P-cadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells

BJU International

Volumn 102, Issue 11, 2008, Pages 1707-1714

  Mandeville, Jessica A ^a   Neto, Brasil Silva ^a   Vanni, Alex J ^a   Smith, Gjanje L ^a   Rieger Christ, Kimberly M ^a   Zeheb, Ron ^a   Loda, Massimo ^b   Libertino, John A ^a   Summerhayes, Ian C ^a  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Bladder cancer; Migration; P cadherin

Indexed keywords

P CADHERIN;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CELL MIGRATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TISSUE MICROARRAY;

AGED; CADHERINS; CARCINOMA, TRANSITIONAL CELL; CELL MOVEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM INVASIVENESS; PROGNOSIS; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 56649100878     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.08115.x     Document Type: Article

References (31)

1. Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995 7 : 619 27
2. Otto T, Goepel M, Enzwi SM, Meyer-Schwickerath M, Rubben H. Motility- and adhesion factors in bladder carcinoma. Invest Urol (Berl) 1994 5 : 80 4
3. Shimazui T, Schalken JA, Giroldi LA et al. Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors. Cancer Res 1996 56 : 4154 8
4. Bukholm IK, Nesland JM, Karesen R, Jacobsen U. Borresen-Dale. E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma. J Pathol 1998 185 : 262 6
5. Syrigos KN, Harrington K, Waxman J, Krausz T, Pignatelli M. Altered gamma-catenin expression correlates with poor survival in patients with bladder cancer. J Urol 1998 160 : 1889 93
6. Morita N, Uemura H, Tsumatani K et al. E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion, Br J Cancer 1999 79 : 1879 83
7. Frixen UH, Behrens J, Sachs M et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991 113 : 173 85
8. Vleminckx K, Vakaet L Mareel M, Fiers W, Van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991 66 : 107 19
9. Rieger-Christ KM, Cain JW, Braasch JW et al. Expression of classic cadherins type I in urothelial neoplastic progression. Hum Pathol 2001 32 : 18 23
10. Tomita K, van Bokhoven A, van Leenders GJ et al. Cadherin switching in human prostate cancer progression. Cancer Res 2000 60 : 3650 4
11. Nagi C, Guttman M, Jaffer S et al. N-cadherin expression in breast cancer: correlation with an aggressive histologic variant - invasive micropapillary carcinoma Breast Cancer Res Treat 2005 94 : 225 35
12. Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 2000 148 : 779 90
13. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999 147 : 631 44
14. Rieger-Christ KM, Lee P, Zagha R et al. Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway. Oncogene 2004 23 : 4745 53
15. Charrasse S, Comunale F, Gilbert E, Delattre O, Gauther-Rouviere C. Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma. Oncogene 2004 23 : 2420 30
16. Miotto E, Sabbioni S, Veronese A et al. Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. Cancer Res 2004 64 : 8156 9
17. Johnson E, Theisen CS, Johnson KR, Wheelock MJ. R-cadherin influences cell motility via Rho family GTPases. J Biol Chem 2004 279 : 31041 9
18. Paredes J, Stove C, Stove V et al. P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Cancer Res 2004 64 : 8309 17
19. Taniuchi K, Nakagawa H, Hosokawa M et al. Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Cancer Res 2005 65 : 3092 9
20. Seline PC, Norris DA, Horikawa T, Fujita M, Middleton MH, Morelli JG. Expression of E and P-cadherin by melanoma cells decreases in progressive melanomas and following ultraviolet radiation. J Invest Dermatol 1996 106 : 1320 4
21. Van Marck V, Stove C, Van Den Bossche K et al. P-cadherin promotes cell-cell adhesion and counteracts invasion in human melanoma. Cancer Res 2005 65 : 8774 83
22. Madhavan M, Srinivas P, Abraham E et al. Cadherins as predictive markers of nodal metastasis in breast cancer. Mod Pathol 2001 14 : 423 7
23. Lo Muzio L, Pannone G, Mignogna MD et al. P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas. Histol Histopathol 2004 19 : 1089 99
24. Bauer R, Wild PJ, Meyer S et al. Prognostic relevance of P-cadherin expression in melanocytic skin tumours analysed by high-throughput tissue microarrays. J Clin Pathol 2006 59 : 699 705
25. Stefansson IM, Salvesen HB, Akslen LA. Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. J Clin Oncol 2004 22 : 1242 52
26. Bachmann IM, Straume O, Puntervoll HE, Kalvenes MB, Akslen LA. Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res 2005 11 : 8606 14
27. Paredes J, Albergaria A, Oliveira JT et al. P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin Cancer Res 2005 11 : 5869 77
28. Baumgart E, Cohen MS, Neto BS et al. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Clin Cancer Res 2007 13 : 1685 94
29. Thykjaer T, Workman C, Kruhoffer M et al. Identification of gene expression patterns in superficial and invasive human bladder cancer. Cancer Res 2001 61 : 2492 9
30. Neto BS, Smith GL, Mandeville JA et al. Prognostic significance of altered p120 (ctn) expression in bladder cancer. BJU Int 2008 101 : 746 52
31. Radice GL, Ferreira-Cornwell MC, Robinson SD et al. Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol 1997 139 : 1025 32