메뉴 건너뛰기




Volumn 3, Issue 3, 2017, Pages 370-380

Nanogel-Integrated pH-Responsive Composite Hydrogels for Controlled Drug Delivery

Author keywords

CHPOA; drug delivery; hybrid hydrogel; nanogel; pH sensitive; pregabalin

Indexed keywords

CHOLESTEROL BEARING PULLULAN NANOGEL; ETHYLENE GLYCOL; NANOCARRIER; POLYMETHACRYLIC ACID; PREGABALIN; UNCLASSIFIED DRUG;

EID: 85015201206     PISSN: None     EISSN: 23739878     Source Type: Journal    
DOI: 10.1021/acsbiomaterials.6b00670     Document Type: Article
Times cited : (83)

References (59)
  • 1
    • 84979031809 scopus 로고    scopus 로고
    • Drug Delivery Research: The Invention Cycle
    • Park, K. Drug Delivery Research: The Invention Cycle Mol. Pharmaceutics 2016, 13, 2143 10.1021/acs.molpharmaceut.6b00015
    • (2016) Mol. Pharmaceutics , vol.13 , pp. 2143
    • Park, K.1
  • 2
    • 84861225855 scopus 로고    scopus 로고
    • PH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents
    • Schoener, C. A.; Hutson, H. N.; Peppas, N. A. pH-Responsive Hydrogels with Dispersed Hydrophobic Nanoparticles for the Delivery of Hydrophobic Therapeutic Agents Polym. Int. 2012, 61 (6) 874-879 10.1002/pi.4219
    • (2012) Polym. Int. , vol.61 , Issue.6 , pp. 874-879
    • Schoener, C.A.1    Hutson, H.N.2    Peppas, N.A.3
  • 3
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs: Barriers and developments
    • Hamman, J. H.; Enslin, G. M.; Kotze, A. F. Oral delivery of peptide drugs: barriers and developments BioDrugs 2005, 19 (3) 165-77 10.2165/00063030-200519030-00003
    • (2005) BioDrugs , vol.19 , Issue.3 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 4
    • 84909969076 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)
    • Nazli, C.; Demirer, G. S.; Yar, Y.; Acar, H. Y.; Kizilel, S. Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs) Colloids Surf., B 2014, 122, 674-683 10.1016/j.colsurfb.2014.07.049
    • (2014) Colloids Surf., B , vol.122 , pp. 674-683
    • Nazli, C.1    Demirer, G.S.2    Yar, Y.3    Acar, H.Y.4    Kizilel, S.5
  • 5
    • 33751195735 scopus 로고    scopus 로고
    • Hydrogels in controlled release formulations: Network design and mathematical modeling
    • Lin, C. C.; Metters, A. T. Hydrogels in controlled release formulations: network design and mathematical modeling Adv. Drug Delivery Rev. 2006, 58 (12-13) 1379-408 10.1016/j.addr.2006.09.004
    • (2006) Adv. Drug Delivery Rev. , vol.58 , Issue.1213 , pp. 1379-1408
    • Lin, C.C.1    Metters, A.T.2
  • 7
    • 84948685792 scopus 로고    scopus 로고
    • Diffusion and controlled release characteristics of pH-sensitive poly(2-(dimethyl amino)ethyl methacrylate-co-2-hydroxyethylacrylate) hydrogels
    • Eswaramma, S.; Krishna Rao, K. S. V.; Madhusudana Rao, K. Diffusion and controlled release characteristics of pH-sensitive poly(2-(dimethyl amino)ethyl methacrylate-co-2-hydroxyethylacrylate) hydrogels Int. J. Polym. Mater. 2016, 65 (3) 134-142 10.1080/00914037.2015.1074910
    • (2016) Int. J. Polym. Mater. , vol.65 , Issue.3 , pp. 134-142
    • Eswaramma, S.1    Krishna Rao, K.S.V.2    Madhusudana Rao, K.3
  • 8
    • 84949238925 scopus 로고    scopus 로고
    • PH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery
    • Koetting, M. C.; Guido, J. F.; Gupta, M.; Zhang, A.; Peppas, N. A. pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery J. Controlled Release 2016, 221, 18-25 10.1016/j.jconrel.2015.11.023
