메뉴 건너뛰기




Volumn 22, Issue , 2016, Pages 32-40

Blood–brain barrier remodeling during brain metastasis formation

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD BRAIN BARRIER; BRAIN CIRCULATION; BRAIN METASTASIS; CANCER GROWTH; CARCINOGENESIS; CELL HOMING; CELL MIGRATION; CELL MOTION; CELL SURVIVAL; EXTRAVASATION; HUMAN; INTRAVASATION; PRIORITY JOURNAL; REVIEW; TUMOR CELL; TUMOR INVASION; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIUM;

EID: 84987681535     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2015.00207     Document Type: Review
Times cited : (62)

References (83)
  • 1
    • 79951865370 scopus 로고    scopus 로고
    • Clinical implications of the cancer genome
    • Macconaill LE, Garraway LA. (2010) Clinical implications of the cancer genome. J. Clin. Oncol. 28:5219–28.
    • (2010) J. Clin. Oncol , vol.28 , pp. 5219-5228
    • Macconaill, L.E.1    Garraway, L.A.2
  • 2
    • 77957664584 scopus 로고    scopus 로고
    • Expansion of cancer care and control in countries of low and middle income: A call to action
    • Farmer P, et al. (2010) Expansion of cancer care and control in countries of low and middle income: a call to action. Lancet. 376:1186–93.
    • (2010) Lancet , vol.376 , pp. 1186-1193
    • Farmer, P.1
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. (2011) Hallmarks of cancer: the next generation. Cell. 144:646–74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. (2002) Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer. 2:563–72.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 5
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. (2011) Tumor metastasis: molecular insights and evolving paradigms. Cell. 147:275–92.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 6
    • 84871485133 scopus 로고    scopus 로고
    • The initial hours of metastasis: The importance of cooperative host-tumor cell interactions during hematogenous dissemination
    • Labelle M, Hynes RO. (2012) The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2:1091–9.
    • (2012) Cancer Discov , vol.2 , pp. 1091-1099
    • Labelle, M.1    Hynes, R.O.2
  • 7
    • 79961208848 scopus 로고    scopus 로고
    • Initial steps of metastasis: Cell invasion and endothelial transmigration
    • van Zijl F, Krupitza G, Mikulits W. (2011) Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat. Res. 728:23–34.
    • (2011) Mutat. Res , vol.728 , pp. 23-34
    • Van Zijl, F.1    Krupitza, G.2    Mikulits, W.3
  • 8
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. (2009) Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer. 9:274–84.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 9
    • 84931572031 scopus 로고    scopus 로고
    • The role of individual inheritance in tumor progression and metastasis
    • Hunter K. (2015) The role of individual inheritance in tumor progression and metastasis. J. Mol. Med. (Berl). 93:719–25.
    • (2015) J. Mol. Med. (Berl). , vol.93 , pp. 719-725
    • Hunter, K.1
  • 10
    • 34648832906 scopus 로고    scopus 로고
    • Illuminating the metastatic process
    • Sahai E. (2007) Illuminating the metastatic process. Nat. Rev. Cancer. 7:737–49.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 737-749
    • Sahai, E.1
  • 11
    • 4344589420 scopus 로고    scopus 로고
    • Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells
    • Kim JW, et al. (2004) Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Lett. 213:203–12.
    • (2004) Cancer Lett , vol.213 , pp. 203-212
    • Kim, J.W.1
  • 12
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited
    • Fidler IJ. (2003) The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat. Rev. Cancer. 3:453–8.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 13
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. (2011) A perspective on cancer cell metastasis. Science. 331:1559–64.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 14
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl P, Wolf K. (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer. 3:362–74.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 15
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S. (2011) Cancer invasion and the microenvironment: plasticity and reciprocity. Cell. 147:992–1009.
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 16
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 141:52–67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 17
    • 77956895981 scopus 로고    scopus 로고
    • Biological characteristics of a specific brain metastatic cell line derived from human lung adenocarcinoma
    • Hu L, et al. (2010) Biological characteristics of a specific brain metastatic cell line derived from human lung adenocarcinoma. Med. Oncol. 27:708–14.
