Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives

Materials Science and Engineering C

Volumn 77, Issue , 2017, Pages 1316-1326

  Hussain, Zahid ^a   Thu, Hnin Ei ^b   Amjad, Muhammad Wahab ^c   Hussain, Fahad ^d   Ahmed, Tarek A ^e   Khan, Shahzeb ^f  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b DEPARTMENT OF PHARMACOLOGY   (Malaysia)

^c NORTHERN BORDER UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF LAHORE   (Pakistan)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^f UNIVERSITY OF MALAKAND   (Pakistan)

Author keywords

Advanced delivery systems; Curcumin; Improved antioxidant, anti inflammatory and antimicrobial efficacies; Liposomes; Nanoconjugates; Nanoparticles

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; BLENDING; LIPOSOMES; MICROORGANISMS; NANOCOMPOSITE FILMS; NANOCONJUGATES; NANOPARTICLES; PLASMA STABILITY; SOLUBILITY;

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY ACTIVITY; CURCUMIN; DELIVERY SYSTEMS; NANOCOMPOSITE HYDROGELS; NANOSTRUCTURED LIPID CARRIERS; PHYSICOCHEMICAL CHARACTERISTICS; POLYMERIC NANOPARTICLES;

POLYMERS;

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CURCUMIN;

MICELLE;

ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CURCUMIN; MICELLES;

EID: 85017157762     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msec.2017.03.226     Document Type: Review

References (111)

