Metabolism of cartilage proteoglycans in health and disease

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Vynios, Demitrios H ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS1 PROTEIN; AGGRECAN; ASPARAGINE LINKED OLIGOSACCHARIDE; CHONDROITIN; CORE PROTEIN; GLYCOSAMINOGLYCAN; OLIGOSACCHARIDE; PROTEOGLYCAN; HYDROLASE;

CARTILAGE; DISEASES; HEALTH; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN STRUCTURE; REVIEW; ARTHROPATHY; GOLGI COMPLEX; HUMAN; LYSOSOME; METABOLISM; PATHOLOGY;

CARTILAGE; GLYCOSAMINOGLYCANS; GOLGI APPARATUS; HUMANS; HYDROLASES; JOINT DISEASES; LYSOSOMES; PROTEOGLYCANS;

EID: 84904818874     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/452315     Document Type: Review

References (63)

1. Hardingham T. E., Fosang A. J., Proteoglycans: many forms and many functions. The FASEB Journal 1992 6 3 861 870 2-s2.0-0026507880
2. Iozzo R. V., Matrix proteoglycans: from molecular design to cellular function. Annual Review of Biochemistry 1998 67 609 652 10.1146/annurev.biochem. 67.1.609 2-s2.0-0031657808 (Pubitemid 28411140)
3. Schwartz N. B., Domowicz M., Chondrodysplasias due to proteoglycan defects. Glycobiology 2002 12 4 57R 68R 2-s2.0-0036019912 (Pubitemid 34760067)
4. Lord M. S., Whitelock J. M., Recombinant production of proteoglycans and their bioactive domains. The FEBS Journal 2013 280 10 2490 2510 10.1111/febs.12197 2-s2.0-84877697421
5. Sajdera S. W., Hascall V. C., Proteinpolysaccharide complex from bovine nasal cartilage. A comparison of low and high shear extraction procedures. Journal of Biological Chemistry 1969 244 1 77 87 2-s2.0-0014669293
6. Aspberg A., The different roles of aggrecan interaction domains. Journal of Histochemistry and Cytochemistry 2012 60 12 987 996 10.1369/0022155412464376 2-s2.0-84873030415
7. Buraschi S., Neill T., Goyal A., Poluzzi C., Smythies J., Owens R. T., Schaefer L., Torres A., Iozzo R. V., Decorin causes autophagy in endothelial cells via Peg3. Proceedings of the National Academy of Sciences of the United States of America 2013 110 28 E2582 E2591 10.1073/pnas.1305732110 2-s2.0-84879905523
8. Neufeld E. F., Muenzer J., Scriver C. R., Beaudet A. L., Sly W. S., Valle D., The mucopolysaccharidoses. The Metabolic and Molecular Bases of Inherited Disease 2001 8th New York, NY, USA McGraw Hill 3421 3452
9. Neill T., Schaefer L., Iozzo R. V., Decorin: a guardian from the matrix. The American Journal of Pathology 2012 181 2 380 387 10.1016/j.ajpath.2012.04. 029 2-s2.0-84864138010
10. Nastase M. V., Young M. F., Schaefer L., Biglycan: a multivalent proteoglycan providing structure and signals. Journal of Histochemistry and Cytochemistry 2012 60 12 963 975 10.1369/0022155412456380 2-s2.0-84873028647
11. Brew C. J., Clegg P. D., Boot-Handford R. P., Andrew J. G., Hardingham T., Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy. Annals of the Rheumatic Diseases 2010 69 1 234 240 10.1136/ard.2008.097139 2-s2.0-73449143498
12. Stevens J. W., Swarm chondrosarcoma: a continued resource for chondroblastic-like extracellular matrix and chondrosarcoma biology research. Connective Tissue Research 2013 54 4-5 252 259 10.3109/03008207.2013.806913
13. Stylianou M., Skandalis S. S., Papadas T. A., Mastronikolis N. S., Theocharis D. A., Papageorgakopoulou N., Vynios D. H., Stage-related decorin and versican expression in human laryngeal cancer. Anticancer Research A 2008 28 1 245 252 2-s2.0-40549095277 (Pubitemid 351362908)
14. Varki A., Cummings R. D., Esko J. D., Essentials of Glycobiology 2009 2nd New York, NY, USA Cold Spring Harbor
15. Mikami T., Kitagawa H., Biosynthesis and function of chondroitin sulfate. Biochimica et Biophysica Acta 2013 1830 10 4719 4733 10.1016/j.bbagen.2013.06. 006 2-s2.0-84879814568
16. Kitagawa H., Uyama T., Sugahara K., Molecular cloning and expression of a human chondroitin synthase. The Journal of Biological Chemistry 2001 276 42 38721 38726 10.1074/jbc.M106871200 2-s2.0-0035914310
