Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Nature

Volumn 542, Issue 7639, 2017, Pages 119-123

  Dey, Prasenjit ^a   Baddour, Joelle ^b   Muller, Florian ^a   Wu, Chia Chin ^a   Wang, Huamin ^a   Liao, Wen Ting ^a   Lan, Zangdao ^a   Chen, Alina ^a   Gutschner, Tony ^a   Kang, Yaan ^a   Fleming, Jason ^a   Satani, Nikunj ^a   Zhao, Di ^a   Achreja, Abhinav ^b   Yang, Lifeng ^b   Lee, Jiyoon ^b   Chang, Edward ^a   Genovese, Giannicola ^a   Viale, Andrea ^a   Ying, Haoqiang ^a   Draetta, Giulio ^a   Maitra, Anirban ^a   Wang, Y Alan ^a   Nagrath, Deepak ^b   Depinho, Ronald A ^a   more..

^a UNIVERSITY OF TEXAS   (United States)

^b Rice University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRANCHED CHAIN AMINO ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALATE DEHYDROGENASE (DECARBOXYLATING); MALIC ENZYME 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; 2 OXOGLUTARIC ACID; ALPHA-KETOGLUTARIC ACID; AMINOTRANSFERASE; BCAT2 PROTEIN, HUMAN; MALATE DEHYDROGENASE; MALIC ENZYME 2; HUMAN; MINOR HISTOCOMPATIBILITY ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PLACENTA PROTEIN;

AMINO ACID; CANCER; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; ENZYME ACTIVITY; GENE EXPRESSION; GENOMICS; HOMEOSTASIS; MOLECULAR ANALYSIS; PROTEIN; REACTIVE OXYGEN SPECIES;

ARTICLE; CANCER CELL; GENE DELETION; HOMEOSTASIS; HUMAN; HUMAN CELL; LETHALITY; METABOLOMICS; NUCLEOTIDE METABOLISM; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; ANIMAL; BIOCATALYSIS; BIOSYNTHESIS; CARCINOMA, PANCREATIC DUCTAL; DEFICIENCY; ENZYMOLOGY; GENETICS; MALE; METABOLISM; MITOCHONDRION; MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; PSYCHOLOGY;

AMINO ACIDS, BRANCHED-CHAIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOCATALYSIS; CARCINOMA, PANCREATIC DUCTAL; GENE DELETION; HUMANS; KETOGLUTARIC ACIDS; MALATE DEHYDROGENASE; MALE; MICE; MINOR HISTOCOMPATIBILITY ANTIGENS; MITOCHONDRIA; NADP; PANCREATIC NEOPLASMS; PREGNANCY PROTEINS; REACTIVE OXYGEN SPECIES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSAMINASES;

EID: 85016161929     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21052     Document Type: Article

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