1. Aadinath, W., Bhushani, A., Anandharamakrishnan, C., Synergistic radical scavenging potency of curcumin-in-β-cyclodextrin-in-nanomagnetoliposomes. Mater. Sci. Eng. C 64:1 (2016), 293–302.
2. Aggarwal, B.B., Sung, B., Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol. Sci. 30:2 (2009), 85–94.
3. Aggarwal, B.B., Harikumar, K.B., Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 41 (2009), 40–59.
4. Ahmad, M.Z., Alkahtani, S.A., Akhter, S., Ahmad, F.J., Ahmad, J., Akhtar, M.S., Mohsin, N., Abdel-Wahab, B.A., Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art. J. Drug Target., 2015, 1–21.
5. Krausz, Aimee E., Adler, Brandon L., Cabral, Vitor, Navati, Mahantesh, Doerner, Jessica, Charafeddine, Rabab A., Chandra, Dinesh, Liang, Hongying, Gunther, Leslie, Clendaniel, Alicea, Harper, Stacey, Friedman, Joel M., Nosanchuk, Joshua D., Friedman, Adam J., Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomed. Nanotechnol. Biol. Med. 11:1 (2015), 195–206.
6. Ak, T., Gulcin, I., Antioxidant and radical scavenging properties of curcumin. Chem. Biol. Interact. 174 (2008), 27–37.
7. Popat, Amirali, Karmakar, Surajit, Jambhrunkar, Siddharth, Xu, Chun, Chengzhong, Yu., Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity., 117, 2014, 520–527.
8. Anand, P., Kunnumakkara, A.B., Newman, R.A., Aggarwal, B.B., Bioavailability of curcumin: problems and promises. Mol. Pharm. 4 (2007), 807–818.
9. Apetz, N., Munch, G., Govindaraghavan, S., Gyengesi, E., Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease—a translational perspective. CNS Neurol. Disord. Drug Targets 13 (2014), 1175–1191.
10. Arora, R., Kuhad, A., Kaur, I.P., Chopra, K., Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur. J. Pain 19 (2015), 940–952.
11. Astete, C.E., Sabliov, C.M., Synthesis and characterization of PLGA nanoparticles. J. Biomater. Sci. Polym. Ed. 17 (2006), 247–289.
12. Basnet, P., Hussain, H., Tho, I., Skalko-Basnet, N., Liposomal delivery system enhances anti-inflammatory properties of curcumin. J. Pharm. Sci. 101 (2012), 598–609.
13. Baxter, Richard, Bramlett, Kenneth, Onel, Erol, Daniels, Stephen, Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies. Clin. Ther., 35(3), 2013 (312–320.e5).
14. Beloqui, Ana, Memvanga, Patrick B., Coco, Régis, Reimondez-Troitiño, Sonia, Alhouayek, Mireille, Muccioli, Giulio G., Alonso, María José, Csaba, Noemi, de la Fuente, María, Préat, Véronique, et al. Colloids Surf. B: Biointerfaces 143 (2016), 27–335.
15. Biswas, S., Hwang, J.W., Kirkham, P.A., Rahman, I., Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. Curr. Med. Chem. 20 (2013), 1496–1530.
16. Bhutani, M.K., Bishnoi, M., Kulkarni, S.K., Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol. Biochem. Behav. 92 (2009), 39–43.
17. Bisht, S., Maitra, A., Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr. Drug Discov. Technol. 6:3 (2009), 192–199.
18. Catanzano, O., D'Esposito, V., Acierno, S., Ambrosio, M.R., De Caro, C., Avagliano, C., Russo, P., Russo, R., Miro, A., Ungaro, F., Calignano, A., Formisano, P., Quaglia, F., Alginate–hyaluronan composite hydrogels accelerate wound healing process. Carbohydr. Polym. 131 (2015), 407–414.
19. Castangia, I., Nácher, A., Caddeo, C., Valenti, D., Fadda, A.M., Díez-Sales, O., et al. Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomater. 10 (2014), 1292–1300.
20. Chandran, B., Goel, A., A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother. Res. 26 (2012), 1719–1725.
21. Chuengsamarn, S., Rattanamongkolgul, S., Phonrat, B., Tungtrongchitr, R., Jirawatnotai, S., Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J. Nutr. Biochem. 25 (2014), 144–150.