17. Kitagawa H., Izumikawa T., Uyama T., Sugahara K., Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. Journal of Biological Chemistry 2003 278 26 23666 23671 10.1074/jbc.M302493200 2-s2.0-0037478786 (Pubitemid 36833253)
18. Izumikawa T., Uyama T., Okuura Y., Sugahara K., Kitagawa H., Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. Biochemical Journal 2007 403 3 545 552 10.1042/BJ20061876 2-s2.0-34247880268 (Pubitemid 46706983)
19. Izumikawa T., Koike T., Shiozawa S., Sugahara K., Tamura J., Kitagawa H., Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. The Journal of Biological Chemistry 2008 283 17 11396 11406 10.1074/jbc.M707549200 2-s2.0-45549097559
20. Yada T., Gotoh M., Sato T., Shionyu M., Go M., Kaseyama H., Iwasaki H., Kikuchi N., Kwon Y., Togayachi A., Kudo T., Watanabe H., Narimatsu H., Kimata K., Chondroitin sulfate synthase-2: molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. Journal of Biological Chemistry 2003 278 32 30235 30247 10.1074/jbc.M303657200 2-s2.0-0043031425 (Pubitemid 36962418)
21. Yamauchi S., Mita S., Matsubara T., Fukuta M., Habuchi H., Kimata K., Habuchi O., Molecular cloning and expression of chondroitin 4-sulfotransferase. Journal of Biological Chemistry 2000 275 12 8975 8981 10.1074/jbc.275.12.8975 2-s2.0-0034708441 (Pubitemid 30180256)
22. Hiraoka N., Nakagawa H., Ong E., Akama T. O., Fukuda M. N., Molecular cloning and expression of two distinct human chondroitin 4- O -sulfotransferases that belong to the HNK-1 sulfotransferase gene family. Journal of Biological Chemistry 2000 275 26 20188 20196 10.1074/jbc.M002443200 2-s2.0-0034733751 (Pubitemid 30441630)
23. Kang H. G., Evers M. R., Xia G., Baenziger J. U., Schachner M., Molecular cloning and characterization of chondroitin-4- O -sulfotransferase-3: a novel member of the HNK-1 family of sulfotransferases. The Journal of Biological Chemistry 2002 277 38 34766 34772 10.1074/jbc.M204907200 2-s2.0-0037144482
24. Evers M. R., Xia G., Kang H. G., Schachner M., Baenziger J. U., Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4- O -sulfotransferase. Journal of Biological Chemistry 2001 276 39 36344 36353 10.1074/jbc.M105848200 2-s2.0-0035965285
25. Mikami T., Mizumoto S., Kago N., Kitagawa H., Sugahara K., Specificities of three distinct human chondroitin/dermatan N -acetylgalactosamine 4- O -sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis. The Journal of Biological Chemistry 2003 278 38 36115 36127 10.1074/jbc.M306044200 2-s2.0-0141481032 (Pubitemid 37139933)
26. Fukuta M., Kobayashi Y., Uchimura K., Kimata K., Habuchi O., Molecular cloning and expression of human chondroitin 6-sulfotransferase. Biochimica et Biophysica Acta-Gene Structure and Expression 1998 1399 1 57 61 10.1016/S0167-4781(98)00089-X 2-s2.0-0032581681 (Pubitemid 28374916)
27. Mitchell D., Hardingham T., The control of chondroitin sulphate biosynthesis and its influence on the structure of cartilage proteoglycans. Biochemical Journal 1982 202 2 387 395 2-s2.0-0020066064 (Pubitemid 12103842)
28. Izumikawa T., Koike T., Kitagawa H., Chondroitin 4- O -sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1. Biochemical Journal 2012 441 2 697 705 10.1042/BJ20111472 2-s2.0-84555195550
29. Izumikawa T., Okuura Y., Koike T., Sakoda N., Kitagawa H., Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Biochemical Journal 2011 434 2 321 331 10.1042/BJ20101456 2-s2.0-79951535271
30. Burditt L. J., Ratcliffe A., Fryer P. R., Hardingham T. E., The intracellular localisation of proteoglycans and their accumulation in chondrocytes treated with monensin. Biochimica et Biophysica Acta: Molecular Cell Research 1985 844 2 247 255 10.1016/0167-4889(85)90097-7 2-s2.0-0021975926 (Pubitemid 15137298)
31. Kresse H., Glössl J., Hoppe W., Rauch U., Quentin E., Biosynthesis and processing of proteodermatan sulphate. Ciba Foundation Symposium Series 1986 124 89 103 2-s2.0-0022827130
32. Wilson D. G., Phamluong K., Lin W. Y., Barck K., Carano R. A. D., Diehl L., Peterson A. S., Martin F., Solloway M. J., Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Developmental Biology 2012 363 2 413 425 10.1016/j.ydbio.2012.01.005 2-s2.0-84857108384