    • (2010) Med. Oncol , vol.27 , pp. 708-714
    • Hu, L.1
  • 18
    • 24744464071 scopus 로고    scopus 로고
    • Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model
    • Mendes O, Kim HT, Stoica G. (2005) Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clin. Exp. Metastasis. 22:237–46.
    • (2005) Clin. Exp. Metastasis , vol.22 , pp. 237-246
    • Mendes, O.1    Kim, H.T.2    Stoica, G.3
  • 19
    • 33645532055 scopus 로고    scopus 로고
    • Activation of stat3 in human melanoma promotes brain metastasis
    • Xie TX, et al. (2006) Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 66:3188–96.
    • (2006) Cancer Res , vol.66 , pp. 3188-3196
    • Xie, T.X.1
  • 20
    • 80051709700 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins
    • Feng S, et al. (2011) Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins. PLoS One. 6:e20599.
    • (2011) Plos One , vol.6
    • Feng, S.1
  • 21
    • 79960741978 scopus 로고    scopus 로고
    • MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia
    • Yang Y, Rosenberg GA. (2011) MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. Methods Mol. Biol. 762:333–45.
    • (2011) Methods Mol. Biol , vol.762 , pp. 333-345
    • Yang, Y.1    Rosenberg, G.A.2
  • 22
    • 79957976779 scopus 로고    scopus 로고
    • Transmigration of melanoma cells through the blood-brain barrier: Role of endothelial tight junctions and melanoma-released serine proteases
    • Fazakas C, et al. (2011) Transmigration of melanoma cells through the blood-brain barrier: role of endothelial tight junctions and melanoma-released serine proteases. PLoS One. 6:e20758.
    • (2011) Plos One , vol.6
    • Fazakas, C.1
  • 23
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. (2009) Microenvironmental regulation of metastasis. Nat. Rev. Cancer. 9:239–52.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 24
    • 84930764392 scopus 로고    scopus 로고
    • Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature
    • 44–46C
    • Deryugina EI, Quigley JP. (2015) Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. Matrix Biol. 44–46C:94–112.
    • (2015) Matrix Biol. , pp. 94-112
    • Deryugina, E.I.1    Quigley, J.P.2
  • 25
    • 84888361416 scopus 로고    scopus 로고
    • Crossing the endothelial barrier during metastasis
    • Reymond N, d’Agua BB, Ridley AJ. (2013) Crossing the endothelial barrier during metastasis. Nat. Rev. Cancer. 13:858–70.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 858-870
    • Reymond, N.1    D’Agua, B.B.2    Ridley, A.J.3
  • 26
    • 76649119448 scopus 로고    scopus 로고
    • Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: A three-dimensional FRET study
    • Khuon S, et al. (2010) Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study. J. Cell Sci. 123:431–40.
    • (2010) J. Cell Sci , vol.123 , pp. 431-440
    • Khuon, S.1
  • 28
    • 0038475948 scopus 로고    scopus 로고
    • Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability
    • Lee TH, Avraham HK, Jiang S, Avraham S. (2003) Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability. J. Biol. Chem. 278:5277–84.
    • (2003) J. Biol. Chem , vol.278 , pp. 5277-5284
    • Lee, T.H.1    Avraham, H.K.2    Jiang, S.3    Avraham, S.4
  • 29
    • 84922581123 scopus 로고    scopus 로고
    • Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis
    • Leong HS, et al. (2014) Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. Cell Rep. 8:1558–70.
    • (2014) Cell Rep , vol.8 , pp. 1558-1570
    • Leong, H.S.1
  • 30
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: Tumor-associated niche cells
    • Wels J, Kaplan RN, Rafii S, Lyden D. (2008) Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev. 22:559–74.
    • (2008) Genes Dev , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4
  • 31
  • 32
    • 77953215400 scopus 로고    scopus 로고
    • Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis
    • Lorger M, Felding-Habermann B. (2010) Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am. J. Pathol. 176:2958–71.
