Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

BMC Complementary and Alternative Medicine

Volumn 17, Issue 1, 2017, Pages

  Nguyen, Thuy Duong ^a   Thuong, Phuong Thien ^b   Hwang, In Hyun ^c   Hoang, Thi Kim Huyen ^a   Nguyen, Minh Khoi ^b   Nguyen, Hoang Anh ^a   Na, MinKyun ^a,d  

^a HANOI UNIVERSITY OF PHARMACY   (Viet Nam)

^b National Institute of Medicinal Materials   (Viet Nam)

^c Woosuk University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Analgesic activity; Anti hyperuricemic activity; Anti inflammatory activity; Caffeic acid analogues; Flavonones; Siegesbeckia orientalis; Xanthine oxidase

Indexed keywords

ALCOHOL; ALLOPURINOL; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; BUTANOL; CAFFEIC ACID; CAFFEIC ACID DERIVATIVE; CARRAGEENAN; FLAVANONE DERIVATIVE; INDOMETACIN; PLANT EXTRACT; SIEGESBECKIA ORIENTALIS EXTRACT; UNCLASSIFIED DRUG; URIC ACID; XANTHINE OXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENOL DERIVATIVE;

ADULT; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERURICEMIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE COMPARISON; ENZYME INHIBITION; EXPERIMENTAL SYNOVITIS; HYPERALGESIA; HYPERURICEMIA; IN VIVO STUDY; INTERMETHOD COMPARISON; LIVER FUNCTION; MALE; MEDICINAL PLANT; NONHUMAN; PAW EDEMA; RAT; RETENTION TIME; SIEGESBECKIA ORIENTALIS; SYNOVITIS; URIC ACID BLOOD LEVEL; VIET NAM; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTERACEAE; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; ISOLATION AND PURIFICATION; LIVER; PHYTOTHERAPY; WISTAR RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTERACEAE; CARRAGEENAN; DISEASE MODELS, ANIMAL; HYPERURICEMIA; LIVER; MALE; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; URIC ACID; VIETNAM; XANTHINE OXIDASE;

EID: 85016969923     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-017-1698-z     Document Type: Article

References (38)

