Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes

Arthritis Research and Therapy

Volumn 17, Issue 1, 2015, Pages

  Hwang, Hyun Sook ^a,b   Park, Su Jin ^a   Cheon, Eun Jeong ^a,b   Lee, Mi Hyun ^a,b   Kim, Hyun Ah ^a,b  

^a Hallym University Sacred Heart Hospital   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Chondrocyte; Fibronectin fragment; MyD88; Osteoarthritis; TLR 2

Indexed keywords

COLLAGENASE 3; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN C JUN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; MYD88 PROTEIN, HUMAN; PEPTIDE FRAGMENT; TLR2 PROTEIN, HUMAN;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CELL VIABILITY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIAL FLUID; AGED; BIOSYNTHESIS; CELL CULTURE; CHONDROCYTE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SIGNAL TRANSDUCTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; CHONDROCYTES; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE FRAGMENTS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

EID: 84946841367     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0833-9     Document Type: Article

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