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Volumn 8, Issue 2, 2017, Pages 119-127

Mystery of the brain metastatic disease in breast cancer patients: Improved patient stratification, disease prediction and targeted prevention on the horizon?

Author keywords

Brain metastasis; Breast cancer; Multilevel diagnostics; Patient stratification; Predictive preventive and personalised medicine; Risk factors

Indexed keywords

2 AMINOBUTYRIC ACID; ALPHA CRYSTALLIN; ALPHA2 6 SIALYLTRANSFERASE; ANGIOGENIC FACTOR; ANGIOPOIETIN 2; ATAXIN 1; CAPECITABINE; CHEMOKINE RECEPTOR CCR4; CYCLOOXYGENASE 2; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; HORMONE RECEPTOR; KI 67 ANTIGEN; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MONOCLONAL ANTIBODY; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROGESTERONE RECEPTOR; RAD51 PROTEIN; TRANSFERASE; TRASTUZUMAB; TUMOR MARKER; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 85016138178     PISSN: 18785077     EISSN: 18785085     Source Type: Journal    
DOI: 10.1007/s13167-017-0087-5     Document Type: Review
Times cited : (45)

References (71)
  • 1
    • 84979519415 scopus 로고    scopus 로고
    • Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures
    • Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, et al. Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumour Biol J Int Soc Oncodevelopmental Biol Med. 2016;37:12941-57.
    • (2016) Tumour Biol J Int Soc Oncodevelopmental Biol Med , vol.37 , pp. 12941-12957
    • Golubnitschaja, O.1    Debald, M.2    Yeghiazaryan, K.3    Kuhn, W.4    Pešta, M.5    Costigliola, V.6
  • 3
    • 84902240314 scopus 로고    scopus 로고
    • New treatment paradigm for patients with anaplastic oligodendroglial tumors
    • Polivka J, Polivka J, Rohan V, Topolcan O. New treatment paradigm for patients with anaplastic oligodendroglial tumors. Anticancer Res. 2014;34:1587-94.
    • (2014) Anticancer Res , vol.34 , pp. 1587-1594
    • Polivka, J.1    Polivka, J.2    Rohan, V.3    Topolcan, O.4
  • 4
    • 84884762456 scopus 로고    scopus 로고
    • Glioblastoma multiforme-a review of pathogenesis, biomarkers and therapeutic perspectives
    • Polivka J, Polivka Jr J, Rohan V, Topolcan O. Glioblastoma multiforme-a review of pathogenesis, biomarkers and therapeutic perspectives. Cesk Slov Neurol N. 2013;76(109):575-83.
    • (2013) Cesk Slov Neurol N , vol.76 , Issue.109 , pp. 575-583
    • Polivka, J.1    Polivka, J.2    Rohan, V.3    Topolcan, O.4
  • 5
    • 85007580039 scopus 로고    scopus 로고
    • Advances in experimental targeted therapy and immunotherapy for patients with glioblastoma multiforme
    • Polivka J, Polivka J, Holubec L, Kubikova T, Priban V, Hes O, et al. Advances in experimental targeted therapy and immunotherapy for patients with glioblastoma multiforme. Anticancer Res. 2017;37:21-33.
    • (2017) Anticancer Res , vol.37 , pp. 21-33
    • Polivka, J.1    Polivka, J.2    Holubec, L.3    Kubikova, T.4    Priban, V.5    Hes, O.6
  • 7
    • 0141888540 scopus 로고    scopus 로고
    • Diagnosis and management of central nervous system metastases from breast cancer
    • Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 2003;8:398-410.
    • (2003) Oncologist , vol.8 , pp. 398-410
    • Chang, E.L.1    Lo, S.2
  • 8
    • 84897823394 scopus 로고    scopus 로고
    • Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients
    • Hung M-H, Liu C-Y, Shiau C-Y, Hsu C-Y, Tsai Y-F, Wang Y-L, et al. Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients. PLoS One. 2014;9:e89389.
