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Volumn 44, Issue 4, 2017, Pages 410-417

The effect of aging and mechanical loading on the metabolism of articular cartilage

Author keywords

AGE; BIOMECHANICS; CARTILAGE; CYTOKINES; OSTEOARTHRITIS

Indexed keywords

ADVANCED GLYCATION END PRODUCT; COLLAGEN; CYTOKINE;

EID: 85016976502     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.160226     Document Type: Review
Times cited : (110)

References (60)
  • 1
    • 79959341732 scopus 로고    scopus 로고
    • Osteoarthritis: An update with relevance for clinical practice
    • Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet 2011;377:2115-26.
    • (2011) Lancet , vol.377 , pp. 2115-2126
    • Bijlsma, J.W.1    Berenbaum, F.2    Lafeber, F.P.3
  • 2
    • 71449114734 scopus 로고    scopus 로고
    • Proteoglycans and more - From molecules to biology
    • Heinegard D. Proteoglycans and more - from molecules to biology. Int J Exp Pathol 2009;90:575-86.
    • (2009) Int J Exp Pathol , vol.90 , pp. 575-586
    • Heinegard, D.1
  • 3
    • 84868657138 scopus 로고    scopus 로고
    • Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
    • Goldring MB. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis 2012;4:269-85.
    • (2012) Ther Adv Musculoskelet Dis , vol.4 , pp. 269-285
    • Goldring, M.B.1
  • 4
    • 84873998045 scopus 로고    scopus 로고
    • Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains
    • Lee HY, Han L, Roughley PJ, Grodzinsky AJ, Ortiz C. Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. J Struct Biol 2013;181:264-73.
    • (2013) J Struct Biol , vol.181 , pp. 264-273
    • Lee, H.Y.1    Han, L.2    Roughley, P.J.3    Grodzinsky, A.J.4    Ortiz, C.5
  • 5
    • 0032519990 scopus 로고    scopus 로고
    • Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. the age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage
    • Bank RA, Bayliss MT, Lafeber FP, Maroudas A, Tekoppele JM. Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage. Biochem J 1998;330:345-51.
    • (1998) Biochem J , vol.330 , pp. 345-351
    • Bank, R.A.1    Bayliss, M.T.2    Lafeber, F.P.3    Maroudas, A.4    Tekoppele, J.M.5
  • 6
    • 33645869542 scopus 로고    scopus 로고
    • The effects of exercise on human articular cartilage
    • Eckstein F, Hudelmaier M, Putz R. The effects of exercise on human articular cartilage. J Anat 2006;208:491-512.
    • (2006) J Anat , vol.208 , pp. 491-512
    • Eckstein, F.1    Hudelmaier, M.2    Putz, R.3
  • 11
    • 0038753871 scopus 로고    scopus 로고
    • The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair
    • Martin JA, Buckwalter JA. The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am 2003;85-A Suppl 2:106-10.
    • (2003) J Bone Joint Surg Am , vol.85 A , pp. 106-110
    • Martin, J.A.1    Buckwalter, J.A.2
  • 12
    • 0036745073 scopus 로고    scopus 로고
    • Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1
    • Loeser RF, Carlson CS, Del Carlo M, Cole A. Detection of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum 2002;46:2349-57.
    • (2002) Arthritis Rheum , vol.46 , pp. 2349-2357
    • Loeser, R.F.1    Carlson, C.S.2    Del Carlo, M.3    Cole, A.4
  • 13
    • 9644301059 scopus 로고    scopus 로고
    • Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage
    • Bobacz K, Erlacher L, Smolen J, Soleiman A, Graninger WB. Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage. Ann Rheum Dis 2004;63:1618-22.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1618-1622
    • Bobacz, K.1    Erlacher, L.2    Smolen, J.3    Soleiman, A.4    Graninger, W.B.5
  • 14
    • 84857742047 scopus 로고    scopus 로고
    • Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
    • Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 2012;64:705-17.
    • (2012) Arthritis Rheum , vol.64 , pp. 705-717
    • Loeser, R.F.1    Olex, A.L.2    McNulty, M.A.3    Carlson, C.S.4    Callahan, M.F.5    Ferguson, C.M.6
  • 15
    • 0036164004 scopus 로고    scopus 로고
    • Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis
    • Verzijl N, DeGroot J, Ben ZC, Brau-Benjamin O, Maroudas A, Bank RA, et al. Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum 2002;46:114-23.