22. Agubata, Chukwuma O., Okereke, Chiadikaobi, Nzekwe, Ifeanyi T., Onoja, Remigius I., Obitte, Nicholas C., Development and evaluation of wound healing hydrogels based on a quinolone, hydroxypropyl methylcellulose and biodegradable microfibers. Eur. J. Pharm. Sci. 89 (2016), 1–10.
23. Dhillon, N., Aggarwal, B.B., Newman, R.A., Wolff, R.A., Kunnumakkara, A.B., Abbruzzese, J.L., Ng, C.S., Badmaev, V., Kurzrock, R., Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res. 14 (2008), 4491–4499.
24. Dong, Y., Wang, W., 14 – In situ–formed bioactive hydrogels for delivery of stem cells and biomolecules for wound healing. Wound Healing Biomaterials Volume 2: Functional Biomaterials, 2016, 289–307.
25. El-Khoury, E., Abiad, M., Kassaify, Z.G., Patra, D., Green synthesis of curcumin conjugated nanosilver for the applications in nucleic acid sensing and anti-bacterial activity. Colloids Surf. B Biointerfaces 1:127 (2015), 274–280.
26. El-Refaie, W.M., Elnaggar, Y.S., El-Massik, M.A., Abdallah, O.Y., Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies. Int. J. Pharm. 486 (2015), 88–98.
27. Ferreira, Helena, Matamá, Teresa, Silva, Raquel, Silva, Carla, Gomesc, Andreia C., Cavaco-Paulo, Artur, Functionalization of gauzes with liposomes entrapping an anti-inflammatory drug: a strategy to improve wound healing. React. Funct. Polym. 73:10 (2013), 1328–1334.
28. Fujisawa, S., Atsumi, T., Ishihara, M., Kadoma, Y., Cytotoxicity, ROS-generation activity and radical-scavenging activity of curcumin and related compounds. Anticancer Res. 24 (2004), 563–569.
29. Galili, Uri, Wigglesworth, Kim, Abdel-Motal, Ussama M., Accelerated healing of skin burns by anti-Gal/α-gal liposomes interaction. Burns 36:2 (2010), 239–251.
30. Del Gaudio, Pasquale, De Cicco, Felicetta, Aquino, Rita P., Picerno, Patrizia, Russo, Paola, Piaz, Fabrizio Dal, Bizzarro, Valentina, Belvedere, Raffaella, Parente, Luca, Petrella, Antonello, Evaluation of in situ injectable hydrogels as controlled release device for ANXA1 derived peptide in wound healing. Carbohydr. Polym. 115 (2015), 629–635.
31. Ghalandarlaki, N., Alizadeh, A.M., Shkani-Esfahani, S., Nanotechnology-applied curcumin for different diseases therapy. Biomed. Res. Int., 2014, 2014, 394264.
32. Goh, Meei Chyn, Hwang, Youngmin, Tae, Giyoong, Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing. Carbohydr. Polym. 147 (2016), 251–260.
33. Gonga, C., Wu, Q., Wang, Y., Zhang, D., Luo, F., Zhao, X., Wei, Y., Qian, Z., A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 34:27 (2013), 6377–6387.
34. Gopinath, D., Ahmed, M.R., Gomathi, K., Chitra, K., Sehgal, P.K., Jayakumar, R., Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25 (2004), 1911–1917.
35. Gou, M., Men, K., Shi, H., Xiang, M., Zhang, J., Song, J., Long, J., Wan, Y., Luo, F., Zhao, X., Qian, Z., Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nano 3:4 (2011), 1558–1567.
36. Hasan, S.T., Zingg, J.M., Kwan, P., Noble, T., Smith, D., Meydani, M., Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis 232 (2014), 40–51.
37. Hussain, Z., Katas, H., Amin, M.C., Kumulosasi, E., Sahudin, S., Antidermatitic perspective of hydrocortisone as chitosan nanocarriers: an ex vivo and in vivo assessment using an NC/Nga mouse model. J. Pharm. Sci. 102:3 (2013), 1063–1075.
38. Hussain, Z., Katas, H., Mohd Amin, M.C., Kumolosasi, E., Buang, F., Sahudin, S., Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model. Int. J. Pharm. 444 (2013), 109–119.
39. Hussain, Z., Katas, H., Mohd Amin, M.C., Kumolosasi, E., Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs. PLoS One 9:11 (2014), e113–e143.