    • (2014) PLoS One , vol.9
    • Hung, M.-H.1    Liu, C.-Y.2    Shiau, C.-Y.3    Hsu, C.-Y.4    Tsai, Y.-F.5    Wang, Y.-L.6
  • 9
    • 33646869874 scopus 로고    scopus 로고
    • Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG)
    • Pestalozzi BC, Zahrieh D, Price KN, Holmberg SB, Lindtner J, Collins J, et al. Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). Ann Oncol Off J Eur Soc Med Oncol. 2006;17:935-44.
    • (2006) Ann Oncol Off J Eur Soc Med Oncol , vol.17 , pp. 935-944
    • Pestalozzi, B.C.1    Zahrieh, D.2    Price, K.N.3    Holmberg, S.B.4    Lindtner, J.5    Collins, J.6
  • 10
    • 33747163007 scopus 로고    scopus 로고
    • Primary breast cancer phenotypes associated with propensity for central nervous system metastases
    • Tham Y-L, Sexton K, Kramer R, Hilsenbeck S, Elledge R. Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Cancer. 2006;107:696-704.
    • (2006) Cancer , vol.107 , pp. 696-704
    • Tham, Y.-L.1    Sexton, K.2    Kramer, R.3    Hilsenbeck, S.4    Elledge, R.5
  • 13
    • 33748040055 scopus 로고    scopus 로고
    • Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR
    • Hicks DG, Short SM, Prescott NL, Tarr SM, Coleman KA, Yoder BJ, et al. Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am J Surg Pathol. 2006;30:1097-104.
    • (2006) Am J Surg Pathol , vol.30 , pp. 1097-1104
    • Hicks, D.G.1    Short, S.M.2    Prescott, N.L.3    Tarr, S.M.4    Coleman, K.A.5    Yoder, B.J.6
  • 14
    • 84863020427 scopus 로고    scopus 로고
    • Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    • Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30:419-25.
    • (2012) J Clin Oncol Off J Am Soc Clin Oncol , vol.30 , pp. 419-425
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3    Xu, Z.4    Shanley, R.5    Luo, X.6
  • 15
    • 84941944189 scopus 로고    scopus 로고
    • Identifying risk factors for brain metastasis in breast cancer patients: implication for a vigorous surveillance program
    • Chow L, Suen D, Ma KK, Kwong A. Identifying risk factors for brain metastasis in breast cancer patients: implication for a vigorous surveillance program. Asian J Surg. 2015;38:220-3.
    • (2015) Asian J Surg , vol.38 , pp. 220-223
    • Chow, L.1    Suen, D.2    Ma, K.K.3    Kwong, A.4
  • 16
    • 70350008453 scopus 로고    scopus 로고
    • Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases
    • Heitz F1, Harter P, Lueck HJ, Fissler-Eckhoff A, Lorenz-Salehi F, Scheil-Bertram S, et al. Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases. Eur J Cancer. 2009;45(16):2792-8. doi: 10.1016/j.ejca.2009.06.027.
    • (2009) Eur J Cancer. , vol.45 , Issue.16 , pp. 2792-2798
    • Heitz, F1.1    Harter, P.2    Lueck, H.J.3    Fissler-Eckhoff, A.4    Lorenz-Salehi, F.5    Scheil-Bertram, S.6
  • 17
    • 85020735430 scopus 로고    scopus 로고
    • [cited 2016 Dec 30]
    • Prevention of breast cancers summary | European Cancer Prevention [Internet]. [cited 2016 Dec 30]. Available from: http://ecpo.org/?page_id=522
  • 19
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Network CGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Network, C.G.A.1
  • 20
    • 84982055971 scopus 로고    scopus 로고
    • Diversity of breast carcinoma: histological subtypes and clinical relevance
    • Makki J. Diversity of breast carcinoma: histological subtypes and clinical relevance. Clin Med Insights Pathol. 2015;8:23-31.
    • (2015) Clin Med Insights Pathol , vol.8 , pp. 23-31
    • Makki, J.1
  • 24
    • 84870758132 scopus 로고    scopus 로고
    • Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival
    • Ishihara M, Mukai H, Nagai S, Onozawa M, Nihei K, Shimada T, et al. Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. Oncology. 2013;84:135-40.
