Anorexia nervosa

Nature Reviews Disease Primers

Volumn 1, Issue , 2015, Pages

  Treasure, Janet ^a   Zipfel, Stephan ^b   Micali, Nadia ^c,d   Wade, Tracey ^e   Stice, Eric ^f   Claudino, Angélica ^g   Schmidt, Ulrike ^a   Frank, Guido K ^h   Bulik, Cynthia M ^i,j   Wentz, Elisabet ^k  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e FLINDERS UNIVERSITY   (Australia)

^f OREGON RESEARCH INSTITUTE   (United States)

^g FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^h UNIVERSITY OF COLORADO   (United States)

ⁱ UNIVERSITY OF NORTH CAROLINA   (United States)

^j KAROLINSKA INSTITUTE   (Sweden)

^k UNIVERSITY OF GOTHENBURG   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT; NUTRITION SUPPLEMENT; PSYCHOTROPIC AGENT;

ANOREXIA NERVOSA; BRAIN FUNCTION; COGNITIVE BEHAVIORAL THERAPY; EARLY INTERVENTION; FAMILY THERAPY; HEREDITY; HUMAN; INCIDENCE; METABOLIC DISORDER; NERVE CELL NETWORK; NEUROIMAGING; OBESITY; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; PSYCHOTHERAPY; QUALITY OF LIFE; REVIEW; RISK FACTOR; SCREENING; SEX RATIO; ADAPTATION; ADOLESCENT; BODY IMAGE; MALNUTRITION; PSYCHOLOGY;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ANOREXIA NERVOSA; BODY IMAGE; HUMANS; MALNUTRITION;

EID: 85017216509     PISSN: None     EISSN: 2056676X     Source Type: Journal    
DOI: 10.1038/nrdp.2015.74     Document Type: Review

References (241)

1. Micali, N., Hagberg, K. W., Petersen, I. & Treasure, J. L. The incidence of eating disorders in the UK in 2000-2009: findings from the General Practice Research Database. BMJ Open 3, e002646 (2013).
2. Serpell, L., Treasure, J., Teasdale, J. & Sullivan, V. Anorexia nervosa: friend or foe? Int. J. Eat. Disord. 25, 177-186 (1999).
3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: DSM-5 (American Psychiatric Association, 2013).
4. Støving, R. K., Andries, A., Brixen, K., Bilenberg, N. & Hørder, K. Gender differences in outcome of eating disorders: a retrospective cohort study. Psychiatry Res. 186, 362-366 (2011).
5. Anckarsäter, H. et al. The sociocommunicative deficit subgroup in anorexia nervosa: autism spectrum disorders and neurocognition in a community-based, longitudinal study. Psychol. Med. 42, 1957-1967 (2012).
6. Kezelman, S., Touyz, S., Hunt, C. & Rhodes, P. Does anxiety improve during weight restoration in anorexia nervosa? A systematic review. J. Eat. Disord. 3, 7 (2015).
7. Rodgers, R. F. & Paxton, S. J. The impact of indicated prevention and early intervention on co-morbid eating disorder and depressive symptoms: a systematic review. J. Eat. Disord. 2, 30 (2014).
8. Eddy, K. T. et al. Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V. Am. J. Psychiatry 165, 245-250 (2008).
9. Milos, G. F., Baur, V., Muehlebach, S. & Spindler, A. Axis-I comorbidity is linked to prospective instability of diagnoses within eating disorders. BMC Psychiatry 13, 295 (2013).
10. Tozzi, F. et al. Symptom fluctuation in eating disorders: correlates of diagnostic crossover. Am. J. Psychiatry 162, 732-740 (2005).
11. Vall, E. & Wade, T. D. Predictors of treatment outcome in individuals with eating disorders: a systematic review and meta-analysis. Int. J. Eat. Disord. 48, 946-971 (2015).
12. Walsh, B. T. The enigmatic persistence of anorexia nervosa. Am. J. Psychiatry 170, 477-484 (2013).
13. Treasure, J., Stein, D. & Maguire, S. Has the time come for a staging model to map the course of eating disorders from high risk to severe enduring illness? An examination of the evidence. Early Interv. Psychiatry 9, 173-184 (2015).
14. Treasure, J. & Schmidt, U. The cognitive-interpersonal maintenance model of anorexia nervosa revisited: a summary of the evidence for cognitive, socio-emotional and interpersonal predisposing and perpetuating factors. J. Eat. Disord. 1, 13 (2013).
15. Gull, W. Anorexia nervosa. Trans. Clin. Soc. 7, 22-28 (1874).
16. Lock, J. An update on evidence-based psychosocial treatments for eating disorders in children and adolescents. J. Clin. Child Adolesc. Psychol. 44, 707-721 (2015).
17. Lock, J. et al. Can adaptive treatment improve outcomes in family-based therapy for adolescents with anorexia nervosa? Feasibility and treatment effects of a multi-site treatment study. Behav. Res. Ther. 73, 90-95 (2015).
18. Hibbs, R. et al. Clinical effectiveness of a skills training intervention for caregivers in improving patient and caregiver health following in-patient treatment for severe anorexia nervosa: pragmatic randomised controlled trial. Br. J. Psychiatry Open 1, 56-66 (2015).
19. Swanson, S. A. et al. Assessing eating disorder symptoms in adolescence: is there a role for multiple informants? Int. J. Eat. Disord. 47, 475-482 (2014).
20. Swanson, S. A., Brown, T. A., Crosby, R. D. & Keel, P. K. What are we missing? The costs versus benefits of skip rule designs. Int. J. Methods Psychiatr. Res. 23, 474-485 (2014).
21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition: DSM-IV-TR (American Psychiatric Association, 1994).
22. Keski-Rahkonen, A. et al. Epidemiology and course of anorexia nervosa in the community. Am. J. Psychiatry 164, 1259-1265 (2007).
