Trauma-associated hyperfibrinolysis

Hamostaseologie

Volumn 32, Issue 1, 2012, Pages 22-27

  Schochl H ^a,b   Voelckel, W ^b   Maegele, M ^c   Solomon, C ^d  

^a LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^b AUVA Trauma Centre   (Austria)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

^d UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Hyperfibrinolysis; ROTEM; TEG; Tranexamic acid; Trauma

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

BLEEDING DISORDER; BLOOD CLOTTING DISORDER; CLINICAL FEATURE; EARLY INTERVENTION; EMERGENCY HEALTH SERVICE; FIBRINOLYSIS; FIBRINOLYTIC THERAPY; HUMAN; HYPERFIBRINOLYSIS; INJURY; INJURY SEVERITY; MORBIDITY; MORTALITY; PATHOPHYSIOLOGY; REVIEW; TISSUE INJURY; TRAUMATIC BRAIN INJURY; TREATMENT PLANNING; VISCOELASTICITY;

BLOOD COAGULATION DISORDERS; CAUSALITY; COMORBIDITY; EVIDENCE-BASED MEDICINE; GERMANY; HUMANS; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; SURVIVAL ANALYSIS; SURVIVAL RATE; WOUNDS AND INJURIES;

EID: 84861152315     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.5482/ha-1178     Document Type: Review

References (38)

1. Hunt B, Segal H. Hyperfibrinolysis. J Clin Pathol 1996; 49: 958.
2. Porte RJ, Bontempo FA, Knot EAR et al. Systemic effects of tPA associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation 1989; 47: 978-984.
3. Annecke T, Geisenberger T, Kürzl R et al. Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis 2010; 21: 95-100.
4. Teufelsbauer H, Proidl S, Havel M, Vukovich T. Early activation of haemostasis during cardiopulmonary bypass: evidence for thrombin mediated hyperfibrinolysis. Thromb Haemost 1992; 68: 250-252.
5. Vorweg M, Hartmann B, Knüttgen D et al. Management of fulminant fibrinolysis during abdominal aortic surgery. J Cardiothorac Vasc Anesth 2001; 15: 764-767.
6. Brohi K, Cohen MJ, Ganter MT et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007; 245: 812-818.
7. Gando S, Tedo I, Kubota M. Posttrauma coagulation and fibrinolysis. Crit Care Med 1992; 20: 594-600.
8. Cosgriff N, Moore EE, Sauaia A et al. Predicting lifethreatening coagulopathy in the massively transfused trauma patient: hypothermia and acidosis revisited. J Trauma 1997; 42: 857-861.
9. Meng ZH, Wolberg AS, Monroe DM III et al. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003; 55: 886-891.
10. Brohi K, Cohen MJ, Ganter MT et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008; 64: 1211-1217.
11. Floccard B, Rugeri L, Faure A et al. Early coagulopathy in trauma patients: An on-scene and hospital admission study. Injury 2010; 42: 697-701.
12. Schöchl H, Frietsch T, Pavelka M et al. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009; 67: 125-131.
13. Theusinger OM, Wanner GA, Emmert MY et al. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM®) is associated with higher mortality in patients with severe trauma. Anesth Analg 2011; DOI:10.1213/ANE.0b013e31822c183f.
14. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007; 3: 680-685.
15. Adelman B, Michelson AD, Losalzo J et al. Plasmin effect on platelet glycoprotein 1b-von Willebrand factor interactions. Blood 1985; 65: 32-40.
16. Sawamura A, Hayakawa M, Gando S et al. Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. Thromb Res 2009; 124: 608-613.
17. Hayakawa M, Sawamura A, Gando S et al. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Surgery 2011; 149: 221-230.
18. Eeckhoudt S, Latinne D, Lambert C, Hermans C. Diagnosis of hyperfibrinolysis: which test(s) should be used? J Thromb Haemost 2009; Supp2: PPMO-220.
19. Lang T, von Depka M. Possibilities and limitations of thrombelastometry/graphy. Hämostaseologie 2006; 26: S21-S29.
20. Urano T, Sakakibara K, Rydzewski A et al. Relationship between euglobulin clot lysis time and the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor 1. Thromb Res 1990; 63: 82-86.
21. Smith AA, Jacobson LJ, Miller BI et al. A new euglobulin clot lysis assay for global fibrinolysis. Thromb Res 2003; 112: 329-337.
22. Schöchl H, Solomon D, Voelckel W. Thromboelastometry in the perioperative setting. Neth J Crit Care 2010; 14: 23-31.
23. Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haematol 2005; 27: 81-89.
24. Spiel AO, Mayr FB, Firbas C. Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans. J Thromb Haemost 2006; 4: 411-416.
25. Schöchl H, Solomon C, Schulz A et al. Thrombo -elastometry (TEM®) Findings in disseminated intravascular coagulation in a pig model of endotoxinemia. Mol Med 2011; 17: 266-272.
26. Franz RC. ROTEM analysis: a significant advance in the field of rotational thrombelastography. S Afr J Surg 2009; 47: 2-6.
27. Robbie LA, Bennett B, Croll AM et al. Proteins of the fibrinolytic system in human thrombi. Thromb Haemost 1996; 71: 127-133.
28. Levrat A, Gros A, Rugeri L et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth 2008; 100: 792-797.
29. Carroll RC, Craft RM, Langdon RJ. Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res 2009; 154: 34-39.
30. Tauber H, Innerhofer P, Breitkopf R et al. Prevalence and impact of abnormal ROTEM® assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIATRE-TIC) study'. Br J Anaesth 2011; 10: 378-387.
31. Kashuk J, Moore E, Sawyer M et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg 2010; 252; 434-442.
32. Schöchl H, Solomon D, Traintinger S et al. Thromboelastometric (ROTEM) findings in patients suffering from isolated severe traumatic brain injury. J Neurotrauma 2011; doi:10.1089/neu.2010.1744.
33. Goodnight SH, Kenoyer G, Rapaport SI et al. Defibrination after brain-tissue destruction. N Engl J Med 1974; 290: 1043-1047.
34. Kushimoto S, Shibata Y, Yamamoto Y. Implications of fibrinogenolysis in patients with closed head injury. J Neurotrauma 2003; 20: 357-363.
35. Brenni M, Worn M, Brüesch M et al. Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. Acta Anaesthesiol Scand 2010; 54: 111-117.
36. Shakur H, Roberts I, Bautista R et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376: 23-32.
37. CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011; 377: 1096-1101.
38. Johansson PI, Ostrowski SR. Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation. Med Hypoth 2010; 75: 564-567.