Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues

Oral Diseases

Volumn 23, Issue 8, 2017, Pages 1052-1057

  Javed, F ^a   Kellesarian, S V ^a   Sundar, I K ^b   Romanos, G E ^c,d   Rahman, I ^b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

e cigarettes; fibrosis; inflammation, lung; oxidative stress; periodontium

Indexed keywords

ALDEHYDE; CARBONYL DERIVATIVE; NICOTINE; REACTIVE OXYGEN METABOLITE;

AEROSOL; AIRWAY REMODELING; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA DAMAGE; ELECTRONIC CIGARETTE; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; IN VITRO STUDY; INFLAMMATION; INNATE IMMUNITY; LUNG PARENCHYMA; MOUTH DISEASE; MYOFIBROBLAST; OXIDATIVE STRESS; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTIUM; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RESPIRATORY SYSTEM; REVIEW; TOOTH TISSUE; WOUND HEALING; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECT; INHALATIONAL DRUG ADMINISTRATION; PHARMACOLOGY;

ADMINISTRATION, INHALATION; AEROSOLS; AIRWAY REMODELING; ANIMALS; CELLULAR SENESCENCE; DNA DAMAGE; ELECTRONIC NICOTINE DELIVERY SYSTEMS; HUMANS; NICOTINE; ORAL SUBMUCOUS FIBROSIS; OXIDATIVE STRESS; PERIODONTAL DISEASES; RESPIRATORY SYSTEM;

EID: 85016995327     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/odi.12652     Document Type: Review

References (70)