23. van Son, G. E., van Hoeken, D., Bartelds, A. I., van Furth, E. F. & Hoek, H. W. Time trends in the incidence of eating disorders: a primary care study in the Netherlands. Int. J. Eat. Disord. 39, 565-569 (2006).
24. Zerwas, S. et al. The incidence of eating disorders in a Danish register study: associations with suicide risk and mortality. J. Psychiatr. Res. 65, 16-22 (2015).
25. Currin, L., Schmidt, U., Treasure, J. & Jick, H. Time trends in eating disorder incidence. Br. J. Psychiatry 186, 132-135 (2005).
26. Smink, F. R., van Hoeken, D. & Hoek, H. W. Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr. Psychiatry Rep. 14, 406-414 (2012).
27. Hoek, H. W. et al. The incidence of anorexia nervosa on Curaçao. Am. J. Psychiatry 162, 748-752 (2005).
28. Nicholls, D. E., Lynn, R. & Viner, R. M. Childhood eating disorders: British national surveillance study. Br. J. Psychiatry 198, 295-301 (2011).
29. Madden, S., Morris, A., Zurynski, Y. A., Kohn, M. & Elliot, E. J. Burden of eating disorders in 5-13-year-old children in Australia. Med. J. Aust. 190, 410-414 (2009).
30. Pinhas, L., Morris, A., Crosby, R. D. & Katzman, D. K. Incidence and age-specific presentation of restrictive eating disorders in children: a Canadian Paediatric Surveillance Program study. Arch. Pediatr. Adolesc. Med. 165, 895-899 (2011).
31. Bulik, C. M. et al. Prevalence, heritability, and prospective risk factors for anorexia nervosa. Arch. Gen. Psychiatry 63, 305-312 (2006).
32. Preti, A. et al. The epidemiology of eating disorders in six European countries: results of the ESEMeD-WMH project. J. Psychiatr. Res. 43, 1125-1132 (2009).
33. Hudson, J. I., Hiripi, E., Pope, H. G. & Kessler, R. C. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol. Psychiatry 61, 348-358 (2007).
34. Wade, T. D., Bergin, J. L., Tiggemann, M., Bulik, C. M. & Fairburn, C. G. Prevalence and long-term course of lifetime eating disorders in an adult Australian twin cohort. Aust. N. Z. J. Psychiatry 40, 121-128 (2006).
35. Swanson, S. A., Crow, S. J., Le Grange, D., Swendsen, J. & Merikangas, K. R. Prevalence and correlates of eating disorders in adolescents: results from the national comorbidity survey replication adolescent supplement. Arch. Gen. Psychiatry 68, 714-723 (2011).
36. Stice, E., Marti, C. N., Shaw, H. & Jaconis, M. An 8-year longitudinal study of the natural history of threshold, subthreshold, and partial eating disorders from a community sample of adolescents. J. Abnorm. Psychol. 118, 587-597 (2009).
37. Nobakht, M. & Dezhkam, M. An epidemiological study of eating disorders in Iran. Int. J. Eat. Disord. 28, 265-271 (2000).
38. Kjelsås, E., Bjørnstrøm, C. & Götestam, K. G. Prevalence of eating disorders in female and male adolescents (14-15 years). Eat. Behav. 5, 13-25 (2004).
39. Smink, F. R., van Hoeken, D., Oldehinkel, A. J. & Hoek, H. W. Prevalence and severity of DSM-5 eating disorders in a community cohort of adolescents. Int. J. Eat. Disord. 47, 610-619 (2014).
40. Bennett, D., Sharpe, M., Freeman, C. & Carson, A. Anorexia nervosa among female secondary school students in Ghana. Br. J. Psychiatry 185, 312-317 (2004).
41. Steinhausen, H.-C., Jakobsen, H., Helenius, D., Munk-Jørgensen, P. & Strober, M. A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. Int. J. Eat. Disord. 48, 1-8 (2015).
42. Bulik, C. M., Yilmaz, Z. & Hardaway, J. A. Genetics and epigenetics of eating disorders. Adv. Genom. Genet. 5, 131-150 (2015).
43. Bulik, C. M. et al. Understanding the relation between anorexia nervosa and bulimia nervosa in a Swedish national twin sample. Biol. Psychiatry 67, 71-77 (2010).
44. Dellava, J. E., Thornton, L. M., Lichtenstein, P., Pedersen, N. L. & Bulik, C. M. Impact of broadening definitions of anorexia nervosa on sample characteristics. J. Psychiatr. Res. 45, 691-698 (2011).
45. Corvin, A., Craddock, N. & Sullivan, P. F. Genome-wide association studies: a primer. Psychol. Med. 40, 1063-1077 (2010).
46. Sullivan, P. F., Daly, M. J. & O'Donovan, M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat. Rev. Genet. 13, 537-551 (2012).
47. Wang, K. et al. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol. Psychiatry 16, 949-959 (2011).
48. Boraska, V. et al. A genome-wide association study of anorexia nervosa. Mol. Psychiatry 19, 1085-1094 (2014).
49. Ripke, S. et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet. 45, 1150-1159 (2013).
50. Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
51. Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
52. Anttila, V. et al. The Brainstorm project; a cross-phenotype analysis of 14 brain disorders by heritability-, constraint-and pathway-based methods, using genome-wide association data from 500,000 samples. ASHG [online], http://www.ashg.org/ 2014meeting/abstracts/fulltext/f140123198.htm (2014).
53. Cederlöf, M. et al. Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: a longitudinal cohort, family and twin study. World Psychiatry 14, 333-338 (2015).
54. Scott-Van Zeeland, A. A. et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol. Psychiatry 19, 724-732 (2014).
55. Cui, H. et al. Eating disorder predisposition is associated with ESRRA and HDAC4 mutations. J. Clin. Invest. 123, 4706-4713 (2013).