40. Hussain, Z., Katas, H., Mohd Amin, M.C., Kumolosasi, E., Sahudin, S., Downregulation of immunological mediators in 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions by hydrocortisone-loaded chitosan nanoparticles. Int. J. Nanomedicine 9 (2014), 5143–5156.
41. Hussain, Z., Thu, H.E., Ng, S.-F., Khan, S., Katas, H., Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: a review of new trends and state-of-the-art. Colloids Surf. B: Biointerfaces 150 (2017), 223–241.
42. Ireson, C.R., Jones, D.J., Orr, S., Coughtrie, M.W., Boocock, D.J., Williams, M.L., Farmer, P.B., Steward, W.P., Gescher, A.J., Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol. Biomark. Prev. 11 (2002), 105–111.
43. Jagetia, G.C., Aggarwal, B.B., “Spicing up” of the immune system by curcumin. J. Clin. Immunol. 27 (2007), 19–35.
44. Jagetia, G., Rajanikant, G., Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated gamma radiation. Int. Wound J. 9 (2012), 76–92.
45. Jiang, H., Wang, Z., Wang, Y., Xie, K., Zhang, Q., Luan, Q., Chen, W., Liu, D., Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 47 (2013), 33–39.
46. Li, Jinglei, Hwang, InCheon, Chen, Xiguang, Park, Hyun Jin, Effects of chitosan coating on curcumin loaded nanoemulsion: study on stability and in vitro digestibility. Food Hydrocoll. 60 (2016), 138–147.
47. Joe, B., Vijaykumar, M., Lokesh, B.R., Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr. 44:2 (2004), 97–111.
48. Kant, V., Gopal, A., Pathak, N.N., Kumar, P., Tandan, S.K., Kumar, D., Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int. Immunopharmacol. 20:2 (2014), 322–330.
49. Kasim, N.A., Whitehouse, M., Ramachandran, C., Bermejo, M., Lennernas, H., Hussain, A.S., Junginger, H.E., Stavchansky, S.A., Midha, K.K., Shah, V.P., Amidon, G.L., Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Mol. Pharm. 1 (2004), 85–96.
50. Kasoju, N., Bora, U., Fabrication and characterization of curcumin-releasing silk fibroin scaffold. J. Biomed. Mater. Res. Part B 100B (2012), 1854–1866 2012.
51. Kerdsakundee, N., Mahattanadul, S., Wiwattanapatapee, R., Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit(R) EPO solid dispersions for gastric ulcer treatment. Eur. J. Pharm. Biopharm., 2015.
52. Kim, D.S., Kim, J.Y., Han, Y., Curcuminoids in neurodegenerative diseases. Recent Pat. CNS Drug Discov. 7 (2012), 184–204.
53. Kim, M.H., Kim, S.H., Yang, W.M., Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. Planta Med. 80 (2014), 1249–1258.
54. Kim, Dong Wuk, Kim, Kyung Soo, Seo, Youn Gee, Lee, Beom-Jin, Park, Young Joon, SeokYoun, Yu, Kim, Jong Oh., Yong, Chul Soon, Jin, Sung Giu, Choi, Han-Gon, Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing. Int. J. Pharm. 495:1 (2015), 67–74.
55. Chereddy, Kiran Kumar, Coco, Régis, Memvanga, Patrick B., Ucakar, Bernard, Rieux, Anne des, Vandermeulen, Gaëlle, Préat, Véronique, Combined effect of PLGA and curcumin on wound healing activity. J. Control. Release 171:2 (2013), 208–215.
56. Kulac, M., Aktas, C., Tulubas, F., Uygur, R., Kanter, M., Erboga, M., Ceber, M., Topcu, B., Ozen, O.A., The effects of topical treatment with curcumin on burn wound healing in rats. J. Mol. Histol. 44:1 (2013), 83–90.
57. Kloesch, B., Becker, T., Dietersdorfer, E., Kiener, H., Steiner, G., Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int. Immunopharmacol. 15:2 (2013), 400–405.
58. Kochi, A., Lee, H.J., Vithanarachchi, S.M., Padmini, V., Allen, M.J., Lim, M.H., Inhibitory activity of curcumin derivatives towards metal-free and metal-induced amyloid-beta aggregation. Curr. Alzheimer Res. 12 (2015), 415–423.
59. Laçin, Nelisa Türkoğlu, Development of biodegradable antibacterial cellulose based hydrogel membranes for wound healing. Int. J. Biol. Macromol. 67 (2014), 22–27.
