Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

Journal of Pathology

Volumn 242, Issue 1, 2017, Pages 16-23

  Hosoda, Waki ^a   Chianchiano, Peter ^a   Griffin, James F ^a   Pittman, Meredith E ^b   Brosens, Lodewijk AA ^c   Noë, Michaël ^a   Yu, Jun ^a   Shindo, Koji ^a   Suenaga, Masaya ^a   Rezaee, Neda ^a   Yonescu, Raluca ^a   Ning, Yi ^a   Albores Saavedra, Jorge ^d   Yoshizawa, Naohiko ^e   Harada, Kenichi ^f   Yoshizawa, Akihiko ^g   Hanada, Keiji ^h   Yonehara, Shuji ^h   Shimizu, Michio ⁱ   Uehara, Takeshi ^j   Samra, Jaswinder S ^k   Gill, Anthony J ^l   Wolfgang, Christopher L ^a   Goggins, Michael G ^a   Hruban, Ralph H ^a   Wood, Laura D ^a   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d LIVER RESEARCH UNIT   (Mexico)

^e MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^g KYOTO UNIVERSITY HOSPITAL   (Japan)

^h ONOMICHI GENERAL HOSPITAL   (Japan)

ⁱ Hakujikai Memorial Hospital   (Japan)

^j SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^k UNIVERSITY OF SYDNEY   (Australia)

^l UNIVERSITY OF SYDNEY   (Australia)

more..

Author keywords

cancerization; HG PanIN; pancreas; pancreatic ductal adenocarcinoma; pancreatic intraepithelial neoplasia; SMAD4; targeted next generation sequencing; TP53; whole exome sequencing

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 2; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; SMAD4 PROTEIN, HUMAN; TUMOR PROTEIN;

ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; FRAMESHIFT MUTATION; GENE; GENE MUTATION; GNAS GENE; HIGH GRADE PANCREATIC INTRAEPITHELIAL NEOPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR PATHOLOGY; NEXT GENERATION SEQUENCING; ONCOGENE K RAS; PANCREAS ADENOMA; PIK3CA GENE; PRIORITY JOURNAL; RNF43 GENE; SOMATIC MUTATION; WHOLE EXOME SEQUENCING; CANCER GRADING; CARCINOMA IN SITU; CLINICAL TRIAL; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN GENOME; METABOLISM; MULTICENTER STUDY; MUTATION; PANCREAS TUMOR; PATHOLOGY; PROCEDURES; TUMOR SUPPRESSOR GENE;

CARCINOMA IN SITU; GENES, P53; GENOME, HUMAN; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MUTATION; NEOPLASM GRADING; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; SMAD4 PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85017359383     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4884     Document Type: Article

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