56. Frank, G. K. What causes eating disorders, and what do they cause? Biol. Psychiatry 77, 602-603 (2015).
57. Lawson, E. A. & Klibanski, A. Endocrine abnormalities in anorexia nervosa. Nat. Clin. Pract. Endocrinol. Metab. 4, 407-414 (2008).
58. Filler, A. Magnetic resonance neurography and diffusion tensor imaging: origins, history, and clinical impact of the first 50,000 cases with an assessment of efficacy and utility in a prospective 5000-patient study group. Neurosurgery 65, A29-A43 (2009).
59. Raichle, M. E. Behind the scenes of functional brain imaging: a historical and physiological perspective. Proc. Natl Acad. Sci. USA 95, 765-772 (1998).
60. Van den Eynde, F. et al. Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies. Eur. Eat. Disord. Rev. 20, 94-105 (2012).
61. Rolls, E. T. Functions of the orbitofrontal and pregenual cingulate cortex in taste, olfaction, appetite and emotion. Acta Physiol. Hung. 95, 131-164 (2008).
62. Critchley, H. D., Wiens, S., Rotshtein, P., Ohman, A. & Dolan, R. J. Neural systems supporting interoceptive awareness. Nat. Neurosci. 7, 189-195 (2004).
63. King, J. A. et al. Global cortical thinning in acute anorexia nervosa normalizes following long-term weight restoration. Biol. Psychiatry 77, 624-632 (2015).
64. Frank, G. K., Shott, M. E., Hagman, J. O. & Mittal, V. A. Alterations in brain structures related to taste reward circuitry in ill and recovered anorexia nervosa and in bulimia nervosa. Am. J. Psychiatry 170, 1152-1160 (2013).
65. Frank, G. K., Shott, M. E., Hagman, J. O. & Yang, T. T. Localized brain volume and white matter integrity alterations in adolescent anorexia nervosa. J. Am. Acad. Child Adolesc. Psychiatry 52, 1066-1075.e5 (2013).
66. Frank, G. K. Recent advances in neuroimaging to model eating disorder neurobiology. Curr. Psychiatry Rep. 17, 559 (2015).
67. Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N. & Bischoff-Grethe, A. Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa. Trends Neurosci. 36, 110-120 (2013).
68. Manuel-Apolinar, L., Rocha, L., Damasio, L., Tesoro-Cruz, E. & Zarate, A. Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: implications of food intake. Mol. Med. Rep. 9, 407-412 (2014).
69. García-García, I. et al. Neural responses to visual food cues: insights from functional magnetic resonance imaging. Eur. Eat. Disord. Rev. 21, 89-98 (2013).
70. Vocks, S., Herpertz, S., Rosenberger, C., Senf, W. & Gizewski, E. R. Effects of gustatory stimulation on brain activity during hunger and satiety in females with restricting-type anorexia nervosa: an fMRI study. J. Psychiatr. Res. 45, 395-403 (2011).
71. Cowdrey, F. A., Park, R. J., Harmer, C. J. & McCabe, C. Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa. Biol. Psychiatry 70, 736-743 (2011).
72. Oberndorfer, T. A. et al. Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. Am. J. Psychiatry 170, 1143-1151 (2013).
73. Wagner, A. et al. Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa. Neuropsychopharmacology 33, 513-523 (2008).
74. Bischoff-Grethe, A. et al. Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Res. 214, 331-340 (2013).
75. Decker, J. H., Figner, B. & Steinglass, J. E. On weight and waiting: delay discounting in anorexia nervosa pretreatment and posttreatment. Biol. Psychiatry 78, 606-614 (2014).
76. Ehrlich, S. et al. Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa. J. Psychiatry Neurosci. 40, 307-315 (2015).
77. Wagner, A. et al. Altered reward processing in women recovered from anorexia nervosa. Am. J. Psychiatry 164, 1842-1849 (2007).
78. Frank, G. K. W. et al. Anorexia nervosa and obesity are associated with opposite brain reward response. Neuropsychopharmacology 37, 2031-2046 (2012).
79. Frank, G. K. W., Reynolds, J. R., Shott, M. E. & O'Reilly, R. C. Altered temporal difference learning in bulimia nervosa. Biol. Psychiatry 70, 728-735 (2011).
80. Avena, N. M., Rada, P. & Hoebel, B. G. Underweight rats have enhanced dopamine release and blunted acetylcholine response in the nucleus accumbens while bingeing on sucrose. Neuroscience 156, 865-871 (2008).
81. Johnson, P. M. & Kenny, P. J. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat. Neurosci. 13, 635-641 (2010).
82. Kim, K. R., Ku, J., Lee, J.-H., Lee, H. & Jung, Y.-C. Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa. Neurosci. Lett. 521, 152-157 (2012).
83. McFadden, K. L., Tregellas, J. R., Shott, M. E. & Frank, G. K. Reduced salience and default mode network activity in women with anorexia nervosa. J. Psychiatry Neurosci. 39, 178-188 (2014).
84. Gaudio, S. & Quattrocchi, C. C. Neural basis of a multidimensional model of body image distortion in anorexia nervosa. Neurosci. Biobehav. Rev. 36, 1839-1847 (2012).
85. Call, C., Walsh, B. T. & Attia, E. From DSM-IV to DSM-5: changes to eating disorder diagnoses. Curr. Opin. Psychiatry 26, 532-536 (2013).
86. Garfinkel, P. E. et al. Should amenorrhoea be necessary for the diagnosis of anorexia nervosa? Evidence from a Canadian community sample. Br. J. Psychiatry 168, 500-506 (1996).
87. Attia, E. & Roberto, C. A. Should amenorrhea be a diagnostic criterion for anorexia nervosa? Int. J. Eat. Disord. 42, 581-589 (2009).
