Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

Nature Communications

Volumn 8, Issue , 2017, Pages

  Kahr, Walter H A ^a,b,c   Pluthero, Fred G ^a   Elkadri, Abdul ^a,b,c   Warner, Neil ^a,b   Drobac, Marko ^a,c   Chen, Chang Hua ^a,c   Lo, Richard W ^a,c   Li, Ling ^a   Li, Ren ^a   Li, Qi ^a,b   Thoeni, Cornelia ^a,b   Pan, Jie ^a,b   Leung, Gabriella ^a,b   Lara Corrales, Irene ^d   Murchie, Ryan ^a,b   Cutz, Ernest ^b   Laxer, Ronald M ^c,e   Upton, Julia ^e   Roifman, Chaim M ^e   Yeung, Rae S M ^c,e   Brumell, John H ^a,b,c   Muise, Aleixo M ^a,b,c   more..

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Division of Genomic Medicine   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; ARPC1B PROTEIN; F ACTIN; PROTEIN; TUBULIN; UNCLASSIFIED DRUG; ACTIN; ARPC1B PROTEIN, HUMAN; FIBRINOGEN;

ABNORMALITY; BLOOD; CELLS AND CELL COMPONENTS; CHILD HEALTH; DISEASE; GENE EXPRESSION; MUTATION; PROTEIN; SYMPTOM;

ACTIN FILAMENT; ARTICLE; CASE REPORT; CONTROLLED STUDY; ELECTRON MICROSCOPY; EOSINOPHILIA; EXON; EXTRACELLULAR MATRIX; FLUORESCENCE MICROSCOPY; FRAMESHIFT MUTATION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; INFLAMMATORY DISEASE; MEGAKARYOCYTE; MICROTHROMBOCYTOPENIA; MISSENSE MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; SANGER SEQUENCING; SCANNING ELECTRON MICROSCOPY; STOP CODON; THROMBOCYTE DISORDER; THROMBOCYTE MEMBRANE; TRANSMISSION ELECTRON MICROSCOPY; TWO-DIMENSIONAL IMAGING; UPREGULATION; WHOLE EXOME SEQUENCING; WISKOTT ALDRICH SYNDROME; BONE MARROW CELL; CELL SHAPE; DEFICIENCY; DISEASE PREDISPOSITION; DRUG EFFECT; GENE KNOCKOUT; GENETICS; INFLAMMATION; METABOLISM; MUTATION; PATHOLOGY; THROMBOCYTE; ULTRASTRUCTURE; VASCULITIS;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; BLOOD PLATELET DISORDERS; BLOOD PLATELETS; BONE MARROW CELLS; CELL SHAPE; DISEASE SUSCEPTIBILITY; FIBRINOGEN; GENE KNOCKOUT TECHNIQUES; HUMANS; INFLAMMATION; MEGAKARYOCYTES; MUTATION; VASCULITIS; WISKOTT-ALDRICH SYNDROME;

EID: 85016791743     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14816     Document Type: Article

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