    • (2016) J. Controlled Release , vol.221 , pp. 18-25
    • Koetting, M.C.1    Guido, J.F.2    Gupta, M.3    Zhang, A.4    Peppas, N.A.5
  • 10
    • 84961754987 scopus 로고    scopus 로고
    • Targeted Drug Delivery and Imaging Using Mobile Milli/Microrobots: A Promising Future Towards Theranostic Pharmaceutical Design
    • Singh, A. V.; Sitti, M. Targeted Drug Delivery and Imaging Using Mobile Milli/Microrobots: A Promising Future Towards Theranostic Pharmaceutical Design Curr. Pharm. Des. 2016, 22 (11) 1418-1428 10.2174/1381612822666151210124326
    • (2016) Curr. Pharm. Des. , vol.22 , Issue.11 , pp. 1418-1428
    • Singh, A.V.1    Sitti, M.2
  • 12
    • 84870236064 scopus 로고    scopus 로고
    • Responsive polymeric delivery systems
    • Kost, J.; Langer, R. Responsive polymeric delivery systems Adv. Drug Delivery Rev. 2012, 64, 327-341 10.1016/j.addr.2012.09.014
    • (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 327-341
    • Kost, J.1    Langer, R.2
  • 13
    • 84870248824 scopus 로고    scopus 로고
    • Environment-sensitive hydrogels for drug delivery
    • Qiu, Y.; Park, K. Environment-sensitive hydrogels for drug delivery Adv. Drug Delivery Rev. 2012, 64, 49-60 10.1016/j.addr.2012.09.024
    • (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 49-60
    • Qiu, Y.1    Park, K.2
  • 14
    • 74749094128 scopus 로고    scopus 로고
    • Polymeric gels and hydrogels for biomedical and pharmaceutical applications
    • Jagur-Grodzinski, J. Polymeric gels and hydrogels for biomedical and pharmaceutical applications Polym. Adv. Technol. 2010, 21 (1) 27-47 10.1002/pat.1504
    • (2010) Polym. Adv. Technol. , vol.21 , Issue.1 , pp. 27-47
    • Jagur-Grodzinski, J.1
  • 15
    • 84949953320 scopus 로고    scopus 로고
    • Synthesis and characterization of a novel pH-thermo dual responsive hydrogel based on salecan and poly(N,N-diethylacrylamide-co-methacrylic acid)
    • Wei, W.; Qi, X. L.; Liu, Y. C.; Li, J. J.; Hu, X. Y.; Zuo, G. C.; Zhang, J. F.; Dong, W. Synthesis and characterization of a novel pH-thermo dual responsive hydrogel based on salecan and poly(N,N-diethylacrylamide-co-methacrylic acid) Colloids Surf., B 2015, 136, 1182-1192 10.1016/j.colsurfb.2015.11.007
    • (2015) Colloids Surf., B , vol.136 , pp. 1182-1192
    • Wei, W.1    Qi, X.L.2    Liu, Y.C.3    Li, J.J.4    Hu, X.Y.5    Zuo, G.C.6    Zhang, J.F.7    Dong, W.8
  • 16
    • 84969247864 scopus 로고    scopus 로고
    • Hydrogel-Coated Near Infrared Absorbing Nanoshells as Light-Responsive Drug Delivery Vehicles
    • Strong, L. E.; West, J. L. Hydrogel-Coated Near Infrared Absorbing Nanoshells as Light-Responsive Drug Delivery Vehicles ACS Biomater. Sci. Eng. 2015, 1 (8) 685-692 10.1021/acsbiomaterials.5b00111
    • (2015) ACS Biomater. Sci. Eng. , vol.1 , Issue.8 , pp. 685-692
    • Strong, L.E.1    West, J.L.2
  • 17
    • 84930666570 scopus 로고    scopus 로고
    • Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation
    • Spera, R.; Apollonio, F.; Liberti, M.; Paffi, A.; Merla, C.; Pinto, R.; Petralito, S. Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation Colloids Surf., B 2015, 131, 136-140 10.1016/j.colsurfb.2015.04.030
    • (2015) Colloids Surf., B , vol.131 , pp. 136-140