88. Fairburn, C. G. & Harrison, P. J. Eating disorders. Lancet 361, 407-416 (2003).
89. Treasure, J., Claudino, A. M. & Zucker, N. Eating disorders. Lancet 375, 583-593 (2010).
90. Pisetsky, E. M., Thornton, L. M., Lichtenstein, P., Pedersen, N. L. & Bulik, C. M. Suicide attempts in women with eating disorders. J. Abnorm. Psychol. 122, 1042-1056 (2013).
91. Allen, K. L., Byrne, S. M., Oddy, W. H. & Crosby, R. D. DSM-IV-TR and DSM-5 eating disorders in adolescents: prevalence, stability, and psychosocial correlates in a population-based sample of male and female adolescents. J. Abnorm. Psychol. 122, 720-732 (2013).
92. Pooni, J., Ninteman, A., Bryant-Waugh, R., Nicholls, D. & Mandy, W. Investigating autism spectrum disorder and autistic traits in early onset eating disorder. Int. J. Eat. Disord. 45, 583-591 (2012).
93. Kaye, W. H., Bulik, C. M., Thornton, L., Barbarich, N. & Masters, K. Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am. J. Psychiatry 161, 2215-2221 (2004).
94. Nilsson, E. W., Gillberg, C., Gillberg, I. C. & Råstam, M. Ten-year follow-up of adolescent-onset anorexia nervosa: personality disorders. J. Am. Acad. Child Adolesc. Psychiatry 38, 1389-1395 (1999).
95. Treasure, J. L. Getting beneath the phenotype of anorexia nervosa: the search for viable endophenotypes and genotypes. Can. J. Psychiatry 52, 212-219 (2007).
96. Wade, T. D. et al. Shared temperament risk factors for anorexia nervosa: a twin study. Psychosom. Med. 70, 239-244 (2008).
97. Holliday, J., Tchanturia, K., Landau, S., Collier, D. & Treasure, J. Is impaired set-shifting an endophenotype of anorexia nervosa? Am. J. Psychiatry 162, 2269-2275 (2005).
98. Vitousek, K., Watson, S. & Wilson, G. T. Enhancing motivation for change in treatment-resistant eating disorders. Clin. Psychol. Rev. 18, 391-420 (1998).
99. Lasègue, C. in Evolution of Psychosomatic Concepts, Anorexia Nervosa: A Paradigm (eds Kaufman, R. M. & Heiman, M.) 141-155 (International Univ. Press, 1964).
100. Konstantakopoulos, G., Tchanturia, K., Surguladze, S. A. & David, A. S. Insight in eating disorders: clinical and cognitive correlates. Psychol. Med. 41, 1951-1961 (2011).
101. World Health Organization. Composite International Diagnostic Interview (CIDI) (Core Version 1.1): Interviewer Manual (American Psychiatric Press, 1993).
102. Thornton, C., Russell, J. & Hudson, J. Does the Composite International Diagnostic Interview underdiagnose the eating disorders? Int. J. Eat. Disord. 23, 341-345 (1998).
103. Fairburn, C. G., Cooper, Z. & O'Connor, M. E. in Cognitive Behaviour Therapy and Eating Disorders (ed. Fairburn, C. G.) 265-308 (Guilford, 2008).
104. Price-Evans, K. & Treasure, J. The use of motivational interviewing in anorexia nervosa. Child Adolesc. Ment. Health 16, 65-70 (2011).
105. Atkinson, M. J. & Wade, T. D. Does mindfulness have potential in eating disorders prevention? A preliminary controlled trial with young adult women. Early Interv. Psychiatry http://dx.doi.org/10.1111/eip.12160 (2014).
106. Stice, E., Marti, C. N., Spoor, S., Presnell, K. & Shaw, H. Dissonance and healthy weight eating disorder prevention programs: long-term effects from a randomized efficacy trial. J. Consult. Clin. Psychol. 76, 329-340 (2008).
107. Stice, E., Rohde, P., Shaw, H. & Marti, C. N. Efficacy trial of a selective prevention program targeting both eating disorders and obesity among female college students: 1-and 2-year follow-up effects. J. Consult. Clin. Psychol. 81, 183-189 (2013).
108. Martinsen, M. et al. Preventing eating disorders among young elite athletes: a randomized controlled trial. Med. Sci. Sports Exerc. 46, 435-447 (2014).
109. Becker, C. B., Smith, L. M. & Ciao, A. C. Reducing eating disorder risk factors in sorority members: a randomized trial. Behav. Ther. 36, 245-253 (2005).
110. Mitchell, K. S., Mazzeo, S. E., Rausch, S. M. & Cooke, K. L. Innovative interventions for disordered eating: evaluating dissonance-based and yoga interventions. Int. J. Eat. Disord. 40, 120-128 (2007).
111. Stice, E., Rohde, P., Shaw, H. & Gau, J. An effectiveness trial of a selected dissonance-based eating disorder prevention program for female high school students: long-term effects. J. Consult. Clin. Psychol. 79, 500-508 (2011).
112. Green, M., Scott, N., Diyankova, I. & Gasser, C. Eating disorder prevention: an experimental comparison of high level dissonance, low level dissonance, and no-treatment control. Eat. Disord. 13, 157-169 (2005).
113. McMillan, W., Stice, E. & Rohde, P. High-and low-level dissonance-based eating disorder prevention programs with young women with body image concerns: an experimental trial. J. Consult. Clin. Psychol. 79, 129-134 (2011).
114. Stice, E., Rohde, P., Shaw, H. & Marti, C. N. Efficacy trial of a selective prevention program targeting both eating disorder symptoms and unhealthy weight gain among female college students. J. Consult. Clin. Psychol. 80, 164-170 (2012).
115. Linville, D. et al. Effectiveness of an eating disorder preventative intervention in primary care medical settings. Behav. Res. Ther. 75, 32-39 (2015).
