Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats

Pharmaceutical Biology

Volumn 55, Issue 1, 2017, Pages 1074-1081

  Irudayaraj, Santiagu Stephen ^a   Christudasa, Sunil ^a   Antony, Stalin ^a   Duraipandiyan, Veeramuthu ^b   Abdullah, Al Dhabi Naif ^b   Ignacimuthu, Savarimuthu ^a,b  

^a LOYOLA COLLEGE   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Ficusin; Hypoglycemic; Hypolipidemic

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIDIABETIC AGENT; CHOLESTEROL; FICUS CARICA EXTRACT; FRUCTOSE BISPHOSPHATASE; GLIBENCLAMIDE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HEXOKINASE; LIPID; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; INSULIN; SOLVENT; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CARBOHYDRATE METABOLISM; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FIG; GLUCOSE UTILIZATION; IMMUNOHISTOCHEMISTRY; LIVER TISSUE; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PLANT LEAF; RAT; RETENTION TIME; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; ENZYMOLOGY; FICUS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; LIPID DIET; LIVER; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; TIME FACTOR;

ACETATES; ANIMALS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; FICUS; GLUCOSE TOLERANCE TEST; GLYBURIDE; GLYCOGEN; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPIDS; LIVER; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS, WISTAR; SOLVENTS; STREPTOZOCIN; TIME FACTORS;

EID: 85015355524     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880209.2017.1279671     Document Type: Article

References (39)