33. Ogawa H., Hatano S., Sugiura N., Nagai N., Sato T., Shimizu K., Kimata K., Narimatsu H., Watanabe H., Chondroitin sulfate synthase-2 Is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS ONE 2012 7 8 e43806 10.1371/journal.pone.0043806 2-s2.0-84865458797
34. Watanabe Y., Takeuchi K., Higa Onaga S., Sato M., Tsujita M., Abe M., Natsume R., Li M., Furuichi T., Saeki M., Izumikawa T., Hasegawa A., Yokoyama M., Ikegawa S., Sakimura K., Amizuka N., Kitagawa H., Igarashi M., Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochemical Journal 2010 432 1 47 55 10.1042/BJ20100847 2-s2.0-78649745551
35. Sato T., Kudo T., Ikehara Y., Ogawa H., Hirano T., Kiyohara K., Hagiwara K., Togayachi A., Ema M., Takahashi S., Kimata K., Watanabe H., Narimatsu H., Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. The Journal of Biological Chemistry 2011 286 7 5803 5812 10.1074/jbc.M110.159244 2-s2.0-79953133504
36. Li Y., Laue K., Temtamy S., Aglan M., Kotan L. D., Yigit G., Canan H., Pawlik B., Nürnberg G., Wakeling E. L., Quarrell O. W., Baessmann I., Lanktree M. B., Yilmaz M., Hegele R. A., Amr K., May K. W., Nürnberg P., Topaloglu A. K., Hammerschmidt M., Wollnik B., Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling. The American Journal of Human Genetics 2010 87 6 757 767 10.1016/j.ajhg.2010.10.003 2-s2.0-78649764733
37. Tian J., Ling L., Shboul M., Lee H., O'Connor B., Merriman B., Nelson S. F., Cool S., Ababneh O. H., Al-Hadidy A., Masri A., Hamamy H., Reversade B., Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. The American Journal of Human Genetics 2010 87 6 768 778 10.1016/j.ajhg.2010.11.005 2-s2.0-78649800686
38. Kalathas D., Triantaphyllidou I. E., Mastronikolis N. S., Goumas P. D., Papadas T. A., Tsiropoulos G., Vynios D. H., The chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: Expressional and epigenetic studies. Head and Neck Oncology 2010 2 1, article no. 27 10.1186/1758-3284-2-27 2-s2.0-77957332442
39. Funderburgh J. L., Keratan sulfate biosynthesis. IUBMB Life 2002 54 4 187 194 10.1080/15216540214932 2-s2.0-0036818333 (Pubitemid 36008327)
40. Barry F. P., Rosenberg L. C., Gaw J. U., Koob T. J., Neame P. J., N-and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage. The Journal of Biological Chemistry 1995 270 35 20516 20524 10.1074/jbc.270.35.20516 2-s2.0-0028982223
41. Platt D., Bird J. L., Bayliss M. T., Ageing of equine articular cartilage: structure and composition of aggrecan and decorin. Equine Veterinary Journal 1998 30 1 43 52 10.1111/j.2042-3306.1998.tb04087.x 2-s2.0-0031606491 (Pubitemid 128526144)
42. Troeberg L., Nagase H., Proteases involved in cartilage matrix degradation in osteoarthritis. Biochimica et Biophysica Acta 2012 1824 1 133 145 10.1016/j.bbapap.2011.06.020 2-s2.0-82755197933
43. Struglics A., Hansson M., Calpain is involved in C-terminal truncation of human aggrecan. Biochemical Journal 2010 430 3 531 538 10.1042/BJ20100591 2-s2.0-77956673890
44. Fonović M., Turk B., Cysteine cathepsins and extracellular matrix degradation. Biochimica et Biophysica Acta 2014 10.1016/j.bbagen.2014.03.017
45. Stanton H., Melrose J., Little C. B., Fosang A. J., Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta-Molecular Basis of Disease 2011 1812 12 1616 1629 10.1016/j.bbadis.2011.08. 009 2-s2.0-80053916564
46. Ariyoshi W., Knudson C. B., Luo N., Fosang A. J., Knudson W., Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44. Journal of Biological Chemistry 2010 285 46 36216 36224 10.1074/jbc.M110.129270 2-s2.0-78149251396
47. Fosang A. J., Neame P. J., Hardingham T. E., Murphy G., Hamilton J. A., Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. Journal of Biological Chemistry 1991 266 24 15579 15582 2-s2.0-0026040194 (Pubitemid 21907691)
