Identity and dynamics of mammary stem cells during branching morphogenesis

Nature

Volumn 542, Issue 7641, 2017, Pages 313-317

  Scheele, Colinda L G J ^a   Hannezo, Edouard ^b,c,d   Muraro, Mauro J ^a   Zomer, Anoek ^a   Langedijk, Nathalia S M ^a   Van Oudenaarden, Alexander ^a   Simons, Benjamin D ^b,c,d   Van Rheenen, Jacco ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUD; CELLS AND CELL COMPONENTS; GENE EXPRESSION; GENETIC MARKER; GROWTH RATE; MAMMAL; MORPHOGENESIS; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRANCHING MORPHOGENESIS; BREAST CELL; BREAST DEVELOPMENT; CELL CYCLE; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DAUGHTER CELL; IDENTITY; INTESTINE CRYPT; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL LINEAGE; CYTOLOGY; FEMALE; GENE EXPRESSION PROFILING; MARKOV CHAIN; METABOLISM; MOLECULAR MODEL; MORPHOGENESIS; SEXUAL MATURATION; SINGLE CELL ANALYSIS; STEM CELL; UDDER;

ANIMALS; CELL LINEAGE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; MAMMARY GLANDS, ANIMAL; MICE; MODELS, MOLECULAR; MORPHOGENESIS; SEXUAL MATURATION; SINGLE-CELL ANALYSIS; STEM CELLS; STOCHASTIC PROCESSES;

EID: 85016139022     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21046     Document Type: Article

References (35)

1. Williams, J. M. & Daniel, C. W. Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis. Dev. Biol. 97, 274-290 (1983).
2. Silberstein, G. B. & Daniel, C. W. Glycosaminoglycans in the basal lamina and extracellular matrix of serially aged mouse mammary ducts. Mech. Ageing Dev. 24, 151-162 (1984).
3. Giraddi, R. R. et al. Stem and progenitor cell division kinetics during postnatal mouse mammary gland development. Nat. Commun. 6, 8487 (2015).
4. Visvader, J. E. & Stingl, J. Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev. 28, 1143-1158 (2014).
5. Inman, J. L., Robertson, C., Mott, J. D. & Bissell, M. J. Mammary gland development: cell fate specification, stem cells and the microenvironment. Development 142, 1028-1042 (2015).
6. Stingl, J. et al. Purification and unique properties of mammary epithelial stem cells. Nature 439, 993-997 (2006).
7. Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
8. dos Santos, C. O. et al. Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proc. Natl Acad. Sci. USA 110, 7123-7130 (2013).
9. Van Keymeulen, A. et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479, 189-193 (2011).
10. Rios, A. C., Fu, N. Y., Lindeman, G. J. & Visvader, J. E. In situ identification of bipotent stem cells in the mammary gland. Nature 506, 322-327 (2014).
11. Prater, M. D. et al. Mammary stem cells have myoepithelial cell properties. Nat. Cell Biol. 16, 942-950 (2014).
12. Bai, L. & Rohrschneider, L. R. s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue. Genes Dev. 24, 1882-1892 (2010).
13. Plaks, V. et al. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Reports 3, 70-78 (2013).
14. de Visser, K. E. et al. Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland. J. Pathol. 228, 300-309 (2012).
15. van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
16. Wang, D. et al. Identification of multipotent mammary stem cells by protein C receptor expression. Nature 517, 81-84 (2015).
17. Zeng, Y. A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010).
18. Badders, N. M. et al. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One 4, e6594 (2009).
19. Metzger, R. J., Klein, O. D., Martin, G. R. & Krasnow, M. A. The branching programme of mouse lung development. Nature 453, 745-750 (2008).
20. Sternlicht, M. D., Kouros-Mehr, H., Lu, P. & Werb, Z. Hormonal and local control of mammary branching morphogenesis. Differentiation 74, 365-381 (2006).
21. Nelson, C. M., Vanduijn, M. M., Inman, J. L., Fletcher, D. A. & Bissell, M. J. Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science 314, 298-300 (2006).
22. Lu, P. & Werb, Z. Patterning mechanisms of branched organs. Science 322, 1506-1509 (2008).
23. Plaks, V. et al. Adaptive immune regulation of mammary postnatal organogenesis. Dev. Cell 34, 493-504 (2015).
24. Zomer, A. et al. Intravital imaging of cancer stem cell plasticity in mammary tumors. Stem Cells 31, 602-606 (2013).
25. Shehata, M., van Amerongen, R., Zeeman, A. L., Giraddi, R. R. & Stingl, J. The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Res. 16, 411 (2014).
26. Grun, D. et al. De novo prediction of stem cell identity using single-cell transcriptome data. Cell Stem Cell 19, 266-277 (2016).
27. Kouros-Mehr, H. & Werb, Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev. Dyn. 235, 3404-3412 (2006).
28. Gjorevski, N. & Nelson, C. M. Integrated morphodynamic signalling of the mammary gland. Nat. Rev. Mol. Cell Biol. 12, 581-593 (2011).
29. Ritsma, L. et al. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 507, 362-365 (2014).
30. Lopez-Garcia, C., Klein, A. M., Simons, B. D. & Winton, D. J. Intestinal stem cell replacement follows a pattern of neutral drift. Science 330, 822-825 (2010).
31. Alieva, M., Ritsma, L., Giedt, R. J., Weissleder, R. & Van Rheenen, J. Imaging windows for long-term intravital imaging. Intravital 3, e29917 (2014).
32. Muraro, M. J. et al. A single-cell transcriptome atlas of the human pancreas. Cell Syst. 3, 385-394.e3 (2016).
33. Hashimshony, T. et al. CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq. Genome Biol. 17, 77 (2016).
34. Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
35. Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).