116. Brown, T. A. & Keel, P. K. A randomized controlled trial of a peer co-led dissonance-based eating disorder prevention program for gay men. Behav. Res. Ther. 74, 1-10 (2015).
117. Stice, E. & Bohon, C. in Child and Adolescent Psychopathology (eds Beauchaine, T. P. & Hinshaw, S. P.) 715-738 (Wiley and Sons, 2013).
118. Stice, E. Interactive and mediational etiologic models of eating disorder onset. Annu. Rev. Clin. Psychol. (in the press).
119. Bedossa, P. et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 56, 1751-1759 (2012).
120. Patton, G. C., Johnson-Sabine, E., Wood, K., Mann, A. H. & Wakeling, A. Abnormal eating attitudes in London schoolgirls - a prospective epidemiological study: outcome at twelve month follow-up. Psychol. Med. 20, 383-394 (1990).
121. Patton, G. C., Selzer, R., Coffey, C., Carlin, J. B. & Wolfe, R. Onset of adolescent eating disorders: population based cohort study over 3 years. BMJ 318, 765-768 (1999).
122. Stice, E., Davis, K., Miller, N. P. & Marti, C. N. Fasting increases risk for onset of binge eating and bulimic pathology: a 5-year prospective study. J. Abnorm. Psychol. 117, 941-946 (2008).
123. Killen, J. D. et al. Weight concerns influence the development of eating disorders: a 4-year prospective study. J. Consult. Clin. Psychol. 64, 936-940 (1996).
124. Stice, E., Marti, C. N. & Durant, S. Risk factors for onset of eating disorders: evidence of multiple risk pathways from an 8-year prospective study. Behav. Res. Ther. 49, 622-627 (2011).
125. Sackett, D. L., Rosenberg, W. M., Gray, J. A., Haynes, R. B. & Richardson, W. S. Evidence based medicine: what it is and what it isn't. Clin. Orthop. Relat. Res. 455, 3-5 (2007).
126. Suárez-Pinilla, P. et al. Inpatient treatment for anorexia nervosa: a systematic review of randomized controlled trials. J. Psychiatr. Pract. 21, 49-59 (2015).
127. Herpertz-Dahlmann, B. et al. Day-patient treatment after short inpatient care versus continued inpatient treatment in adolescents with anorexia nervosa (ANDI): a multicentre, randomised, open-label, non-inferiority trial. Lancet 383, 1222-1229 (2014).
128. Madden, S. et al. A randomized controlled trial of in-patient treatment for anorexia nervosa in medically unstable adolescents. Psychol. Med. 45, 415-427 (2015).
129. Goddard, E. et al. A multi-centre cohort study of short term outcomes of hospital treatment for anorexia nervosa in the UK. BMC Psychiatry 13, 287 (2013).
130. Hibbs, R. et al. Clinical effectiveness of a skills training intervention for caregivers (ECHO, Experienced Caregivers Helping Others) in improving patient and caregiver health following inpatient treatment for severe anorexia nervosa: pragmatic randomised controlled trial. Br. J. Psychiatry Open 1, 56-66 (2015).
131. The Royal Colleges of Psychiatrists, Physicians and Pathologists. CR189 MARSIPAN: Management of Really Sick Patients with Anorexia Nervosa 2nd edn (The Royal College of Psychiatrists, 2014).
132. Misra, M. et al. Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa. J. Bone Miner. Res. 26, 2430-2438 (2011).
133. Miller, K. K. et al. Effects of risedronate and low-dose transdermal testosterone on bone mineral density in women with anorexia nervosa: a randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 96, 2081-2088 (2011).
134. Misra, M. & Klibanski, A. Anorexia nervosa and bone. J. Endocrinol. 221, R163-R176 (2014).
135. De Vos, J. et al. Meta analysis on the efficacy of pharmacotherapy versus placebo on anorexia nervosa. J. Eat. Disord. 2, 27 (2014).
136. Gowers, S. G. et al. A randomised controlled multicentre trial of treatments for adolescent anorexia nervosa including assessment of cost-effectiveness and patient acceptability - the TOuCAN trial. Health Technol. Assess. 14, 1-98 (2010).
137. Halmi, K. A. et al. Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designs. Arch. Gen. Psychiatry 62, 776-781 (2005).
138. Lock, J. et al. Challenges in conducting a multi-site randomized clinical trial comparing treatments for adolescent anorexia nervosa. Int. J. Eat. Disord. 45, 202-213 (2012).
139. American Psychiatric Association. Treatment of patients with eating disorders, third edition. Am. J. Psychiatry 163, S4-S54 (2006).
140. Hay, P. et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of eating disorders. Aust. N. Z. J. Psychiatry 48, 977-1008 (2014).
141. National Collaborating Centre for Mental Health. Eating disorders: core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. NICE [online], https://www.nice.org.uk/guidance/cg009 (2004).
142. S3-leitlinie diagnostik und therapie der essstörungen. AWMF [online], http://www.awmf.org/uploads/tx- szleitlinien/051-026k-S3-Diagnostik-Therapie- Essstörungen-2011-12.pdf (in German) (2001).
143. Schmidt, U. et al. The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: a randomized controlled trial. J. Consult. Clin. Psychol. 83, 796-807 (2015).
144. Zipfel, S. et al. Focal psychodynamic therapy, cognitive behaviour therapy, and optimised treatment as usual in outpatients with anorexia nervosa (ANTOP study): randomised controlled trial. Lancet 383, 127-137 (2014).
145. Lock, J. et al. Randomized clinical trial comparing family-based treatment with adolescent-focused individual therapy for adolescents with anorexia nervosa. Arch. Gen. Psychiatry 67, 1025-1032 (2010).
