Quantification of b-Cell Mass in Intramuscular Islet Grafts Using Radiolabeled Exendin-4

Transplantation Direct

Volumn 2, Issue 8, 2016, Pages E93-

  Espes, Daniel ^a   Selvaraju, Ramkumar ^a   Velikyan, Irina ^a,b   Krajcovic, Martin ^a   Carlsson, Per Ola ^a   Eriksson, Olof ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c TURKU PET CENTRE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85015697347     PISSN: None     EISSN: 23738731     Source Type: Journal    
DOI: 10.1097/TXD.0000000000000598     Document Type: Article

References (37)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230–238.
2. Barton FB, Rickels MR, Alejandro R, et al. Improvement in outcomes of clinical islet transplantation: 1999–2010. Diabetes Care. 2012;35: 1436–1445.
3. Keymeulen B, Gillard P, Mathieu C, et al. Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. Proc Natl Acad Sci U S A. 2006;103:17444–17449.
4. Eriksson O, Eich T, Sundin A, et al. Positron emission tomography in clinical islet transplantation. Am J Transplant. 2009;9:2816–2824.
5. Bennet W, Sundberg B, Groth CG, et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes. 1999;48:1907–1914.
6. Olsson R, Olerud J, Pettersson U, et al. Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation. Diabetes. 2011;60:2350–2353.
7. Lau J, Carlsson PO. Low revascularization of human islets when experimentally transplanted into the liver. Transplantation. 2009;87:322–325.
8. Henriksnas J, Lau J, Zang G, et al. Markedly decreased blood perfusion of pancreatic islets transplanted intraportally into the liver: disruption of islet integrity necessary for islet revascularization. Diabetes. 2012;61:665–673.
9. Shapiro AM, Gallant HL, Hao EG, et al. The portal immunosuppressive storm: relevance to islet transplantation? Ther Drug Monit. 2005;27:35–37.
10. Westermark P, Eizirik DL, Pipeleers DG, et al. Rapid deposition of amyloid in human islets transplanted into nude mice. Diabetologia. 1995;38: 543–549.
11. Westermark GT, Westermark P, Berne C, et al. Widespread amyloid deposition in transplanted human pancreatic islets. N Engl J Med. 2008;359: 977–979.
12. Svensson J, Lau J, Sandberg M, et al. High Vascular density and oxygenation of pancreatic islets transplanted in clusters into striated muscle. Cell Transplant. 20;2010:783–788.
13. Christoffersson G, Henriksnas J, Johansson L, et al. Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets. Diabetes. 2010;59: 2569–2578.
14. Espes D, Lau J, Quach M, et al. Cotransplantation of polymerized hemoglobin reduces beta-cell hypoxia and improves beta-cell function in intramuscular islet grafts. Transplantation. 2015;99:2077–2082.
15. Weber CJ, Hardy MA, Pi-Sunyer F, et al. Tissue culture preservation and intramuscular transplantation of pancreatic islets. Surgery. 1978;84:166–174.
16. Lund T, Korsgren O, Aursnes IA, et al. Sustained reversal of diabetes following islet transplantation to striated musculature in the rat. J Surg Res. 2010;160:145–154.
17. Yasunami Y, Lacy PE, Finke EH. A new site for islet transplantation—a peritoneal-omental pouch. Transplantation. 1983;36:181–182.
18. D. Jacobs-Tulleneers-Thevissen, Bartholomeus K, Suenens K, et al. Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity. Diabetologia. 2010;53:1690–1699.
19. Bartholomeus K, D. Jacobs-Tulleneers-Thevissen, Shouyue S, et al. Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine beta-cell implants in immunodeficient rats. Transplantation. 2013;96:1026–1033.
20. Cantarelli E, Melzi R, Mercalli A, et al. Bone marrow as an alternative site for islet transplantation. Blood. 2009;114:4566–4574.
21. Korsgren O, Jansson L, Andersson A, et al. Reinnervation of transplanted pancreatic islets. A comparison among islets implanted into the kidney, spleen, and liver. Transplantation. 1993;56:138–143.
22. Carlsson PO, Palm F, Andersson A, et al. Chronically decreased oxygen tension in rat pancreatic islets transplanted under the kidney capsule. Transplantation. 2000;69:761–766.
23. Carlsson PO, Palm F, Andersson A, et al. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes. 2001;50:489–495.
24. Stagner JI, Rilo HL, White KK. The pancreas as an islet transplantation site. Confirmation in a syngeneic rodent and canine autotransplant model. JOP. 2007;8:628–636.
25. Lau J, Kampf C, Mattsson G, et al. Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets. Cell Transplant. 2009;18:23–30
26. Perez VL, Caicedo A, Berman DM, et al. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. Diabetologia. 2011;54:1121–1126.
27. Abdulreda MH, Caicedo A, Berggren PO. Transplantation into the anterior chamber of the eye for longitudinal, non-invasive in vivo imaging with single-cell resolution in real-time. J Vis Exp. 2013;73:e50466.
28. Pattou F, Kerr-Conte J, Wild D. GLP-1-receptor scanning for imaging of human beta cells transplanted in muscle. N Engl J Med. 2010;363: 1289–1290.
29. Brom M, Joosten L, Frielink C, et al. (111)In-exendin uptake in the pancreas correlates with the beta-cell mass and not with the alpha-cell mass. Diabetes. 2015;64:1324–1328.
30. Eter WA, Bos D, Frielink C, et al. Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin. Sci Rep. 2015;5:15521.
31. Nalin L, Selvaraju RK, Velikyan I, et al. Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs. Eur J Nucl Med Mol Imaging. 2014;41:1800–1810.
32. Selvaraju RK, Velikyan I, Johansson L, et al. In vivo imaging of the glucagonlike peptide 1 receptor in the pancreas with 68Ga-labeled DO3A-exendin-4. J Nucl Med. 2013;54:1458–1463.
33. Eriksson O, Velikyan I, Selvaraju RK, et al. Detection of metastatic insulinoma by positron emission tomography with [(68)ga]exendin-4-a case report. J Clin Endocrinol Metab. 2014;99:1519–1524.
34. Selvaraju RK, Bulenga TN, Espes D, et al. Dosimetry of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 in rodents, pigs, non-human primates and human—repeated scanning in human is possible. Am J Nucl Med Mol Imaging. 2015;5:259–269.
35. Velikyan I, Bulenga TN, Selvaraju R, et al. Dosimetry of [(177)Lu]-DO3A-VS-Cys(40)-Exendin-4—impact on the feasibility of insulinoma internal radiotherapy. Am J Nucl Med Mol Imaging. 2015;5:109–126.
36. Ullsten S, Lau J, Carlsson PO. Vascular heterogeneity between native rat pancreatic islets is responsible for differences in survival and revascularisation post transplantation. Diabetologia. 2015;58:132–139.
37. In't Veld P, Marichal M. Microscopic anatomy of the human islet of Langerhans. Adv Exp Med Biol. 2010;654:1–19.