    • (2002) Arthritis Rheum , vol.46 , pp. 114-123
    • Verzijl, N.1    DeGroot, J.2    Ben, Z.C.3    Brau-Benjamin, O.4    Maroudas, A.5    Bank, R.A.6
  • 16
    • 0035157124 scopus 로고    scopus 로고
    • Age-related changes in the morphology and deformational behavior of knee joint cartilage
    • Hudelmaier M, Glaser C, Hohe J, Englmeier KH, Reiser M, Putz R, et al. Age-related changes in the morphology and deformational behavior of knee joint cartilage. Arthritis Rheum 2001;44:2556-61.
    • (2001) Arthritis Rheum , vol.44 , pp. 2556-2561
    • Hudelmaier, M.1    Glaser, C.2    Hohe, J.3    Englmeier, K.H.4    Reiser, M.5    Putz, R.6
  • 17
    • 84938063012 scopus 로고    scopus 로고
    • Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis
    • Kim JH, Lee G, Won Y, Lee M, Kwak JS, Chun CH, et al. Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis. Proc Natl Acad Sci U S A 2015;112:9424-9.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 9424-9429
    • Kim, J.H.1    Lee, G.2    Won, Y.3    Lee, M.4    Kwak, J.S.5    Chun, C.H.6
  • 18
    • 23644436200 scopus 로고    scopus 로고
    • Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
    • Loeser RF, Yammani RR, Carlson CS, Chen H, Cole A, Im HJ, et al. Articular chondrocytes express the receptor for advanced glycation end products: potential role in osteoarthritis. Arthritis Rheum 2005;52:2376-85.
    • (2005) Arthritis Rheum , vol.52 , pp. 2376-2385
    • Loeser, R.F.1    Yammani, R.R.2    Carlson, C.S.3    Chen, H.4    Cole, A.5    Im, H.J.6
  • 19
    • 0027017770 scopus 로고
    • Racemization of aspartic acid in human articular cartilage
    • Maroudas A, Palla G, Gilav E. Racemization of aspartic acid in human articular cartilage. Connect Tissue Res 1992;28:161-9.
    • (1992) Connect Tissue Res , vol.28 , pp. 161-169
    • Maroudas, A.1    Palla, G.2    Gilav, E.3
  • 21
    • 84865165620 scopus 로고    scopus 로고
    • MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover
    • Struglics A, Hansson M. MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover. Biochem J 2012;446:213-23.
    • (2012) Biochem J , vol.446 , pp. 213-223
    • Struglics, A.1    Hansson, M.2
  • 22
    • 84904818874 scopus 로고    scopus 로고
    • Metabolism of cartilage proteoglycans in health and disease
    • Vynios DH. Metabolism of cartilage proteoglycans in health and disease. Biomed Res Int 2014;2014:452315.
    • (2014) Biomed Res Int , vol.2014 , pp. 452315
    • Vynios, D.H.1
  • 23
    • 30544436016 scopus 로고    scopus 로고
    • A contentious issue finds some clarity: On the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis
    • Sandy JD. A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis. Osteoarthritis Cartilage 2006;14:95-100.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 95-100
    • Sandy, J.D.1
  • 24
    • 0030069604 scopus 로고    scopus 로고
    • Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage
    • Dudhia J, Davidson CM, Wells TM, Vynios DH, Hardingham TE, Bayliss MT. Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. Biochem J 1996;313:933-40.
    • (1996) Biochem J , vol.313 , pp. 933-940
    • Dudhia, J.1    Davidson, C.M.2    Wells, T.M.3    Vynios, D.H.4    Hardingham, T.E.5    Bayliss, M.T.6
  • 25
    • 18744437369 scopus 로고    scopus 로고
    • Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints
    • Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, et al. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 1997;100:93-106.
    • (1997) J Clin Invest , vol.100 , pp. 93-106
    • Lark, M.W.1    Bayne, E.K.2    Flanagan, J.3    Harper, C.F.4    Hoerrner, L.A.5    Hutchinson, N.I.6
  • 26
    • 0035159518 scopus 로고    scopus 로고
    • Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage
    • DeGroot J, Verzijl N, Jacobs KM, Budde M, Bank RA, Bijlsma JW, et al. Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage. Osteoarthritis Cartilage 2001;9:720-6.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 720-726
    • DeGroot, J.1    Verzijl, N.2    Jacobs, K.M.3    Budde, M.4    Bank, R.A.5    Bijlsma, J.W.6
  • 27
    • 0031857259 scopus 로고    scopus 로고
    • Aggrecan turnover in human articular cartilage: Use of aspartic acid racemization as a marker of molecular age
    • Maroudas A, Bayliss MT, Uchitel-Kaushansky N, Schneiderman R, Gilav E. Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 1998;350:61-71.