146. Von, H.-C., Friederich, W., Herzog, B., Wild, S. & Zipfel, H. S. Anorexia Nervosa Fokale Psychodynamische Psychotherapie (in German) (Hogrefe, 2014).
147. Fairburn, C. G. Cognitive Behavior Therapy and Eating Disorders (Guilford Press, 2008).
148. McIntosh, V. V. et al. Specialist supportive clinical management for anorexia nervosa. Int. J. Eat. Disord. 39, 625-632 (2006).
149. Wild, B. et al. The ANTOP study: focal psychodynamic psychotherapy, cognitive-behavioural therapy, and treatment-as-usual in outpatients with anorexia nervosa - a randomized controlled trial. Trials 10, 23 (2009).
150. McIntosh, V. V. et al. Three psychotherapies for anorexia nervosa: a randomized, controlled trial. Am. J. Psychiatry 162, 741-747 (2005).
151. Carter, F. A. et al. The long-term efficacy of three psychotherapies for anorexia nervosa: a randomized, controlled trial. Int. J. Eat. Disord. 44, 647-654 (2011).
152. Schmidt, U. et al. Out-patient psychological therapies for adults with anorexia nervosa: randomised controlled trial. Br. J. Psychiatry 201, 392-399 (2012).
153. Treasure, J. & Schmidt, U. The cognitive-interpersonal maintenance model of anorexia nervosa revisited: a summary of the evidence for cognitive, socio-emotional and interpersonal predisposing and perpetuating factors. J. Eat. Disord. 1, 13 (2013).
154. Goddard, E., Macdonald, P. & Treasure, J. An examination of the impact of the Maudsley Collaborative Care skills training workshops on patients with anorexia nervosa: a qualitative study. Eur. Eat. Disord. Rev. 19, 150-161 (2011).
155. Grover, M. et al. A randomized controlled trial of an Internet-based cognitive-behavioural skills package for carers of people with anorexia nervosa. Psychol. Med. 41, 2581-2591 (2011).
156. Hoyle, D., Slater, J., Williams, C., Schmidt, U. & Wade, T. D. Evaluation of a web-based skills intervention for carers of people with anorexia nervosa: a randomized controlled trial. Int. J. Eat. Disord. 46, 634-638 (2013).
157. Watson, H. J. & Bulik, C. M. Update on the treatment of anorexia nervosa: review of clinical trials, practice guidelines and emerging interventions. Psychol. Med. 43, 2477-2500 (2013).
158. Hay, P. J. & Claudino, A. M. Clinical psychopharmacology of eating disorders: a research update. Int. J. Neuropsychopharmacol. 15, 209-222 (2012).
159. Kishi, T., Kafantaris, V., Sunday, S., Sheridan, E. M. & Correll, C. U. Are antipsychotics effective for the treatment of anorexia nervosa? Results from a systematic review and meta-analysis. J. Clin. Psychiatry 73, e757-e766 (2012).
160. Lebow, J., Sim, L. A., Erwin, P. J. & Murad, M. H. The effect of atypical antipsychotic medications in individuals with anorexia nervosa: a systematic review and meta-analysis. Int. J. Eat. Disord. 46, 332-339 (2013).
161. Dold, M., Aigner, M., Klabunde, M., Treasure, J. & Kasper, S. Second-generation antipsychotic drugs in anorexia nervosa: a meta-analysis of randomized controlled trials. Psychother. Psychosom. 84, 110-116 (2015).
162. Aigner, M., Treasure, J., Kaye, W. & Kasper, S. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of eating disorders. World J. Biol. Psychiatry 12, 400-443 (2011).
163. Kaye, W. H. et al. Double-blind placebo-controlled administration of fluoxetine in restricting-and restricting-purging-type anorexia nervosa. Biol. Psychiatry 49, 644-652 (2001).
164. Walsh, B. T. et al. Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial. JAMA 295, 2605-2612 (2006).
165. Kaye, W. H., Fudge, J. L. & Paulus, M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat. Rev. Neurosci. 10, 573-584 (2009).
166. Wade, T. D., Bulik, C. M., Neale, M. & Kendler, K. S. Anorexia nervosa and major depression: shared genetic and environmental risk factors. Am. J. Psychiatry 157, 469-471 (2000).
167. Pizarro, M. et al. An updated review of antidepressants with marked serotonergic effects in obsessive-compulsive disorder. Expert Opin. Pharmacother. 15, 1391-1401 (2014).
168. Claudino, A. M. et al. Antidepressants for anorexia nervosa. Cochrane Database Syst. Rev. 1, CD004365 (2006).
169. Attia, E. et al. Olanzapine versus placebo for out-patients with anorexia nervosa. Psychol. Med. 41, 2177-2182 (2011).
170. Bissada, H., Tasca, G. A., Barber, A. M. & Bradwejn, J. Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial. Am. J. Psychiatry 165, 1281-1288 (2008).
171. Brambilla, F. et al. Olanzapine therapy in anorexia nervosa: psychobiological effects. Int. Clin. Psychopharmacol. 22, 197-204 (2007).
172. Mondraty, N. et al. Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. Australas. Psychiatry 13, 72-75 (2005).
173. Kafantaris, V. et al. A placebo-controlled pilot study of adjunctive olanzapine for adolescents with anorexia nervosa. J. Child Adolesc. Psychopharmacol. 21, 207-212 (2011).
174. Court, A. et al. Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: a pilot study. J. Psychiatr. Res. 44, 1027-1034 (2010).
175. Powers, P. S., Klabunde, M. & Kaye, W. Double-blind placebo-controlled trial of quetiapine in anorexia nervosa. Eur. Eat. Disord. Rev. 20, 331-334 (2012).
176. Hagman, J. et al. A double-blind, placebo-controlled study of risperidone for the treatment of adolescents and young adults with anorexia nervosa: a pilot study. J. Am. Acad. Child Adolesc. Psychiatry 50, 915-924 (2011).