    • (2010) Am. J. Pathol , vol.176 , pp. 2958-2971
    • Lorger, M.1    Felding-Habermann, B.2
  • 33
    • 0034849958 scopus 로고    scopus 로고
    • Organ-specificity of the extravasation process: An ultrastructural study. Clin. Exp
    • Paku S, Dome B, Toth R, Timar J. (2000) Organ-specificity of the extravasation process: an ultrastructural study. Clin. Exp. Metastasis. 18:481–92.
    • (2000) Metastasis , vol.18 , pp. 481-492
    • Paku, S.1    Dome, B.2    Toth, R.3    Timar, J.4
  • 34
    • 73849129203 scopus 로고    scopus 로고
    • Real-time imaging reveals the single steps of brain metastasis formation
    • Kienast Y, et al. (2010) Real-time imaging reveals the single steps of brain metastasis formation. Nat. Med. 16:116–22.
    • (2010) Nat. Med , vol.16 , pp. 116-122
    • Kienast, Y.1
  • 35
    • 67349264881 scopus 로고    scopus 로고
    • Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model
    • JuanYin J, et al. (2009) Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clin. Exp. Metastasis. 26:403–14.
    • (2009) Clin. Exp. Metastasis , vol.26 , pp. 403-414
    • Juanyin, J.1
  • 36
    • 84907512767 scopus 로고    scopus 로고
    • The molecular biology of lung cancer brain metastasis: An overview of current comprehensions and future perspectives
    • Hanibuchi M, Kim SJ, Fidler IJ, Nishioka Y. (2014) The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives. J. Med. Invest. 61:241–53.
    • (2014) J. Med. Invest , vol.61 , pp. 241-253
    • Hanibuchi, M.1    Kim, S.J.2    Fidler, I.J.3    Nishioka, Y.4
  • 38
    • 0030910463 scopus 로고    scopus 로고
    • Endothelial-selectin ligands sialyl Lewis(X) and sialyl Lewis(a) are differentiation antigens immunogenic in human melanoma
    • Ravindranath MH, et al. (1997) Endothelial-selectin ligands sialyl Lewis(x) and sialyl Lewis(a) are differentiation antigens immunogenic in human melanoma. Cancer. 79:1686–97.
    • (1997) Cancer , vol.79 , pp. 1686-1697
    • Ravindranath, M.H.1
  • 39
    • 84867027385 scopus 로고    scopus 로고
    • LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro
    • Ghislin S, et al. (2012) LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro. BMC Cancer. 12:455.
    • (2012) BMC Cancer , vol.12 , pp. 455
    • Ghislin, S.1
  • 40
    • 34347393710 scopus 로고    scopus 로고
    • High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers
    • Klemke M, Weschenfelder T, Konstandin MH, Samstag Y. (2007) High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J. Cell. Physiol. 212:368–74.
    • (2007) J. Cell. Physiol , vol.212 , pp. 368-374
    • Klemke, M.1    Weschenfelder, T.2    Konstandin, M.H.3    Samstag, Y.4
  • 41
    • 57349172005 scopus 로고    scopus 로고
    • Melanoma cell adhesion can be blocked by heparin in vitro: Suggestion of VLA-4 as a novel target for antimetastatic approaches
    • Fritzsche J, Simonis D, Bendas G. (2008) Melanoma cell adhesion can be blocked by heparin in vitro: suggestion of VLA-4 as a novel target for antimetastatic approaches. Thromb. Haemost. 100:1166–75.
    • (2008) Thromb. Haemost , vol.100 , pp. 1166-1175
    • Fritzsche, J.1    Simonis, D.2    Bendas, G.3
  • 42
    • 77955034793 scopus 로고    scopus 로고
    • Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development
    • Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. (2010) Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 70:6071–82.
    • (2010) Cancer Res , vol.70 , pp. 6071-6082
    • Huh, S.J.1    Liang, S.2    Sharma, A.3    Dong, C.4    Robertson, G.P.5
  • 43
    • 84892381025 scopus 로고    scopus 로고
    • Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain
    • Avraham HK, et al. (2014) Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain. J. Pathol. 232:369–81.
    • (2014) J. Pathol , vol.232 , pp. 369-381
    • Avraham, H.K.1
  • 44
    • 84908118492 scopus 로고    scopus 로고
    • Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
    • Sevenich L, et al. (2014) Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat. Cell. Biol. 16:876–88.
