Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling

Oncogene

Volumn 35, Issue 20, 2016, Pages 2634-2644

  Sanchez Lopez, E ^a   Flashner Abramson, E ^b   Shalapour, S ^a   Zhong, Z ^a   Taniguchi, K ^a,c   Levitzki, A ^b   Karin, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHEMOKINE; CXCL7 CHEMOKINE; CYTOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; GROWTH FACTOR; INSULIN RECEPTOR SUBSTRATE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NT 157; RANTES; SOMATOMEDIN C RECEPTOR; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOMATOUS POLYPOSIS COLI PROTEIN, MOUSE; APC PROTEIN; INSULIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APC GENE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR GENE; ANIMAL; C57BL MOUSE; COLORECTAL TUMOR; DRUG EFFECTS; GENETICS; IMMUNOLOGY; MACROPHAGE ACTIVATION; METABOLISM; METASTASIS; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROCEDURES; TUMOR CELL LINE; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR BURDEN; TUMOR MICROENVIRONMENT;

EID: 84941729778     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.326     Document Type: Article

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