    • (1998) Arch Biochem Biophys , vol.350 , pp. 61-71
    • Maroudas, A.1    Bayliss, M.T.2    Uchitel-Kaushansky, N.3    Schneiderman, R.4    Gilav, E.5
  • 28
    • 0348111231 scopus 로고    scopus 로고
    • Longitudinal analysis of cartilage atrophy in the knees of patients with spinal cord injury
    • Vanwanseele B, Eckstein F, Knecht H, Spaepen A, Stussi E. Longitudinal analysis of cartilage atrophy in the knees of patients with spinal cord injury. Arthritis Rheum 2003;48:3377-81.
    • (2003) Arthritis Rheum , vol.48 , pp. 3377-3381
    • Vanwanseele, B.1    Eckstein, F.2    Knecht, H.3    Spaepen, A.4    Stussi, E.5
  • 30
    • 0033972310 scopus 로고    scopus 로고
    • Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization
    • Haapala J, Arokoski J, Pirttimaki J, Lyyra T, Jurvelin J, Tammi M, et al. Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization. Int J Sports Med 2000;21:76-81.
    • (2000) Int J Sports Med , vol.21 , pp. 76-81
    • Haapala, J.1    Arokoski, J.2    Pirttimaki, J.3    Lyyra, T.4    Jurvelin, J.5    Tammi, M.6
  • 32
    • 24644452139 scopus 로고    scopus 로고
    • Strain-controlled enzymatic cleavage of collagen in loaded matrix
    • Ruberti JW, Hallab NJ. Strain-controlled enzymatic cleavage of collagen in loaded matrix. Biochem Biophys Res Commun 2005;336:483-9.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 483-489
    • Ruberti, J.W.1    Hallab, N.J.2
  • 33
    • 79251578611 scopus 로고    scopus 로고
    • Physiological loading of joints prevents cartilage degradation through CITED2
    • Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, et al. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J 2011;25:182-91.
    • (2011) FASEB J , vol.25 , pp. 182-191
    • Leong, D.J.1    Li, Y.H.2    Gu, X.I.3    Sun, L.4    Zhou, Z.5    Nasser, P.6
  • 34
    • 77954459789 scopus 로고    scopus 로고
    • Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion
    • Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, et al. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol 2010;29:420-6.
    • (2010) Matrix Biol , vol.29 , pp. 420-426
    • Leong, D.J.1    Gu, X.I.2    Li, Y.3    Lee, J.Y.4    Laudier, D.M.5    Majeska, R.J.6
  • 35
    • 84952881581 scopus 로고    scopus 로고
    • Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes
    • He Z, Leong DJ, Zhuo Z, Majeska RJ, Cardoso L, Spray DC, et al. Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes. Osteoarthritis Cartilage 2016;24:892-901.
    • (2016) Osteoarthritis Cartilage , vol.24 , pp. 892-901
    • He, Z.1    Leong, D.J.2    Zhuo, Z.3    Majeska, R.J.4    Cardoso, L.5    Spray, D.C.6
  • 38
    • 77953799146 scopus 로고    scopus 로고
    • Effects of exercise intervention on knee morphology in middle-aged women: A longitudinal analysis using magnetic resonance imaging
    • Cotofana S, Ring-Dimitriou S, Hudelmaier M, Himmer M, Wirth W, Sanger AM, et al. Effects of exercise intervention on knee morphology in middle-aged women: a longitudinal analysis using magnetic resonance imaging. Cells Tissues Organs 2010;192:64-72.
