Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Jarrett, Kelsey E ^a   Lee, Ciaran M ^b   Yeh, Yi Hsien ^a   Hsu, Rachel H ^a   Gupta, Rajat ^a   Zhang, Min ^a   Rodriguez, Perla J ^a,c   Lee, Chang Seok ^a   Gillard, Baiba K ^c,d   Bissig, Karl Dimiter ^e   Pownall, Henry J ^c,d   Martin, James F ^a,f   Bao, Gang ^b   Lagor, William R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Rice University   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e CENTER FOR CELL AND GENE THERAPY   (United States)

^f TEXAS HEART INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL; C57BL MOUSE; CHEMISTRY; CRISPR CAS SYSTEM; DEPENDOPARVOVIRUS; GENE EDITING; GENE EXPRESSION REGULATION; GENETICS; GENOME; HIGH THROUGHPUT SEQUENCING; KNOCKOUT MOUSE; MALE; METABOLIC DISORDER; METABOLISM; NUCLEOTIDE SEQUENCE;

ANIMALS; APOLIPOPROTEINS B; BASE SEQUENCE; CRISPR-CAS SYSTEMS; DEPENDOVIRUS; GENE EDITING; GENOME; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; LIPIDS; MALE; METABOLIC DISEASES; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; RECEPTORS, LDL;

EID: 85015434401     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep44624     Document Type: Article

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