Effects of circadian clock genes and healthrelated behavior on metabolic syndrome in a Taiwanese population: Evidence from

PLoS ONE

Volumn 12, Issue 3, 2017, Pages

  Lin, Eugene ^a,b,c   Kuo, Po Hsiu ^d   Liu, Yu Li ^e   Yang, Albert C ^f,g   Kao, Chung Feng ^h   Tsai, Shih Jen ^f,g  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b VITA GENOMICS INC   (Taiwan)

^c TickleFish Systems Corporation   (United States)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

^h NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ALCOHOL CONSUMPTION; ARNTL GENE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CIRCADIAN RHYTHM; DIASTOLIC BLOOD PRESSURE; ENVIRONMENTAL FACTOR; FEMALE; GENE; GENE INTERACTION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GSKB GENE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PER3 GENE; PHYSICAL ACTIVITY; RORA GENE; RORB GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SYSTOLIC BLOOD PRESSURE; TAIWANESE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; GENETICS; HEALTH BEHAVIOR; MIDDLE AGED; TAIWAN;

ADULT; CIRCADIAN CLOCKS; FEMALE; HEALTH BEHAVIOR; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TAIWAN;

EID: 85015335511     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0173861     Document Type: Article

References (49)

1. Ribas-Latre A, Eckel-Mahan K. Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health. Mol Metab. 2016; 5: 133-52. https://doi.org/10.1016/j.molmet.2015. 12.006 PMID: 26977390
2. Buhr ED, Takahashi JS. Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol. 2013; (217): 3-27. https://doi.org/10.1007/978-3-642-25950-0-1 PMID: 23604473
3. Cagampang FR, Poore KR, Hanson MA. Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain Behav Immun. 2011; 25: 214-20. https://doi.org/10.1016/j.bbi. 2010.09.005 PMID: 20851177
4. Maury E, Hong HK, Bass J. Circadian disruption in the pathogenesis of metabolic syndrome. Diabetes Metab. 2014; 40: 338-46. https://doi.org/10.1016/j.diabet.2013.12.005 PMID: 24433933
5. Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004; 2: e377. https://doi.org/10.1371/journal.pbio.0020377 PMID: 15523558
6. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005; 308: 1043-5. https://doi.org/10.1126/science. 1108750 PMID: 15845877
7. Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008; 32: 658-62.
8. Kovanen L, Donner K, Kaunisto M, Partonen T. CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome. Hypertens Res. 2015; 38: 186-92. https://doi.org/10.1038/hr.2014.157 PMID: 25391456
9. Woon PY, Kaisaki PJ, Bragança J, Bihoreau MT, Levy JC, Farrall M, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007; 104: 14412-7. https://doi.org/10.1073/pnas.0703247104 PMID: 17728404
10. Englund A, Kovanen L, Saarikoski ST, Haukka J, Reunanen A, Aromaa A, et al. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. J Circadian Rhythms. 2009; 7: 5. https://doi.org/10.1186/1740-3391-7-5 PMID: 19470168
11. Gómez-Abellán P, Hernández-Morante JJ, Luján JA, Madrid JA, Garaulet M. Clock genes are implicated in the human metabolic syndrome. Int J Obes (Lond). 2008; 32: 121-8.
12. Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010; 466: 627-31. https://doi.org/10.1038/nature09253 PMID: 20562852
13. Shimba S, Ogawa T, Hitosugi S, Ichihashi Y, Nakadaira Y, Kobayashi M, et al. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One. 2011; 6: e25231. https://doi.org/10.1371/journal.pone.0025231 PMID: 21966465
14. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, et al. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011; 286: 9063-70. https://doi.org/10.1074/jbc. M110.164558 PMID: 21228270
15. Gonzalez R, Gonzalez S, Villa E, Ramirez M, Zavala J, Armas R, et al. Identification of circadian gene variants in bipolar disorder in Latino populations. J Affect Disord. 2015; 186: 367-75. https://doi.org/10.1016/j.jad.2015.07.014 PMID: 26283580
16. Jim HS, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Chornokur G, et al. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC). J Genet Genome Res. 2015; 2. PMID: 26807442
17. Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ. Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. Oncotarget. 2017; Forthcoming.
18. Shakes LA, Du H, Wolf HM, Hatcher C, Norford DC, Precht P, et al. Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans. BMC Genomics. 2012; 13: 451. https://doi.org/10.1186/1471-2164-13-451 PMID: 22947103
19. Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009; 11: 701-10. https://doi.org/10.1111/j.1399-5618.2009.00756.x PMID: 19839995
20. Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA. Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008; 4: e1000023. https://doi.org/10.1371/journal.pgen.1000023 PMID: 18454201
21. Wang H, Chu W, Das SK, Zheng Z, Hasstedt SJ, Elbein SC. Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. Mol Genet Metab. 2003; 79: 176-82. PMID: 12855222
22. Fan CT, Lin JC, Lee CH. Taiwan Biobank: a project aiming to aid Taiwan's transition into a biomedical island. Pharmacogenomics. 2008; 9: 235-46. https://doi.org/10.2217/14622416.9.2.235 PMID: 18370851
23. Lin E, Kuo PH, Liu YL, Yang AC, Kao CF, Tsai SJ. Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. Sci Rep. 2016; 6: 36830. https://doi.org/10.1038/srep36830 PMID: 27827461