    • (2010) Cells Tissues Organs , vol.192 , pp. 64-72
    • Cotofana, S.1    Ring-Dimitriou, S.2    Hudelmaier, M.3    Himmer, M.4    Wirth, W.5    Sanger, A.M.6
  • 39
    • 78649698398 scopus 로고    scopus 로고
    • Functional adaptation of knee cartilage in asymptomatic female novice runners compared to sedentary controls. A longitudinal analysis using delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)
    • Van Ginckel A, Baelde N, Almqvist KF, Roosen P, McNair P, Witvrouw E. Functional adaptation of knee cartilage in asymptomatic female novice runners compared to sedentary controls. A longitudinal analysis using delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC). Osteoarthritis Cartilage 2010;18:1564-9.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 1564-1569
    • Van Ginckel, A.1    Baelde, N.2    Almqvist, K.F.3    Roosen, P.4    McNair, P.5    Witvrouw, E.6
  • 40
    • 13244252640 scopus 로고    scopus 로고
    • In vivo cartilage deformation after different types of activity and its dependence on physical training status
    • Eckstein F, Lemberger B, Gratzke C, Hudelmaier M, Glaser C, Englmeier KH, et al. In vivo cartilage deformation after different types of activity and its dependence on physical training status. Ann Rheum Dis 2005;64:291-5.
    • (2005) Ann Rheum Dis , vol.64 , pp. 291-295
    • Eckstein, F.1    Lemberger, B.2    Gratzke, C.3    Hudelmaier, M.4    Glaser, C.5    Englmeier, K.H.6
  • 41
    • 34447550737 scopus 로고    scopus 로고
    • Knee cartilage morphologic characteristics and muscle status of professional weight lifters and sprinters: A magnetic resonance imaging study
    • Gratzke C, Hudelmaier M, Hitzl W, Glaser C, Eckstein F. Knee cartilage morphologic characteristics and muscle status of professional weight lifters and sprinters: a magnetic resonance imaging study. Am J Sports Med 2007;35:1346-53.
    • (2007) Am J Sports Med , vol.35 , pp. 1346-1353
    • Gratzke, C.1    Hudelmaier, M.2    Hitzl, W.3    Glaser, C.4    Eckstein, F.5
  • 43
    • 84890944411 scopus 로고    scopus 로고
    • Effects of high-impact training on bone and articular cartilage: 12-month randomized controlled quantitative MRI study
    • Multanen J, Nieminen MT, Hakkinen A, Kujala UM, Jamsa T, Kautiainen H, et al. Effects of high-impact training on bone and articular cartilage: 12-month randomized controlled quantitative MRI study. J Bone Miner Res 2014;29:192-201.
    • (2014) J Bone Miner Res , vol.29 , pp. 192-201
    • Multanen, J.1    Nieminen, M.T.2    Hakkinen, A.3    Kujala, U.M.4    Jamsa, T.5    Kautiainen, H.6
  • 44
    • 0023639253 scopus 로고
    • Chondrons in cartilage: Ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages
    • Poole CA, Flint MH, Beaumont BW. Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages. J Orthop Res 1987;5:509-22.
    • (1987) J Orthop Res , vol.5 , pp. 509-522
    • Poole, C.A.1    Flint, M.H.2    Beaumont, B.W.3
  • 45
    • 34249987876 scopus 로고    scopus 로고
    • FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer
    • Vincent TL, McLean CJ, Full LE, Peston D, Saklatvala J. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage 2007;15:752-63.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 752-763
    • Vincent, T.L.1    McLean, C.J.2    Full, L.E.3    Peston, D.4    Saklatvala, J.5
  • 46
    • 0033526051 scopus 로고    scopus 로고
    • Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes
    • Millward-Sadler SJ, Wright MO, Lee H, Nishida K, Caldwell H, Nuki G, et al. Integrin-regulated secretion of interleukin 4: a novel pathway of mechanotransduction in human articular chondrocytes. J Cell Biol 1999;145:183-9.
    • (1999) J Cell Biol , vol.145 , pp. 183-189
    • Millward-Sadler, S.J.1    Wright, M.O.2    Lee, H.3    Nishida, K.4    Caldwell, H.5    Nuki, G.6
  • 47
    • 84908378136 scopus 로고    scopus 로고
    • Integrins and chondrocyte-matrix interactions in articular cartilage
    • Loeser RF. Integrins and chondrocyte-matrix interactions in articular cartilage. Matrix Biol 2014;39:11-6.
    • (2014) Matrix Biol , vol.39 , pp. 11-16
    • Loeser, R.F.1
  • 48
    • 0033711025 scopus 로고    scopus 로고
    • Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes
    • Millward-Sadler SJ, Wright MO, Davies LW, Nuki G, Salter DM. Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum 2000;43:2091-9.
