COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology

American Journal of Psychiatry

Volumn 172, Issue 2, 2015, Pages 163-172

  Qiu, Anqi ^a,b,c,d,e,f   Tuan, Ta Anh ^a,b,c,d,e,f   Ong, Mei Lyn ^a,b,c,d,e,f   Li, Yue ^a,b,c,d,e,f   Chen, Helen ^a,b,c,d,e,f   Rifkin Graboi, Anne ^a,b,c,d,e,f   Broekman, Birit F P ^a,b,c,d,e,f   Kwek, Kenneth ^a,b,c,d,e,f   Saw, Seang Mei ^a,b,c,d,e,f   Chong, Yap Seng ^a,b,c,d,e,f   Gluckman, Peter D ^a,b,c,d,e,f   Fortier, Marielle V ^a,b,c,d,e,f   Holbrook, Joanna Dawn ^a,b,c,d,e,f   Meaney, Michael J ^a,b,c,d,e,f  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOLAMINE; METHIONINE; VALINE;

AMINO ACID SUBSTITUTION; ANXIETY; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CHROMOSOME 22Q; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); EMOTIONAL STABILITY; FEMALE; FETUS DEVELOPMENT; GENE LOCATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; GESTATION PERIOD; HAPLOTYPE; HUMAN; MALE; MATERNAL DISEASE; MATERNAL WELFARE; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PARIETAL CORTEX; PHENOTYPE; PRECUNEUS; PREFRONTAL CORTEX; PRENATAL DEVELOPMENT; PRIMARY MOTOR CORTEX; PROBABILITY; PROGENY; REGRESSION ANALYSIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STATE TRAIT ANXIETY INVENTORY; STRESS; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOTHER FETUS RELATIONSHIP; PARIETAL LOBE; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SINGAPORE;

ANXIETY; CATECHOL O-METHYLTRANSFERASE; FEMALE; FETAL DEVELOPMENT; HAPLOTYPES; HUMANS; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; MATERNAL-FETAL RELATIONS; PARIETAL LOBE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHIATRIC STATUS RATING SCALES; SINGAPORE;

EID: 84922219619     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2014.14030313     Document Type: Article

References (71)

