Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses

Cell Reports

Volumn 19, Issue 1, 2017, Pages 86-100

  Lehigh, Kathryn M ^a,b   West, Katherine M ^a   Ginty, David D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

dendrites; microfluidic chambers; neurotrophin; NFG; PLGA microspheres; ptosis; signaling endosome; sympathetic neuron; synapse formation; TrkA

Indexed keywords

MEMBRANE PROTEIN; NERVE GROWTH FACTOR; POSTSYNAPTIC DENSITY PROTEIN; PROTEIN TYROSINE KINASE A; UNCLASSIFIED DRUG; MICROSPHERE; NEUROTROPIN; POLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AXON; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DENDRITE; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; POSTGANGLIONIC NEURON; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; SYMPATHETIC GANGLION; SYMPATHETIC NERVE CELL; SYNAPSE; ADRENERGIC SYSTEM; ANIMAL; FLUORESCENCE IMAGING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TIME LAPSE IMAGING; TRANSGENIC MOUSE;

ANIMALS; AXONS; DENDRITES; ENDOSOMES; MALE; MICE; MICE, TRANSGENIC; MICROSPHERES; NERVE GROWTH FACTOR; NEURONS; OPTICAL IMAGING; PHOSPHORYLATION; POLYSACCHARIDES; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM; SYNAPSES; TIME-LAPSE IMAGING;

EID: 85017027292     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.028     Document Type: Article

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