    • (2013) Oncology , vol.84 , pp. 135-140
    • Ishihara, M.1    Mukai, H.2    Nagai, S.3    Onozawa, M.4    Nihei, K.5    Shimada, T.6
  • 25
    • 84959084796 scopus 로고    scopus 로고
    • Risk factors for brain metastasis as a first site of disease recurrence in patients with HER2 positive early stage breast cancer treated with adjuvant trastuzumab
    • Tonyali O, Coskun U, Yuksel S, Inanc M, Bal O, Akman T, et al. Risk factors for brain metastasis as a first site of disease recurrence in patients with HER2 positive early stage breast cancer treated with adjuvant trastuzumab. Breast Edinb Scotl. 2016;25:22-6.
    • (2016) Breast Edinb Scotl , vol.25 , pp. 22-26
    • Tonyali, O.1    Coskun, U.2    Yuksel, S.3    Inanc, M.4    Bal, O.5    Akman, T.6
  • 26
    • 84978024386 scopus 로고    scopus 로고
    • Breast cancer brain metastases: the last frontier
    • Leone JP, Leone BA. Breast cancer brain metastases: the last frontier. Exp Hematol Oncol. 2015;4:33.
    • (2015) Exp Hematol Oncol , vol.4 , pp. 33
    • Leone, J.P.1    Leone, B.A.2
  • 27
    • 84987704177 scopus 로고    scopus 로고
    • Targeted therapies for brain metastases from breast cancer
    • Venur VA, Leone JP. Targeted therapies for brain metastases from breast cancer. Int J Mol Sci. 2016;17.
    • (2016) Int J Mol Sci. , pp. 17
    • Venur, V.A.1    Leone, J.P.2
  • 29
    • 84949535312 scopus 로고    scopus 로고
    • Testing for oncogenic molecular aberrations in cell-free DNA-based liquid biopsies in the clinic: are we there yet?
    • Polivka J, Pesta M, Janku F. Testing for oncogenic molecular aberrations in cell-free DNA-based liquid biopsies in the clinic: are we there yet? Expert Rev Mol Diagn. 2015;15:1631-44.
    • (2015) Expert Rev Mol Diagn , vol.15 , pp. 1631-1644
    • Polivka, J.1    Pesta, M.2    Janku, F.3
  • 30
  • 31
    • 80052666221 scopus 로고    scopus 로고
    • Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study
    • Sihto H, Lundin J, Lundin M, Lehtimäki T, Ristimäki A, Holli K, et al. Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study. Breast Cancer Res BCR. 2011;13:R87.
    • (2011) Breast Cancer Res BCR , vol.13 , pp. R87
    • Sihto, H.1    Lundin, J.2    Lundin, M.3    Lehtimäki, T.4    Ristimäki, A.5    Holli, K.6
  • 36
    • 78650880204 scopus 로고    scopus 로고
    • HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
    • Da Silva L, Simpson PT, Smart CE, Cocciardi S, Waddell N, Lane A, et al. HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Res BCR. 2010;12:R46.
    • (2010) Breast Cancer Res BCR , vol.12 , pp. R46
    • Silva, L.1    Simpson, P.T.2    Smart, C.E.3    Cocciardi, S.4    Waddell, N.5    Lane, A.6
  • 39
    • 79960668961 scopus 로고    scopus 로고
    • Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer
    • McGowan PM, Simedrea C, Ribot EJ, Foster PJ, Palmieri D, Steeg PS, et al. Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Mol Cancer Res MCR. 2011;9:834-44.
    • (2011) Mol Cancer Res MCR , vol.9 , pp. 834-844
    • McGowan, P.M.1    Simedrea, C.2    Ribot, E.J.3    Foster, P.J.4    Palmieri, D.5    Steeg, P.S.6
  • 40
    • 0038475948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability
    • Lee T-H, Avraham HK, Jiang S, Avraham S. Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability. J Biol Chem. 2003;278:5277-84.