48. Hughes C. E., Little C. B., Büttner F. H., Bartnik E., Caterson B., Differential expression of aggrecanase and matrix metalloproteinase activity in chondrocytes isolated from bovine and porcine articular cartilage. The Journal of Biological Chemistry 1998 273 46 30576 30582 10.1074/jbc.273.46.30576 2-s2.0-0032515157 (Pubitemid 28545535)
49. Apte S. S., A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family. International Journal of Biochemistry & Cell Biology 2004 36 6 981 985 10.1016/j.biocel.2004.01.014 2-s2.0-4143112912 (Pubitemid 38501549)
50. Kuno K., Okada Y., Kawashima H., Nakamura H., Miyasaka M., Ohno H., Matsushima K., ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Letters 2000 478 3 241 245 10.1016/S0014-5793(00)01854-8 2-s2.0-0034604613 (Pubitemid 30621625)
51. Somerville R. P., Longpre J.-M., Jungers K. A., Engle J. M., Ross M., Evanko S., Wight T. N., Leduc R., Aptell S. S., Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. The Journal of Biological Chemistry 2003 278 11 9503 9513 10.1074/jbc.M211009200 2-s2.0-0038237345 (Pubitemid 36800443)
52. Collins-Racie L. A., Flannery C. R., Zeng W., Corcoran C., Annis-Freeman B., Agostino M. J., Arai M., Diblasio-Smith E., Dorner A. J., Georgiadis K. E., Jin M., Tan X., Morris E. A., Lavallie E. R., ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. Matrix Biology 2004 23 4 219 230 10.1016/j.matbio.2004.05.004 2-s2.0-3543043776 (Pubitemid 39013980)
53. Zeng W., Corcoran C., Collins-Racie L. A., LaVallie E. R., Morris E. A., Flannery C. R., Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Biochimica et Biophysica Acta 2006 1760 3 517 524 10.1016/j.bbagen.2006.01.013 2-s2.0-33644883338
54. Gendron C., Kashiwagi M., Lim N. H., Enghild J. J., Thøgersen I. B., Hughes C., Caterson B., Nagase H., Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. Journal of Biological Chemistry 2007 282 25 18294 18306 10.1074/jbc.M701523200 2-s2.0-34547110152 (Pubitemid 47100219)
55. Fushimi K., Troeberg L., Nakamura H., Lim N. H., Nagase H., Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. Journal of Biological Chemistry 2008 283 11 6706 6716 10.1074/jbc.M708647200 2-s2.0-43749117128
56. Lark M. W., Bayne E. K., Flanagan J., Harper C. F., Hoerrner L. A., Hutchinson N. I., Singer I. I., Donatelli S. A., Weidner J. R., Williams H. R., Mumford R. A., Lohmander L. S., Aggrecan degradation in human cartilage: evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. Journal of Clinical Investigation 1997 100 1 93 106 10.1172/JCI119526 2-s2.0-18744437369 (Pubitemid 27311247)
57. Melching L. I., Fisher W. D., Lee E. R., Mort J. S., Roughley P. J., The cleavage of biglycan by aggrecanases. Osteoarthritis and Cartilage 2006 14 11 1147 1154 10.1016/j.joca.2006.05.014 2-s2.0-33749332291 (Pubitemid 44490319)
58. Konttinen Y. T., Mandelin J., Li T. F., Salo J., Lassus J., Liljeström M., Hukkanen M., Takagi M., Virtanen I., Santavirta S., Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Arthritis and Rheumatism 2002 46 4 953 960 10.1002/art.10185 2-s2.0-0036226928 (Pubitemid 34303807)
59. Filou S., Stylianou M., Triantaphyllidou I. E., Papadas T., Mastronikolis N. S., Goumas P. D., Papachristou D. J., Ravazoula P., Skandalis S. S., Vynios D. H., Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma. Biochimie 2013 95 4 725 734 10.1016/j.biochi.2012.10.022 2-s2.0-84874666262
60. Rosenthal E. L., Matrisian L. M., Matrix metalloproteases in head and neck cancer. Head & Neck 2006 28 7 639 648 10.1002/hed.20365 2-s2.0-33745779881 (Pubitemid 44025114)
61. Csoka A. B., Frost G. I., Stern R., The six hyaluronidase-like genes in the human and mouse genomes. Matrix Biology 2001 20 8 499 508 10.1016/S0945-053X(01)00172-X 2-s2.0-0035202430 (Pubitemid 33109098)
62. Kaneiwa T., Mizumoto S., Sugahara K., Yamada S., Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. Glycobiology 2009 20 3 300 309 10.1093/glycob/cwp174 2-s2.0-77949909575
63. Coutinho M. F., Lacerda L., Alves S., Glycosaminoglycan storage disorders: a review. Biochemistry Research International 2012 2012 16 471325 10.1155/2012/471325 2-s2.0-84855268685