60. Lao, C.D., Ruffin, M.T., Normolle, D., Heath, D.D., Murray, S.I., Bailey, J.M., Boggs, M.E., Crowell, J., Rock, C.L., Brenner, D.E., Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med., 6, 2006, 10.
61. Lee, W.H., Loo, C.Y., Bebawy, M., Luk, F., Mason, R.S., Rohanizadeh, R., Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr. Neuropharmacol. 11 (2013), 338–378.
62. Liang, G., Yang, S., Zhou, H., Shao, L., Huang, K., Xiao, J., Huang, Z., Li, X., Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. Eur. J. Med. Chem. 44:2 (2009), 915–919.
63. Li, X.Y., Kong, X.Y., Shi, S., Gu, Y.C., Yang, L., Guo, G., Luo, F., Zhao, X., Wei, Y.Q., Qian, Z.Y., Biodegradable MPEG-g-Chitosan and methoxy poly (ethylene glycol)-b-poly ([epsilon]-caprolactone) composite films. Part 1: preparation and characterization. Carbohydr. Polym. 79 (2010), 429–436.
64. Li, Xingyi, Chen, Shuo, Zhang, Binjun, Li, Mei, Diao, Kai, Zhang, Zhaoliang, Jie Li, Yu Xu, Wang, Xianhuo, Chen, Hao, In situ injectable nanocomposite hydrogel composed of curcumin, N,O carboxymethyl chitosan and oxidized alginate for wound healing application. Int. J. Pharm. 437, 1–2:1 (2012), 110–119.
65. Liu, Yujia, Cai, Yanxue, Jiang, Xueying, Wu, Jinping, Le, Xueyi, Molecular interactions, characterization and antimicrobial activity of curcumin–chitosan blend films. Food Hydrocoll. 52 (2016), 564–572.
66. Lv, H., Liu, J., Wang, L., Zhang, H., Yu, S., Li, Z., Jiang, F., Niu, Y., Yuan, J., Cui, X., Wang, W., Ameliorating effects of combined curcumin and desferrioxamine on 6-OHDA-induced rat mode of Parkinson's disease. Cell Biochem. Biophys. 70 (2014), 1433–1438.
67. Ma, Z., Haddadi, A., Molavi, O., Lavasanifar, A., Lai, R., Samuel, J., Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J. Biomed. Mater. Res. A 86 (2008), 300–310.
68. Mahmood, Kashif, Zia, Khalid Mahmood, Zuber, Mohammad, Salman, Mahwish, Anjum, Muhammad Naveed, Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: a review. Int. J. Biol. Macromol. 81 (2015), 877–890.
69. Mahmood, Kashif, Noreen, Iqra, Riaz, Muhammad, Zuber, Mohammad, Salman, Mahwish, Rehman, Saima, Zia, Khalid Mahmood, Synthesis and characterization of novel curcumin based polyurethanes varying diisocyanates structure. J. Polym. Res., 23, 2016, 233.
70. Manca, M.L., Castangia, I., Zaru, M., Nácher, A., Valenti, D., Fernàndez-Busquets, X., Fadda, A.M., Manconi, M., Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring. Biomaterials 71 (2015), 100–109.
71. Vázquez-González, Martha L., Calpena, Ana C., Domènech, Òscar, Teresa Montero, M., Borrell, Jordi H., Enhanced topical delivery of hyaluronic acid encapsulated in liposomes: a surface-dependent phenomenon. Colloids Surf. B: Biointerfaces 134:1 (2015), 31–39.
72. Mohammadi, Marziyeh Ranjbar, Rabbani, Shahram, HajirBahrami, S., Joghataei, M.T., Moayer, F., Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth/poly(ε-caprolactone) electrospunnanofibers. Mater. Sci. Eng. C 69 (2016), 1183–1191.
73. Moghaddam, S.J., Barta, P., Mirabolfathinejad, S.G., Ammar-Aouchiche, Z., Garza, N.T., Vo, T.T., Newman, R.A., Aggarwal, B.B., Evans, C.M., Tuvim, M.J., Lotan, R., Dickey, B.F., Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 30 (2009), 1949–1956.
74. Mohanty, Chandana, Das, Manasi, Sahoo, Sanjeeb K., Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. Mol. Pharm. 9:10 (2012), 2801–2811.
75. Mourtas, S., Lazar, A.N., Markoutsa, E., Duyckaerts, C., Antimisiaris, S.G., Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease. Eur. J. Med. Chem. 80 (2014), 175–183.