1. Al Amri MD, Kellesarian SV, Abduljabbar TS, Al-Rifaiy MQ, Al Baker AM, Al-Keraif AA (2017). Comparison of peri-implant soft tissue parameters and crestal bone loss around immediately-loaded and delayed loaded implants among smokers and nonsmokers: 5-year follow-up results. J Periodontol 88: 3–9.
2. Albandar JM, Brunelle JA, Kingman A (1999). Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 70: 13–29.
3. Ara T, Kurata K, Hirai K et al (2009). Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J Periodontal Res 44: 21–27.
4. Baltacioglu E, Akalin FA, Alver A, Deger O, Karabulut E (2008). Protein carbonyl levels in serum and gingival crevicular fluid in patients with chronic periodontitis. Arch Oral Biol 53: 716–722.
5. Barrington-Trimis JL, Samet JM, McConnell R (2014). Flavorings in electronic cigarettes: an unrecognized respiratory health hazard? JAMA 312: 2493–2494.
6. Benowitz NL, Gourlay SG (1997). Cardiovascular toxicity of nicotine: implications for nicotine replacement therapy. J Am Coll Cardiol 29: 1422–1431.
7. Berley J, Yamano S, Sukotjo C (2010). The effect of systemic nicotine on osseointegration of titanium implants in the rat femur. J Oral Implantol 36: 185–193.
8. Brown LJ, Brunelle JA, Kingman A (1996). Periodontal status in the United States, 1988-1991: prevalence, extent, and demographic variation. J Dent Res 75: 672–683.
9. Cahn Z, Siegel M (2011). Electronic cigarettes as a harm reduction strategy for tobacco control: a step forward or a repeat of past mistakes? J Public Health Policy 32: 16–31.
10. Carlisle DL, Hopkins TM, Gaither-Davis A et al (2004). Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts. Respir Res 5: 27.
11. Cervellati F, Muresan XM, Sticozzi C et al (2014). Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol In Vitro 28: 999–1005.
12. Cesar-Neto JB, Benatti BB, Sallum EA, Casati MZ, Nociti FH Jr (2006). The influence of cigarette smoke inhalation and its cessation on the tooth-supporting alveolar bone: a histometric study in rats. J Periodontal Res 41: 118–123.
13. Chen EY, Sun A, Chen CS, Mintz AJ, Chin WC (2014). Nicotine alters mucin rheological properties. Am J Physiol Lung Cell Mol Physiol 307: L149–L157.
14. Cheng T (2014). Chemical evaluation of electronic cigarettes. Tob Control 23(Suppl 2): ii11–ii17.
15. Cobb NK, Abrams DB (2011). E-cigarette or drug-delivery device? Regulating novel nicotine products. N Engl J Med 365: 193–195.
16. Correa MG, Campos ML, Benatti BB et al (2010). The impact of cigarette smoke inhalation on the outcome of enamel matrix derivative treatment in rats: histometric analysis. J Periodontol 81: 1820–1828.
17. Flouris AD, Chorti MS, Poulianiti KP et al (2013). Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhalation Toxicol 25: 91–101.
18. Frazer-Abel AA, Baksh S, Fosmire SP et al (2004). Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 311: 758–769.
19. Fu XW, Wood K, Spindel ER (2011). Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol 44: 222–229.
20. Gao YJ, Ling TY, Yin XM, Li X, Huang Y (2007). [Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi =. Chin J Stomatol 42: 26–30.
21. Gerloff J, Sundar IK, Freter R et al (2017). Inflammatory response and barrier dysfunction by different e-cigarette flavoring chemicals identified by GC-MS in e-liquids and e-vapors on human lung epithelial cells and fibroblasts. Appl In Vitro Toxicol doi: 10.1089/aivt.2016.0030.
22. Giorgetti AP, Cesar Neto JB, Casati MZ, Sallum EA, Nociti Junior FH (2012). Cigarette smoke inhalation influences bone healing of post-extraction tooth socket: a histometric study in rats. Braz Dental J 23: 228–234.
23. Giovino GA, Mirza SA, Samet JM et al (2012). Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet 380: 668–679.
24. Girdler SS, Jamner LD, Jarvik M, Soles JR, Shapiro D (1997). Smoking status and nicotine administration differentially modify hemodynamic stress reactivity in men and women. Psychosom Med 59: 294–306.
25. Gundavarapu S, Wilder JA, Mishra NC et al (2012). Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol 130: 770–780 e11.
26. Hahn HL, Lang M, Bleicher S, Zwerenz S, Rausch C (1992). Nicotine-induced airway smooth muscle contraction: neural mechanisms involving the airway epithelium. Functional and histologic studies in vitro. Clin Investig 70: 252–262.
27. Hajishengallis G (2015). Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 15: 30–44.
28. Harrison R, Hicklin D Jr (2016). Electronic cigarette explosions involving the oral cavity. J Am Dent Assoc 147: 891–896.
29. Hasturk H, Kantarci A, Goguet-Surmenian E et al (2007). Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 179: 7021–7029.
30. Hogg JC, Chu F, Utokaparch S et al (2004). The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645–2653.
31. Holliday R, Kist R, Bauld L (2016). E-cigarette vapour is not inert and exposure can lead to cell damage. Evid Based Dent 17: 2–3.
32. Javed F, Bashir Ahmed H, Romanos GE (2014). Association between environmental tobacco smoke and periodontal disease: a systematic review. Environ Res 133: 117–122.
33. Jensen K, Nizamutdinov D, Guerrier M, Afroze S, Dostal D, Glaser S (2012). General mechanisms of nicotine-induced fibrogenesis. FASEB J 26: 4778–4787.
34. Jensen RP, Luo W, Pankow JF, Strongin RM, Peyton DH (2015). Hidden formaldehyde in E-cigarette aerosols. N Engl J Med 372: 392–394.
35. Ji W, Lim MN, Bak SH et al (2016). Differences in chronic obstructive pulmonary disease phenotypes between non-smokers and smokers. Clin Respir J doi: 10.1111/crj.12577.
36. Jorenby DE, Smith SS, Fiore MC, Baker TB (2016). Nicotine levels, withdrawal symptoms, and smoking reduction success in real world use: a comparison of cigarette smokers and dual users of both cigarettes and E-cigarettes. Drug Alcohol Depend 170: 93–101.