    • Spera, R.1    Apollonio, F.2    Liberti, M.3    Paffi, A.4    Merla, C.5    Pinto, R.6    Petralito, S.7
  • 18
    • 0141921483 scopus 로고    scopus 로고
    • Polymeric micelle for tumor pH and folate-mediated targeting
    • Lee, E. S.; Na, K.; Bae, Y. H. Polymeric micelle for tumor pH and folate-mediated targeting J. Controlled Release 2003, 91 (1-2) 103-113 10.1016/S0168-3659(03)00239-6
    • (2003) J. Controlled Release , vol.91 , Issue.12 , pp. 103-113
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 19
    • 84969255762 scopus 로고    scopus 로고
    • Fabrication and Characterization of a Novel Anticancer Drug Delivery System: Salecan/Poly(methacrylic acid) Semi-interpenetrating Polymer Network Hydrogel
    • Qi, X. L.; Wei, W.; Li, J. J.; Liu, Y. C.; Hu, X. Y.; Zhang, J. F.; Bi, L. R.; Dong, W. Fabrication and Characterization of a Novel Anticancer Drug Delivery System: Salecan/Poly(methacrylic acid) Semi-interpenetrating Polymer Network Hydrogel ACS Biomater. Sci. Eng. 2015, 1 (12) 1287-1299 10.1021/acsbiomaterials.5b00346
    • (2015) ACS Biomater. Sci. Eng. , vol.1 , Issue.12 , pp. 1287-1299
    • Qi, X.L.1    Wei, W.2    Li, J.J.3    Liu, Y.C.4    Hu, X.Y.5    Zhang, J.F.6    Bi, L.R.7    Dong, W.8
  • 20
    • 0035981078 scopus 로고    scopus 로고
    • Environment-sensitive hydrogels for drug delivery
    • Qiu, Y.; Park, K. Environment-sensitive hydrogels for drug delivery Adv. Drug Delivery Rev. 2001, 53 (3) 321-39 10.1016/S0169-409X(01)00203-4
    • (2001) Adv. Drug Delivery Rev. , vol.53 , Issue.3 , pp. 321-339
    • Qiu, Y.1    Park, K.2
  • 21
    • 0037092619 scopus 로고    scopus 로고
    • Hydrogels: From controlled release to pH-responsive drug delivery
    • Gupta, P.; Vermani, K.; Garg, S. Hydrogels: from controlled release to pH-responsive drug delivery Drug Discovery Today 2002, 7 (10) 569-79 10.1016/S1359-6446(02)02255-9
    • (2002) Drug Discovery Today , vol.7 , Issue.10 , pp. 569-579
    • Gupta, P.1    Vermani, K.2    Garg, S.3
  • 22
    • 84901287572 scopus 로고    scopus 로고
    • Therapeutic applications of hydrogels in oral drug delivery
    • Sharpe, L. A.; Daily, A. M.; Horava, S. D.; Peppas, N. A. Therapeutic applications of hydrogels in oral drug delivery Expert Opin. Drug Delivery 2014, 11 (6) 901-15 10.1517/17425247.2014.902047
    • (2014) Expert Opin. Drug Delivery , vol.11 , Issue.6 , pp. 901-915
    • Sharpe, L.A.1    Daily, A.M.2    Horava, S.D.3    Peppas, N.A.4
  • 23
    • 84958767452 scopus 로고    scopus 로고
    • Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX
    • Horava, S. D.; Peppas, N. A. Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX Ann. Biomed. Eng. 2016, 44, 1970 10.1007/s10439-016-1566-x
    • (2016) Ann. Biomed. Eng. , vol.44 , pp. 1970
    • Horava, S.D.1    Peppas, N.A.2
  • 24
    • 84925046800 scopus 로고    scopus 로고
    • Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin
    • Cevik, O.; Gidon, D.; Kizilel, S. Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin Acta Biomater. 2015, 11, 151-161 10.1016/j.actbio.2014.09.018
    • (2015) Acta Biomater. , vol.11 , pp. 151-161
    • Cevik, O.1    Gidon, D.2    Kizilel, S.3
  • 25
    • 0032595912 scopus 로고    scopus 로고
    • Molecular Design and in Vitro Studies of Novel pH-Sensitive Hydrogels for the Oral Delivery of Calcitonin