177. Fava, G. A. Rational use of antidepressant drugs. Psychother. Psychosom. 83, 197-204 (2014).
178. Andries, A., Frystyk, J., Flyvbjerg, A. & Støving, R. K. Dronabinol in severe, enduring anorexia nervosa: a randomized controlled trial. Int. J. Eat. Disord. 47, 18-23 (2014).
179. Gross, H. et al. A double-blind trial of Δ9-tetrahydrocannabinol in primary anorexia nervosa. J. Clin. Psychopharmacol. 3, 165-171 (1983).
180. Park, R. J., Godier, L. R. & Cowdrey, F. A. Hungry for reward: how can neuroscience inform the development of treatment for anorexia nervosa? Behav. Res. Ther. 62, 47-59 (2014).
181. Keilen, M., Treasure, T., Schmidt, U. & Treasure, J. Quality of life measurements in eating disorders, angina, and transplant candidates: are they comparable? J. R. Soc. Med. 87, 441-444 (1994).
182. Bamford, B. et al. Eating disorder symptoms and quality of life: where should clinicians place their focus in severe and enduring anorexia nervosa? Int. J. Eat. Disord. 48, 133-138 (2015).
183. Ware, J. E. & Sherbourne, C. D. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med. Care 30, 473-483 (1992).
184. Padierna, A., Quintana, J. M., Arostegui, I., Gonzalez, N. & Horcajo, M. J. The health-related quality of life in eating disorders. Qual. Life Res. 9, 667-674 (2000).
185. De la Rie, S. M., Noordenbos, G. & van Furth, E. F. Quality of life and eating disorders. Qual. Life Res. 14, 1511-1522 (2005).
186. Sy, R., Ponton, K., De Marco, P., Pi, S. & Ishak, W. W. Quality of life in anorexia nervosa: a review of the literature. Eat. Disord. 21, 206-222 (2013).
187. Morgan, H. G. & Russell, G. F. Value of family background and clinical features as predictors of long-term outcome in anorexia nervosa: four-year follow-up study of 41 patients. Psychol. Med. 5, 355-371 (1975).
188. Ratnasuriya, R. H., Eisler, I., Szmukler, G. I. & Russell, G. F. Anorexia nervosa: outcome and prognostic factors after 20 years. Br. J. Psychiatry 158, 495-502 (1991).
189. Ekéus, C., Lindberg, L., Lindblad, F. & Hjern, A. Birth outcomes and pregnancy complications in women with a history of anorexia nervosa. BJOG 113, 925-929 (2006).
190. Wentz, E., Gillberg, I. C., Anckarsäter, H., Gillberg, C. & Råstam, M. Reproduction and offspring status 18 years after teenage-onset anorexia nervosa - a controlled community-based study. Int. J. Eat. Disord. 42, 483-491 (2009).
191. Lindblad, F., Lindberg, L. & Hjern, A. Anorexia nervosa in young men: a cohort study. Int. J. Eat. Disord. 39, 662-666 (2006).
192. Wentz, E., Gillberg, I. C., Anckarsäter, H., Gillberg, C. & Råstam, M. Adolescent-onset anorexia nervosa: 18-year outcome. Br. J. Psychiatry 194, 168-174 (2009).
193. Nielsen, S. et al. Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study. Mol. Autism 6, 14 (2015).
194. Wentz, E. et al. Bone density 11 years after anorexia nervosa onset in a controlled study of 39 cases. Int. J. Eat. Disord. 34, 314-318 (2003).
195. Lo Russo, L. et al. Oral manifestations of eating disorders: a critical review. Oral Dis. 14, 479-484 (2008).
196. Nilsson, K. & Hägglöf, B. Long-term follow-up of adolescent onset anorexia nervosa in northern Sweden. Eur. Eat. Disord. Rev. 13, 89-100 (2005).
197. Nielsen, S. Epidemiology and mortality of eating disorders. Psychiatr. Clin. North Am. 24, 201-214 (2001).
198. Arcelus, J., Mitchell, A. J., Wales, J. & Nielsen, S. Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. Arch. Gen. Psychiatry 68, 724-731 (2011).
199. Campbell, I. C., Mill, J., Uher, R. & Schmidt, U. Eating disorders, gene-environment interactions and epigenetics. Neurosci. Biobehav. Rev. 35, 784-793 (2011).
200. Kothari, R., Solmi, F., Treasure, J. & Micali, N. The neuropsychological profile of children at high risk of developing an eating disorder. Psychol. Med. 43, 1543-1554 (2013).
201. Kothari, R., Rosinska, M., Treasure, J. & Micali, N. The early cognitive development of children at high risk of developing an eating disorder. Eur. Eat. Disord. Rev. 22, 152-156 (2014).
202. Montigny, C. et al. A phenotypic structure and neural correlates of compulsive behaviors in adolescents. PLoS ONE 8, e80151 (2013).
203. Wierenga, C. E. et al. Are extremes of consumption in eating disorders related to an altered balance between reward and inhibition? Front. Behav. Neurosci. 8, 410 (2014).
204. Guarda, A. S., Schreyer, C. C., Boersma, G. J., Tamashiro, K. L. & Moran, T. H. Anorexia nervosa as a motivated behavior: relevance of anxiety, stress, fear and learning. Physiol. Behav. http://dx.doi.org/ 10.1016/j.physbeh.2015.04.007 (2015).
205. O'Hara, C. B., Campbell, I. C. & Schmidt, U. A reward-centred model of anorexia nervosa: a focussed narrative review of the neurological and psychophysiological literature. Neurosci. Biobehav. Rev. 52, 131-152 (2015).
206. Godier, L. R. & Park, R. J. Compulsivity in anorexia nervosa: a transdiagnostic concept. Front. Psychol. 5, 778 (2014).