    • (2014) Nat. Cell. Biol , vol.16 , pp. 876-888
    • Sevenich, L.1
  • 45
    • 12144290954 scopus 로고    scopus 로고
    • Increased expression of integrin alpha3beta1 in highly brain metastatic subclone of a human non-small cell lung cancer cell line
    • Yoshimasu T, et al. (2004) Increased expression of integrin alpha3beta1 in highly brain metastatic subclone of a human non-small cell lung cancer cell line. Cancer Sci. 95:142–8.
    • (2004) Cancer Sci , vol.95 , pp. 142-148
    • Yoshimasu, T.1
  • 46
    • 0035158462 scopus 로고    scopus 로고
    • Involvement of integrin alpha(V) beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells
    • Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH. (2001) Involvement of integrin alpha(v) beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol. Biol. Cell. 12:2699–710.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2699-2710
    • Voura, E.B.1    Ramjeesingh, R.A.2    Montgomery, A.M.3    Siu, C.H.4
  • 47
    • 84892176637 scopus 로고    scopus 로고
    • AlphaB-crystallin: A novel regulator of breast cancer metastasis to the brain
    • Malin D, et al. (2014) alphaB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clin. Cancer Res. 20:56–67.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 56-67
    • Malin, D.1
  • 48
    • 84926298898 scopus 로고    scopus 로고
    • Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier
    • Tominaga N, et al. (2015) Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat. Commun. 6:6716.
    • (2015) Nat. Commun , vol.6 , pp. 6716
    • Tominaga, N.1
  • 49
    • 84863246877 scopus 로고    scopus 로고
    • N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors
    • Gligorijevic B, et al. (2012) N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J. Cell Sci. 125:724–34.
    • (2012) J. Cell Sci , vol.125 , pp. 724-734
    • Gligorijevic, B.1
  • 51
    • 84947418401 scopus 로고    scopus 로고
    • AKT1 activation promotes development of melanoma metastases
    • Cho JH, et al. (2015) AKT1 activation promotes development of melanoma metastases. Cell Rep. 13:898–905.
    • (2015) Cell Rep , vol.13 , pp. 898-905
    • Cho, J.H.1
  • 52
    • 84862649113 scopus 로고    scopus 로고
    • Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-; Il2rg-/-mice and treatment with PI3K inhibitor
    • Nanni P, et al. (2012) Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-; Il2rg-/-mice and treatment with PI3K inhibitor. PLoS One. 7:e39626.
    • (2012) Plos One , vol.7
    • Nanni, P.1
  • 53
    • 84987643511 scopus 로고    scopus 로고
    • Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K
    • 8 December, [Epub ahead of print]
    • Molnar J, et al. (2015) Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K. Cell Adh. Migr. 8 December 2015 [Epub ahead of print]
    • (2015) Cell Adh. Migr.
    • Molnar, J.1
  • 54
    • 0032530218 scopus 로고    scopus 로고
    • Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
    • Oku T, et al. (1998) Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts. Cancer Res. 58:4185–92.
    • (1998) Cancer Res , vol.58 , pp. 4185-4192
    • Oku, T.1
  • 55
    • 0034282780 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis
    • Yano S, et al. (2000) Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. Cancer Res. 60:4959–67.
    • (2000) Cancer Res , vol.60 , pp. 4959-4967
    • Yano, S.1
  • 57
    • 84897009392 scopus 로고    scopus 로고
    • Functional role of endothelial adhesion molecules in the early stages of brain metastasis
    • Soto MS, Serres S, Anthony DC, Sibson NR. (2014) Functional role of endothelial adhesion molecules in the early stages of brain metastasis. Neuro. Oncol. 16:540–51.
    • (2014) Neuro. Oncol , vol.16 , pp. 540-551
    • Soto, M.S.1    Serres, S.2    Anthony, D.C.3    Sibson, N.R.4
  • 58
    • 79958045766 scopus 로고    scopus 로고
    • The biology of brain metastases: Translation to new therapies
    • Eichler AF, et al. (2011) The biology of brain metastases: translation to new therapies. Nat. Rev. Clin. Oncol. 8:344–56.
