Human breast cancer metastases to the brain display GABAergic properties in the neural niche

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 984-989

  Neman, Josh ^a   Termini, John ^b   Wilczynski, Sharon ^c   Vaidehi, Nagarajan ^c   Choy, Cecilia ^a,c   Kowolik, Claudia M ^c   Li, Hubert ^c   Hambrecht, Amanda C ^a,d   Roberts, Eugene ^e   Jandial, Rahul ^a,d  

^a Division of Neurosurgery City of Hope   (United States)

^b City of Hope   (United States)

^c Department of Molecular Medicine ^*  (United States)

^d Irell and Manella Graduate School of Biological Sciences   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Brain metastasis; Tumor microenvironment

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID CARRIER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUTAMATE DECARBOXYLASE 67; PARVALBUMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REELIN; SUCCINIC ACID;

ADULT; ARTICLE; BRAIN METASTASIS; BREAST CANCER; CANCER CELL; CANCER PATIENT; CANCER SURGERY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MIDDLE AGED; NEURAL STEM CELL; PHENOTYPE; PRIORITY JOURNAL; STEM CELL NICHE; TUMOR MICROENVIRONMENT;

BRAIN METASTASIS; TUMOR MICROENVIRONMENT;

4-AMINOBUTYRATE TRANSAMINASE; BRAIN NEOPLASMS; BREAST NEOPLASMS; CELL ADHESION MOLECULES, NEURONAL; CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATE DECARBOXYLASE; HUMANS; INTERNEURONS; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NEOPLASM METASTASIS; NERVE TISSUE PROTEINS; NEURONS; PARVALBUMINS; PHENOTYPE; RECEPTORS, GABA-A; SERINE ENDOPEPTIDASES; TUMOR MICROENVIRONMENT;

EID: 84892942826     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322098111     Document Type: Article

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