Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes

Osteoarthritis and Cartilage

Volumn 24, Issue 5, 2016, Pages 892-901

  He, Z ^a   Leong, D J ^a   Zhuo, Z ^a,b   Majeska, R J ^c   Cardoso, L ^c   Spray, D C ^a   Goldring, M B ^d   Cobelli, N J ^a   Sun, H B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^c City College of New York   (United States)

^d HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Chondrocyte mechanotransduction; Cyclic tensile strain; Primary cilia

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARRIER PROTEIN; COLLAGENASE 3; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERSTITIAL COLLAGENASE; INTRAFLAGELLAR TRANSPORT PROTEIN 88; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PURINERGIC P2 RECEPTOR; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; CITED2 PROTEIN, HUMAN; CITED2 PROTEIN, MOUSE; MMP1 PROTEIN, HUMAN; MMP13 PROTEIN, HUMAN; MMP13 PROTEIN, MOUSE; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CALCIUM SIGNALING; CARTILAGE CELL; CASE REPORT; CITED2 GENE; CONTROLLED STUDY; DOWN REGULATION; EUKARYOTIC FLAGELLUM; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MALE; MECHANOTRANSDUCTION; MIDDLE AGED; MOUSE; MUTANT; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS RESPONSE ELEMENT; TRANSACTIVATION; TRANSCRIPTION REGULATION; TREADMILL EXERCISE; UPREGULATION; WESTERN BLOTTING; WILD TYPE; YOUNG ADULT; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHONDROCYTE; CILIUM; CYTOLOGY; EXERCISE; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM SIGNALING; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; CILIA; DOWN-REGULATION; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MECHANOTRANSDUCTION, CELLULAR; MICE, INBRED C57BL; PHYSICAL EXERTION; REPRESSOR PROTEINS; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84952881581     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.11.015     Document Type: Article

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