    • Torres-Lugo, M.; Peppas, N. A. Molecular Design and in Vitro Studies of Novel pH-Sensitive Hydrogels for the Oral Delivery of Calcitonin Macromolecules 1999, 32 (20) 6646-6651 10.1021/ma990541c
    • (1999) Macromolecules , vol.32 , Issue.20 , pp. 6646-6651
    • Torres-Lugo, M.1    Peppas, N.A.2
  • 26
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens, D. E.; Peppas, N. A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int. J. Pharm. 2006, 307 (1) 93-102 10.1016/j.ijpharm.2005.10.010
    • (2006) Int. J. Pharm. , vol.307 , Issue.1 , pp. 93-102
    • Owens, D.E.1    Peppas, N.A.2
  • 27
    • 84255172282 scopus 로고    scopus 로고
    • Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix
    • Geng, H. Q.; Song, H.; Qi, J.; Cui, D. X. Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix Nanoscale Res. Lett. 2011, 6, 312 10.1186/1556-276X-6-312
    • (2011) Nanoscale Res. Lett. , vol.6 , pp. 312
    • Geng, H.Q.1    Song, H.2    Qi, J.3    Cui, D.X.4
  • 29
    • 84879607798 scopus 로고    scopus 로고
    • A hybrid hydrogel biomaterial by nanogel engineering: Bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system
    • Sekine, Y.; Moritani, Y.; Ikeda-Fukazawa, T.; Sasaki, Y.; Akiyoshi, K. A hybrid hydrogel biomaterial by nanogel engineering: bottom-up design with nanogel and liposome building blocks to develop a multidrug delivery system Adv. Healthcare Mater. 2012, 1 (6) 722-8 10.1002/adhm.201200175
    • (2012) Adv. Healthcare Mater. , vol.1 , Issue.6 , pp. 722-728
    • Sekine, Y.1    Moritani, Y.2    Ikeda-Fukazawa, T.3    Sasaki, Y.4    Akiyoshi, K.5
  • 30
    • 84863356189 scopus 로고    scopus 로고
    • The chaperone-like activity of rat HspB8/Hsp22 and dynamic molecular transition related to oligomeric architectures in vitro
    • Yang, Z.; Lu, Y.; Liu, J.; Wang, Y.; Zhao, X. The chaperone-like activity of rat HspB8/Hsp22 and dynamic molecular transition related to oligomeric architectures in vitro Protein Pept. Lett. 2012, 19 (3) 353-9 10.2174/092986612799363073
    • (2012) Protein Pept. Lett. , vol.19 , Issue.3 , pp. 353-359
    • Yang, Z.1    Lu, Y.2    Liu, J.3    Wang, Y.4    Zhao, X.5
  • 31
    • 84976530795 scopus 로고    scopus 로고
    • Magnetically Guided Protein Transduction by Hybrid Nanogel Chaperones with Iron Oxide Nanoparticles
    • Kawasaki, R.; Sasaki, Y.; Katagiri, K.; Mukai, S. A.; Sawada, S. I.; Akiyoshi, K. Magnetically Guided Protein Transduction by Hybrid Nanogel Chaperones with Iron Oxide Nanoparticles Angew. Chem., Int. Ed. 2016, 55, 11377 10.1002/anie.201602577
    • (2016) Angew. Chem., Int. Ed. , vol.55 , pp. 11377
    • Kawasaki, R.1    Sasaki, Y.2    Katagiri, K.3    Mukai, S.A.4    Sawada, S.I.5    Akiyoshi, K.6
  • 33
    • 84941024821 scopus 로고    scopus 로고
    • Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems
    • Tahara, Y.; Mukai, S. A.; Sawada, S.; Sasaki, Y.; Akiyoshi, K. Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems Adv. Mater. 2015, 27 (34) 5080-8 10.1002/adma.201501557
    • (2015) Adv. Mater. , vol.27 , Issue.34 , pp. 5080-5088
    • Tahara, Y.1    Mukai, S.A.2    Sawada, S.3    Sasaki, Y.4    Akiyoshi, K.5
  • 34
    • 84922218831 scopus 로고    scopus 로고
    • Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold
    • Hashimoto, Y.; Mukai, S. A.; Sawada, S.; Sasaki, Y.; Akiyoshi, K. Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold Biomaterials 2015, 37, 107-15 10.1016/j.biomaterials.2014.10.045