1. Hettema JM, Neale MC, Kendler KS: A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001; 158:1568-1578
2. Rice F, Jones I, Thapar A: The impact of gestational stress and prenatal growth on emotional problems in offspring: a review. Acta Psychiatr Scand 2007; 115:171-183
3. Van den Bergh BR, Mulder EJ, Mennes M, Glover V: Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms: a review. Neurosci Biobehav Rev 2005; 29:237-258
4. Teixeira JM, Fisk NM, Glover V: Association between maternal anxiety in pregnancy and increased uterine artery resistance index: cohort based study. BMJ 1999; 318:153-157
5. Mennes M, Stiers P, Lagae L, Van den Bergh B: Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex. Neurosci Biobehav Rev 2006; 30: 1078-1086
6. Buss C, Davis EP, Muftuler LT, Head K, Sandman CA: High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psycho-neuroendocrinology 2010; 35:141-153
7. Huizink AC, de Medina PG, Mulder EJ, Visser GH, Buitelaar JK: Psychological measures of prenatal stress as predictors of infant temperament. J Am Acad Child Adolesc Psychiatry 2002; 41:1078-1085
8. Qiu A, Rifkin-Graboi A, Chen H, Chong YS, Kwek K, Gluckman PD, Fortier MV, Meaney MJ: Maternal anxiety and infants' hip-pocampal development: timing matters. Transl Psychiatr 2013; 3: e306
9. Baumann C, Klauke B, Weber H, Domschke K, Zwanzger P, Pauli P, Deckert J, Reif A: The interaction of early life experiences with COMT val158met affects anxiety sensitivity. Genes Brain Behav 2013; 12:821-829
10. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N: Spatio-temporal transcriptome of the human brain. Nature 2011; 478:483-489
11. Tunbridge EM, Weickert CS, Kleinman JE, Herman MM, Chen J, Kolachana BS, Harrison PJ, Weinberger DR: Catechol-O-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cereb Cortex 2007; 17:1206-1212
12. Mier D, Kirsch P, Meyer-Lindenberg A: Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mol Psychiatry 2010; 15:918-927
13. Desbonnet L, Tighe O, Karayiorgou M, Gogos JA, Waddington JL, O'Tuathaigh CM: Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice. Behav Brain Res 2012; 228:351-358
14. Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ, O'Donovan MC: A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73:152-161
15. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR: Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 2004; 75:807-821
16. Knickmeyer RC, Wang J, Zhu H, Geng X, Woolson S, Hamer RM, Konneker T, Lin W, Styner M, Gilmore JH: Common variants in psychiatric risk genes predict brain structure at birth. Cereb Cortex 2014; 24:1230-1246
17. Raznahan A, Greenstein D, Lee Y, Long R, Clasen L, Gochman P, Addington A, Giedd JN, Rapoport JL, Gogtay N: Catechol-O-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. Neuroimage 2011; 57:1517-1523
18. Smolka MN, Schumann G, Wrase J, Grüsser SM, Flor H, Mann K, Braus DF, Goldman D, Büchel C, Heinz A: Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 2005; 25:836-842
19. Massat I, Souery D, Del-Favero J, Nothen M, Blackwood D, Muir W, Kaneva R, Serretti A, Lorenzi C, Rietschel M, Milanova V, Papadimitriou GN, Dikeos D, Van Broekhoven C, Mendlewicz J: Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry 2005; 10:598-605
20. Rothe C, Koszycki D, Bradwejn J, King N, Deluca V, Tharmalingam S, Macciardi F, Deckert J, Kennedy JL: Association of the Val158-Met catechol-O-methyltransferase genetic polymorphism with panic disorder. Neuropsychopharmacology 2006; 31:2237-2242
21. McGrath M, Kawachi I, Ascherio A, Colditz GA, Hunter DJ, De Vivo I: Association between catechol-O-methyltransferase and phobic anxiety. Am J Psychiatry 2004; 161:1703-1705
22. Sheikh HI, Kryski KR, Smith HJ, Dougherty LR, Klein DN, Bufferd SJ, Singh SM, Hayden EP: Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood. Am J Med Genet B Neuropsychiatr Genet 2013; 162B: 245-252
23. Woo JM, Yoon KS, Choi YH, Oh KS, Lee YS, Yu BH: The association between panic disorder and the L/L genotype of catechol-O-methyltransferase. J Psychiatr Res 2004; 38:365-370
24. Domschke K, Deckert J, O'donovan MC, Glatt SJ: Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. Am J Med Genet B Neuropsychiatr Genet 2007; 144B:667-673
25. Hettema JM, An SS, Bukszar J, van den Oord EJ, Neale MC, Kendler KS, Chen X: Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biol Psychiatry 2008; 64:302-310
26. Stein MB, Fallin MD, Schork NJ, Gelernter J: COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology 2005; 30:2092-2102
27. Funke B, Malhotra AK, Finn CT, Plocik AM, Lake SL, Lencz T, DeRosse P, Kane JM, Kucherlapati R: COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct 2005; 1:19
28. Meyer-Lindenberg A, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J, Mattay VS, Egan M, Weinberger DR: Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry 2006; 11:867-877
29. Stephens M, Donnelly P: A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73:1162-1169
30. Meades R, Ayers S: Anxiety measures validated in perinatal populations: a systematic review. J Affect Disord 2011; 133:1-15
31. Roesch SC, Schetter CD, Woo G, Hobel CJ: Modeling the types and timing of stress in pregnancy. Anxiety Stress Coping 2004; 17: 87-102
32. Dipietro JA, Costigan KA, Sipsma HL: Continuity in self-report measures of maternal anxiety, stress, and depressive symptoms from pregnancy through two years postpartum. J Psychosom Obstet Gynaecol 2008; 29:115-124
33. Smith SM: Fast robust automated brain extraction. Hum Brain Mapp 2002; 17:143-155
34. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33:341-355
35. Han X, Xu C, Braga-Neto U, Prince JL: Topology correction in brain cortex segmentation using a multiscale, graph-based algorithm. IEEE Trans Med Imaging 2002; 21:109-121
36. Zhong J, Qiu A: Multi-manifold diffeomorphic metric mapping for aligning cortical hemispheric surfaces. Neuroimage 2010; 49:355-365
