Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects

Stem Cell Reports

Volumn 7, Issue 2, 2016, Pages 139-148

  Laskowski, Tamara J ^a   Van Caeneghem, Yasmine ^b   Pourebrahim, Rasoul ^a   Ma, Chao ^c   Ni, Zhenya ^c   Garate, Zita ^a,d,e   Crane, Ana M ^a   Li, Xuan Shirley ^a   Liao, Wei ^a   Gonzalez Garay, Manuel ^a   Segovia, Jose Carlos ^d,e   Paschon, David E ^f   Rebar, Edward J ^f   Holmes, Michael C ^f   Kaufman, Dan ^c   Vandekerckhove, Bart ^b   Davis, Brian R ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d CIEMAT   (Spain)

^e UAM)   (Spain)

^f SANGAMO BIOSCIENCES INC   (United States)

Author keywords

genome editing; immune deficiency; induced pluripotent stem cells; T cells

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR; WISKOTT ALDRICH SYNDROME PROTEIN; ZINC FINGER NUCLEASE; WAS PROTEIN, HUMAN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CD3+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; ERYTHROID CELL; FLOW CYTOMETRY; GENE LOCUS; GENE MUTATION; GENETIC PREDISPOSITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; LYMPHOCYTE DIFFERENTIATION; LYMPHOID TISSUE; LYMPHOPOIESIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TARGETED GENE REPAIR; THROMBOCYTE; TRANSGENE; WESTERN BLOTTING; WISKOTT ALDRICH SYNDROME; GENE THERAPY; GENETICS; IMMUNOLOGY; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY; T LYMPHOCYTE;

GENETIC THERAPY; HEMATOPOIETIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KILLER CELLS, NATURAL; LYMPHOPOIESIS; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 84991573979     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2016.06.003     Document Type: Article

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