    • (2003) J Biol Chem , vol.278 , pp. 5277-5284
    • Lee, T.-H.1    Avraham, H.K.2    Jiang, S.3    Avraham, S.4
  • 41
    • 84892381025 scopus 로고    scopus 로고
    • Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain
    • Avraham HK, Jiang S, Fu Y, Nakshatri H, Ovadia H, Avraham S. Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain. J Pathol. 2014;232:369-81.
    • (2014) J Pathol , vol.232 , pp. 369-381
    • Avraham, H.K.1    Jiang, S.2    Fu, Y.3    Nakshatri, H.4    Ovadia, H.5    Avraham, S.6
  • 42
    • 3543065871 scopus 로고    scopus 로고
    • Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells
    • Lee B-C, Lee T-H, Avraham S, Avraham HK. Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res MCR. 2004;2:327-38.
    • (2004) Mol Cancer Res MCR , vol.2 , pp. 327-338
    • Lee, B.-C.1    Lee, T.-H.2    Avraham, S.3    Avraham, H.K.4
  • 43
    • 84940669496 scopus 로고    scopus 로고
    • CXCR4 in breast cancer: oncogenic role and therapeutic targeting
    • Xu C, Zhao H, Chen H, Yao Q. CXCR4 in breast cancer: oncogenic role and therapeutic targeting. Drug Des Devel Ther. 2015;9:4953-64.
    • (2015) Drug Des Devel Ther , vol.9 , pp. 4953-4964
    • Xu, C.1    Zhao, H.2    Chen, H.3    Yao, Q.4
  • 44
    • 84987681535 scopus 로고    scopus 로고
    • Blood-brain barrier remodeling during brain metastasis formation
    • Wrobel JK, Toborek M. Blood-brain barrier remodeling during brain metastasis formation. Mol Med Camb Mass. 2016.
    • (2016) Mol Med Camb Mass.
    • Wrobel, J.K.1    Toborek, M.2
  • 45
    • 3342959040 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice
    • Kim LS, Huang S, Lu W, Lev DC, Price JE. Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin Exp Metastasis. 2004;21:107-18.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 107-118
    • Kim, L.S.1    Huang, S.2    Lu, W.3    Lev, D.C.4    Price, J.E.5
  • 46
    • 84930634266 scopus 로고    scopus 로고
    • The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
    • Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, et al. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature. 2015;522:106-10.
    • (2015) Nature , vol.522 , pp. 106-110
    • Cox, T.R.1    Rumney, R.M.H.2    Schoof, E.M.3    Perryman, L.4    Høye, A.M.5    Agrawal, A.6
  • 48
    • 84899885077 scopus 로고    scopus 로고
    • Breast cancer brain metastases: evidence for neuronal-like adaptation in a "breast-to-brain" transition?
    • Van Swearingen AE, Siegel MB, Anders CK. Breast cancer brain metastases: evidence for neuronal-like adaptation in a "breast-to-brain" transition? Breast Cancer Res BCR. 2014;16:304.
    • (2014) Breast Cancer Res BCR , vol.16 , pp. 304
    • Swearingen, A.E.1    Siegel, M.B.2    Anders, C.K.3
  • 49
    • 84905472306 scopus 로고    scopus 로고
    • Role of the neural niche in brain metastatic cancer
    • Termini J, Neman J, Jandial R. Role of the neural niche in brain metastatic cancer. Cancer Res. 2014;74:4011-5.
    • (2014) Cancer Res , vol.74 , pp. 4011-4015
    • Termini, J.1    Neman, J.2    Jandial, R.3
  • 50
    • 77956603258 scopus 로고    scopus 로고
    • Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way
    • Pukrop T, Dehghani F, Chuang H-N, Lohaus R, Bayanga K, Heermann S, et al. Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia. 2010;58:1477-89.