37. Bai J, Abdul-Rahman MF, Rifkin-Graboi A, Chong YS, Kwek K, Saw SM, Godfrey KM, Gluckman PD, Fortier MV, Meaney MJ, Qiu A: Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates. PLoS ONE 2012; 7: e47816
38. Joshi S, Davis B, Jomier M, Gerig G: Unbiased diffeomorphic atlas construction for computational anatomy. Neuroimage 2004; 23 (suppl 1):S151-S160
39. Jiang L, Willner D, Danoy P, Xu H, Brown MA: Comparison of the performance of two commercial genome-wide association study genotyping platforms in Han Chinese samples. G3 (Bethesda) 2013; 3:23-29
40. Oliphant A, Barker DL, Stuelpnagel JR, Chee MS: BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques 2002; (suppl):56-58, 60-61
41. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265
42. Chung MK, Robbins SM, Dalton KM, Davidson RJ, Alexander AL, Evans AC: Cortical thickness analysis in autism with heat kernel smoothing. Neuroimage 2005; 25:1256-1265
43. Chung MK, Worsley KJ, Nacewicz BM, Dalton KM, Davidson RJ: General multivariate linear modeling of surface shapes using SurfStat. Neuroimage 2010; 53:491-505
44. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG: Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 2002; 53:79-91
45. Loomans EM, van der Stelt O, van Eijsden M, Gemke RJ, Vrijkotte TG, Van den Bergh BR: High levels of antenatal maternal anxiety are associated with altered cognitive control in five-year-old children. Dev Psychobiol 2012; 54:441-450
46. Van den Bergh BR, Mennes M, Oosterlaan J, Stevens V, Stiers P, Marcoen A, Lagae L: High antenatal maternal anxiety is related to impulsivity during performance on cognitive tasks in 14-and 15-year-olds. Neurosci Biobehav Rev 2005; 29:259-269
47. Murmu MS, Salomon S, Biala Y, Weinstock M, Braun K, Bock J: Changes of spine density and dendritic complexity in the pre-frontal cortex in offspring of mothers exposed to stress during pregnancy. Eur J Neurosci 2006; 24:1477-1487
48. Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM: The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease. Neurobiol Aging 2010; 31:1064-1068
49. Collip D, van Winkel R, Peerbooms O, Lataster T, Thewissen V, Lardinois M, Drukker M, Rutten BP, Van Os J, Myin-Germeys I: COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. CNS Neurosci Ther 2011; 17:612-619
50. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR: Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 2003; 60:889-896
51. Butts KA, Weinberg J, Young AH, Phillips AG: Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc Natl Acad Sci USA 2011; 108:18459-18464
52. Nestler EJ, Carlezon WA Jr: The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 2006; 59:1151-1159
53. Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG: Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 2002; 59:1027-1034
54. Monk CS, Nelson EE, McClure EB, Mogg K, Bradley BP, Leibenluft E, Blair RJ, Chen G, Charney DS, Ernst M, Pine DS: Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry 2006; 163:1091-1097
55. Doehrmann O, Ghosh SS, Polli FE, Reynolds GO, Horn F, Keshavan A, Triantafyllou C, Saygin ZM, Whitfield-Gabrieli S, Hofmann SG, Pollack M, Gabrieli JD: Predicting treatment response in social anxiety disorder from functional magnetic resonance imaging. JAMA Psychiatry 2013; 70:87-97
56. Goldin PR, Manber T, Hakimi S, Canli T, Gross JJ: Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Arch Gen Psychiatry 2009; 66:170-180
57. Burdick KE, Funke B, Goldberg JF, Bates JA, Jaeger J, Kucherlapati R, Malhotra AK: COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord 2007; 9:370-376
58. Chan RC, Chen RY, Chen EY, Hui TC, Cheung EF, Cheung HK, Sham P, Li T, Collier D: The differential clinical and neuro-cognitive profiles of COMT SNP rs165599 genotypes in schizophrenia. J Int Neuropsychol Soc 2005; 11:202-204
59. Barnett JH, Heron J, Goldman D, Jones PB, Xu K: Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry 2009; 166:909-916
60. Bullmore E, Sporns O: Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 2009; 10:186-198
61. Golkar A, Lonsdorf TB, Olsson A, Lindstrom KM, Berrebi J, Fransson P, Schalling M, Ingvar M, Öhman A: Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation. PLoS ONE 2012; 7:e48107
62. 1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology (Berl) 2004; 174:3-16
63. Hardee JE, Benson BE, Bar-Haim Y, Mogg K, Bradley BP, Chen G, Britton JC, Ernst M, Fox NA, Pine DS, Pérez-Edgar K: Patterns of neural connectivity during an attention bias task moderate associations between early childhood temperament and internalizing symptoms in young adulthood. Biol Psychiatry 2013; 74:273-279
64. Gilmore JH, Kang C, Evans DD, Wolfe HM, Smith JK, Lieberman JA, Lin W, Hamer RM, Styner M, Gerig G: Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia. Am J Psychiatry 2010; 167:1083-1091
65. Peterson BS, Weissman MM: A brain-based endophenotype for major depressive disorder. Annu Rev Med 2011; 62:461-474
66. Chen MC, Hamilton JP, Gotlib IH: Decreased hippocampal volume in healthy girls at risk of depression. Arch Gen Psychiatry 2010; 67:270-276
67. Field T, Diego M, Dieter J, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D: Prenatal depression effects on the fetus and the newborn. Infant Behav Dev 2004; 27:216-229
68. Fleming AS, Flett GL, Ruble DN, Shaul DL: Postpartum adjustment in 1st-time mothers: relations between mood, maternal attitudes, and mother infant interactions. Dev Psychol 1988; 24:71-81
69. Heron J, O'Connor TG, Evans J, Golding J, Glover V; ALSPAC Study Team: The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord 2004; 80:65-73
70. Goldman-Rakic PS, Brown RM: Postnatal development of mono-amine content and synthesis in the cerebral cortex of rhesus monkeys. Brain Res 1982; 256:339-349
71. Weickert CS, Webster MJ, Gondipalli P, Rothmond D, Fatula RJ, Herman MM, Kleinman JE, Akil M: Postnatal alterations in do-paminergic markers in the human prefrontal cortex. Neuroscience 2007; 144:1109-1119