    • (2015) Biomaterials , vol.37 , pp. 107-115
    • Hashimoto, Y.1    Mukai, S.A.2    Sawada, S.3    Sasaki, Y.4    Akiyoshi, K.5
  • 35
    • 84862812866 scopus 로고    scopus 로고
    • Photopolymerization of cell-encapsulating hydrogels: Crosslinking efficiency versus cytotoxicity
    • Mironi-Harpaz, I.; Wang, D. Y.; Venkatraman, S.; Seliktar, D. Photopolymerization of cell-encapsulating hydrogels: crosslinking efficiency versus cytotoxicity Acta Biomater. 2012, 8 (5) 1838-48 10.1016/j.actbio.2011.12.034
    • (2012) Acta Biomater. , vol.8 , Issue.5 , pp. 1838-1848
    • Mironi-Harpaz, I.1    Wang, D.Y.2    Venkatraman, S.3    Seliktar, D.4
  • 36
    • 0032981428 scopus 로고    scopus 로고
    • Electron beam crosslinked PEO and PEO PVA hydrogels for wound dressing
    • Yoshii, F.; Zhanshan, Y.; Isobe, K.; Shinozaki, K.; Makuuchi, K. Electron beam crosslinked PEO and PEO PVA hydrogels for wound dressing Radiat. Phys. Chem. 1999, 55 (2) 133-138 10.1016/S0969-806X(98)00318-1
    • (1999) Radiat. Phys. Chem. , vol.55 , Issue.2 , pp. 133-138
    • Yoshii, F.1    Zhanshan, Y.2    Isobe, K.3    Shinozaki, K.4    Makuuchi, K.5
  • 38
    • 84898813941 scopus 로고    scopus 로고
    • Biodegradable, pH-responsive carboxymethyl cellulose/poly(acrylic acid) hydrogels for oral insulin delivery
    • Gao, X.; Cao, Y.; Song, X.; Zhang, Z.; Zhuang, X.; He, C.; Chen, X. Biodegradable, pH-responsive carboxymethyl cellulose/poly(acrylic acid) hydrogels for oral insulin delivery Macromol. Biosci. 2014, 14 (4) 565-75 10.1002/mabi.201300384
    • (2014) Macromol. Biosci. , vol.14 , Issue.4 , pp. 565-575
    • Gao, X.1    Cao, Y.2    Song, X.3    Zhang, Z.4    Zhuang, X.5    He, C.6    Chen, X.7
  • 39
    • 85015232193 scopus 로고    scopus 로고
    • http://www.accessdata.fda.gov/drugsatfda-docs/nda/2010/022488s000chemr.pdf.
  • 40
    • 84890562665 scopus 로고    scopus 로고
    • Characterization of protein release from poly(ethylene glycol) hydrogels with crosslink density gradients
    • Bal, T.; Kepsutlu, B.; Kizilel, S. Characterization of protein release from poly(ethylene glycol) hydrogels with crosslink density gradients J. Biomed. Mater. Res., Part A 2014, 102 (2) 487-95 10.1002/jbm.a.34701
    • (2014) J. Biomed. Mater. Res., Part A , vol.102 , Issue.2 , pp. 487-495
    • Bal, T.1    Kepsutlu, B.2    Kizilel, S.3
  • 41
    • 80855144303 scopus 로고    scopus 로고
    • Amphiphilic Interpenetrating Networks for the Delivery of Hydrophobic, Low Molecular Weight Therapeutic Agents
    • Schoener, C. A.; Hutson, H. N.; Fletcher, G. K.; Peppas, N. A. Amphiphilic Interpenetrating Networks for the Delivery of Hydrophobic, Low Molecular Weight Therapeutic Agents Ind. Eng. Chem. Res. 2011, 50 (22) 12556-12561 10.1021/ie201593h
    • (2011) Ind. Eng. Chem. Res. , vol.50 , Issue.22 , pp. 12556-12561
    • Schoener, C.A.1    Hutson, H.N.2    Fletcher, G.K.3    Peppas, N.A.4
  • 44
    • 78650026344 scopus 로고    scopus 로고
    • Mathematical Model for Microencapsulation of Pancreatic Islets within a Biofunctional PEG Hydrogel
    • Kizilel, S. Mathematical Model for Microencapsulation of Pancreatic Islets within a Biofunctional PEG Hydrogel Macromol. Theory Simul. 2010, 19 (8-9) 514-531 10.1002/mats.201000033
    • (2010) Macromol. Theory Simul. , vol.19 , Issue.89 , pp. 514-531
    • Kizilel, S.1