76. Mun, S.H., Joung, D.K., Kim, Y.S., Kang, O.H., Kim, S.B., Seo, Y.S., Kim, Y.C., Lee, D.S., Shin, D.W., Kweon, K.T., Kwon, D.Y., Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine 20:8–9 (2013), 714–718.
77. Tummalapalli, Mythili, MorganeBerthet, Bernard Verrier, Deopura, B.L., Alam, M.S., Gupta, Bhuvanesh, Composite wound dressings of pectin and gelatin with Aloe vera and curcumin as bioactive agents. Int. J. Biol. Macromol. 82 (2016), 104–113.
78. Nabavi, S.F., Thiagarajan, R., Rastrelli, L., Daglia, M., Sobarzo-Sanchez, E., Alinezhad, H., Nabavi, S.M., Curcumin: a natural product for diabetes and its complications. Curr. Top. Med. Chem., 2015.
79. Ferreira, Maria Onaira Gonçalves, Leite, Layara Lorrana Ribeiro, de Lima, IdglanSá, Barreto, Humberto Medeiros, Nunes, Lívio César Cunha, Ribeiro, Alessandra Braga, Osajima, Josy Anteveli, da Silva Filho, Edson Cavalcanti, Chitosan Hydrogel in combination with Nerolidol for healing wounds. Carbohydr. Polym. 152 (2016), 409–418.
80. Pan, M.H., Huang, T.M., Lin, J.K., Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos. 27 (1999), 486–494.
81. Pari, L., Tewas, D., Eckel, J., Role of curcumin in health and disease. Arch. Physiol. Biochem. 114 (2008), 127–149.
82. Chen, Ping, Zhang, Hui, Cheng, Shucang, Zhai, Guangxi, Shen, Chengwu, Development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery. Colloids Surf. A Physicochem. Eng. Asp. 506 (2016), 356–362.
83. Rivera-Mancia, S., Lozada-Garcia, M.C., Pedraza-Chaverri, J., Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications. Eur. J. Pharmacol. 756 (2015), 30–37.
84. Sahebkar, A., Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant-antioxidant mechanisms. Nat. Prod. Res. 29 (2015), 491–492.
85. Sarika, P.R., James, Nirmala Rachel, Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery. Carbohydr. Polym. 148 (2016), 354–361.
86. Schmitz, K., Barthelmes, J., Stolz, L., Beyer, S., Diehl, O., Tegeder, I., “Disease modifying nutricals” for multiple sclerosis. Pharmacol. Ther. 148 (2015), 85–113.
87. Shao, Mei, Hussain, Zahid, Thu, Hnin Ei, Khan, Shahzeb, Katas, Haliza, Ahmed, Tarek A., Tripathy, Minaketan, Leng, Jing, Qin, Hua-Li, Bukhari, Syed Nasir Abbas, Drug nanocarrier, the future of atopic diseases: advanced drug delivery systems and smart management of disease. Colloids Surf. B: Biointerfaces 1:147 (2016), 475–491.
88. Singh, S., From exotic spice to modern drug?. Cell 130 (2007), 765–768.
89. Singh, R.K., Rai, D., Yadav, D., Bhargava, A., Balzarini, J., De Clercq, E., Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur. J. Med. Chem. 45 (2010), 1078–1086.
90. Souza, C.R.A., Osme, S.F., Gloria, M.B.A., Stability of curcuminoid pigments in model systems. J. Food Process. Preserv. 21 (1997), 353–363.
91. Facchi, Suelen P., Scariot, Débora B., Bueno, Pedro V.A., Souza, Paulo R., Figueiredo, Luana C., Follmann, Heveline D.M., Nunes, Cátia S., Monteiro, Johny P., Bonafé, Elton G., Nakamura, Celso V., Muniz, Edvani C., Martins, Alessandro F., Preparation and cytotoxicity of N-modified chitosan nanoparticles applied in curcumin delivery. Int. J. Biol. Macromol. 87 (2016), 237–245.
92. Sun, M., Su, X., Ding, B., He, X., Liu, X., Yu, A., Lou, H., Zhai, G., Advances in nanotechnology-based delivery systems for curcumin. Nanomedicine (London) 7 (2012), 1085–1100.
93. Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Odajima, N., Moriyama, C., Nasuhara, Y., Nishimura, M., Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 296 (2009), L614–L623.
94. Thangapazham, R.L., Sharad, S., Maheshwari, R.K., Skin regenerative potentials of curcumin. Biofactors 39:1 (2013), 141–149.