    • (2000) Arthritis Rheum , vol.43 , pp. 2091-2099
    • Millward-Sadler, S.J.1    Wright, M.O.2    Davies, L.W.3    Nuki, G.4    Salter, D.M.5
  • 50
    • 77954073360 scopus 로고    scopus 로고
    • Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: A randomized controlled trial
    • Helmark IC, Mikkelsen UR, Borglum J, Rothe A, Petersen MC, Andersen O, et al. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther 2010;12:R126.
    • (2010) Arthritis Res Ther , vol.12 , pp. R126
    • Helmark, I.C.1    Mikkelsen, U.R.2    Borglum, J.3    Rothe, A.4    Petersen, M.C.5    Andersen, O.6
  • 52
    • 84878577507 scopus 로고    scopus 로고
    • The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis
    • Musumeci G, Loreto C, Leonardi R, Castorina S, Giunta S, Carnazza ML, et al. The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis. J Bone Miner Metab 2013;31:274-84.
    • (2013) J Bone Miner Metab , vol.31 , pp. 274-284
    • Musumeci, G.1    Loreto, C.2    Leonardi, R.3    Castorina, S.4    Giunta, S.5    Carnazza, M.L.6
  • 53
    • 84959421625 scopus 로고    scopus 로고
    • A novel method to simulate the progression of collagen degeneration of cartilage in the knee: Data from the Osteoarthritis Initiative
    • Mononen ME, Tanska P, Isaksson H, Korhonen RK. A novel method to simulate the progression of collagen degeneration of cartilage in the knee: data from the Osteoarthritis Initiative. Sci Rep 2016;6:21415.
    • (2016) Sci Rep , vol.6 , pp. 21415
    • Mononen, M.E.1    Tanska, P.2    Isaksson, H.3    Korhonen, R.K.4
  • 54
    • 84946841367 scopus 로고    scopus 로고
    • Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes
    • Hwang HS, Park SJ, Cheon EJ, Lee MH, Kim HA. Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes. Arthritis Res Ther 2015;17:320.
    • (2015) Arthritis Res Ther , vol.17 , pp. 320
    • Hwang, H.S.1    Park, S.J.2    Cheon, E.J.3    Lee, M.H.4    Kim, H.A.5
  • 55
    • 33745879478 scopus 로고    scopus 로고
    • The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes
    • Kim HA, Cho ML, Choi HY, Yoon CS, Jhun JY, Oh HJ, et al. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum 2006;54:2152-63.
    • (2006) Arthritis Rheum , vol.54 , pp. 2152-2163
    • Kim, H.A.1    Cho, M.L.2    Choi, H.Y.3    Yoon, C.S.4    Jhun, J.Y.5    Oh, H.J.6
  • 56
    • 84954158026 scopus 로고    scopus 로고
    • Lubricin/proteoglycan 4 binds to and regulates the activity of toll-like receptors in vitro
    • Iqbal SM, Leonard C, Regmi SC, De Rantere D, Tailor P, Ren G, et al. Lubricin/proteoglycan 4 binds to and regulates the activity of toll-like receptors in vitro. Sci Rep 2016;6:18910.
    • (2016) Sci Rep , vol.6 , pp. 18910
    • Iqbal, S.M.1    Leonard, C.2    Regmi, S.C.3    De Rantere, D.4    Tailor, P.5    Ren, G.6
  • 58
    • 0036282863 scopus 로고    scopus 로고
    • Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation
    • Salter DM, Millward-Sadler SJ, Nuki G, Wright MO. Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation. Biorheology 2002;39:97-108.
    • (2002) Biorheology , vol.39 , pp. 97-108
    • Salter, D.M.1    Millward-Sadler, S.J.2    Nuki, G.3    Wright, M.O.4
  • 59
    • 84868649296 scopus 로고    scopus 로고
    • Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis
    • Goldring SR. Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis 2012;4:249-58.
    • (2012) Ther Adv Musculoskelet Dis , vol.4 , pp. 249-258
    • Goldring, S.R.1
  • 60
    • 84973307572 scopus 로고    scopus 로고
    • Which is the best physical treatment for osteoarthritis?
    • Castrogiovanni P, Musumeci G. Which is the best physical treatment for osteoarthritis? J Funct Morphol Kinesiol 2016;1:54-68.
    • (2016) J Funct Morphol Kinesiol , vol.1 , pp. 54-68
    • Castrogiovanni, P.1    Musumeci, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.