    • (2011) Nat. Rev. Clin. Oncol , vol.8 , pp. 344-356
    • Eichler, A.F.1
  • 60
    • 79952073192 scopus 로고    scopus 로고
    • The role of the organ microenvironment in brain metastasis. Semin
    • Fidler IJ. (2011) The role of the organ microenvironment in brain metastasis. Semin. Cancer Biol. 21:107–12.
    • (2011) Cancer Biol , vol.21 , pp. 107-112
    • Fidler, I.J.1
  • 61
    • 84881332287 scopus 로고    scopus 로고
    • Junctional adhesion molecules in cerebral endothelial tight junction and brain metastasis
    • Jia W, Martin TA, Zhang G, Jiang WG. (2013) Junctional adhesion molecules in cerebral endothelial tight junction and brain metastasis. Anticancer Res. 33:2353–9.
    • (2013) Anticancer Res , vol.33 , pp. 2353-2359
    • Jia, W.1    Martin, T.A.2    Zhang, G.3    Jiang, W.G.4
  • 62
    • 0035576934 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
    • Huber JD, Egleton RD, Davis TP. (2001) Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 24:719–25.
    • (2001) Trends Neurosci , vol.24 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 63
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier. Nat
    • Abbott NJ, Ronnback L, Hansson E. (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7:41–53.
    • (2006) Rev. Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 64
    • 58449117658 scopus 로고    scopus 로고
    • Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface
    • Rolland Y, Demeule M, Fenart L, Beliveau R. (2009) Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface. Pigment Cell Melanoma Res. 22:86–98.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 86-98
    • Rolland, Y.1    Demeule, M.2    Fenart, L.3    Beliveau, R.4
  • 65
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos PD, et al. (2009) Genes that mediate breast cancer metastasis to the brain. Nature. 459:1005–9.
    • (2009) Nature , vol.459 , pp. 1005-1009
    • Bos, P.D.1
  • 66
    • 34247346051 scopus 로고    scopus 로고
    • Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer
    • Gabos Z, et al. (2006) Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer. J. Clin. Oncol. 24:5658–63.
    • (2006) J. Clin. Oncol , vol.24 , pp. 5658-5663
    • Gabos, Z.1
  • 67
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature. 436:518–24.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1
  • 68
    • 63449101161 scopus 로고    scopus 로고
    • The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain
    • Grinberg-Rashi H, et al. (2009) The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. Clin. Cancer Res. 15:1755–61.
    • (2009) Clin. Cancer Res , vol.15 , pp. 1755-1761
    • Grinberg-Rashi, H.1
  • 69
    • 0037591510 scopus 로고    scopus 로고
    • Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
    • Nakashima T, et al. (2003) Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients. Br. J. Cancer. 88:1727–33.
    • (2003) Br. J. Cancer , vol.88 , pp. 1727-1733
    • Nakashima, T.1
  • 70
    • 84866930450 scopus 로고    scopus 로고
    • Immunohistochemical expression of DCUN1D1 in non-small cell lung carcinoma: Its relation to brain metastasis
    • Yoo J, et al. (2012) Immunohistochemical expression of DCUN1D1 in non-small cell lung carcinoma: its relation to brain metastasis. Cancer Res. Treat. 44:57–62.
    • (2012) Cancer Res. Treat , vol.44 , pp. 57-62
    • Yoo, J.1
  • 71
    • 84946490769 scopus 로고    scopus 로고
    • The brain metastatic niche
    • Winkler F. (2015) The brain metastatic niche. J. Mol. Med. (Berl.). 93:1213–20.
    • (2015) J. Mol. Med. (Berl.). , vol.93 , pp. 1213-1220
    • Winkler, F.1
  • 72
    • 0034282497 scopus 로고    scopus 로고
    • Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase
    • Marchetti D, Li J, Shen R. (2000) Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res. 60:4767–70.
