Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration, invasion, adhersion and angiogenesis

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Zhao, Jingkun ^a   Li, Pu ^a   Feng, Hao ^a   Wang, Puxiongzhi ^a   Zong, Yaping ^a   Ma, Junjun ^a   Zhang, Zhuo ^a   Chen, Xuehua ^a   Zheng, Minhua ^a   Zhu, Zhenggang ^a   Lu, Aiguo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiogenesis; Cadherin12; Cell adhesion; Cell invasion; Cell migration; Cell proliferation; Colorectal cancer

Indexed keywords

CADHERIN; CADHERIN 12; CHOLECYSTOKININ OCTAPEPTIDE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

AGED; ANGIOGENESIS; ARTICLE; CANCER CELL; CARCINOGENICITY; CELL ADHESION; CELL ADHESION ASSAY; CELL AGGREGATION; CELL INVASION; CELL JUNCTION; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL TUBE FORMATION; ENDOTHELIUM CELL; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGED; BASE SEQUENCE; BLOTTING, WESTERN; CADHERINS; CELL ADHESION; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA PRIMERS; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84887524736     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-288     Document Type: Article

References (20)

1. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996, 84:345-357. 10.1016/S0092-8674(00)81279-9, 8608588.
2. Li K, He W, Lin N, Wang X, Fan QX. Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma. Cancer Invest 2010, 28:479-486. 10.3109/07357900903476745, 20014942.
3. Yang Z, Zhang X, Gang H, Li X, Li Z, Wang T, Han J, Luo T, Wen F, Wu X. Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression. Biochem Biophys Res Commun 2007, 358:925-930. 10.1016/j.bbrc.2007.05.023, 17512904.
4. Hulit J, Suyama K, Chung S, Keren R, Agiostratidou G, Shan W, Dong X, Williams TM, Lisanti MP, Knudsen K, Hazan RB. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activation. Cancer Res 2007, 67:3106-3116. 10.1158/0008-5472.CAN-06-3401, 17409417.
5. Alexander NR, Tran NL, Rekapally H, Summers CE, Glackin C, Heimark RL. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 2006, 66:3365-3369. 10.1158/0008-5472.CAN-05-3401, 16585154.
6. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switching. J Cell Sci 2008, 121:727-735. 10.1242/jcs.000455, 18322269.
7. Center MM, Jemal A, Ward E. International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev 2009, 18:1688-1694. 10.1158/1055-9965.EPI-09-0090, 19505900.
8. Redies C, Hertel N, Hubner CA. Cadherins and neuropsychiatric disorders. Brain Res 2012, 1470:130-144.
9. Mayer M, Bercsenyi K, Geczi K, Szabo G, Lele Z. Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain. Gene Expr Patterns 2010, 10:351-360. 10.1016/j.gep.2010.08.002, 20723620.
10. Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. Identification of genes associated with non-small-cell lung cancer promotion and progression. Lung Cancer 2010, 67:151-159. 10.1016/j.lungcan.2009.04.010, 19473719.
11. Wang JF, She L, Su BH, Ding LC, Zheng FF, Zheng DL, Lu YG. CDH12 promotes the invasion of salivary adenoid cystic carcinoma. Oncol Rep 2011, 26:101-108.
12. Hu H, Krasinskas A, Willis J. Perspectives on current tumor-node-metastasis (TNM) staging of cancers of the colon and rectum. Semin Oncol 2011, 38:500-510. 10.1053/j.seminoncol.2011.05.004, 21810509.
13. Shimazui T, Kojima T, Onozawa M, Suzuki M, Asano T, Akaza H. Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma. Oncol Rep 2006, 15:1181-1184.
14. Zhan DQ, Wei S, Liu C, Liang BY, Ji GB, Chen XP, Xiong M, Huang ZY. Reduced N-cadherin expression is associated with metastatic potential and poor surgical outcomes of hepatocellular carcinoma. J Gastroenterol Hepatol 2012, 27:173-180. 10.1111/j.1440-1746.2011.06847.x, 21777276.
15. Li P, Lin Y, Zhang Y, Zhu Z, Huo K. SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma. J Transl Med 2013, 11:52. 10.1186/1479-5876-11-52, 3599991, 23452395.
16. Li P, Chen X, Su L, Li C, Zhi Q, Yu B, Sheng H, Wang J, Feng R, Cai Q, et al. Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. PLoS One 2013, 8:e66782. 10.1371/journal.pone.0066782, 3691322, 23826132.
17. Mirshahi P, Rafii A, Vincent L, Berthaut A, Varin R, Kalantar G, Marzac C, Calandini OA, Marie JP, Soria C, et al. Vasculogenic mimicry of acute leukemic bone marrow stromal cells. Leukemia 2009, 23:1039-1048. 10.1038/leu.2009.10, 19340002.
18. Natalwala A, Spychal R, Tselepis C. Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World J Gastroenterol 2008, 14:3792-3797. 10.3748/wjg.14.3792, 2721434, 18609701.
19. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011, 147:275-292. 10.1016/j.cell.2011.09.024, 3261217, 22000009.
20. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013, 21376230.