High vascular density and oxygenation of pancreatic islets transplanted in clusters into striated muscle

Cell Transplantation

Volumn 20, Issue 5, 2011, Pages 783-788

  Svensson, Johanna ^a   Lau, Joey ^a   Sandberg, Monica ^a   Carlsson, Per Ola ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Angiogenesis; Engraftment; Islet graft; Muscle; Oxygenation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; COMPARATIVE STUDY; KIDNEY CORTEX; MALE; NONHUMAN; OXYGEN TENSION; OXYGENATION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; REVASCULARIZATION; SKELETAL MUSCLE;

ANIMALS; INJECTIONS, INTRAMUSCULAR; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MUSCLE, STRIATED; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; RATS; RATS, WISTAR;

EID: 79959928331     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X536527     Document Type: Article

References (29)

1. Andersson A. Isolated mouse pancreatic islets in culture: Effects of serum and different culture media on the insulin production of the islets. Diabetologia 14:397-404; 1978.
2. Bergsten, P.; Westerlund, J.; Liss, P.; Carlsson, P. O. Pri-mary in vivo oscillations of metabolism in the pancreas. Diabetes 51:699-703; 2002.
3. Bonner-Weir, S.; Orci, L. New perspectives on the micro-vasculature of the islets of Langerhans in the rat. Diabetes 31:883-889; 1982.
4. Carlsson, P. O.; Liss, P.; Andersson, A.; Jansson, L. Mea-surements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes 47:1027-1032; 1998.
5. Carlsson, P. O.; Nordin, A.; Palm, F. pH is decreased in transplanted rat pancreatic islets. Am. J. Physiol. Endocri- nol. Metab. 284:E499-504; 2003.
6. Carlsson, P. O.; Palm, F.; Andersson, A.; Liss, P. Chroni-cally decreased oxygen tension in rat pancreatic islets transplanted under the kidney capsule. Transplantation 69: 761-766; 2000.
7. Carlsson, P. O.; Palm, F.; Andersson, A.; Liss, P. Mark-edly decreased oxygen tension in transplanted rat pancre- atic islets irrespective of the implantation site. Diabetes 50:489-495; 2001.
8. 2A agonist administration improves islet trans- plant outcome: Evidence for the role of innate immunity in islet graft rejection. Cell Transplant. 19:597-612; 2010.
9. CITR Research Group. 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR). Cell Transplant. 18:753-767; 2009.
10. Hughes, S. J.; Davies, S. E.; Powis, S. H.; Press, M. Hy-peroxia improves the survival of intraportally transplanted syngeneic pancreatic islets. Transplantation 75:1954-1959; 2003.
11. Johansson, A.; Sandvik, D.; Carlsson, P. O. Inhibition of p38 MAP kinase in the early posttransplantation phase re- distributes blood vessels from the surrounding stroma into the transplanted endocrine tissue. Cell Transplant. 15: 483-488; 2006.
12. Kampf, C.; Lau, T.; Olsson, R.; Leung, P. S.; Carlsson, P. O. Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascu- larised syngeneic mouse islet grafts. Diabetologia 48: 1159-1167; 2005.
13. Lau, J.; Carlsson, P. O. Low revascularization of human islets when experimentally transplanted into the liver. Transplantation 87:322-325; 2009.
14. Lau, J.; Mattsson, G.; Carlsson, C.; Nyqvist, D.; Kohler, M.; Berggren, P. O.; Jansson, L.; Carlsson, P. O. Implan- tation site-dependent dysfunction of transplanted pancre- atic islets. Diabetes 56:1544-1550; 2007.
15. Lund, T.; Korsgren, O.; Aursnes, I. A.; Scholz, H.; Foss, A. Sustained reversal of diabetes following islet transplan- tation to striated musculature in the rat. J. Surg. Res. 160: 145-154; 2010.
16. Mattsson, G.; Jansson, L.; Carlsson, P. O. Decreased vas-cular density in mouse pancreatic islets after transplanta- tion. Diabetes 51:1362-1366; 2002.
17. Mattsson, G.; Jansson, L.; Nordin, A.; Andersson, A.; Carlsson, P. O. Evidence of functional impairment of syn- geneically transplanted mouse pancreatic islets retrieved from the liver. Diabetes 53:948-954; 2004.
18. Moberg, L.; Johansson, H.; Lukinius, A.; Berne, C.; Foss, A.; Kallen, R.; Ostraat, O.; Salmela, K.; Tibell, A.; Tufve- son, G.; Elgue, G.; Nilsson Ekdahl, K.; Korsgren, O.; Nilsson, B. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 360:2039-2045; 2002.
19. Nyman, L. R.; Wells, K. S.; Head, W. S.; McCaughey, M.; Ford, E.; Brissova, M.; Piston, D. W.; Powers, A. C. Real-time, multidimensional in vivo imaging used to in- vestigate blood flow in mouse pancreatic islets. J. Clin. Invest. 118:3790-3797; 2008.
20. Olerud, J.; Johansson, M.; Lawler, J.; Welsh, N.; Carlsson, P. O. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes 57:1870-1877; 2008.
21. Olsson, R. The microvasculature of endogenous and trans-planted pancreatic islets. Uppsala, Sweden: Uppsala Uni- versity; 2006:1-83.
22. Prior, B. M.; Yang, H. T.; Terjung, R. L. What makes vessels grow with exercise training? J. Appl. Physiol. 97: 1119-1128; 2004.
23. Rafael, E.; Tibell, A.; Ryden, M.; Lundgren, T.; Saven-dahl, L.; Borgstrom, B.; Arnelo, U.; Isaksson, B.; Nilsson, B.; Korsgren, O.; Permert, J. Intramuscular autotransplant- ation of pancreatic islets in a 7-year-old child: A 2-year follow-up. Am. J. Transplant. 8:458-462; 2008.
24. Revsbech, P. N. An oxygen microsensor with a guard cathode. Limnol. Oceanogr. 34:474-478; 1989.
25. Ryan, E. A.; Paty, B. W.; Senior, P. A.; Bigam, D.; Alfad-hli, E.; Kneteman, N. M.; Lakey, J. R.; Shapiro, A. M. Five-year follow-up after clinical islet transplantation. Di- abetes 54:2060-2069; 2005.
26. Shapiro, A. M.; Lakey, J. R.; Ryan, E. A.; Korbutt, G. S.; Toth, E.; Warnock, G. L.; Kneteman, N. M.; Rajotte, R. V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosup- pressive regimen. N. Engl. J. Med. 343:230-238; 2000.
27. Shapiro, A. M.; Ricordi, C.; Hering, B. J.; Auchincloss, H.; Lindblad, R.; Robertson, R. P.; Secchi, A.; Brendel, M. D.; Berney, T.; Brennan, D. C.; Cagliero, E.; Alejan- dro, R.; Ryan, E. A.; DiMercurio, B.; Morel, P.; Polonsky, K. S.; Reems, J. A.; Bretzel, R. G.; Bertuzzi, F.; Froud, T.; Kandaswamy, R.; Sutherland, D. E.; Eisenbarth, G.; Segal, M.; Preiksaitis, J.; Korbutt, G. S.; Barton, F. B.; Viviano, L.; Seyfert-Margolis, V.; Bluestone, J.; Lakey, J. R. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355:1318-1330; 2006.
28. van der Windt, D. J.; Echeverri, G. J.; Ijzermans, J. N.; Cooper, D. K. The choice of anatomical site for islet trans- plantation. Cell Transplant. 17:1005-1014; 2008.
29. Weibel, E. Practical methods for biological morphometry. London: Academic Press; 1979.