1. NIMM. (National Institute of Medicinal Materials of Vietnam). Medicinal Plant Resource of Vietnam. Hanoi: Science and Technology Publishing House; 1993.
2. Wang JP, Zhou YM, Ye YJ, Shang XM, Cai YL, Xiong CM, Wu YX, Xu HX. Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis. J Ethnopharmacol. 2011;137:1089-94.
3. Do TL. Vietnamese Medicinal Plants and Remedies. Hanoi: Hong Duc Publishing House; 2012.
4. Vo VC. The Dictionary of Vietnamese Medicinal Plant. Hochiminh: Medical Publishing House; 2012.
5. Zhang ZF, Yang LR, Li YB, Yan LH. Summary on chemical composition and pharmacological action of Herba Siegesbeckiae. Inf Tradit. Chin. Med. 2006;23:15-7.
6. Xiang Y, Zhang H, Fan CQ, Yue JM. Novel diterpenoids and diterpenoid glycosides from Siegesbeckia orientalis. J Nat Prod. 2004;67:1517-21.
7. Giang PM, Son PT, Otsuka H. ent-pimarane-type diterpenoids from Siegesbeckia orientalis L. Chem Pharm Bull. 2005;53:232-4.
8. Wang F, Cheng XL, Li YJ, Shi S, Liu JK. ent-Pimarane diterpenoids from Siegesbeckia orientalis and structure revision of a related compound. J Nat Prod. 2009;72:2005-8.
9. Hong Y-H, Weng L-W, Chang C-C, Hsu H-F, Wang C-P, Wang S-W, Houng J-Y. Anti-inflammatory effects of Siegesbeckia orientalis ethanol extract in in vitro and in vivo models. Biomed Res Int. 2014;2014:329712.
10. Busso N, So A. Gout: mechanisms of inflammation in gout. Arthritis Res Ther. 2010;12:206.
11. Zdero C, Bohlmann F, King RM, Robinson H. Sesquiterpene lactones and other constituents from Siegesbeckia orientalis and Guizotia scabra. Phytochemistry. 1991;30:1579-84.
12. Xiang Y, Fan CQ, Yue JM. Novel sesquiterpenoids from Siegesbeckia orientalis. Helv Chim Acta. 2005;88:160-70.
13. Wang LL, Hu LH. Chemical constituents of Siegesbeckia orientalis L. J Integr Plant Biol. 2006;48:991-5.
14. Le TKN. Study on chemical constituents with antioxidant and antimicrobial activities from the Vietnamese plants hy thiem (Siegesbeckia orientalis L.) and bon-bot (Glochidion eriocarpum Champ.). Hanoi: Doctorate thesis, College of Chemistry, Hanoi National University; 2001.
15. Masuda T, et al. Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acid. Free Radic Biol Med. 2010;69:300-7.
16. Masuoka N, Kubo I. Suppression of superoxide anion generation catalyzed by xanthine oxidase with alkyl caffeates and the scavenging activity. Int J Food Sci Nutr. 2016;67:283-7.
17. Nguyen MT, et al. Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol Pharm Bull. 2004;27:1414-21.
18. Huang J, et al. Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food and Chem Toxicol. 2011;49:1943-7.
19. Emmerson BT. The management of gout. N Engl J Med. 1996;334:445-51.
20. Cao H, Pauff JM, Hille R. X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin. J Nat Prod. 2014;77:1693-9.
21. Zimmermann M. Ethical considerations in relation to pain in animal experimentation. Acta Physiol Scand Suppl. 1986;554:221-33.
22. Stavric B, Clayman S, Gadd RE, Hébert D. Some in vivo effects in the rat induced by chlorprothixene and potassium oxonate. Pharmacol Res Commun. 1975;7:117-24.
23. Carroll JJ, Roberta Douglass HC, Babson AL. A simplified alkaline phosphotungstate assay for uric acid in serum. Clin Chem. 1971;17:158-60.
24. Mo SF, Zhou F, Yao-Zhong LV, Hu QH, Zhang DM, Kong LD. Hypouricemic action of selected flavonoids in mice: Structure-activity relationships. Biol Pharm Bull. 2007;30:1551-6.
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin-phenol reagent. J Biol Chem. 1951;193:265-75.
26. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of rats as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med. 1962;111:544-7.
27. Walker KM, Urban L, Medhurst SJ, Patel S, Panesar M, Fox AJ, Mcintyre P. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J Pharm Experimental Therapeutics. 2003;304:56-62.
28. Safieh-Garabedian B, Kanaan SA, Haddad JJ, Jaoude PA, Jabbur SJ, Saadé NE. Involvement of interleukin-1ß, nerve growth factor and prostaglandin E2 in endotoxin-induced localized inflammatory hyperalgesia. Br J Pharmacol. 1997;121:1619-26.
29. Urban L, Campbell EA, Gentry C, Patel S, Chaudry N, James I. Pharmacological profile of SDZ 249-665, a novel capsaicin agonist. Pain. 2000;89:65-74.
30. Thuong PT, Su ND, Ngoc TM, Hung TM, Dang NH, Thuan ND, Bae KH, Oh WK. Antioxidant activity and principles of Vietnamese bitter tea Ilex kudingcha. Food Chem. 2009;113:139-45.
31. Nguyen MT, Awale S, Tezuka Y, Shi L, Zaidi SF, Ueda JY, Tran QL, Murakami Y, Matsumoto K, Kadota S. Hypouricemic effects of acacetin and 4,5-O-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats. Biol Pharm Bull. 2005;28:2231-4.
32. Yonathan M, Asres K, Assefa A, Bucar F. In vivo anti-inflammatory and anti-nociceptive activities of Cheilanthes farinosa. J Ethnopharmacol. 2006;108:462-70.
33. Han T, Li HL, Zhang QY, Han P, Zheng HC, Rahman K, Qin LP. Bioactivity-guided fractionation for anti-inflammatory and analgesic properties and constituents of Xanthium strumarium L. Phytomedicine. 2007;14:825-9.
34. Masuda T, Shingai Y, Takahashi C, Inai M, Miura Y, Honda S, Masuda A. Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acid. Free Radic Biol Med. 2014;69:300-7.
35. Zhu JX, Wang Y, Kong LD, Yang C, Zhang X. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2004;93:133-40.
36. Cannella AC, Mikuls TR. Understanding Treatments for Gout. Am J Manag Care. 2005;11(Suppl):S451-8.
37. Neogi T. Gout. New Eng J Med. 2011;364:443-5.
38. Ling X, Bochu WA. A review of phytotherapy of gout: perspective of new pharmacological treatments. Pharmazie. 2014;69:243-56.