207. Kaye, W. H. et al. Temperament-based treatment for anorexia nervosa. Eur. Eat. Disord. Rev. 23, 12-18 (2015).
208. Lindvall Dahlgren, C. & Rø, O. A systematic review of cognitive remediation therapy for anorexia nervosa - development, current state and implications for future research and clinical practice. J. Eat. Disord. 2, 26 (2014).
209. Tchanturia, K., Lounes, N. & Holttum, S. Cognitive remediation in anorexia nervosa and related conditions: a systematic review. Eur. Eat. Disord. Rev. 22, 454-462 (2014).
210. Strober, M. Pathologic fear conditioning and anorexia nervosa: on the search for novel paradigms. Int. J. Eat. Disord. 35, 504-508 (2004).
211. Koskina, A., Campbell, I. C. & Schmidt, U. Exposure therapy in eating disorders revisited. Neurosci. Biobehav. Rev. 37, 193-208 (2013).
212. Renwick, B., Campbell, I. C. & Schmidt, U. Review of attentional bias modification: a brain-directed treatment for eating disorders. Eur. Eat. Disord. Rev. 21, 464-474 (2013).
213. Kim, Y.-R., Kim, C.-H., Park, J. H., Pyo, J. & Treasure, J. The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: a double blind within-subject cross-over experiment. PLoS ONE 9, e90721 (2014).
214. Maguire, S., O'Dell, A., Touyz, L. & Russell, J. Oxytocin and anorexia nervosa: a review of the emerging literature. Eur. Eat. Disord. Rev. 21, 475-478 (2013).
215. Lipsman, N., Woodside, D. B. & Lozano, A. M. Neurocircuitry of limbic dysfunction in anorexia nervosa. Cortex 62, 109-118 (2015).
216. McClelland, J., Bozhilova, N., Campbell, I. & Schmidt, U. A systematic review of the effects of neuromodulation on eating and body weight: evidence from human and animal studies. Eur. Eat. Disord. Rev. 21, 436-455 (2013).
217. Lipsman, N. et al. Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial. Lancet 381, 1361-1370 (2013).
218. Schork, N. J. Personalized medicine: time for one-person trials. Nature 520, 609-611 (2015).
219. Schumann, G. et al. Stratified medicine for mental disorders. Eur. Neuropsychopharmacol. 24, 5-50 (2014).
220. Gérard, N., Pieters, G., Goffin, K., Bormans, G. & Van Laere, K. Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa. Biol. Psychiatry 70, 777-784 (2011).
221. Broft, A. et al. Striatal dopamine type 2 receptor availability in anorexia nervosa. Psychiatry Res. 233, 380-387 (2015).
222. Frank, G. K. et al. Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C] raclopride. Biol. Psychiatry 58, 908-912 (2005).
223. Yoshizawa, M. et al. Increased brain histamine H1 receptor binding in patients with anorexia nervosa. Biol. Psychiatry 65, 329-335 (2009).
224. Galusca, B. et al. Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan study. Biol. Psychiatry 64, 1009-1013 (2008).
225. Bailer, U. F. et al. Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa. Biol. Psychiatry 61, 1090-1099 (2007).
226. Bailer, U. F. et al. Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635. Arch. Gen. Psychiatry 62, 1032-1041 (2005).
227. Bailer, U. F. et al. Altered 5-HT2A receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness. Neuropsychopharmacology 29, 1143-1155 (2004).
228. Frank, G. K. et al. Reduced 5-HT2A receptor binding after recovery from anorexia nervosa. Biol. Psychiatry 52, 896-906 (2002).
229. Bailer, U. F. et al. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology (Berl.) 195, 315-324 (2007).
230. Shott, M. E., Pryor, T. L., Yang, T. T. & Frank, G. K. Greater insula white matter fiber connectivity in women recovered from anorexia nervosa. Neuropsychopharmacology http:// dx.doi.org/10.1038/npp.2015.172 (2015).
231. Via, E. et al. Disruption of brain white matter microstructure in women with anorexia nervosa. J. Psychiatry Neurosci. 39, 367-375 (2014).
232. Nagahara, Y. et al. A tract-based spatial statistics study in anorexia nervosa: abnormality in the fornix and the cerebellum. Prog. Neuropsychopharmacol. Biol. Psychiatry 51, 72-77 (2014).
233. Yau, W.-Y. W. et al. Alterations in white matter microstructure in women recovered from anorexia nervosa. Int. J. Eat. Disord. 46, 701-708 (2013).
234. Frieling, H. et al. Microstructural abnormalities of the posterior thalamic radiation and the mediodorsal thalamic nuclei in females with anorexia nervosa - a voxel based diffusion tensor imaging (DTI) study. J. Psychiatr. Res. 46, 1237-1242 (2012).
235. Kazlouski, D. et al. Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance. Psychiatry Res. 192, 109-116 (2011).
236. Hill, K. et al. Pilot study of growth hormone administration during the refeeding of malnourished anorexia nervosa patients. J. Child Adolesc. Psychopharmacol. 10, 3-8 (2000).
237. Nakahara, T. et al. The effects of bone therapy on tibial bone loss in young women with anorexia nervosa. Int. J. Eat. Disord. 39, 20-26 (2006).
238. Fazeli, P. K. et al. Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 95, 4889-4897 (2010).
239. Howgate, D. J. et al. Bone metabolism in anorexia nervosa: molecular pathways and current treatment modalities. Osteoporos. Int. 24, 407-421 (2013).
240. Sim, L. A. et al. Effect on bone health of estrogen preparations in premenopausal women with anorexia nervosa: a systematic review and meta-analyses. Int. J. Eat. Disord. 43, 218-225 (2010).
241. National Health and Medical Research Council. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines. NHMRC [online], www.nhmrc.gov.au/-files-nhmrc/file/ guidelines/developers/nhmrc-levels-grades- evidence-120423.pdf (2009).