    • (2000) Cancer Res , vol.60 , pp. 4767-4770
    • Marchetti, D.1    Li, J.2    Shen, R.3
  • 73
    • 79951672873 scopus 로고    scopus 로고
    • Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis
    • Seike T, et al. (2011) Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin. Exp. Metastasis. 28:13–25.
    • (2011) Clin. Exp. Metastasis , vol.28 , pp. 13-25
    • Seike, T.1
  • 74
    • 84896690172 scopus 로고    scopus 로고
    • Serpins promote cancer cell survival and vascular co-option in brain metastasis
    • Valiente M, et al. (2014) Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 156:1002–16.
    • (2014) Cell , vol.156 , pp. 1002-1016
    • Valiente, M.1
  • 75
    • 84883487600 scopus 로고    scopus 로고
    • Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis
    • Louie E, et al. (2013) Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis. Oncogene. 32:4064–77.
    • (2013) Oncogene , vol.32 , pp. 4064-4077
    • Louie, E.1
  • 76
    • 84892942826 scopus 로고    scopus 로고
    • Human breast cancer metastases to the brain display GABAergic properties in the neural niche
    • Neman J, et al. (2014) Human breast cancer metastases to the brain display GABAergic properties in the neural niche. Proc. Natl. Acad. Sci. U. S. A. 111:984–9.
    • (2014) Proc. Natl. Acad. Sci. U. S. A , vol.111 , pp. 984-989
    • Neman, J.1
  • 77
    • 75649093779 scopus 로고    scopus 로고
    • Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/ neu-positive breast cancer
    • Yonemori K, et al. (2010) Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/ neu-positive breast cancer. Cancer. 116:302–8.
    • (2010) Cancer , vol.116 , pp. 302-308
    • Yonemori, K.1
  • 78
    • 84941076547 scopus 로고    scopus 로고
    • Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography
    • Wanek T, et al. (2015) Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with positron emission tomography. Mol. Pharm. 12:3214–25.
    • (2015) Mol. Pharm , vol.12 , pp. 3214-3225
    • Wanek, T.1
  • 79
    • 84866844026 scopus 로고    scopus 로고
    • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    • Cannon RE, Peart JC, Hawkins BT, Campos CR, Miller DS. (2012) Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc. Natl. Acad. Sci. U. S. A. 109:15930–5.
    • (2012) Proc. Natl. Acad. Sci. U. S. A , vol.109 , pp. 15930-15935
    • Cannon, R.E.1    Peart, J.C.2    Hawkins, B.T.3    Campos, C.R.4    Miller, D.S.5
  • 80
    • 35948984530 scopus 로고    scopus 로고
    • P-glycoprotein and breast cancer resistance protein: Two dominant transporters working together in limiting the brain penetration of topotecan
    • de Vries NA, et al. (2007) P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan. Clin. Cancer Res. 13:6440–9.
    • (2007) Clin. Cancer Res , vol.13 , pp. 6440-6449
    • De Vries, N.A.1
  • 81
    • 40349098162 scopus 로고    scopus 로고
    • Drug transporters: Recent advances concerning BCRP and tyrosine kinase inhibitors
    • Lemos C, Jansen G, Peters GJ. (2008) Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors. Br. J. Cancer. 98:857–62.
    • (2008) Br. J. Cancer , vol.98 , pp. 857-862
    • Lemos, C.1    Jansen, G.2    Peters, G.J.3
  • 82
    • 77958025244 scopus 로고    scopus 로고
    • Structure and function of the human breast cancer resistance protein (BCRP/ABCG2)
    • Ni Z, Bikadi Z, Rosenberg MF, Mao Q. (2010) Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr. Drug Metab. 11:603–17.
    • (2010) Curr. Drug Metab , vol.11 , pp. 603-617
    • Ni, Z.1    Bikadi, Z.2    Rosenberg, M.F.3    Mao, Q.4
  • 83
    • 77952393660 scopus 로고    scopus 로고
    • Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
    • Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y. (2010) Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone. J. Pharmacol. Exp. Ther. 333:788–96.
    • (2010) J. Pharmacol. Exp. Ther , vol.333 , pp. 788-796
    • Kodaira, H.1    Kusuhara, H.2    Ushiki, J.3    Fuse, E.4    Sugiyama, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.