1. Benwahhoud M, Jouad H, Eddouks M, Lyoussi B. 2001. Hypoglycemic effect of Suaeda fruticosa in streptozotocin-induced diabetic rats. J Ethnopharmacol. 76:35-38.
2. Brandstrup N, Kirk JE, Bruni C. 1957. The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages. J Gerontol. 12:166-171.
3. Canal JR, Torres DM, Romero A, Perez C. 2000. A chloroform extract obtained from a decoction of Ficus carica L. leaves improve the cholesterolaemic status of rats with streptozotocin induced diabetes. Acta Vet Hung. 87:71-76.
4. Dayanand K, Kishanchandra K. 2014. Phytochemical investigation and evaluation of antihyperlipidemic activity of Ficus carica Linn. fruit extracts. Global J Res Analysis. 3:2277-8160.
5. El Hilaly J, Lyoussi B. 2002. Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats. J Ethnopharmacol. 80:109-113.
6. Ferrer JC, Favre C, Gomis RR, Fernández-Novell JM, Garcia-Rocha M, De LaIglesia N. 2003. Control of glycogen deposition. FEBS Lett. 546:127-132.
7. Foster LB, Dunn RT. 1973. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem. 19:338-340.
8. Gancedo JM, Gancedo C. 1971. Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts. Arch Microbiol. 76:132-138.
9. Gandhi GR, Ignacimuthu S, Paulraj MG. 2012. Hypoglycemic and β-cells regenerative effects of Aegle marmelos (L.) Corr. bark extract in streptozotocin-induced diabetic rats. Food Chem Toxicol. 50:1667-1674.
10. Henley AA. 1957. The determination of serum cholesterol. Analyst. 82:286-287.
11. Joerin L, Kauschka M, Bonnländer B, Pischel I, Benedek B, Butterweck V. 2014. Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C. Phytother Res. 28:261-267.
12. Koide H, Oda T. 1959. Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin Chim Acta. 4:554-561.
13. Koning EJ, Weir BS, Rabelink TJ. 2008. Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci. 29:218-227.
14. Liang HJ, Suk FM, Wang CK, Hung LF, Liu DZ, Chen NQ, Chen YC, Chang CC, Liang YC. 2009. Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice. Chem Biol Interact. 181:309-315.
15. Liou SS, Liu IM, Hsu JH, Wu YC, Hsu SF, Chen JT. 2002. Release of acetylcholine by Die-Huang-Wan to enhance insulin secretion for lowering plasma glucose in Wistar rats. Auton Neurosci. 100:21-26.
16. Manda SC, Mukherjee KP, Saha K, Das J, Pal M, Saba PB. 1997. Hypoglycemic activity of Ficus carica L. leaves in streptozotoin-induced diabetic rats. Nat Prod Sci. 3:38-41.
17. Menaka CT, Ravirajsinh NJ, Ansarullah, Ranjitsinh VD, Ramachandran AV. 2010. Prevention of high fat diet induced insulin resistance in C57BL/6J mice by Sida rhomboidea Roxb. extract. J Health Sci. 56:92-98.
18. Naik SR, Niture NT, Ansari AA, Shah PD. 2013. Anti-diabetic activity of embelin: involvement of cellular inflammatory mediators, oxidative stress and other biomarkers. Phytomedicine. 20:797-804.
19. Oliveira HC, Santos MPD, Grigulo R, Lima LL, Martins DTO, Lima CS. 2008. Antidiabetic activity of Vatairea macrocarpa extract in rats. J Ethnopharmacol. 115:515-519.
20. Perez C, Dominguez E, Ramiro JM, Romero A, Campillo JE, Torres MD. 1996. A study on the glycaemic balance in streptozotocin diabetic rats treated with aqueous extract of Ficus carica (Fig tree) leaves. Phytother Res. 10:82-83.
21. Qin B, Panickar KS, Anderson RA. 2010. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 4:685-693.
22. Saxena A, Bhatnagar M, Garg NK. 1984. Enzymes changes in rat tissues during hyperglycemia. Arogya - J Health Sci. 10:33-37.
23. Shaw JE, Sicree RA, Zimmet PZ. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 87:4-14.
24. Stalin C, Dineshkumar P, Nithiyananthan K. 2012. Evaluation of antidiabetic activity of methanolic leaf extract of Ficus carica in alloxan induced diabetic rats. Asian J Pharm Clin Res. 5:85-87.
25. Stephen Irudayaraj S, Sunil C, Duraipandiyan V, Ignacimuthu S. 2012. Antidiabetic and antioxidant activities of Toddalia asiatica (L.) Lam. leaves in streptozotocin induced diabetic rats. J Ethnopharmacol. 143:515-523.
26. Stephen Irudayaraj S, Stalin A, Sunil C, Duraipandiyan V, Al-Dhabi NA, Ignacimuthu S. 2016. Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats. Chem Biol Interact. 256:85-93.
27. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM. 2001. The hormone resistin links obesity to diabetes. Nature. 409:307-312.
28. Sunil C, Agastian P, Ignacimuthu I. 2012a. In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore. bark. Food Chem Toxicol. 50:1547-1553.
29. Sunil C, Duraipandiyan V, Ignacimuthu S, Agastian P. 2012b. Antidiabetic effect of Plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 50:4356-4363.
30. Surya S, Dhaliya Salam A, Dawn VT, Carla B, Arun Kumar R, Sunil C. 2014. Diabetes mellitus and medicinal plants - a review. Asian Pac J Trop Dis. 4:337-347.
31. Trinder P. 1969. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 6:24-27.
32. Van Handel E. 1965. Estimation of glycogen in small amounts of tissue. Anal Biochem. 11:256-265.
33. Veerapur VP, Prabhakar KR, Thippeswamy BS, Bansal P, Srinivasan KK, Unnikrishnan MK. 2012. Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: a mechanistic study. Food Chem. 132:186-193.
34. Vestergard H. 1999. Studies of gene expression and activity of hexokinase, phosphofructokinase and glycogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism. Danish Med Bull. 46:13-34.
35. Vikas VP, Vijay RP. 2011. Ficus carica Linn - an overview. Res J Med Plant. 5:246-253.
36. Vinholes J, Grosso C, Andrade PB, Gil-Izquierdo A, Valentao P, Pinho PGD. 2011. In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. Food Chem. 129:454-462.
37. Warnholtz A, Mollnau M, Oleze M, Wendt Munzel T. 2001. Antioxidants and endothelial dysfunction in hyperlipidemia. Curr Hypertens Rep. 3:53-60.
38. Yuan M, Konstantopoulos N, Lee J. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-1677.
39. Zhang L, Yang J, Chen X, Zan K, Chen H, Wang Q, Lai M. 2010. Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin. J Ethnopharmacol. 132:518-524.