    • (2010) Glia , vol.58 , pp. 1477-1489
    • Pukrop, T.1    Dehghani, F.2    Chuang, H.-N.3    Lohaus, R.4    Bayanga, K.5    Heermann, S.6
  • 51
    • 53949093698 scopus 로고    scopus 로고
    • Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization
    • Fitzgerald DP, Palmieri D, Hua E, Hargrave E, Herring JM, Qian Y, et al. Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization. Clin Exp Metastasis. 2008;25:799-810.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 799-810
    • Fitzgerald, D.P.1    Palmieri, D.2    Hua, E.3    Hargrave, E.4    Herring, J.M.5    Qian, Y.6
  • 55
    • 84859110592 scopus 로고    scopus 로고
    • Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse
    • Harrell JC, Prat A, Parker JS, Fan C, He X, Carey L, et al. Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse. Breast Cancer Res Treat. 2012;132:523-35.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 523-535
    • Harrell, J.C.1    Prat, A.2    Parker, J.S.3    Fan, C.4    He, X.5    Carey, L.6
  • 56
    • 84946215072 scopus 로고    scopus 로고
    • Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets
    • Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, et al. Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov. 2015;5:1164-77.
    • (2015) Cancer Discov , vol.5 , pp. 1164-1177
    • Brastianos, P.K.1    Carter, S.L.2    Santagata, S.3    Cahill, D.P.4    Taylor-Weiner, A.5    Jones, R.T.6
  • 58
    • 84878430061 scopus 로고    scopus 로고
    • Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab
    • Olson EM, Abdel-Rasoul M, Maly J, Wu CS, Lin NU, Shapiro CL. Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab. Ann Oncol Off J Eur Soc Med Oncol. 2013;24:1526-33.
    • (2013) Ann Oncol Off J Eur Soc Med Oncol , vol.24 , pp. 1526-1533
    • Olson, E.M.1    Abdel-Rasoul, M.2    Maly, J.3    Wu, C.S.4    Lin, N.U.5    Shapiro, C.L.6
  • 59
    • 38549134656 scopus 로고    scopus 로고
    • Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials
    • Bria E, Cuppone F, Fornier M, Nisticò C, Carlini P, Milella M, et al. Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials. Breast Cancer Res Treat. 2008;109:231-9.
    • (2008) Breast Cancer Res Treat , vol.109 , pp. 231-239
    • Bria, E.1    Cuppone, F.2    Fornier, M.3    Nisticò, C.4    Carlini, P.5    Milella, M.6
  • 60
    • 34548444589 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials
    • Viani GA, Afonso SL, Stefano EJ, De Fendi LI, Soares FV. Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer. 2007;7:153.
    • (2007) BMC Cancer , vol.7 , pp. 153
    • Viani, G.A.1    Afonso, S.L.2    Stefano, E.J.3    Fendi, L.I.4    Soares, F.V.5
  • 61
    • 46149111250 scopus 로고    scopus 로고
    • Trastuzumab in the adjuvant treatment of early-stage breast cancer: a systematic review and meta-analysis of randomized controlled trials
    • Dahabreh IJ, Linardou H, Siannis F, Fountzilas G, Murray S. Trastuzumab in the adjuvant treatment of early-stage breast cancer: a systematic review and meta-analysis of randomized controlled trials. Oncologist. 2008;13:620-30.
    • (2008) Oncologist , vol.13 , pp. 620-630
    • Dahabreh, I.J.1    Linardou, H.2    Siannis, F.3    Fountzilas, G.4    Murray, S.5
  • 62
    • 84875236228 scopus 로고    scopus 로고
    • CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)
    • Pestalozzi BC, Holmes E, de Azambuja E, Metzger-Filho O, Hogge L, Scullion M, et al. CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01). Lancet Oncol. 2013;14:244-8.
    • (2013) Lancet Oncol , vol.14 , pp. 244-248
    • Pestalozzi, B.C.1    Holmes, E.2    Azambuja, E.3    Metzger-Filho, O.4    Hogge, L.5    Scullion, M.6
  • 63
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
    • Swain SM, Kim S-B, Cortés J, Ro J, Semiglazov V, Campone M, et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2013;14:461-71.
    • (2013) Lancet Oncol , vol.14 , pp. 461-471
    • Swain, S.M.1    Kim, S.-B.2    Cortés, J.3    Ro, J.4    Semiglazov, V.5    Campone, M.6
  • 64
    • 84903885321 scopus 로고    scopus 로고
    • Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study CLEOPATRA
    • Swain SM, Baselga J, Miles D, Im Y-H, Quah C, Lee LF, et al. Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study CLEOPATRA. Ann Oncol Off J Eur Soc Med Oncol. 2014;25:1116-21.