24. Chen CH, Yang JH, Chiang CW, Hsiung CN, Wu PE, Chang LC, et al. Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project. Hum Mol Genet. 2016 [Epub ahead of print].
25. Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF, Yang CH. The rs1277306 variant of the REST gene confers susceptibility to cognitive aging in the elderly in a Taiwanese population. Dement Geriatr Cogn Disord. 2016; 43: 119-127.
26. Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF. Association and interaction effects of Alzheimer's disease-Associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. Oncotarget. 2017; Forthcoming.
27. Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Kao CF, Yang CH. The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. PLoS One. 2017; Forthcoming.
28. Liou YJ, Bai YM, Lin E, Chen JY, Chen TT, Hong CJ, et al. Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics. Pharmacogenomics J. 2012; 12: 54-61
29. Hsiao TJ, Lin E. The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population. Mol Cell Endocrinol. 2016; 433: 20-25. https://doi.org/10.1016/j.mce.2016.05.020 PMID: 27238374
30. Hsiao TJ, Lin E. The Pro12Ala polymorphism in the peroxisome proliferator-Activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. Endocrine. 2015; 48: 786-93. https://doi.org/10.1007/s12020-014-0407-7 PMID: 25182148
31. Hsiao TJ, Hwang Y, Liu CH, Chang HM, Lin E. Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population. Genes Nutr. 2013; 8: 137-44. https://doi.org/10.1007/s12263-012-0304-8 PMID: 22791279
32. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003; 100: 9440-5. https://doi.org/10.1073/pnas.1530509100 PMID: 12883005
33. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, et al. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet. 2007; 80: 1125-1137. https://doi.org/10.1086/518312 PMID: 17503330
34. Lane HY, Tsai GE, Lin E. Assessing gene-gene interactions in pharmacogenomics. Mol Diagn Ther. 2012; 16: 15-27.
35. Kaidanovich-Beilin O, Woodgett JR. GSK-3: Functional Insights from Cell Biology and Animal Models. Front Mol Neurosci. 2011; 4 https://doi.org/10.3389/fnmol.2011.00040 PMID: 22110425
36. Chen H, Fajol A, Hoene M, Zhang B, Schleicher ED, Lin Y, et al. PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome. Proc Natl Acad Sci U S A. 2016; 113: 5754-9. https://doi.org/10.1073/pnas.1601355113 PMID: 27140617
37. Marcheva B, Ramsey KM, Peek CB, Affinati A, Maury E, Bass J. Circadian clocks and metabolism. Handb Exp Pharmacol. 2013; 217: 127-55.
38. Dallmann R, Weaver DR. Altered body mass regulation in male mPeriod mutant mice on high-fat diet. Chronobiol Int. 2010; 27: 1317-28. https://doi.org/10.3109/07420528.2010.489166 PMID: 20653457
39. Pendergast JS, Niswender KD, Yamazaki S. Tissue-specific function of Period3 in circadian rhythmicity. PLoS One. 2012; 7: e30254. https://doi.org/10.1371/journal.pone.0030254 PMID: 22253927
40. Duez H, Staels B. Rev-erb-Alpha: an integrator of circadian rhythms and metabolism. J Appl Physiol (1985). 2009; 107: 1972-80.
41. Kang HS, Okamoto K, Takeda Y, Beak JY, Gerrish K, Bortner CD, et al. Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-Associated inflammation and hepatic steatosis. Physiol Genomics. 2011; 43: 818-28. https://doi.org/10.1152/physiolgenomics.00206.2010 PMID: 21540300
42. Lee SH, Harold D, Nyholt DR; ANZGene Consortium; International Endogene Consortium; Genetic and Environmental Risk for Alzheimer's disease Consortium, Goddard ME, Zondervan KT, Williams J, et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Hum Mol Genet. 2013; 22:832-41. https://doi.org/10.1093/hmg/dds491 PMID: 23193196
43. Hwang LC, Bai CH, Chen CJ. Prevalence of obesity and metabolic syndrome in Taiwan. J Formos Med Assoc. 2006; 105: 626-35. https://doi.org/10.1016/S0929-6646(09)60161-3 PMID: 16935763
44. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287: 356-9. PMID: 11790215
45. Hsiao TJ, Hwang Y, Chang HM, Lin E. Association of the rs6235 variant in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene with obesity and related traits in a Taiwanese population. Gene. 2014; 533: 32-7. https://doi.org/10.1016/j.gene.2013.10.016 PMID: 24140494
46. Hsiao TJ, Lin E. A common rs7903146 variant of the transcription factor 7 like 2 gene is associated with type 2 diabetes mellitus and fasting glucose in a Taiwanese population. Diabetes Metab. 2017; 43: 83-85 https://doi.org/10.1016/j.diabet.2016.05.003 PMID: 27286737
47. Hsiao TJ, Lin E. Evaluation of the glutamine 27 glutamic acid polymorphism in the adrenoceptor beta 2 surface gene on obesity and metabolic phenotypes in Taiwan. J Investig Med. 2014; 62: 310-5. https://doi.org/10.2310/JIM.0000000000000030 PMID: 24322328
48. Hsiao TJ, Lin E. Association of a common rs9939609 variant in the fat mass and obesity-Associated (FTO) gene with obesity and metabolic phenotypes in a Taiwanese population: a replication study. J Genet. 2016; 95: 595-601. PMID: 27659330
49. Hsiao TJ, Lin E. A validation study of adiponectin rs266729 gene variant with type 2 diabetes, obesity, and metabolic phenotypes in a Taiwanese population. Biochem Genet. 2016; 54: 830-841. https://doi.org/10.1007/s10528-016-9760-y PMID: 27388775