , vol.64 , pp. 937-946
    • Ricardo, S.1    Vieira, A.F.2    Gerhard, R.3    Leitao, D.4    Pinto, R.5    Cameselle-Teijeiro, J.F.6
  • 63
    • 84908094892 scopus 로고    scopus 로고
    • The basal epithelial marker p-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype
    • Sousa B, Ribeiro AS, Nobre AR, Lopes N, Martins D, Pinheiro C, et al. The basal epithelial marker p-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype. BMC Cancer (2014) 14:734. doi:10.1186/1471-2407-14-734
    • (2014) BMC Cancer , vol.14 , pp. 734
    • Sousa, B.1    Ribeiro, A.S.2    Nobre, A.R.3    Lopes, N.4    Martins, D.5    Pinheiro, C.6
  • 64
    • 78049460090 scopus 로고    scopus 로고
    • Pf-03732010: a fully human monoclonal antibody against p-cadherin with antitumor and antimetastatic activity
    • Zhang CC, Yan Z, Zhang Q, Kuszpit K, Zasadny K, Qiu M, et al. Pf-03732010: a fully human monoclonal antibody against p-cadherin with antitumor and antimetastatic activity. Clin Cancer Res (2010) 16:5177-88. doi:10.1158/1078-0432.CCR-10-1343
    • (2010) Clin Cancer Res , vol.16 , pp. 5177-5188
    • Zhang, C.C.1    Yan, Z.2    Zhang, Q.3    Kuszpit, K.4    Zasadny, K.5    Qiu, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.