Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Molecular Cancer

Volumn 16, Issue 1, 2017, Pages

  Zhao, Jingkun ^a,b,c   Ou, Baochi ^a,b   Han, Dingpei ^a   Wang, Puxiongzhi ^a   Zong, Yaping ^a   Zhu, Congcong ^a,b   Liu, Di ^a   Zheng, Minhua ^a   Sun, Jing ^a   Feng, Hao ^c   Lu, Aiguo ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute of Digestive Surgery   (China)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Colorectal cancer; CXCL5; EMT; Snail; catenin

Indexed keywords

BETA CATENIN; CHEMOKINE RECEPTOR CXCR2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GLYCOGEN SYNTHASE KINASE 3BETA; LENTIVIRUS VECTOR; MATRILYSIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR SNAIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL INVASION; CELL MEMBRANE; CELL MIGRATION; CELL STRUCTURE; COLORECTAL CANCER CELL LINE; COLORECTAL LIVER METASTASIS; CONTROLLED STUDY; CYTOLOGY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FIBROBLAST; GENE SILENCING; GENETIC TRANSFECTION; HCT 116 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SW 480 CELL LINE; TUMOR MICROENVIRONMENT; ANIMAL; BIOLOGICAL MODEL; CELL MOTION; CELL PROLIFERATION; CLUSTER ANALYSIS; COLORECTAL TUMOR; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; LIVER TUMOR; METABOLISM; PATHOLOGY; PROGNOSIS; SECONDARY; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BETA CATENIN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL5; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; ETS-DOMAIN PROTEIN ELK-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION PROFILING; GLYCOGEN SYNTHASE KINASE 3 BETA; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MICE; MODELS, BIOLOGICAL; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION; SNAIL FAMILY TRANSCRIPTION FACTORS;

EID: 85016475182     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-017-0629-4     Document Type: Article

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