37. Kosmider L, Sobczak A, Fik M et al (2014). Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res 16: 1319–1326.
38. Krishnan-Sarin S, Morean ME, Camenga DR, Cavallo DA, Kong G (2015). E-cigarette use among high school and middle school adolescents in connecticut. Nicotine Tob Res 17: 810–818.
39. Lei W, Lerner C, Sundar IK, Rahman I (2017). Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III. Sci Rep 7: 43213.
40. Lerner CA, Sundar IK, Watson RM et al (2015a). Environmental health hazards of e-cigarettes and their components: oxidants and copper in e-cigarette aerosols. Environ Pollut 198: 100–107.
41. Lerner CA, Sundar IK, Yao H et al (2015b). Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10: e0116732.
42. Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I (2016). Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts. Biochem Biophys Res Commun 477: 620–625.
43. Levin L, Schwartz-Arad D (2005). The effect of cigarette smoking on dental implants and related surgery. Implant Dent 14: 357–361.
44. Li ZZ, Dai QY (2012). Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors. Mediators Inflamm 2012: 103120.
45. Lisko JG, Tran H, Stanfill SB, Blount BC, Watson CH (2015). Chemical composition and evaluation of nicotine, tobacco alkaloids, pH, and selected flavors in E-cigarette cartridges and refill solutions. Nicotine Tob Res 17: 1270–1278.
46. Liu B, Shen M, Xiong J et al (2015). Synergistic effects of betel quid chewing, tobacco use (in the form of cigarette smoking), and alcohol consumption on the risk of malignant transformation of oral submucous fibrosis (OSF): a case-control study in Hunan Province, China. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 120: 337–345.
47. McDonough JE, Yuan R, Suzuki M et al (2011). Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 365: 1567–1575.
48. Mustafa M, Zarrough A, Bolstad AI et al (2013). Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol 305: C673–C679.
49. Odusanwo O, Chinthamani S, McCall A, Duffey ME, Baker OJ (2012). Resolvin D1 prevents TNF-alpha-mediated disruption of salivary epithelial formation. Am J Physiol Cell Physiol 302: C1331–C1345.
50. Pisinger C, Dossing M (2014). A systematic review of health effects of electronic cigarettes. Prev Med 69C: 248–260.
51. Pradeep AR, Ramchandraprasad MV, Bajaj P, Rao NS, Agarwal E (2013). Protein carbonyl: an oxidative stress marker in gingival crevicular fluid in healthy, gingivitis, and chronic periodontitis subjects. Contemp Clin Dent 4: 27–31.
52. Raes S, Rocci A, Raes F, Cooper L, De Bruyn H, Cosyn J (2015). A prospective cohort study on the impact of smoking on soft tissue alterations around single implants. Clin Oral Implants Res 26: 1086–1090.
53. Regan AK, Promoff G, Dube SR, Arrazola R (2013). Electronic nicotine delivery systems: adult use and awareness of the ‘e-cigarette’ in the USA. Tob Control 22: 19–23.
54. Reibel J (2003). Tobacco and oral diseases. Update on the evidence, with recommendations. Med Princ Pract 12(Suppl 1): 22–32.
55. Rothem DE, Rothem L, Soudry M, Dahan A, Eliakim R (2009). Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. J Bone Miner Metab 27: 555–561.
56. Rouabhia M, Park HJ, Semlali A, Zakrzewski A, Chmielewski W, Chakir J (2016). E-cigarette vapor induces an apoptotic response in human gingival epithelial cells through the caspase-3 pathway. J Cell Physiol doi:10.1002/jcp.25677.
57. Ruhe M, Haller-Stevenson E, Roulston K, Jourdan M (2017). Strengthening the capacity of local health departments to reduce exposure to electronic nicotine delivery systems. J Public Health Manag Pract 23: 93–94.
58. Sancilio S, Gallorini M, Cataldi A, di Giacomo V (2015). Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts. Clin Oral Invest 20: 477–483.
59. Schweitzer KS, Chen SX, Law S et al (2015). Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol 309: L175–L187.
60. Sekhon HS, Keller JA, Proskocil BJ, Martin EL, Spindel ER (2002). Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol 26: 31–41.
61. Shimosato T, Geddawy A, Tawa M, Imamura T, Okamura T (2012). Chronic administration of nicotine-free cigarette smoke extract impaired endothelium-dependent vascular relaxation in rats via increased vascular oxidative stress. J Pharmacol Sci 118: 206–214.
62. Sundar IK, Javed F, Romanos GE, Rahman I (2016). E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget 7: 77196–77204.
63. Twito D, Sade P (2014). The effect of cigarette smoking habits on the outcome of dental implant treatment. PeerJ 2: e546.
64. Ullah M, Cox S, Kelly E, Moore MA, Zoellner H (2015). Arecoline increases basic fibroblast growth factor but reduces expression of IL-1, IL-6, G-CSF and GM-CSF in human umbilical vein endothelium. J Oral Pathol Med 44: 591–601.
65. Vardavas CI, Anagnostopoulos N, Kougias M, Evangelopoulou V, Connolly GN, Behrakis PK (2012). Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide. Chest 141: 1400–1406.
66. Varlet V, Farsalinos K, Augsburger M, Thomas A, Etter JF (2015). Toxicity assessment of refill liquids for electronic cigarettes. Int J Environ Res Public Health 12: 4796–4815.
67. Wilk JB, Shrine NR, Loehr LR et al (2012). Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med 186: 622–632.
68. Willershausen I, Wolf T, Weyer V, Sader R, Ghanaati S, Willershausen B (2014). Influence of E-smoking liquids on human periodontal ligament fibroblasts. Head Face Med 10: 39.
69. Wu Q, Jiang D, Minor M, Chu HW (2014). Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells. PLoS One 9: e108342.
70. Yamano S, Berley JA, Kuo WP, Gallucci GO, Weber HP, Sukotjo C (2010). Effects of nicotine on gene expression and osseointegration in rats. Clin Oral Implant Res 21: 1353–1359.