Dual role of IL-21 in megakaryopoiesis and platelet homeostasis

Haematologica

Volumn 102, Issue 4, 2017, Pages 637-646

  Benbarche, Salima ^a   Strassel, Catherine ^a   Angénieux, Catherine ^a   Mallo, Léa ^a   Freund, Monique ^a   Gachet, Christian ^a   Lanza, François ^a   de la Salle, Henri ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; CD34 ANTIGEN; FIBRINOGEN RECEPTOR; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 21 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE 3; STAT3 PROTEIN; TOFACITINIB; INTERLEUKIN 21; INTERLEUKIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; DOWN REGULATION; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS; TRANSIENT TRANSFECTION; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENETICS; HOMEOSTASIS; MEGAKARYOBLAST; METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION; HOMEOSTASIS; HUMANS; INTERLEUKINS; JANUS KINASE 3; MEGAKARYOCYTE PROGENITOR CELLS; MEGAKARYOCYTES; MICE; PHENOTYPE; RECEPTORS, INTERLEUKIN-21; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; THROMBOPOIESIS;

EID: 85017021271     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2016.143958     Document Type: Article

References (35)

1. Cortin V, Garnier A, Pineault N, Lemieux R, Boyer L, Proulx C. Efficient in vitro megakaryocyte maturation using cytokine cocktails optimized by statistical experimental design. Exp Hematol. 2005; 33(10):1182-1191.
2. Dan K, Gomi S, Inokuchi K, et al. Effects of interleukin-1 and tumor necrosis factor on megakaryocytopoiesis: mechanism of reactive thrombocytosis. Acta Haematol. 1995; 93(2-4):67-72.
3. Lotem J, Shabo Y, Sachs L. Regulation of megakaryocyte development by interleukin-6. Blood. 1989;74(5):1545-1551.
4. Catani L, Amabile M, Luatti S, et al. Interleukin-4 downregulates nuclear factor-erythroid 2 (NF-E2) expression in primary megakaryocytes and in megakaryoblastic cell lines. Stem Cells. 2001;19(4):339-347.
5. Mitjavila MT, Vinci G, Villeval JL, et al. Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta). J Cell Physiol. 1988;134(1):93-100.
6. Sosman JA, Verma A, Moss S, et al. Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production. Br J Haematol. 2000;111(1):104-111.
7. Griesshammer M, Bangerter M, Sauer T, Wennauer R, Bergmann L, Heimpel H. Aetiology and clinical significance of thrombocytosis: analysis of 732 patients with an elevated platelet count. J Intern Med. 1999;245(3):295-300.
8. Kaser A, Brandacher G, Steurer W, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood. 2001; 98(9): 2720-2725.
9. Nishimura S, Nagasaki M, Kunishima S, et al. IL-1alpha induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015;209(3):453-466.
10. Ferrari F, Bortoluzzi S, Coppe A, et al. Genomic expression during human myelopoiesis. BMC Genomics. 2007;8:264.
11. Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov. 2014;13(5):379-395.
12. Hodge LS, Ziesmer SC, Yang ZZ, et al. IL-21 in the BM microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood. 2012; 120(18):3774-3782.
13. Yu H, Zhang J, Fu R, et al. Increased frequency of BM T follicular helper cells in patients with immune-related pancytopenia. Clin Dev Immunol. 2013;2013:730450.
14. Chen CI, Zhang L, Datta SK. Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the BM of normal and lupus mice. Clin Immunol. 2016;162:9-26.
15. Suda T, Liu D. Hydrodynamic gene delivery: its principles and applications. Mol Ther. 2007;15(12):2063-2069.
16. Sun S, Wang W, Latchman Y, Gao D, Aronow B, Reems JA. Expression of plasma membrane receptor genes during megakaryocyte development. Physiol Genomics. 2013;45(6):217-227.
17. Miyakawa Y, Oda A, Druker BJ, et al. Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood. 1996;87(2):439-446.
18. Zhu M, Pleasic-Williams S, Lin TH, Wunderlich DA, Cheng JB, Masferrer JL. pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood. J Transl Med. 2013;11:65.
19. Sui X, Tsuji K, Ebihara Y, et al. Soluble interleukin-6 (IL-6) receptor with IL-6 stimulates megakaryopoiesis from human CD34(+) cells through glycoprotein (gp)130 signaling. Blood. 1999;93(8):2525-2532.
20. Ng AP, Kauppi M, Metcalf D, Di Rago L, Hyland CD, Alexander WS. Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse BM with in vivo megakaryocyte and erythroid potential. Proc Natl Acad Sci USA. 2012;109(7):2364-2369.
21. Penny R, Rozenberg MC, Firkin BG. The splenic platelet pool. Blood. 1966;27(1):1-16.
22. Tomer A. Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood. 2004; 104(9):2722-2727.
23. Bacon CM, Tortolani PJ, Shimosaka A, Rees RC, Longo DL, O’Shea JJ. Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett. 1995;370(1-2):63-68.
24. Drachman JG, Kaushansky K. Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc Natl Acad Sci USA. 1997;94(6):2350-2355.
25. Majka M, Ratajczak J, Villaire G, et al. Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets. Exp Hematol. 2002;30(7):751-760.
26. Kirito K, Osawa M, Morita H, et al. A functional role of Stat3 in in vivo megakaryopoiesis. Blood. 2002;99(9):3220-3227.
27. Jenkins BJ, Roberts AW, Greenhill CJ, et al. Pathologic consequences of STAT3 hyperac- tivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. 2007;109(6):2380-2388.
28. Kotlarz D, Zietara N, Uzel G, et al. Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med. 2013;210(3):433-443.
29. Salzer E, Kansu A, Sic H, et al. Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency. J Allergy Clin Immunol. 2014;133(6):1651-1659 e1612.
30. Wang G, Tschoi M, Spolski R, et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 2003; 63(24):9016-9022.
31. Waggie KS, Holdren MS, Byrnes-Blake K, et al. Preclinical safety, pharmacokinetics, and pharmacodynamics of recombinant human interleukin-21 in cynomolgus macaques (Macaca fascicularis). Int J Toxicol. 2012; 31(4):303-316.
32. Tsang AP, Fujiwara Y, Hom DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998;12(8):1176-1188.
33. Ozaki K, Hishiya A, Hatanaka K, et al. Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol. 2006;84(3):224-230.
34. Grozovsky R, Hoffmeister KM, Falet H. Novel clearance mechanisms of platelets. Curr Opin Hematol. 2010;17(6):585-589.
35. Hashmi MH, Van Veldhuizen PJ. Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin’s lymphoma. Expert Opin Biol Ther. 2010; 10(5):807-817.