    • (2014) Ann Oncol Off J Eur Soc Med Oncol , vol.25 , pp. 1116-1121
    • Swain, S.M.1    Baselga, J.2    Miles, D.3    Im, Y.-H.4    Quah, C.5    Lee, L.F.6
  • 65
    • 84933556321 scopus 로고    scopus 로고
    • CEREBEL (EGF111438): a phase III, randomized, open-label study of lapatinib plus capecitabine versus trastuzumab plus capecitabine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
    • Pivot X, Manikhas A, Zurawski B, Chmielowska E, Karaszewska B, Allerton R, et al. CEREBEL (EGF111438): a phase III, randomized, open-label study of lapatinib plus capecitabine versus trastuzumab plus capecitabine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2015;33:1564-73.
    • (2015) J Clin Oncol Off J Am Soc Clin Oncol , vol.33 , pp. 1564-1573
    • Pivot, X.1    Manikhas, A.2    Zurawski, B.3    Chmielowska, E.4    Karaszewska, B.5    Allerton, R.6
  • 66
    • 84953364603 scopus 로고    scopus 로고
    • Pathogenesis of breast cancer metastasis to brain: a comprehensive approach to the signaling network
    • Tayyeb B, Parvin M. Pathogenesis of breast cancer metastasis to brain: a comprehensive approach to the signaling network. Mol Neurobiol. 2016;53:446-54.
    • (2016) Mol Neurobiol , vol.53 , pp. 446-454
    • Tayyeb, B.1    Parvin, M.2
  • 67
    • 84940663493 scopus 로고    scopus 로고
    • A hypoxic ticket to the bone metastatic niche
    • Vanharanta S. A hypoxic ticket to the bone metastatic niche. Breast Cancer Res BCR. 2015;17:122.
    • (2015) Breast Cancer Res BCR , vol.17 , pp. 122
    • Vanharanta, S.1
  • 68
    • 85016150683 scopus 로고    scopus 로고
    • Flammer syndrome and potential formation of pre-metastatic niches: a multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease
    • Golubnitschaja O, Debald M, Kuhn W, Yeghiazaryan K, Bubnov RV, Goncharenko VM, et al. Flammer syndrome and potential formation of pre-metastatic niches: a multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease. EPMA J. 2016;7:A25.
    • (2016) EPMA J , vol.7 , pp. A25
    • Golubnitschaja, O.1    Debald, M.2    Kuhn, W.3    Yeghiazaryan, K.4    Bubnov, R.V.5    Goncharenko, V.M.6
  • 69
    • 84864134608 scopus 로고    scopus 로고
    • Predicting survival in women with breast cancer and brain metastasis: a nomogram outperforms current survival prediction models
    • Marko NF, Xu Z, Gao T, Kattan MW, Weil RJ. Predicting survival in women with breast cancer and brain metastasis: a nomogram outperforms current survival prediction models. Cancer. 2012;118:3749-57.
    • (2012) Cancer , vol.118 , pp. 3749-3757
    • Marko, N.F.1    Xu, Z.2    Gao, T.3    Kattan, M.W.4    Weil, R.J.5
  • 70
    • 84941334997 scopus 로고    scopus 로고
    • Validation and development of a modified breast graded prognostic assessment as a tool for survival in patients with breast cancer and brain metastases
    • Subbiah IM, Lei X, Weinberg JS, Sulman EP, Chavez-MacGregor M, Tripathy D, et al. Validation and development of a modified breast graded prognostic assessment as a tool for survival in patients with breast cancer and brain metastases. J Clin Oncol Off J Am Soc Clin Oncol. 2015;33:2239-45.
    • (2015) J Clin Oncol Off J Am Soc Clin Oncol , vol.33 , pp. 2239-2245
    • Subbiah, I.M.1    Lei, X.2    Weinberg, J.S.3    Sulman, E.P.4    Chavez-MacGregor, M.5    Tripathy, D.6


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