95. Tonnesen, H.H., Masson, M., Loftsson, T., Studies of curcumin and curcuminoids. XXVII. Cyclodextrincomplexation: solubility, chemical and photochemical stability. Int. J. Pharm. 244 (2002), 127–135.
96. Torchilin, V., Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 58:14 (2006), 1532–1555.
97. Tsai, Y.M., Chien, C.F., Lin, L.C., Tsai, T.H., Curcumin and its nano-formulation: the kinetics of tissue distribution and blood–brain barrier penetration. Int. J. Pharm. 416 (2011), 331–338.
98. Karri, Veera Venkata Satyanarayana Reddy, Kuppusamy, Gowthamarajan, Talluri, Siddhartha Venkata, Mannemala, Sai Sandeep, Kollipara, Radhakrishna, Wadhwani, Ashish Devidas, Mulukutla, Shashank, Raju, Kalidhindi Rama Satyanarayana, Malayandi, Rajkumar, Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. Int. J. Biol. Macromol. 93 (2016), 1519–1529, 10.1016/j.ijbiomac.2016.05.038.
99. Kant, Vinay, AnuGopal, Dhirendra Kumar, Pathak, Nitya N., Ram, Mahendra, Jangir, Babu L., Tandan, Surendra K., Kumar, Dinesh, Curcumin-induced angiogenesis hastens wound healing in diabetic rats. J. Surg. Res. 193 (2015), 978–988.
100. Vorauer-Uhl, Karola, Fürnschlief, Eckhard, Wagner, Andreas, Ferko, Boris, Katinger, Hermann, Topically applied liposome encapsulated superoxide dismutase reduces postburn wound size and edema formation. Eur. J. Pharm. Sci. 14 (2001), 63–67.
101. Wahlstrom, B., Blennow, G., A study on the fate of curcumin in the rat. Acta Pharmacol. Toxicol. (Copenh) 43 (1978), 86–92.
102. Wang, S., Tan, M., Zhong, Z., Chen, M., Wang, Y., Nanotechnologies for Curcumin: an ancient puzzler meets modern solutions. J. Nanomater. 2011 (2011), 1–8.
103. Xiang, Qi, Xiao, Jian, Zhang, Hongbo, Xie, Zhang, Lu, Meifei, Zhang, Hui, Zhijian, Su, Zhao, Wen, Lin, Cai, Huang, Yadong, Li, Xiaokun, Preparation and characterisation of bFGF-encapsulated liposomes and evaluation of wound-healing activities in the rat. Burns 37 (2011), 886–895.
104. Li, Xingyi, Nan, Kaihui, Li, Lingli, Zhang, Zhaoliang, Chen, Hao, In vivo evaluation of curcumin nanoformulation loaded methoxypoly(ethylene glycol)-graft-chitosan composite film for wound healing application. Carbohydr. Polym. 88 (2012), 84–90.
105. Li, Xingyi, Chen, Shuo, Zhang, Binjun, Li, Mei, Diao, Kai, Zhang, Zhaoliang, Jie Li, Yu Xu, Wang, Xianhuo, Chen, Hao, In situ injectable nanocomposite hydrogel composed of curcumin, N,O carboxymethyl chitosan and oxidized alginate for wound healing application. Int. J. Pharm. 437 (2012), 110–119.
106. Yadav, S.K., Sah, A.K., Jha, R.K., Sah, P., Shah, D.K., Turmeric (curcumin) remedies gastroprotective action. Pharmacogn. Rev. 7 (2013), 42–46.
107. Yang, Y., Wu, X., Wei, Z., Dou, Y., Zhao, D., Wang, T., Bian, D., Tong, B., Xia, Y., Xia, Y., Dai, Y., Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2 +)/CaMKII signaling pathways in the small intestine. Pharmacol. Res. 95-96 (2015), 71–81.
108. Yang, C., Su, X., Liu, A., Zhang, L., Yu, A., Xi, Y., Zhai, G., Advances in clinical study of curcumin. Curr. Pharm. Des. 19:11 (2013), 1966–1973.
109. Zia, Fatima, Zia, Khalid Mahmood, Zuber, Mohammad, Rehman, Saima, Tabasum, Shazia, Sultana, Salma, Synthesis and characterization of chitosan/curcumin blends based polyurethanes. Int. J. Biol. Macromol. 92 (2016), 1074–1081.
110. Ranjbar-Mohammadi, M., Rabbani, S., Bahrami, S.H., Joghataei, M.T., Moayer, F., Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth/poly((-caprolactone) electrospun nanofibers. Mat. Sci. Eng. C 69 (2016), 1183–1191.
111. Meng, B., Li, J., Cao, H., Antioxidant and anti-inflammatory activities of curcumin on diabetes mellitus and its complications. Curr. Pharm. Des. 19:11 (2013), 2101–2113.