  • 45
    • 5444223013 scopus 로고    scopus 로고
    • Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces
    • Kizilel, S.; Perez-Luna, V. H.; Teymour, F. Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces Langmuir 2004, 20 (20) 8652-8 10.1021/la0496744
    • (2004) Langmuir , vol.20 , Issue.20 , pp. 8652-8658
    • Kizilel, S.1    Perez-Luna, V.H.2    Teymour, F.3
  • 46
    • 33846015070 scopus 로고    scopus 로고
    • Mathematical model for surface-initiated photopolymerization of poly(ethylene glycol) diacrylate
    • Kizilel, S.; Perez-Luna, V. H.; Teymour, F. Mathematical model for surface-initiated photopolymerization of poly(ethylene glycol) diacrylate Macromol. Theory Simul. 2006, 15 (9) 686-700 10.1002/mats.200600030
    • (2006) Macromol. Theory Simul. , vol.15 , Issue.9 , pp. 686-700
    • Kizilel, S.1    Perez-Luna, V.H.2    Teymour, F.3
  • 47
    • 85015081856 scopus 로고    scopus 로고
    • Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets
    • Bal, T.; Nazli, C.; Okcu, A.; Duruksu, G.; Karaoz, E.; Kizilel, S. Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets J. Tissue Eng. Regener. Med. 2014, 10.1002/term.1965
    • (2014) J. Tissue Eng. Regener. Med.
    • Bal, T.1    Nazli, C.2    Okcu, A.3    Duruksu, G.4    Karaoz, E.5    Kizilel, S.6
  • 48
    • 84861220998 scopus 로고    scopus 로고
    • Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine ″click″ Chemistry at Room Temperature
    • Buruaga, L.; Pomposo, J. A. Metal-Free Polymethyl Methacrylate (PMMA) Nanoparticles by Enamine ″Click″ Chemistry at Room Temperature Polymers 2011, 3 (4) 1673-1683 10.3390/polym3041673
    • (2011) Polymers , vol.3 , Issue.4 , pp. 1673-1683
    • Buruaga, L.1    Pomposo, J.A.2
  • 49
    • 33344472484 scopus 로고    scopus 로고
    • Synthesis, preparation, and conformation of stimulus-responsive end-grafted poly(methacrylic acid-g-ethylene glycol) layers
    • Ye, M.; Zhang, D.; Han, L.; Tejada, J.; Ortiz, C. Synthesis, preparation, and conformation of stimulus-responsive end-grafted poly(methacrylic acid-g-ethylene glycol) layers Soft Matter 2006, 2 (3) 243-256 10.1039/b510894b
    • (2006) Soft Matter , vol.2 , Issue.3 , pp. 243-256
    • Ye, M.1    Zhang, D.2    Han, L.3    Tejada, J.4    Ortiz, C.5
  • 50
    • 41549148288 scopus 로고    scopus 로고
    • Hydrogels in drug delivery: Progress and challenges
    • Hoare, T. R.; Kohane, D. S. Hydrogels in drug delivery: Progress and challenges Polymer 2008, 49 (8) 1993-2007 10.1016/j.polymer.2008.01.027
    • (2008) Polymer , vol.49 , Issue.8 , pp. 1993-2007
    • Hoare, T.R.1    Kohane, D.S.2
  • 51
    • 34247581349 scopus 로고    scopus 로고
    • Drug release from pH-responsive thermogelling pentablock copolymers
    • Determan, M. D.; Cox, J. P.; Mallapragada, S. K. Drug release from pH-responsive thermogelling pentablock copolymers J. Biomed. Mater. Res., Part A 2007, 81A (2) 326-333 10.1002/jbm.a.30991
    • (2007) J. Biomed. Mater. Res., Part A , vol.81 , Issue.2 , pp. 326-333
    • Determan, M.D.1    Cox, J.P.2    Mallapragada, S.K.3
  • 52
    • 84859105839 scopus 로고    scopus 로고
    • Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system
    • Giray, S.; Bal, T.; Kartal, A. M.; Kizilel, S.; Erkey, C. Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system J. Biomed. Mater. Res., Part A 2012, 100 (5) 1307-1315 10.1002/jbm.a.34056
    • (2012) J. Biomed. Mater. Res., Part A , vol.100 , Issue.5 , pp. 1307-1315
    • Giray, S.1    Bal, T.2    Kartal, A.M.3    Kizilel, S.4    Erkey, C.5
  • 53
    • 0032697699 scopus 로고    scopus 로고
    • Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys
    • Kessler, R. C.; DuPont, R. L.; Berglund, P.; Wittchen, H. U. Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys Am. J. Psychiatry 1999, 156 (12) 1915-1923 10.1176/ajp.156.12.1915
    • (1999) Am. J. Psychiatry , vol.156 , Issue.12 , pp. 1915-1923
    • Kessler, R.C.1    DuPont, R.L.2    Berglund, P.3    Wittchen, H.U.4
  • 54
    • 27644559080 scopus 로고    scopus 로고
    • Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels
    • Chivukula, P.; Dusek, K.; Wang, D.; Duskova-Smrckova, M.; Kopeckova, P.; Kopecek, J. Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels Biomaterials 2006, 27 (7) 1140-1151 10.1016/j.biomaterials.2005.07.020
    • (2006) Biomaterials , vol.27 , Issue.7 , pp. 1140-1151
    • Chivukula, P.1    Dusek, K.2    Wang, D.3    Duskova-Smrckova, M.4    Kopeckova, P.5    Kopecek, J.6
  • 55
    • 43449127183 scopus 로고    scopus 로고
    • New insight into modified release pellets - Internal structure and drug release mechanism
    • Ensslin, S.; Moll, K. P.; Paulus, K.; Mader, K. New insight into modified release pellets-Internal structure and drug release mechanism J. Controlled Release 2008, 128 (2) 149-156 10.1016/j.jconrel.2008.02.015
    • (2008) J. Controlled Release , vol.128 , Issue.2 , pp. 149-156
    • Ensslin, S.1    Moll, K.P.2    Paulus, K.3    Mader, K.4
  • 56
    • 77649216630 scopus 로고    scopus 로고
    • Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents
    • Betancourt, T.; Pardo, J.; Soo, K.; Peppas, N. A. Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents J. Biomed. Mater. Res., Part A 2010, 93 (1) 175-188 10.1002/jbm.a.32510
    • (2010) J. Biomed. Mater. Res., Part A , vol.93 , Issue.1 , pp. 175-188
    • Betancourt, T.1    Pardo, J.2    Soo, K.3    Peppas, N.A.4
  • 57
    • 84958767452 scopus 로고    scopus 로고
    • Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX
    • Horava, S. D.; Peppas, N. A. Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX Ann. Biomed. Eng. 2016, 44 (6) 1970-1982 10.1007/s10439-016-1566-x
    • (2016) Ann. Biomed. Eng. , vol.44 , Issue.6 , pp. 1970-1982
    • Horava, S.D.1    Peppas, N.A.2
  • 58
    • 84879504285 scopus 로고    scopus 로고
    • PH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics
    • Schoener, C. A.; Hutson, H. N.; Peppas, N. A. pH-responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics J. Biomed. Mater. Res., Part A 2013, 101 (8) 2229-2236 10.1002/jbm.a.34532
    • (2013) J. Biomed. Mater. Res., Part A , vol.101 , Issue.8 , pp. 2229-2236
    • Schoener, C.A.1    Hutson, H.N.2    Peppas, N.A.3
  • 59
    • 11144221611 scopus 로고    scopus 로고
    • Compatibility of mammalian cells on surfaces of poly(dimethylsiloxane)
    • Lee, J. N.; Jiang, X.; Ryan, D.; Whitesides, G. M. Compatibility of mammalian cells on surfaces of poly(dimethylsiloxane) Langmuir 2004, 20 (26) 11684-11691 10.1021/la048562+
    • (2004) Langmuir , vol.20 , Issue.26 , pp. 11684-11691
    • Lee, J.N.1    Jiang, X.2    Ryan, D.3    Whitesides, G.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.